Age of Onset

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  Subject Areas on Research

  • A PHEX gene mutation is responsible for adult-onset vitamin D-resistant hypophosphatemic osteomalacia: evidence that the disorder is not a distinct entity from X-linked hypophosphatemic rickets. 
  • A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease. 
  • A common biological basis of obesity and nicotine addiction. 
  • A common variant on chromosome 9p21 affects the risk of myocardial infarction. 
  • A dynamic cascade model of the development of substance-use onset. 
  • A gene for autosomal dominant juvenile amyotrophic lateral sclerosis (ALS4) localizes to a 500-kb interval on chromosome 9q34. 
  • A genome-wide association study of myasthenia gravis. 
  • A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study. 
  • A genomic copy number variant analysis implicates the MBD5 and HNRNPU genes in Chinese children with infantile spasms and expands the clinical spectrum of 2q23.1 deletion. 
  • A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14. 
  • A mixture-model approach to linking ADHD to adolescent onset of illicit drug use. 
  • A mouse model of adult-onset anaemia due to erythropoietin deficiency. 
  • A novel human disease with abnormal prion protein sensitive to protease. 
  • A randomized study of alglucosidase alfa in late-onset Pompe's disease. 
  • A reevaluation of the duration of survival after the onset of dementia. 
  • A report on older-age bipolar disorder from the International Society for Bipolar Disorders Task Force. 
  • A second locus for familial high myopia maps to chromosome 12q. 
  • A single-gene cause in 29.5% of cases of steroid-resistant nephrotic syndrome. 
  • A twin study of late-onset depression and apolipoprotein E epsilon 4 as risk factors for Alzheimer's disease. 
  • A variable age of onset segregation model for linkage analysis, with correction for ascertainment, applied to glioma. 
  • A very large Brazilian pedigree with 11778 Leber's hereditary optic neuropathy. 
  • ADHD and smoking: from genes to brain to behavior. 
  • ALSUntangled 41: "Eric Is Winning". 
  • APOE and AD concordance in twin pairs as predictors of AD in first-degree relatives. 
  • APOE genotype predicts when--not whether--one is predisposed to develop Alzheimer disease. 
  • Abdominal obesity, liver fat, and muscle composition in survivors of childhood acute lymphoblastic leukemia. 
  • Abuse liability of medications used to treat attention-deficit/hyperactivity disorder (ADHD). 
  • Academic achievement, close up work parameters, and myopia in Singapore military conscripts. 
  • Adenosine deaminase deficiency: genotype-phenotype correlations based on expressed activity of 29 mutant alleles. 
  • Adjustment of caregivers of pediatric patients with brain tumors: a cross-sectional analysis. 
  • Adolescent-onset nicotine self-administration modeled in female rats. 
  • Adult-onset primary open angle glaucoma does not localize to chromosome 2cen-q13 in North American families. 
  • Age at diagnosis and multiple primary cancers of the breast and ovary. 
  • Age at menarche, time to regular cycling, and breast cancer (North Carolina, United States). 
  • Age at onset in two common neurodegenerative diseases is genetically controlled. 
  • Age of onset for binge eating: are there different pathways to binge eating? 
  • Age of onset of hypertension and risk of dementia in the oldest-old: The 90+ Study. 
  • Age of onset of myopia predicts risk of high myopia in later childhood in myopic Singapore children. 
  • Aging-related diagnostic variations: need for diagnostic criteria appropriate for elderly psychiatric patients. 
  • Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis. 
  • Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression. 
  • Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. 
  • Alzheimer's disease and apolipoprotein E-4 allele in an Amish population. 
  • Alzheimer's disease: the genetics of risk. 
  • Amygdala volume in late-life depression: relationship with age of onset. 
  • An miR-502-binding site single-nucleotide polymorphism in the 3'-untranslated region of the SET8 gene is associated with early age of breast cancer onset. 
  • Analysis of association at single nucleotide polymorphisms in the APOE region. 
  • Anatomic location and laterality of MRI signal hyperintensities in late-life depression. 
  • Anhedonia in Japanese patients with Parkinson's disease: analysis using the Snaith-Hamilton Pleasure Scale. 
  • Antibodies in sera of patients with late-onset myasthenia gravis recognize the PEVK domain of titin. 
  • Apolipoprotein E and Alzheimer's disease. 
  • Apolipoprotein E controls the risk and age at onset of Parkinson disease. 
  • Apolipoprotein E epsilon 4. 
  • Apolipoprotein E epsilon2 does not increase risk of early-onset sporadic Alzheimer's disease. 
  • Apolipoprotein E is associated with age at onset of amyotrophic lateral sclerosis. 
  • Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease. 
  • Appetite loss and neurocognitive deficits in late-life depression. 
  • Application of a rank-based genetic association test to age-at-onset data from the Collaborative Study on the Genetics of Alcoholism study. 
  • Are Patients with Childhood Onset of Insomnia and Depression More Difficult to Treat Than Are Those with Adult Onsets of These Disorders? A Report from the TRIAD Study. 
  • Are quit attempts among U.S. female nurses who smoke different from female smokers in the general population? An analysis of the 2006/2007 tobacco use supplement to the current population survey. 
  • Assessing Acute Secondary Treatment Outcomes in Early-Onset Obsessive-Compulsive Disorder. 
  • Association between smoking and attention-deficit/hyperactivity disorder symptoms in a population-based sample of young adults. 
  • Association between the neuron-specific RNA-binding protein ELAVL4 and Parkinson disease. 
  • Association of AGTR1 with 18-month treatment outcome in late-life depression. 
  • Association of MDMA/ecstasy and other substance use with self-reported sexually transmitted diseases among college-aged adults: a national study. 
  • Association of circadian genes with diurnal blood pressure changes and non-dipper essential hypertension: a genetic association with young-onset hypertension. 
  • Association of five-factor model personality domains and facets with presence, onset, and treatment outcomes of major depression in older adults. 
  • Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis. 
  • Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease. 
  • Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer. 
  • Association test for X-linked QTL in family-based designs. 
  • Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity. 
  • Autopsy findings in late-onset Pompe disease: a case report and systematic review of the literature. 
  • Autosomal-dominant distal myopathy associated with a recurrent missense mutation in the gene encoding the nuclear matrix protein, matrin 3. 
  • BRCA mutations in women with ductal carcinoma in situ. 
  • BRCA1 mutations in primary breast and ovarian carcinomas. 
  • Bariatric Surgery: A Potential Treatment for Type 2 Diabetes in Youth. 
  • Benzoate treatment and the glycine index in nonketotic hyperglycinaemia. 
  • Blood Lead, Bone Turnover, and Survival in Amyotrophic Lateral Sclerosis. 
  • Body mass index and risk, age of onset, and survival in patients with pancreatic cancer. 
  • Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease. 
  • Brain-stem auditory and visual evoked potentials in children with Krabbe disease. 
  • Burden of disease in adult patients with hypophosphatasia: Results from two patient-reported surveys. 
  • CC-chemokine receptor 5 polymorphism and age of onset in familial multiple sclerosis. Multiple Sclerosis Genetics Group. 
  • Can We RISE to the Challenge of Youth-Onset Type 2 Diabetes? 
  • Cancer risk in childhood-onset systemic lupus. 
  • Cardiogenic shock. 
  • Cardiovascular abnormalities in late-onset Pompe disease and response to enzyme replacement therapy. 
  • Case reports of heart failure after therapy with a tumor necrosis factor antagonist. 
  • Caudate volume measurement in older adults with bipolar disorder. 
  • Causal attributions about disease onset and relapse in patients with systemic vasculitis. 
  • Challenges in the phenotypic characterisation of patients in genetic studies of coronary artery disease. 
  • Changes in Aβ biomarkers and associations with APOE genotype in 2 longitudinal cohorts. 
  • Characteristics, management, and outcomes of patients with hepatocellular carcinoma in Africa: a multicountry observational study from the Africa Liver Cancer Consortium. 
  • Child, parent, and peer predictors of early-onset substance use: a multisite longitudinal study. 
  • Child-, adolescent- and young adult-onset depressions: differential risk factors in development? 
  • Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium. 
  • Childhood trauma is associated with depressive symptoms in Mexico City women. 
  • Children in South Asia have higher body mass-adjusted blood pressure levels than white children in the United States: a comparative study. 
  • Chorea-acanthocytosis: genetic linkage to chromosome 9q21. 
  • Chromosomal localization of two genes underlying late-infantile neuronal ceroid lipofuscinosis. 
  • Chromosome 17q12 variants contribute to risk of early-onset prostate cancer. 
  • Chromosome 8q24 markers: risk of early-onset and familial prostate cancer. 
  • Clinical and electrographic manifestations of lesional neocortical temporal lobe epilepsy. 
  • Clinical and molecular predictors of disease severity and survival in chronic lymphocytic leukemia. 
  • Clinical and neuropsychological differences between patients with earlier and later onset of Alzheimer's disease: A CERAD analysis, Part XII. 
  • Clinical and pathological features of ovarian cancer in women with germ-line mutations of BRCA1. 
  • Clinical and phenomenological comparisons of late-onset and early-onset depression. 
  • Clinical and treatment response characteristics of late-life depression associated with vascular disease: a pooled analysis of two multicenter trials with sertraline. 
  • Clinical aspects of ALS in Gulf War veterans. 
  • Clinical characteristics of African Americans vs Caucasian Americans with multiple sclerosis. 
  • Clinical characteristics of African-American men with hereditary prostate cancer: the AAHPC Study. 
  • Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression. 
  • Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan. 
  • Clinical manifestations in a large hereditary hemorrhagic telangiectasia (HHT) type 2 kindred. 
  • Clinicopathological and molecular characterization of neuronal ceroid lipofuscinosis in the Portuguese population. 
  • Cognitive and academic outcomes in long-term survivors of infantile-onset Pompe disease: A longitudinal follow-up. 
  • Cognitive functioning throughout the treatment history of clinical late-life depression. 
  • Cognitive impairment in rapid-onset dystonia-parkinsonism. 
  • Cognitive improvement following treatment in late-life depression: relationship to vascular risk and age of onset. 
  • Cognitive performance and informant reports in the diagnosis of cognitive impairment and dementia in African Americans and whites. 
  • Combined effects of E2F1 and E2F2 polymorphisms on risk and early onset of squamous cell carcinoma of the head and neck. 
  • Combined immunodeficiency in the United States and Kuwait: Comparison of patients' characteristics and molecular diagnosis. 
  • Coming closer to describing the variable onset patterns in autism. 
  • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. 
  • Comorbidity. 
  • Comparative phenotypic and CARD15 mutational analysis among African American, Hispanic, and White children with Crohn's disease. 
  • Comparison of brain structural variables, neuropsychological factors, and treatment outcome in early-onset versus late-onset late-life depression. 
  • Comparison of short bowel syndrome acquired early in life and during adolescence. 
  • Complete genomic screen in Parkinson disease: evidence for multiple genes. 
  • Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12. 
  • Complete genomic screen in late-onset familial Alzheimer's disease. 
  • Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer disease. 
  • Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets. 
  • Concurrent use of methamphetamine, MDMA, LSD, ketamine, GHB, and flunitrazepam among American youths. 
  • Confirmation of linkage of oculopharyngeal muscular dystrophy to chromosome 14q11.2-q13 in American families suggests the existence of a second causal mutation. 
  • Confirmation of linkage of oculopharyngeal muscular dystrophy to chromosome 14q11.2-q13. 
  • Consensus statement on generalized anxiety disorder from the International Consensus Group on Depression and Anxiety. 
  • Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism. 
  • Correlations between apolipoprotein E epsilon4 gene dose and whole brain atrophy rates. 
  • Correspondence re: E. Hawk, et al., Male pattern baldness and clinical prostate cancer in the epidemiologic follow-up of the First National Health and Nutrition Examination Survey. Cancer Epidemiol.Biomark. Prev., 9: 523-527, 2000. 
  • Covariate analysis of late-onset Alzheimer disease refines the chromosome 12 locus. 
  • Cumulative prevalence of psychiatric disorders by young adulthood: a prospective cohort analysis from the Great Smoky Mountains Study. 
  • Current concepts in pediatric temporomandibular joint disorders: Part 1. Etiology, epidemiology, and classification. 
  • Cyclin D1 polymorphism and increased risk of colorectal cancer at young age. 
  • DNA/RNA helicase gene mutations in a form of juvenile amyotrophic lateral sclerosis (ALS4). 
  • DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset. 
  • Death from supine asphyxia in late onset pompe disease: Two patients. 
  • Decreased cognitive function in extended family members from the single late-onset-Alzheimer's-disease pedigree. 
  • Decreasing age at prostate cancer diagnosis over successive generations in prostate cancer families. 
  • Default mode network connectivity in children with a history of preschool onset depression. 
  • Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs. 
  • Delays to Care in Pediatric Lupus Patients: Data From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry. 
  • Depression and generalized anxiety disorder: cumulative and sequential comorbidity in a birth cohort followed prospectively to age 32 years. 
  • Design of the Genetics of Early Onset Cardiovascular Disease (GENECARD) study. 
  • Diagnosis of late-onset Pompe disease and other muscle disorders by next-generation sequencing. 
  • Diagnostic and treatment challenges of neuronopathic Gaucher disease: two cases with an intermediate phenotype. 
  • Disability in geriatric depression. 
  • Disc excavation in dominant optic atrophy: differentiation from normal tension glaucoma. 
  • Disrupted amygdala reactivity in depressed 4- to 6-year-old children. 
  • Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking. 
  • Do acetylcholine receptor and striated muscle antibodies predict the presence of thymoma in patients with myasthenia gravis? 
  • Double-blind comparison of sertraline, imipramine, and placebo in the treatment of dysthymia: psychosocial outcomes. 
  • Ductal carcinoma in situ in BRCA mutation carriers. 
  • Duration of empirical antibiotic therapy for infants suspected of early-onset sepsis. 
  • EMK: a novel program for family-based allelic and genotypic association tests on quantitative traits. 
  • Early and self-injurious behavior in young children born at-risk: a preliminary analysis. 
  • Early onset baldness and prostate cancer risk. 
  • Early onset neonatal sepsis: the burden of group B Streptococcal and E. coli disease continues. 
  • Early onset prostate cancer has a significant genetic component. 
  • Early onset prostate cancer: predictors of clinical grade. 
  • Early-onset degeneration of the intervertebral disc and vertebral end plate in mice deficient in type IX collagen. 
  • Early-onset obesity and the unwanted promise of thrombosis. 
  • Early-onset stroke and vasculopathy associated with mutations in ADA2. 
  • Effect of extended-release niacin on new-onset diabetes among hyperlipidemic patients treated with ezetimibe/simvastatin in a randomized controlled trial. 
  • Effectiveness of second-generation antipsychotics in patients with treatment-resistant schizophrenia: a review and meta-analysis of randomized trials. 
  • Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck. 
  • Effects of alcohol consumption on disability among the near elderly: a longitudinal analysis. 
  • Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. 
  • Efficacy, safety profile, and immunogenicity of alglucosidase alfa produced at the 4,000-liter scale in US children and adolescents with Pompe disease: ADVANCE, a phase IV, open-label, prospective study. 
  • Electroencephalographic changes in pyridoxine-dependant epilepsy: new observations. 
  • Enhancing recovery in coronary heart disease (ENRICHD): baseline characteristics. 
  • Epileptic and electroencephalographic manifestations of guanidinoacetate-methyltransferase deficiency. 
  • Ethnic issues in the epidemiology of childhood obesity. 
  • European Collaborative Project on Affective Disorders: interactions between genetic and psychosocial vulnerability factors. 
  • Evaluation and treatment of dystonia. 
  • Evaluation of underlying mechanisms in the link between childhood ADHD symptoms and risk for early initiation of substance use. 
  • Exclusion of homozygous PLCE1 (NPHS3) mutations in 69 families with idiopathic and hereditary FSGS. 
  • Exercise has a disproportionate role in the pathogenesis of arrhythmogenic right ventricular dysplasia/cardiomyopathy in patients without desmosomal mutations. 
  • Exogenous hormone use, reproductive factors, and risk of intracranial meningioma in females. 
  • Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. 
  • Expanding the phenotype of late-onset Pompe disease: tongue weakness: a new clinical observation. 
  • Facioscapulohumeral muscular dystrophy can be a cause of isolated childhood cognitive dysfunction. 
  • Factors associated with survival in the National Registry of Veterans with ALS. 
  • Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a final common pathway. 
  • Familial influence and childhood trauma in female alcoholism. 
  • Familial leukoencephalopathy in bipolar disorder. 
  • Familial spastic paraparesis: evaluation of locus heterogeneity, anticipation, and haplotype mapping of the SPG4 locus on the short arm of chromosome 2. 
  • Family history of atrial fibrillation is associated with earlier-onset and more symptomatic atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry. 
  • Family physician preferences and knowledge gaps regarding the care of adolescent and young adult survivors of childhood cancer. 
  • Family-based case-control study of cigarette smoking and Parkinson disease. 
  • Fasting Glucose Variability in Young Adulthood and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. 
  • Female and male antisocial trajectories: from childhood origins to adult outcomes. 
  • Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity. 
  • Fine-mapping the putative chromosome 17q21-22 prostate cancer susceptibility gene to a 10 cM region based on linkage analysis. 
  • Fluvoxamine treatment of social phobia (social anxiety disorder): a double-blind, placebo-controlled study. 
  • Folate metabolism genes, dietary folate and response to antidepressant medications in late-life depression. 
  • Food group intake and brain lesions in late-life vascular depression. 
  • Functional brain activation to emotionally valenced faces in school-aged children with a history of preschool-onset major depression. 
  • Functional connectivity of the amygdala in early-childhood-onset depression. 
  • Functional evidence implicating a novel TOR1A mutation in idiopathic, late-onset focal dystonia. 
  • Functional polymorphism in ABCA1 influences age of symptom onset in coronary artery disease patients. 
  • GATA2 is associated with familial early-onset coronary artery disease. 
  • Gender and race/ethnicity differences for initiation of alcohol-related service use among persons with alcohol dependence. 
  • Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytes. 
  • Gene-smoking interactions in multiple Rho-GTPase pathway genes in an early-onset coronary artery disease cohort. 
  • General health status and incidence of first-onset temporomandibular disorder: the OPPERA prospective cohort study. 
  • Generalized anxiety disorder: nature and course. 
  • Genetic analysis of eight breast-ovarian cancer families with suspected BRCA1 mutations. 
  • Genetic association tests based on ranks (GATOR) for quantitative traits with and without censoring. 
  • Genetic complexity and Parkinson's disease. Deane Laboratory Parkinson Disease Research Group. 
  • Genetic diagnosis in Lafora disease: genotype-phenotype correlations and diagnostic pitfalls. 
  • Genetic epidemiologic studies on age-specified traits. NIA Aging and Genetic Epidemiology Working Group. 
  • Genetic susceptibility for lung cancer: interactions with gender and smoking history and impact on early detection policies. 
  • Genetic variation at a single locus and age of onset for Alzheimer's disease. 
  • Genetics of Alzheimer's disease. 
  • Genetics of parkin-linked disease. 
  • Genetics of pediatric epilepsy. 
  • Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci. 
  • Genome-wide scan for adult onset primary open angle glaucoma. 
  • Genome-wide scan for prostate cancer susceptibility genes using families from the University of Michigan prostate cancer genetics project finds evidence for linkage on chromosome 17 near BRCA1. 
  • Genomewide search for type 2 diabetes susceptibility genes in four American populations. 
  • Genomics of human health and aging. 
  • Genotype-phenotype correlation in two frequent mutations and mutation update in type III glycogen storage disease. 
  • Germline genetic variants in men with prostate cancer and one or more additional cancers. 
  • Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors. 
  • Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. 
  • Growing up with a chronic illness: social success, educational/vocational distress. 
  • HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome. 
  • Hereditary spastic paraplegia: advances in genetic research. Hereditary Spastic Paraplegia Working group. 
  • Hierarchy of risk of childhood-onset rheumatoid arthritis conferred by HLA-DRB1 alleles encoding the shared epitope. 
  • High heritability of metabolomic profiles in families burdened with premature cardiovascular disease. 
  • Hippocampal volume in adolescent-onset alcohol use disorders. 
  • Hippocampus shape analysis and late-life depression. 
  • How common is misdiagnosis in late-onset Pompe disease? 
  • Human epidermal growth factor receptor-2 and estrogen receptor expression, a demonstration project using the residual tissue repository of the Surveillance, Epidemiology, and End Results (SEER) program. 
  • Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH. 
  • Identification and expression analysis of spastin gene mutations in hereditary spastic paraplegia. 
  • Identification of a novel locus on 2q for autosomal dominant high-grade myopia. 
  • Identification of novel genes in late-onset Alzheimer's disease. 
  • Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease. 
  • Identifying risk factors for first-episode neck pain: A systematic review. 
  • Imaging and genetics advances in understanding geriatric depression. 
  • Imaging frontostriatal function in ultra-high-risk, early, and chronic schizophrenia during executive processing. 
  • Impact of age at diagnosis on racial disparities in endometrial cancer patients. 
  • Impact of early and late age-related macular degeneration on vision-specific functioning. 
  • Impact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan. 
  • Implications of extending the ADHD age-of-onset criterion to age 12: results from a prospectively studied birth cohort. 
  • Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. 
  • Infantile Pompe disease on ERT: update on clinical presentation, musculoskeletal management, and exercise considerations. 
  • Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to treatment in patients with major depressive disorder. 
  • Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression. 
  • Influence of the susceptibility genes apolipoprotein E-epsilon 4 and apolipoprotein E-epsilon 2 on the rate of disease expressivity of late-onset Alzheimer's disease. 
  • Injection drug use among stimulant users in a national sample. 
  • Insulin resistance and risk factors for cardiovascular disease in young adult survivors of childhood acute lymphoblastic leukemia. 
  • Intellectual, neurocognitive, and academic achievement in abstinent adolescents with cannabis use disorder. 
  • Intima-media thickness and age of first depressive episode. 
  • Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models. 
  • Inverse association of general joint hypermobility with hand and knee osteoarthritis and serum cartilage oligomeric matrix protein levels. 
  • Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype. 
  • Is aspirin intake associated with early age-related macular degeneration? The Singapore Indian Eye Study. 
  • Is there a link between passive smoke exposure and early-onset myopia in preschool Asian children? 
  • Kinetics of visual field loss in Usher syndrome Type II. 
  • Krabbe disease: neurophysiologic studies and MRI correlations. 
  • Lack of association between apolipoprotein E genotype and sporadic amyotrophic lateral sclerosis. 
  • Late onset N-acetylglutamate synthase deficiency caused by hypomorphic alleles. 
  • Late-Onset ADHD Reconsidered With Comprehensive Repeated Assessments Between Ages 10 and 25. 
  • Late-life onset bipolar disorder presenting as a case of pseudo-dementia: a case discussion and review of literature. 
  • Late-onset hereditary axonal neuropathies. 
  • Lifetime perturbations of bipolar disorder. 
  • Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers. 
  • Linkage of a gene causing familial focal segmental glomerulosclerosis to chromosome 11 and further evidence of genetic heterogeneity. 
  • Linkage of a locus (CMT4A) for autosomal recessive Charcot-Marie-Tooth disease to chromosome 8q. 
  • Linkage of familial dilated cardiomyopathy with conduction defect and muscular dystrophy to chromosome 6q23. 
  • Linkage of frontotemporal dementia to chromosome 17: clinical and neuropathological characterization of phenotype. 
  • Locus heterogeneity, anticipation and reduction of the chromosome 2p minimal candidate region in autosomal dominant familial spastic paraplegia. 
  • Long-Term Blood Pressure Variability, New-Onset Diabetes Mellitus, and New-Onset Chronic Kidney Disease in the Japanese General Population. 
  • Long-term health-related outcomes in survivors of childhood cancer treated with HSCT versus conventional therapy: a report from the Bone Marrow Transplant Survivor Study (BMTSS) and Childhood Cancer Survivor Study (CCSS). 
  • Long-term seizure control outcomes after resection of gangliogliomas. 
  • Longitudinal Cognitive Outcomes of Clinical Phenotypes of Late-Life Depression. 
  • Longitudinal follow-up of late-onset Alzheimer disease families. 
  • Longitudinal study of low serum LDL cholesterol and depressive symptom onset in postmenopause. 
  • Lyme disease serology in amyotrophic lateral sclerosis. 
  • MRI subcortical hyperintensities in old and very old depressed outpatients: the important role of age in late-life depression. 
  • MRI-defined vascular depression. 
  • Magnetic resonance imaging correlates of depression in early- and late-onset Alzheimer's disease. 
  • Magnetic resonance imaging signal hypointensity and iron content of putamen nuclei in elderly depressed patients. 
  • Major depressive disorder in youths with IDDM. A controlled prospective study of course and outcome. 
  • Management patterns of childhood-onset nephrotic syndrome. 
  • Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. 
  • Medial orbital frontal lesions in late-onset depression. 
  • Medical comorbidity in late-life depression. 
  • Melancholia in later life: late and early onset differences in presentation, course, and dementia risk. 
  • Mental health antecedents of early midlife insomnia: evidence from a four-decade longitudinal study. 
  • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. 
  • Meta-analysis of age at onset in spastin-associated hereditary spastic paraplegia provides no evidence for a correlation with mutational class. 
  • Metabolic profiling of patients with schizophrenia. 
  • Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. 
  • Microphthalmia-associated transcription factor (MITF) locus lacks linkage to human vitiligo or osteopetrosis: an evaluation. 
  • Midlife activity predicts risk of dementia in older male twin pairs. 
  • Missense mutations in TCF8 cause late-onset Fuchs corneal dystrophy and interact with FCD4 on chromosome 9p. 
  • Mitochondrial myopathy with anemia, cardiomyopathy, and lactic acidosis: a distinct late onset mitochondrial disorder. 
  • Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction. 
  • Molecular analysis and protein processing in late-onset Pompe disease patients with low levels of acid α-glucosidase activity. 
  • Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism. 
  • MuSK-antibody positive myasthenia gravis: questions from the clinic. 
  • Multifocal motor neuropathy: 30 years from onset to diagnosis. 
  • Myasthenia gravis in the tenth decade. 
  • NOS2A and the modulating effect of cigarette smoking in Parkinson's disease. 
  • Neural correlates associated with cognitive decline in late-life depression. 
  • Neurodevelopmental outcomes of umbilical cord blood transplantation in metachromatic leukodystrophy. 
  • Neuropathological features of frontotemporal dementia and parkinsonism linked to chromosome 17q21-22 (FTDP-17): Duke Family 1684. 
  • Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis. 
  • New onset and remission of suicidal ideation among a depressed adult sample. 
  • New onset focal weakness in children with Down syndrome. 
  • Newfoundland rod-cone dystrophy, an early-onset retinal dystrophy, is caused by splice-junction mutations in RLBP1. 
  • No association between OPA1 polymorphisms and primary open-angle glaucoma in three different populations. 
  • No association between polymorphisms in the serotonin transporter gene and susceptibility to cocaine dependence among African-American individuals. 
  • No association between the HLA-A2 allele and Alzheimer disease. 
  • No association between the MDM2 -309 T/G promoter polymorphism and breast cancer in African-Americans or Whites. 
  • No association of alpha1-antichymotrypsin flanking region polymorphism and Alzheimer disease risk in early- and late-onset Alzheimer disease patients. 
  • No association or linkage between an intronic polymorphism of presenilin-1 and sporadic or late-onset familial Alzheimer disease. 
  • No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease. 
  • Novel long QT syndrome-associated missense mutation, L762F, in CACNA1C-encoded L-type calcium channel imparts a slower inactivation tau and increased sustained and window current. 
  • Novel mutations in spastin gene and absence of correlation with age at onset of symptoms. 
  • Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy. 
  • Obesity and age of first non-ST-segment elevation myocardial infarction. 
  • Occurrence of amyotrophic lateral sclerosis among Gulf War veterans. 
  • Occurrence of cancer among people with mental health claims in an insured population. 
  • Ocular motility in North Carolina autosomal dominant ataxia. 
  • Open-label extension study following the Late-Onset Treatment Study (LOTS) of alglucosidase alfa. 
  • Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22. 
  • Origins of depression in later life. 
  • Outcomes in two Japanese adenosine deaminase-deficiency patients treated by stem cell gene therapy with no cytoreductive conditioning. 
  • PLEKHG5 deficiency leads to an intermediate form of autosomal-recessive Charcot-Marie-Tooth disease. 
  • Paediatric rheumatic disease: lessons from SLE: children are not little adults. 
  • Pain coping and the pain experience in children with juvenile chronic arthritis. 
  • Patent foramen ovale in adults with sickle cell disease and stroke. 
  • Pathologic changes in highly myopic eyes of young males in Singapore. 
  • Pathways to PTSD, part II: Sexually abused children. 
  • Pediatric spinal deformities. 
  • Perinatal factors associated with clinical presentation of osteosarcoma in children and adolescents. 
  • Personality--life event congruence effects in late-life depression. 
  • Phenol sulfotransferases: hormonal regulation, polymorphism, and age of onset of breast cancer. 
  • Phenotypic analysis of 303 multiplex families with common epilepsies. 
  • Phenotypic homogeneity provides increased support for linkage on chromosome 2 in autistic disorder. 
  • Physical therapy and chiropractic use among childhood cancer survivors with chronic disease: impact on health-related quality of life. 
  • Polymorphism in the TOMM40 gene modifies the risk of developing sporadic inclusion body myositis and the age of onset of symptoms. 
  • Polymorphisms in hMLH1 and risk of early-onset lung cancer in a southeast Chinese population. 
  • Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer. 
  • Polymorphisms of p21 and p27 jointly contribute to an earlier age at diagnosis of pancreatic cancer. 
  • Polymorphisms of the tumor suppressor gene LSAMP are associated with left main coronary artery disease. 
  • Pompe disease: design, methodology, and early findings from the Pompe Registry. 
  • Precision, reliability and accuracy in the dating of symptom onsets in child and adolescent psychopathology. 
  • Prediction of differential adult health burden by conduct problem subtypes in males. 
  • Predictive value of family history on severity of illness: the case for depression, anxiety, alcohol dependence, and drug dependence. 
  • Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders. 
  • Predictors of recurrence in remitted late-life depression. 
  • Predictors of treatment response in patients with posttraumatic stress disorder. 
  • Prefrontal cortex, thalamus, and cerebellar volumes in adolescents and young adults with adolescent-onset alcohol use disorders and comorbid mental disorders. 
  • Preliminary criteria for global flares in childhood-onset systemic lupus erythematosus. 
  • Preschool psychopathology: lessons for the lifespan. 
  • Presenilin-1 mutations in Alzheimer's disease. 
  • Presenilin-1 polymorphism and Alzheimer's disease. 
  • Presenilin-1 polymorphism and Alzheimer's disease. 
  • Prevalence of ALDH7A1 mutations in 18 North American pyridoxine-dependent seizure (PDS) patients. 
  • Prevalence of mutations in TIGR/Myocilin in patients with adult and juvenile primary open-angle glaucoma. 
  • Prevalence, correlates, and course of minor depression and major depression in the National Comorbidity Survey. 
  • Probable exclusion of GLC1A as a candidate glaucoma gene in a family with middle-age-onset primary open-angle glaucoma. 
  • Probing the role of PPARγ in the regulation of late-onset Alzheimer's disease-associated genes. 
  • Prognostic factors in early-onset epithelial ovarian cancer: a population-based study. 
  • Progression of cognitive, functional, and neuropsychiatric symptom domains in a population cohort with Alzheimer dementia: the Cache County Dementia Progression study. 
  • Projections of future numbers of dementia cases in Australia with and without prevention. 
  • Prominent reduction in pyramidal neurons density in the orbitofrontal cortex of elderly depressed patients. 
  • Prospective developmental subtypes of alcohol dependence from age 18 to 32 years: implications for nosology, etiology, and intervention. 
  • Prostate cancer in young men: an important clinical entity. 
  • Prostate cancer susceptibility locus on chromosome 1q: a confirmatory study. 
  • Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. 
  • Quantifying the Dynamics of Field Cancerization in Tobacco-Related Head and Neck Cancer: A Multiscale Modeling Approach. 
  • Quantitative assessment of early diabetic retinopathy using fractal analysis. 
  • Quantitative assessment of lingual strength in late-onset Pompe disease. 
  • Reduction in Late Mortality among 5-Year Survivors of Childhood Cancer. 
  • Refractory calculation-induced idiopathic generalized epilepsy: a case report and review of the literature. 
  • Relational aggression in children with preschool-onset psychiatric disorders. 
  • Relationship Between Binocular Summation and Stereoacuity After Strabismus Surgery. 
  • Relationship of cognitive reserve and APOE status to the emergence of clinical symptoms in preclinical Alzheimer's disease. 
  • Relative effectiveness of reappraisal and distraction in regulating emotion in late-life depression. 
  • Religious service attendance and major depression: a case of reverse causality? 
  • Reproductive risk factors for ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study. 
  • Research review: DSM-V conduct disorder: research needs for an evidence base. 
  • Respiratory muscle training (RMT) in late-onset Pompe disease (LOPD): Effects of training and detraining. 
  • Response inhibition predicts poor antidepressant treatment response in very old depressed patients. 
  • Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases. 
  • Risk factors and prevention of late-onset sepsis in premature infants. 
  • Risk of Alzheimer disease with the epsilon4 allele for apolipoprotein E in a population-based study of men aged 62-73 years. 
  • Risk of second primary tumors in men diagnosed with prostate cancer: a population-based cohort study. 
  • SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease. 
  • Safety and efficacy of alternative alglucosidase alfa regimens in Pompe disease. 
  • Screening for Pompe disease using a rapid dried blood spot method: experience of a clinical diagnostic laboratory. 
  • Seven novel mutations in the adenosine deaminase (ADA) gene in patients with severe and delayed onset combined immunodeficiency: G74C, V129M, G140E, R149W, Q199P, 462delG, and E337del. Mutations in brief no. 142. Online. 
  • Severe Cardiac Involvement Is Rare in Patients with Late-Onset Pompe Disease and the Common c.-32-13T>G Variant: Implications for Newborn Screening. 
  • Severe disease presentation and poor outcomes among pediatric systemic lupus erythematosus patients in South Africa. 
  • Severe stress and adjustment disorder diagnoses in the population of Denmark. 
  • Signs and symptoms of first-onset TMD and sociodemographic predictors of its development: the OPPERA prospective cohort study. 
  • Single nucleotide polymorphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarction. 
  • Smoking Paradox in Patients Hospitalized With Coronary Artery Disease or Acute Ischemic Stroke: Findings From Get With The Guidelines. 
  • Social support in elderly patients with bipolar disorder. 
  • Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia. 
  • Specific podocin mutations correlate with age of onset in steroid-resistant nephrotic syndrome. 
  • Strategies for dissecting genetic-environmental interactions in neurodegenerative disorders. 
  • Structural brain changes as biomarkers and outcome predictors in patients with late-life depression: a cross-sectional and prospective study. 
  • Studying health histories of cancer: a new model connecting cancer incidence and survival. 
  • Substance abuse, treatment needs and access among female sex workers and non-sex workers in Pretoria, South Africa. 
  • Substance use disorders among inhalant users: results from the National Epidemiologic Survey on alcohol and related conditions. 
  • Summary of findings from the OPPERA prospective cohort study of incidence of first-onset temporomandibular disorder: implications and future directions. 
  • Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial. 
  • Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study. 
  • TM4SF20 ancestral deletion and susceptibility to a pediatric disorder of early language delay and cerebral white matter hyperintensities. 
  • TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions. 
  • TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial. 
  • The Localized Scleroderma Cutaneous Assessment Tool: responsiveness to change in a pediatric clinical population. 
  • The Systemic Juvenile Idiopathic Arthritis Cohort of the Childhood Arthritis and Rheumatology Research Alliance Registry: 2010-2013. 
  • The association of strabismus, amblyopia, and refractive errors in spasmus nutans. 
  • The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression. 
  • The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes. 
  • The distinction between juvenile and adult-onset primary open-angle glaucoma. 
  • The emerging phenotype of late-onset Pompe disease: A systematic literature review. 
  • The epidemiology of social phobia: findings from the Duke Epidemiological Catchment Area Study. 
  • The genetic attributable risk of breast and ovarian cancer. 
  • The high prevalence of substance use disorders among recent MDMA users compared with other drug users: Implications for intervention. 
  • The impact of antibodies in late-onset Pompe disease: a case series and literature review. 
  • The influence of neighborhood disadvantage and perceived disapproval on early substance use initiation. 
  • The polymorphic exon 1 androgen receptor CAG repeat in men with a potential inherited predisposition to prostate cancer. 
  • The prevalence and 3-year incidence of dementia in older Black and White community residents. 
  • The relation of prophylactic inoculations to the onset of poliomyelitis. 1950. 
  • The stability of psychopathy across adolescence. 
  • The ubiquilin 1 gene and Alzheimer's disease. 
  • The undertreatment of dysthymia. 
  • The value of muscle biopsies in Pompe disease: identifying lipofuscin inclusions in juvenile- and adult-onset patients. 
  • Thought suppression and treatment outcome in late-life depression. 
  • Tibiofibular synostosis stress fracture: a case report. 
  • Time to diagnosis in the National Registry of Veterans with Amyotrophic Lateral Sclerosis. 
  • Time trends of incidence of age-associated diseases in the US elderly population: Medicare-based analysis. 
  • Timing of diagnosis of patients with Pompe disease: data from the Pompe registry. 
  • Tobacco smoke exposure and respiratory morbidity in young children. 
  • Trade-off in the effect of the APOE gene on the ages at onset of cardiocascular disease and cancer across ages, gender, and human generations. 
  • Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan. 
  • Transancestral mapping and genetic load in systemic lupus erythematosus. 
  • Trends in cannabis use prior to first presentation with schizophrenia, in South-East London between 1965 and 1999. 
  • Trends in risk profiles for and mortality associated with invasive aspergillosis among liver transplant recipients. 
  • Twenty-five year follow-up of childhood Wilms tumor: a report from the Childhood Cancer Survivor Study. 
  • Twin pairs discordant for neuropathologically confirmed Lewy body dementia. 
  • Two Sides of the Same Coin: Pediatric-Onset and Adult-Onset Common Variable Immune Deficiency. 
  • Tyrosine hydroxylase polymorphism and phenotypic heterogeneity in bipolar affective disorder: a multicenter association study. 
  • Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration. 
  • Unusually high rate of young-onset pancreatic cancer in the East Nile Delta region of Egypt. 
  • Urea cycle disorders: clinical presentation outside the newborn period. 
  • Use of decrease in apparent diffusion coefficient values to predict infarct age. 
  • Use of the complete blood cell count in early-onset neonatal sepsis. 
  • Use of the complete blood cell count in late-onset neonatal sepsis. 
  • Using gene carrier probability to select high risk families for identifying germline mutations in breast cancer susceptibility genes. 
  • Validation of the Davidson Trauma Scale in a sample of survivors of childhood sexual abuse. 
  • Validation of the phenomenon of autistic regression using home videotapes. 
  • Validation study of genetic associations with coronary artery disease on chromosome 3q13-21 and potential effect modification by smoking. 
  • Vascular nutritional correlates of late-life depression. 
  • Very late onset infections in the neonatal intensive care unit. 
  • Very low birth weight neonates who survive early-onset sepsis do not have an increased risk of developing late-onset sepsis. 
  • Very low birth weight preterm infants with early onset neonatal sepsis: the predominance of gram-negative infections continues in the National Institute of Child Health and Human Development Neonatal Research Network, 2002-2003. 
  • Vitamin D receptor gene as a candidate gene for Parkinson disease. 
  • White matter lesion volumes and caudate volumes in late-life depression. 
  • Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. 
  • X-linked high myopia associated with cone dysfunction. 
  • Young adult weight trajectories through midlife by body mass category. 
  • Youth employment, income, and smoking initiation: results from Korean panel data. 
  • [Analysis of genetic heterogeneity of bronchial asthma in relation with the age at the onset of disease] 
  • [Comparison and analysis of clinicopathology of lung cancer between 1980s and 1990s in the Shenyang area (1,224 cases)]. 
  • [Population risk of bronchial asthma occurrence in Moscow] 
• 

  Keywords of People

  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Cohen-Wolkowiez, Michael, Professor of Pediatrics, Pediatrics, Infectious Diseases
  • Dodge, Kenneth A., Pritzker Professor of Early Learning Policy Studies, Duke Science & Society
  • Grambow, Steven C., Assistant Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
  • Li, Yi-Ju, Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics
  • MacFall, James R., Adjunct Professor in the Department of Radiology, Radiology
  • Odgers, Candice L., Research Professor in the Sanford School of Public Policy, Sanford School of Public Policy
  • Schanberg, Laura Eve, Professor of Pediatrics, Pediatrics, Rheumatology
  • Wu, Li-Tzy, Professor in Psychiatry and Behavioral Sciences, Medicine, General Internal Medicine