Immunoglobulin Class Switching

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  Subject Areas on Research

  • AID expression during B-cell development: searching for answers. 
  • Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma. 
  • Alterations of the B-cell response by HIV-1 replication. 
  • Critical role for mouse marginal zone B cells in PF4/heparin antibody production. 
  • Disparity in the kinetics of onset of hypermutation in immunoglobulin heavy and light chains. 
  • Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification. 
  • Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination. 
  • Forced expression of AID facilitates the isolation of class switch variants from hybridoma cells. 
  • Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination. 
  • Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells. 
  • Hapten-induced primary and memory humoral responses are inhibited by the infusion of anti-CD20 monoclonal antibody (IDEC-C2B8, Rituximab). 
  • Identification of an activity in B-cell extracts that selectively impairs the formation of an immunoglobulin mu s poly(A) site processing complex. 
  • Immunization with the Haemophilus ducreyi trimeric autotransporter adhesin DsrA with alum, CpG or imiquimod generates a persistent humoral immune response that recognizes the bacterial surface. 
  • Immunoglobulin class switch recombination in chronic lymphocytic leukemia. 
  • Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination. 
  • Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. 
  • PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance. 
  • Plexin-D1 is a novel regulator of germinal centers and humoral immune responses. 
  • Role of JAK3 in CD40-mediated signaling. 
  • T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells. 
  • The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation. 
  • The GS Protein-coupled A2a Adenosine Receptor Controls T Cell Help in the Germinal Center. 
  • The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus. 
  • Type I IFN signaling on both B and CD4 T cells is required for protective antibody response to adenovirus. 
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  Keywords of People

  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor of Pediatrics, in the School of Medicine, Immunology