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Subject Areas on Research
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25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner.
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A Brief Discussion on Lipid Activated Nuclear Receptors and their Potential Role in Regulating Microglia in Age-Related Macular Degeneration (AMD).
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A Combination of Ontogeny and CNS Environment Establishes Microglial Identity.
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A human pluripotent stem cell platform for assessing developmental neural toxicity screening.
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A neurovascular-unit-on-a-chip for the evaluation of the restorative potential of stem cell therapies for ischaemic stroke.
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A possible mechanism underlying mood disorders associated with LUTS: Chronic bladder outlet obstruction causes NLRP3-dependent inflammation in the hippocampus and depressive behavior in rats.
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AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia.
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APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress.
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APOE genotype-specific differences in human and mouse macrophage nitric oxide production.
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APOE genotype-specific differences in the innate immune response.
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Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity.
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Activated human microglia produce the excitotoxin quinolinic acid.
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Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside.
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Activation of p38 mitogen-activated protein kinase in spinal microglia contributes to incision-induced mechanical allodynia.
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Adolescent morphine exposure affects long-term microglial function and later-life relapse liability in a model of addiction.
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Agathisflavone isolated from Anacardium occidentale suppresses SIRT1-mediated neuroinflammation in BV2 microglia and neurotoxicity in APPSwe-transfected SH-SY5Y cells.
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Alterations in brain TREM2 and Amyloid-β levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy.
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An apoE-derived mimic peptide, COG1410, alleviates early brain injury via reducing apoptosis and neuroinflammation in a mouse model of subarachnoid hemorrhage.
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An apolipoprotein E-based therapeutic improves outcome and reduces Alzheimer's disease pathology following closed head injury: evidence of pharmacogenomic interaction.
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Androgen-mediated immune function is altered by the apolipoprotein E gene.
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Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia.
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Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia Through Nrf2-Dependent Mechanisms.
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ApoE mimetic ameliorates motor deficit and tissue damage in rat spinal cord injury.
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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
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Apolipoprotein E Exerts a Whole-Brain Protective Property by Promoting M1? Microglia Quiescence After Experimental Subarachnoid Hemorrhage in Mice.
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Apolipoprotein E isoform mediated regulation of nitric oxide release.
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Apolipoprotein E mimetic peptide CN-105 improves outcome in a murine model of SAH.
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Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response.
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Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma.
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Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease.
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Assessing activation states in microglia.
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Beyond infection - Maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders.
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Blood-derived macrophages infiltrate the retina and activate Muller glial cells under experimental choroidal neovascularization.
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Brain Tumor Microenvironment and Host State: Implications for Immunotherapy.
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CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells.
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CNS inflammation and bone marrow neuropathy in type 1 diabetes.
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COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury.
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Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities.
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Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain.
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Central immune overactivation in the presence of reduced plasma corticosterone contributes to swim stress-induced hyperalgesia.
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Characterization of NO and cytokine production in immune-activated microglia and peritoneal macrophages derived from a mouse model expressing the human NOS2 gene on a mouse NOS2 knockout background.
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Complement activation contributes to perioperative neurocognitive disorders in mice.
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Control protocol for robust in vitro glial scar formation around microwires: essential roles of bFGF and serum in gliosis.
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Controlled release of anti-inflammatory agent alpha-MSH from neural implants.
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Correlates and Predictors of Cerebrospinal Fluid Cholesterol Efflux Capacity from Neural Cells, a Family of Biomarkers for Cholesterol Epidemiology in Alzheimer's Disease.
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Cyclophosphamide-induced cystitis results in NLRP3-mediated inflammation in the hippocampus and symptoms of depression in rats.
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Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq.
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Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction.
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Delayed activation of spinal microglia contributes to the maintenance of bone cancer pain in female Wistar rats via P2X7 receptor and IL-18.
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Dexamethasone-coated neural probes elicit attenuated inflammatory response and neuronal loss compared to uncoated neural probes.
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Dietary fat: a potent microglial influencer.
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Different immune cells mediate mechanical pain hypersensitivity in male and female mice.
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Differential CD4/CCR5 utilization, gp120 conformation, and neutralization sensitivity between envelopes from a microglia-adapted human immunodeficiency virus type 1 and its parental isolate.
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Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice.
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Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain.
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Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides.
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Dramatic increase in autism prevalence parallels explosion of research into its biology and causes.
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ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model.
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Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression.
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Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors.
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Emerging Role of PD-1 in the Central Nervous System and Brain Diseases.
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Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production.
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Endogenous opioids and HIV infection.
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Engineering Controlled Peritumoral Inflammation to Constrain Brain Tumor Growth.
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Environment matters: microglia function and dysfunction in a changing world.
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Environmental enrichment alters glial antigen expression and neuroimmune function in the adult rat hippocampus.
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Ethanol induced changes in superoxide anion and nitric oxide in cultured microglia.
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Evaluation of M2-like macrophage enrichment after diffuse traumatic brain injury through transient interleukin-4 expression from engineered mesenchymal stromal cells.
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Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion.
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FACS analysis of neuronal-glial interactions in the nucleus accumbens following morphine administration.
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Fate Mapping In Vivo to Distinguish Bona Fide Microglia Versus Recruited Monocyte-Derived Macrophages in Retinal Disease.
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Fate mapping reveals that microglia and recruited monocyte-derived macrophages are definitively distinguishable by phenotype in the retina.
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Frank A. Beach award: programming of neuroendocrine function by early-life experience: a critical role for the immune system.
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Function of microglia in organotypic slice cultures.
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Gene and protein expression pilot profiling and biomarkers in an experimental mouse model of hypertensive glaucoma.
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Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity.
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Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse.
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Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production.
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Got worms? Perinatal exposure to helminths prevents persistent immune sensitization and cognitive dysfunction induced by early-life infection.
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Gut-microbiota-microglia-brain interactions in Alzheimer's disease: knowledge-based, multi-dimensional characterization.
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HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration.
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Heterogeneity of microglial activation in the innate immune response in the brain.
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Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice.
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Human pluripotent stem cell-derived neural constructs for predicting neural toxicity.
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Human umbilical cord blood monocytes, but not adult blood monocytes, rescue brain cells from hypoxic-ischemic injury: Mechanistic and therapeutic implications.
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IKKβ and mutant huntingtin interactions regulate the expression of IL-34: implications for microglial-mediated neurodegeneration in HD.
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INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice.
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Identification of a Unique Subretinal Microglia Type in Retinal Degeneration Using Single Cell RNA-Seq.
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Immune cells in the retina and choroid: Two different tissue environments that require different defenses and surveillance.
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Immune heterogeneity in neuroinflammation: dendritic cells in the brain.
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Immunobiology of malignant astrocytomas.
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In vivo single microglial cell isolation after intracerebral hemorrhage in mice.
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Increased miR-124-3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons.
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Increases in miR-124-3p in Microglial Exosomes Confer Neuroprotective Effects by Targeting FIP200-Mediated Neuronal Autophagy Following Traumatic Brain Injury.
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Induction of Autophagy and Activation of SIRT-1 Deacetylation Mechanisms Mediate Neuroprotection by the Pomegranate Metabolite Urolithin A in BV2 Microglia and Differentiated 3D Human Neural Progenitor Cells.
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Induction of nitric oxide in cultured microglia: evidence for a cytoprotective role.
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Induction of superoxide anion and nitric oxide production in cultured microglia.
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Inhibition of microglial superoxide anion production by isoproterenol and dexamethasone.
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Inhibition of neuroinflammation by thymoquinone requires activation of Nrf2/ARE signalling.
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Inhibition of neuroinflammation in BV2 microglia by the biflavonoid kolaviron is dependent on the Nrf2/ARE antioxidant protective mechanism.
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Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke.
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Interaction of NG2(+) glial progenitors and microglia/macrophages from the injured spinal cord.
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Intrathecal administration of antisense oligonucleotide against p38α but not p38β MAP kinase isoform reduces neuropathic and postoperative pain and TLR4-induced pain in male mice.
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Intravenous immunoglobulin G improves neurobehavioral and histological outcomes after traumatic brain injury in mice.
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Isolation of Microglia from Mouse or Human Tissue.
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K+ modulation of microglial superoxide production: involvement of voltage-gated Ca2+ channels.
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KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.
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LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes.
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LRRK2 inhibition attenuates microglial inflammatory responses.
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Lacosamide improves outcome in a murine model of traumatic brain injury.
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Large A-fiber activity is required for microglial proliferation and p38 MAPK activation in the spinal cord: different effects of resiniferatoxin and bupivacaine on spinal microglial changes after spared nerve injury.
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Large-scale death of retinal astrocytes during normal development is non-apoptotic and implemented by microglia.
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Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection.
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Long-term male-specific chronic pain via telomere- and p53‑mediated spinal cord cellular senescence.
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M1 and M2 immune activation in Parkinson's Disease: Foe and ally?
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Maternal stress and effects of prenatal air pollution on offspring mental health outcomes in mice.
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Microglia Drive Pockets of Neuroinflammation in Middle Age.
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Microglia Promote Increased Pain Behavior through Enhanced Inflammation in the Spinal Cord during Repeated Social Defeat Stress.
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Microglia Sculpt Sex Differences in Social Behavior.
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Microglia and Sensitive Periods in Brain Development.
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Microglia and memory: modulation by early-life infection.
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Microglia and sexual differentiation of the developing brain: A focus on ontogeny and intrinsic factors.
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Microglia and spinal cord synaptic plasticity in persistent pain.
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Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma.
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Microglia are not exclusively associated with plaque-rich regions of the dentate gyrus in Alzheimer's disease.
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Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model.
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Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain.
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Microglia states and nomenclature: A field at its crossroads.
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Microglia versus Monocytes: Distinct Roles in Degenerative Diseases of the Retina.
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Microglia-mediated degradation of perineuronal nets promotes pain.
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Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance.
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Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration.
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Microglial Signaling in Chronic Pain with a Special Focus on Caspase 6, p38 MAP Kinase, and Sex Dependence.
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Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.
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Microglial contribution to oxidative stress in Alzheimer's disease.
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Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats.
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Microglial function in human APOE3 and APOE4 transgenic mice: altered arginine transport.
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Microglial oxyradical production: causes and consequences.
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Microglial-neuronal interactions during neurodegenerative diseases.
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Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation/phagocytosis.
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Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells.
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Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.
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NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data.
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Neonatal immune challenge induces female-specific changes in social behavior and somatostatin cell number.
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Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model.
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Neuroimmunology in 2017: The central nervous system: privileged by immune connections.
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Neuroinflammation and behavioral abnormalities after neonatal terbutaline treatment in rats: implications for autism.
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Neuroinflammation in Alzheimer's disease.
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Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury.
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Neuronal vulnerability and multilineage diversity in multiple sclerosis.
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Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.
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New concepts in macrophage ontogeny in the adult neural retina.
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New tools for studying microglia in the mouse and human CNS.
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Optimized solubilization of TRIzol-precipitated protein permits Western blotting analysis to maximize data available from brain tissue.
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Overcoming endogenous constraints on neuronal regeneration
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Peripheral blood detection of systemic graft-specific xeno-antibodies following transplantation of human neural progenitor cells into the porcine spinal cord.
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Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia.
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Persistent postoperative pain: mechanisms and modulators.
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Placental Macrophages: A Window Into Fetal Microglial Function in Maternal Obesity.
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Positive feedback loop of autocrine BDNF from microglia causes prolonged microglia activation.
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Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner.
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Prenatal environmental stressors impair postnatal microglia function and adult behavior in males.
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Prenatal opioid exposure inhibits microglial sculpting of the dopamine system selectively in adolescent male offspring.
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Primetime for microglia: When stress and infection collide.
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Prophylactic treatment with CN-105 improves functional outcomes in a murine model of closed head injury.
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Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes.
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Punicalagin inhibits neuroinflammation in LPS-activated rat primary microglia.
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Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse.
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Quantitative 1H magnetic resonance spectroscopic imaging determines therapeutic immunization efficacy in an animal model of Parkinson's disease.
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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
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Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice.
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Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice.
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Removal of microglial-specific MyD88 signaling alters dentate gyrus doublecortin and enhances opioid addiction-like behaviors.
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Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels.
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Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury.
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Retinal pigment epithelium and microglia express the CD5 antigen-like protein, a novel autoantigen in age-related macular degeneration.
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Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine.
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Sex differences in microglial appetites during development: Inferences and implications.
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Sex differences in microglial colonization of the developing rat brain.
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Sex differences in neurodevelopmental and neurodegenerative disorders: Focus on microglial function and neuroinflammation during development.
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Sex steroids, APOE genotype and the innate immune system.
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Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes.
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Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain.
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Single-cell genomics identifies cell type-specific molecular changes in autism.
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Single-cell transcriptomic analysis of the immune cell landscape in the aged mouse brain after ischemic stroke.
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Species differences in the generation of reactive oxygen species by microglia.
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Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord.
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Sustained stimulation of β2- and β3-adrenergic receptors leads to persistent functional pain and neuroinflammation.
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Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retina.
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T cell engagement of cross-presenting microglia protects the brain from a nasal virus infection.
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T-Cell Mediation of Pregnancy Analgesia Affecting Chronic Pain in Mice.
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TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage.
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TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and neuroinflammation.
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TT-301 inhibits microglial activation and improves outcome after central nervous system injury in adult mice.
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Targeting Hv1 proton channel for pain control.
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Targeting microglia to mitigate perioperative neurocognitive disorders.
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Targeting microglial purinergic signaling to improve morphine analgesia.
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Th17 lymphocytes drive vascular and neuronal deficits in a mouse model of postinfectious autoimmune encephalitis.
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The APOE4 genotype alters the response of microglia and macrophages to 17beta-estradiol.
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The brain's immune system.
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The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders.
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The diverse culinary habits of microglia.
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The effect of inflammatory cell-derived MCP-1 loss on neuronal survival during chronic neuroinflammation.
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The effect of intrathecal administration of glial activation inhibitors on dorsal horn BDNF overexpression and hind paw mechanical allodynia in spinal nerve ligated rats.
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The immune system and developmental programming of brain and behavior.
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The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction.
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The tiliroside derivative, 3-O-[(E)-(2-oxo-4-(p-tolyl) but-3-en-1-yl] kaempferol produced inhibition of neuroinflammation and activation of AMPK and Nrf2/HO-1 pathways in BV-2 microglia.
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The upregulation of specific interleukin (IL) receptor antagonists and paradoxical enhancement of neuronal apoptosis due to electrode induced strain and brain micromotion.
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Transcriptome analysis of cortical tissue reveals shared sets of downregulated genes in autism and schizophrenia.
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Traumatic Brain Injury Causes Chronic Cortical Inflammation and Neuronal Dysfunction Mediated by Microglia.
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Traumatic brain injury-induced neuronal damage in the somatosensory cortex causes formation of rod-shaped microglia that promote astrogliosis and persistent neuroinflammation.
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Updating Neuroimmune Targets in Central Nervous System Dysfunction.
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beta-Endorphin enhances the replication of neurotropic human immunodeficiency virus in fetal perivascular microglia.
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miR-21 improves the neurological outcome after traumatic brain injury in rats.
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p38 MAPK, microglial signaling, and neuropathic pain.
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p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain.
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α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration.
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Keywords of People
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Bilbo, Staci D.,
Haley Family Professor of Psycology and Neuroscience,
Psychology & Neuroscience
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Ferreira, Paulo Alexandre,
Associate Professor in Ophthalmology,
Pathology
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James, Michael Lucas,
Associate Professor of Anesthesiology,
Anesthesiology
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Nackley, Andrea Gail,
Associate Professor in Anesthesiology,
Pharmacology & Cancer Biology
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Savage, Justin,
Student,
Neurobiology
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Shinohara, Mari L.,
Associate Professor of Immunology,
Cell Biology
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Terrando, Niccolò,
Associate Professor of Anesthesiology,
Cell Biology
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West, Andrew Bradley,
Professor of Pharmacology and Cancer Biology,
Cell Biology