Adipocytes

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  Subject Areas on Research

  • A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity. 
  • A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. 
  • A futile metabolic cycle activated in adipocytes by antidiabetic agents. 
  • A new strategy for studying protein kinase B and its three isoforms. Role of protein kinase B in phosphorylating glycogen synthase kinase-3, tuberin, WNK1, and ATP citrate lyase. 
  • A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. 
  • Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice. 
  • Adipocyte Xbp1s overexpression drives uridine production and reduces obesity. 
  • Adipocyte mesenchymal transition contributes to mammary tumor progression. 
  • Adipocytes. 
  • Adipogenic and lipolytic effects of chronic glucocorticoid exposure. 
  • Adipogenic differentiation of adipose tissue-derived human mesenchymal stem cells: effect of gastric bypass surgery. 
  • Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration. 
  • Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis. 
  • Adipose-derived adult stem cells for cartilage tissue engineering. 
  • Adrenoceptors, uncoupling proteins, and energy expenditure. 
  • Adult adipose-derived stem cell attachment to biomaterials. 
  • An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents. 
  • Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology. 
  • Apolipoprotein E knock-out and knock-in mice: atherosclerosis, metabolic syndrome, and beyond. 
  • Association of protein kinase C(lambda) with adducin in 3T3-L1 adipocytes. 
  • BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation. 
  • Bicarbonate alters cellular responses in respiration assays. 
  • Biomimetic Surface Patterning Promotes Mesenchymal Stem Cell Differentiation. 
  • Body weight and fat deposition in prolactin receptor-deficient mice. 
  • CD10 marks non-canonical PPARγ-independent adipocyte maturation and browning potential of adipose-derived stem cells. 
  • Cell-autonomous adiposity through increased cell surface GLUT4 due to ankyrin-B deficiency. 
  • Changes in blubber distribution and morphology associated with starvation in the harbor porpoise (Phocoena phocoena): evidence for regional differences in blubber structure and function. 
  • Characterization of Adipogenic Chemicals in Three Different Cell Culture Systems: Implications for Reproducibility Based on Cell Source and Handling. 
  • Characterization of a canine model of glycogen storage disease type IIIa. 
  • Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy. 
  • Combined bone allograft and adipose-derived stem cell autograft in a rabbit model. 
  • Comparison of the Viability and Yield of Adipose-Derived Stem Cells (ASCs) from Different Donor Areas. 
  • Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. 
  • De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity. 
  • Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity. 
  • Deletion of angiotensin II type 2 receptor accelerates adipogenesis in murine mesenchymal stem cells via Wnt10b/beta-catenin signaling. 
  • Depressed expression of adipocyte beta-adrenergic receptors is a common feature of congenital and diet-induced obesity in rodents. 
  • Determination of estrogen receptor messenger ribonucleic acid (mRNA) and cytochrome P450 aromatase mRNA levels in adipocytes and adipose stromal cells by competitive polymerase chain reaction amplification. 
  • Developmental origins and environmental influences--Introduction. NIEHS symposium. 
  • Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes. 
  • Differences in the estrogen content of breast adipose tissue in women by menopausal status and hormone use. 
  • Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation. 
  • Discovery of an inhibitor of insulin-like growth factor 1 receptor activation: implications for cellular potency and selectivity over insulin receptor. 
  • Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations. 
  • Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator. 
  • Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation. 
  • Do Adipocytes Emerge from Mural Progenitors? 
  • Dwarfism and increased adiposity in the gh1 mutant zebrafish vizzini. 
  • Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytes. 
  • Effect of a Low-Rank Denoising Algorithm on Quantitative Magnetic Resonance Imaging-Based Measures of Liver Fat and Iron. 
  • Exercise and Diet: Uncovering Prospective Mediators of Skeletal Fragility in Bone and Marrow Adipose Tissue. 
  • Exercise to Mend Aged-tissue Crosstalk in Bone Targeting Osteoporosis & Osteoarthritis. 
  • Exploratory secondary analyses of a cognitive-behavioral intervention for knee osteoarthritis demonstrate reduction in biomarkers of adipocyte inflammation. 
  • FGF21-FGFR1 Coordinates Phospholipid Homeostasis, Lipid Droplet Function, and ER Stress in Obesity. 
  • Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis. 
  • Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter. 
  • Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. 
  • High-content image informatics of the structural nuclear protein NuMA parses trajectories for stem/progenitor cell lineages and oncogenic transformation. 
  • Human Adipose-Derived Stem Cells Labeled with Plasmonic Gold Nanostars for Cellular Tracking and Photothermal Cancer Cell Ablation. 
  • Hungry irony. 
  • Hypertrophic chondrocytes serve as a reservoir for marrow-associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development. 
  • Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice. 
  • Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes. 
  • Improved methodologies for the study of adipose biology: insights gained and opportunities ahead. 
  • In vitro assessment of human nuclear hormone receptor activity and cytotoxicity of the flame retardant mixture FM 550 and its triarylphosphate and brominated components. 
  • In vivo analysis of white adipose tissue in zebrafish. 
  • In vivo imaging and quantification of regional adiposity in zebrafish. 
  • Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. 
  • Insulin activates a novel adipocyte mitogen-activated protein kinase kinase kinase that shows rapid phasic kinetics and is distinct from c-Raf. 
  • Insulin-triggered repositioning of munc18c on syntaxin-4 in GLUT4 signalling. 
  • Interferon regulatory factors are transcriptional regulators of adipogenesis. 
  • Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity. 
  • Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism. 
  • Ligand binding and activation of PPARγ by Firemaster® 550: effects on adipogenesis and osteogenesis in vitro. 
  • Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases. 
  • Lipoblastomatosis: case report and review of the literature. 
  • Liver X receptor is a regulator of orphan nuclear receptor NOR-1 gene transcription in adipocytes. 
  • Local renin angiotensin expression regulates human mesenchymal stem cell differentiation to adipocytes. 
  • Loss of pericyte smoothened activity in mice with genetic deficiency of leptin. 
  • Macrophage and adipocyte interaction as a source of inflammation in kidney disease. 
  • Making Biological Sense of GWAS Data: Lessons from the FTO Locus. 
  • Maximal beta3-adrenergic regulation of lipolysis involves Src and epidermal growth factor receptor-dependent ERK1/2 activation. 
  • Metabolic remodeling of human skeletal myocytes by cocultured adipocytes depends on the lipolytic state of the system. 
  • Mitochondrial GLUT10 facilitates dehydroascorbic acid import and protects cells against oxidative stress: mechanistic insight into arterial tortuosity syndrome. 
  • Molecular diffusion in tissue-engineered cartilage constructs: effects of scaffold material, time, and culture conditions. 
  • Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation. 
  • Multilayered electrospun scaffolds for tendon tissue engineering. 
  • Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity. 
  • Myolipoma of the eyelid. 
  • Nanoparticle engineered TRAIL-overexpressing adipose-derived stem cells target and eradicate glioblastoma via intracranial delivery. 
  • Necdin-E2F4 interaction provides insulin-sensitizing effect after weight loss induced by gastric bypass surgery. 
  • New genetic loci link adipose and insulin biology to body fat distribution. 
  • Nonionic Ethoxylated Surfactants Induce Adipogenesis in 3T3-L1 Cells. 
  • Nuclear hormone receptor LXRα inhibits adipocyte differentiation of mesenchymal stem cells with Wnt/beta-catenin signaling. 
  • Ontogeny and nutritional control of adipogenesis in zebrafish (Danio rerio). 
  • Open Chromatin Profiling in Adipose Tissue Marks Genomic Regions with Functional Roles in Cardiometabolic Traits. 
  • Optical spectral surveillance of breast tissue landscapes for detection of residual disease in breast tumor margins. 
  • PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity. 
  • PHAS-I as a link between mitogen-activated protein kinase and translation initiation. 
  • PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells. 
  • Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats. II. Effects on lipolysis, glucose production, and liver acyl-CoA profile. 
  • Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity. 
  • Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice. 
  • Perivascular Fibro-Adipogenic Progenitor Tracing during Post-Traumatic Osteoarthritis. 
  • Permanent Cutaneous Adverse Events After Injection With Deoxycholic Acid. 
  • Peroxisome Proliferator-Activated Receptor γ and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization. 
  • Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes. 
  • Phosphorylation of the translational regulator, PHAS-I, by protein kinase CK2. 
  • Poly(ethylene glycol) hydrogel system supports preadipocyte viability, adhesion, and proliferation. 
  • RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro. 
  • Regeneration of fat cells from myofibroblasts during wound healing. 
  • Regulation of early adipose commitment by Zfp521. 
  • Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines. 
  • Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis. 
  • Relationship between adipose stromal-vascular cells and adipocytes in human adipose tissue. 
  • Reproducibility of adipogenic responses to metabolism disrupting chemicals in the 3T3-L1 pre-adipocyte model system: An interlaboratory study. 
  • Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease. 
  • Response of adipose tissue to early infection with Trypanosoma cruzi (Brazil strain). 
  • Reversing adipocyte differentiation: implications for treatment of obesity. 
  • Role of transcription factor NFAT in glucose and insulin homeostasis. 
  • Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes. 
  • Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. 
  • Stem cell differentiation indicated by noninvasive photonic characterization and fractal analysis of subcellular architecture. 
  • Stem cell therapy for neurologic disorders: therapeutic potential of adipose-derived stem cells. 
  • Strain-specific response to beta 3-adrenergic receptor agonist treatment of diet-induced obesity in mice. 
  • Succination of Protein Disulfide Isomerase Links Mitochondrial Stress and Endoplasmic Reticulum Stress in the Adipocyte During Diabetes. 
  • Surface protein characterization of human adipose tissue-derived stromal cells. 
  • TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. 
  • TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. 
  • The beta3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism. 
  • The expanding problem of adipose depot remodeling and postnatal adipocyte progenitor recruitment. 
  • The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPARγ activation, in 3T3-L1 cells. 
  • Thyroid receptor antagonism as a contributory mechanism for adipogenesis induced by environmental mixtures in 3T3-L1 cells. 
  • Time-restricted feeding mitigates obesity through adipocyte thermogenesis. 
  • Tissue engraftment of hypoxic-preconditioned adipose-derived stem cells improves flap viability. 
  • Transcriptional brakes on the road to adipocyte thermogenesis. 
  • Transgenic ω-3 PUFA enrichment alters morphology and gene expression profile in adipose tissue of obese mice: Potential role for protectins. 
  • Tγδ17 cells build up the nerve. 
  • Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells. 
  • Visceral Adipose Tissue Mesothelial Cells: Living on the Edge or Just Taking Up Space? 
  • Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes. 
  • X-ray crystallographic analysis of adipocyte fatty acid binding protein (aP2) modified with 4-hydroxy-2-nonenal. 
  • Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. 
  • beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase. 
  • beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. 
  • p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Gupta, Rana K., Professor in Medicine, Cell Biology