Lignans

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  Subject Areas on Research

  • Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations. 
  • Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity. 
  • Constituents from the root and stem of Aristolochia elegans. 
  • Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements. 
  • Evaluation of Manassantin A Tetrahydrofuran Core Region Analogues and Cooperative Therapeutic Effects with EGFR Inhibition. 
  • False-positive rate determination of protein target discovery using a covalent modification- and mass spectrometry-based proteomics platform. 
  • Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer. 
  • Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness. 
  • Insight into the Mode of Action of Haedoxan A from Phryma leptostachya. 
  • Manipulating JNK signaling with (--)-zuonin A. 
  • Negative cross-resistance of a pyrethroid-resistant Drosophila mutant to Phryma leptostachya-derived haedoxan A. 
  • Nucleophilic addition of organozinc reagents to 2-sulfonyl cyclic ethers: stereoselective synthesis of manassantins A and B. 
  • Phytochemicals and cancer risk: a review of the epidemiological evidence. 
  • Stereoselective synthesis of tetrahydrofuran lignans via BF(3) x OEt(2)-promoted reductive deoxygenation/epimerization of cyclic hemiketal: synthesis of (-)-odoratisol C, (-)-futokadsurin A, (-)-veraguensin, (+)-fragransin A(2), (+)-galbelgin, and (+)-talaumidin. 
  • Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition. 
  • The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis. 
  • The relationship between phytoestrogens and speed of processing. 
  • Use of alternative therapies in menopause.