Clonal Deletion

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  Subject Areas on Research

  • Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice. 
  • An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. 
  • CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells. 
  • Genetic elimination of α3(IV) collagen fails to rescue anti-collagen B cells. 
  • Involvement of multiple factors in the clonal deletion of self-reactive T cells. 
  • Kappa editing rescues autoreactive B cells destined for deletion in mice transgenic for a dual specific anti-laminin Ig. 
  • Lack of galectin-1 or galectin-3 alters B cell deletion and anergy in an autoantibody transgene model. 
  • Orphan nuclear receptors in T lymphocyte development. 
  • Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs. 
  • T cell-mediated elimination of B7.2 transgenic B cells. 
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  Keywords of People

  • Chen, Jun, Professor of Medicine, Duke Cancer Institute