Gap Junctions

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  Subject Areas on Research

  • A biophysical model for cardiac microimpedance measurements. 
  • A microstructural model of reentry arising from focal breakthrough at sites of source-load mismatch in a central region of slow conduction. 
  • Altering the topology of gap junctions a major therapeutic target for atrial fibrillation. 
  • Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. 
  • Autoregulation and conduction of vasomotor responses in a mathematical model of the rat afferent arteriole. 
  • Cell size and communication: role in structural and electrical development and remodeling of the heart. 
  • Changes in anisotropic conduction caused by remodeling cell size and the cellular distribution of gap junctions and Na(+) channels. 
  • Characterizing the Bladder's Response to Onabotulinum Toxin Type A Using a Rat Model. 
  • Connexin 39.9 protein is necessary for coordinated activation of slow-twitch muscle and normal behavior in zebrafish. 
  • Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis. 
  • Effect of gap junction distribution on impulse propagation in a monolayer of myocytes: a model study. 
  • Effects of electroporation on transmembrane potential induced by defibrillation shocks. 
  • Electric field stimulation of excitable tissue. 
  • Electrophysiological effects of remodeling cardiac gap junctions and cell size: experimental and model studies of normal cardiac growth. 
  • Electrotonic loading of anisotropic cardiac monolayers by unexcitable cells depends on connexin type and expression level. 
  • Feasibility of cardiac microimpedance measurement using multisite interstitial stimulation. 
  • Fiber cell morphology and cytoplasmic texture in cataractous and normal human lens nuclei. 
  • Gap Junctions Contribute to Differential Light Adaptation across Direction-Selective Retinal Ganglion Cells. 
  • Heptanol but not fluoroacetate prevents the propagation of spreading depression in rat hippocampal slices. 
  • High-sensitivity rod photoreceptor input to the blue-yellow color opponent pathway in macaque retina. 
  • Increased interstitial loading reduces the effect of microstructural variations in cardiac tissue. 
  • Influence of dynamic gap junction resistance on impulse propagation in ventricular myocardium: a computer simulation study. 
  • Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: insights from a microstructure model. 
  • Minding the gap: connexin 40 at the heart of renin release. 
  • Neuropeptides modulate compound postsynaptic potentials in basolateral amygdala. 
  • Prolonged dark adaptation changes connexin expression in the mouse retina. 
  • Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme. 
  • Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons. 
  • Regulation of endothelial cell adherens junctions by a Ras-dependent signal transduction pathway. 
  • Regulation of neuronal axon specification by glia-neuron gap junctions in C. elegans. 
  • Spatial profiles of electrical mismatch determine vulnerability to conduction failure across a host-donor cell interface. 
  • The effect of stimulus pulse duration on selectivity of neural stimulation. 
  • The shunt problem: control of functional shunting in normal and tumour vasculature. 
  • Tumor-induced loss of mural Connexin 43 gap junction activity promotes endothelial proliferation. 
  • Tyrosine-dependent basolateral targeting of human connexin43-eYFP in Madin-Darby canine kidney cells can be disrupted by the oculodentodigital dysplasia mutation L90V. 
  • Ultrastructural analysis of the human lens fiber cell remodeling zone and the initiation of cellular compaction. 
  • Unidirectional block in a computer model of partially coupled segments of cardiac Purkinje tissue. 
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  Keywords of People

  • Henriquez, Craig S., Professor of Biomedical Engineering, Pratt School of Engineering
  • Starmer, Charles Franklin, Professor Emeritus of Computer Science, Computer Science