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Subject Areas on Research
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A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity.
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A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate.
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A futile metabolic cycle activated in adipocytes by antidiabetic agents.
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A new strategy for studying protein kinase B and its three isoforms. Role of protein kinase B in phosphorylating glycogen synthase kinase-3, tuberin, WNK1, and ATP citrate lyase.
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A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism.
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Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice.
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Adipocyte Xbp1s overexpression drives uridine production and reduces obesity.
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Adipocyte mesenchymal transition contributes to mammary tumor progression.
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Adipocytes.
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Adipogenic and lipolytic effects of chronic glucocorticoid exposure.
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Adipogenic differentiation of adipose tissue-derived human mesenchymal stem cells: effect of gastric bypass surgery.
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Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration.
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Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis.
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Adipose-derived adult stem cells for cartilage tissue engineering.
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Adrenoceptors, uncoupling proteins, and energy expenditure.
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Adult adipose-derived stem cell attachment to biomaterials.
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An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents.
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Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology.
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Apolipoprotein E knock-out and knock-in mice: atherosclerosis, metabolic syndrome, and beyond.
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Association of protein kinase C(lambda) with adducin in 3T3-L1 adipocytes.
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BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation.
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Bicarbonate alters cellular responses in respiration assays.
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Biomimetic Surface Patterning Promotes Mesenchymal Stem Cell Differentiation.
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Body weight and fat deposition in prolactin receptor-deficient mice.
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CD10 marks non-canonical PPARγ-independent adipocyte maturation and browning potential of adipose-derived stem cells.
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Cell-autonomous adiposity through increased cell surface GLUT4 due to ankyrin-B deficiency.
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Changes in blubber distribution and morphology associated with starvation in the harbor porpoise (Phocoena phocoena): evidence for regional differences in blubber structure and function.
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Characterization of Adipogenic Chemicals in Three Different Cell Culture Systems: Implications for Reproducibility Based on Cell Source and Handling.
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Characterization of a canine model of glycogen storage disease type IIIa.
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Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy.
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Combined bone allograft and adipose-derived stem cell autograft in a rabbit model.
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Comparison of the Viability and Yield of Adipose-Derived Stem Cells (ASCs) from Different Donor Areas.
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Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment.
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De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity.
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Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity.
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Deletion of angiotensin II type 2 receptor accelerates adipogenesis in murine mesenchymal stem cells via Wnt10b/beta-catenin signaling.
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Depressed expression of adipocyte beta-adrenergic receptors is a common feature of congenital and diet-induced obesity in rodents.
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Determination of estrogen receptor messenger ribonucleic acid (mRNA) and cytochrome P450 aromatase mRNA levels in adipocytes and adipose stromal cells by competitive polymerase chain reaction amplification.
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Developmental origins and environmental influences--Introduction. NIEHS symposium.
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Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes.
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Differences in the estrogen content of breast adipose tissue in women by menopausal status and hormone use.
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Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation.
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Discovery of an inhibitor of insulin-like growth factor 1 receptor activation: implications for cellular potency and selectivity over insulin receptor.
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Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations.
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Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator.
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Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation.
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Do Adipocytes Emerge from Mural Progenitors?
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Dwarfism and increased adiposity in the gh1 mutant zebrafish vizzini.
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Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytes.
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Effect of a Low-Rank Denoising Algorithm on Quantitative Magnetic Resonance Imaging-Based Measures of Liver Fat and Iron.
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Exercise and Diet: Uncovering Prospective Mediators of Skeletal Fragility in Bone and Marrow Adipose Tissue.
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Exercise to Mend Aged-tissue Crosstalk in Bone Targeting Osteoporosis & Osteoarthritis.
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Exploratory secondary analyses of a cognitive-behavioral intervention for knee osteoarthritis demonstrate reduction in biomarkers of adipocyte inflammation.
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FGF21-FGFR1 Coordinates Phospholipid Homeostasis, Lipid Droplet Function, and ER Stress in Obesity.
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Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis.
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Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter.
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Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony.
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High-content image informatics of the structural nuclear protein NuMA parses trajectories for stem/progenitor cell lineages and oncogenic transformation.
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Human Adipose-Derived Stem Cells Labeled with Plasmonic Gold Nanostars for Cellular Tracking and Photothermal Cancer Cell Ablation.
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Hungry irony.
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Hypertrophic chondrocytes serve as a reservoir for marrow-associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development.
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Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice.
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Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes.
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Improved methodologies for the study of adipose biology: insights gained and opportunities ahead.
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In vitro assessment of human nuclear hormone receptor activity and cytotoxicity of the flame retardant mixture FM 550 and its triarylphosphate and brominated components.
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In vivo analysis of white adipose tissue in zebrafish.
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In vivo imaging and quantification of regional adiposity in zebrafish.
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Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation.
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Insulin activates a novel adipocyte mitogen-activated protein kinase kinase kinase that shows rapid phasic kinetics and is distinct from c-Raf.
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Insulin-triggered repositioning of munc18c on syntaxin-4 in GLUT4 signalling.
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Interferon regulatory factors are transcriptional regulators of adipogenesis.
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Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity.
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Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism.
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Ligand binding and activation of PPARγ by Firemaster® 550: effects on adipogenesis and osteogenesis in vitro.
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Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases.
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Lipoblastomatosis: case report and review of the literature.
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Liver X receptor is a regulator of orphan nuclear receptor NOR-1 gene transcription in adipocytes.
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Local renin angiotensin expression regulates human mesenchymal stem cell differentiation to adipocytes.
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Loss of pericyte smoothened activity in mice with genetic deficiency of leptin.
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Macrophage and adipocyte interaction as a source of inflammation in kidney disease.
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Making Biological Sense of GWAS Data: Lessons from the FTO Locus.
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Maximal beta3-adrenergic regulation of lipolysis involves Src and epidermal growth factor receptor-dependent ERK1/2 activation.
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Metabolic remodeling of human skeletal myocytes by cocultured adipocytes depends on the lipolytic state of the system.
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Mitochondrial GLUT10 facilitates dehydroascorbic acid import and protects cells against oxidative stress: mechanistic insight into arterial tortuosity syndrome.
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Molecular diffusion in tissue-engineered cartilage constructs: effects of scaffold material, time, and culture conditions.
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Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation.
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Multilayered electrospun scaffolds for tendon tissue engineering.
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Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity.
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Myolipoma of the eyelid.
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Nanoparticle engineered TRAIL-overexpressing adipose-derived stem cells target and eradicate glioblastoma via intracranial delivery.
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Necdin-E2F4 interaction provides insulin-sensitizing effect after weight loss induced by gastric bypass surgery.
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New genetic loci link adipose and insulin biology to body fat distribution.
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Nonionic Ethoxylated Surfactants Induce Adipogenesis in 3T3-L1 Cells.
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Nuclear hormone receptor LXRα inhibits adipocyte differentiation of mesenchymal stem cells with Wnt/beta-catenin signaling.
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Ontogeny and nutritional control of adipogenesis in zebrafish (Danio rerio).
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Open Chromatin Profiling in Adipose Tissue Marks Genomic Regions with Functional Roles in Cardiometabolic Traits.
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Optical spectral surveillance of breast tissue landscapes for detection of residual disease in breast tumor margins.
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PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity.
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PHAS-I as a link between mitogen-activated protein kinase and translation initiation.
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PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells.
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Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats. II. Effects on lipolysis, glucose production, and liver acyl-CoA profile.
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Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity.
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Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice.
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Perivascular Fibro-Adipogenic Progenitor Tracing during Post-Traumatic Osteoarthritis.
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Permanent Cutaneous Adverse Events After Injection With Deoxycholic Acid.
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Peroxisome Proliferator-Activated Receptor γ and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization.
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Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes.
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Phosphorylation of the translational regulator, PHAS-I, by protein kinase CK2.
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Poly(ethylene glycol) hydrogel system supports preadipocyte viability, adhesion, and proliferation.
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RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro.
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Regeneration of fat cells from myofibroblasts during wound healing.
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Regulation of early adipose commitment by Zfp521.
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Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines.
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Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis.
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Relationship between adipose stromal-vascular cells and adipocytes in human adipose tissue.
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Reproducibility of adipogenic responses to metabolism disrupting chemicals in the 3T3-L1 pre-adipocyte model system: An interlaboratory study.
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Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease.
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Response of adipose tissue to early infection with Trypanosoma cruzi (Brazil strain).
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Reversing adipocyte differentiation: implications for treatment of obesity.
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Role of transcription factor NFAT in glucose and insulin homeostasis.
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Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
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Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury.
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Stem cell differentiation indicated by noninvasive photonic characterization and fractal analysis of subcellular architecture.
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Stem cell therapy for neurologic disorders: therapeutic potential of adipose-derived stem cells.
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Strain-specific response to beta 3-adrenergic receptor agonist treatment of diet-induced obesity in mice.
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Succination of Protein Disulfide Isomerase Links Mitochondrial Stress and Endoplasmic Reticulum Stress in the Adipocyte During Diabetes.
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Surface protein characterization of human adipose tissue-derived stromal cells.
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TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism.
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TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis.
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The beta3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism.
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The expanding problem of adipose depot remodeling and postnatal adipocyte progenitor recruitment.
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The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPARγ activation, in 3T3-L1 cells.
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Thyroid receptor antagonism as a contributory mechanism for adipogenesis induced by environmental mixtures in 3T3-L1 cells.
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Time-restricted feeding mitigates obesity through adipocyte thermogenesis.
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Tissue engraftment of hypoxic-preconditioned adipose-derived stem cells improves flap viability.
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Transcriptional brakes on the road to adipocyte thermogenesis.
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Transgenic ω-3 PUFA enrichment alters morphology and gene expression profile in adipose tissue of obese mice: Potential role for protectins.
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Tγδ17 cells build up the nerve.
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Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells.
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Visceral Adipose Tissue Mesothelial Cells: Living on the Edge or Just Taking Up Space?
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Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes.
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X-ray crystallographic analysis of adipocyte fatty acid binding protein (aP2) modified with 4-hydroxy-2-nonenal.
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Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells.
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beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase.
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beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.
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p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
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Keywords of People
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Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
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Freemark, Michael Scott,
Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine,
Pediatrics, Endocrinology
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Gupta, Rana K.,
Professor in Medicine,
Cell Biology