Erythrocyte Transfusion

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  Subject Areas on Research

  • A Randomized Controlled Trial of Low-Dose Tranexamic Acid versus Placebo to Reduce Red Blood Cell Transfusion During Complex Multilevel Spine Fusion Surgery. 
  • A clinical prediction tool to estimate the number of units of red blood cells needed in primary elective coronary artery bypass surgery. 
  • A descriptive evaluation of transfusion practices in patients receiving mechanical ventilation. 
  • A phase 2 prospective, randomized, double-blind trial comparing the effects of tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery with cardiopulmonary bypass (CONSERV-2 Trial). 
  • A prospective, double-blind, randomized clinical feasibility trial of controlling the storage age of red blood cells for transfusion in cardiac surgical patients. 
  • A randomized controlled pilot study of VO2 max testing: a potential model for measuring relative in vivo efficacy of different red blood cell products. 
  • A retrospective comparison of anesthetic management of robot-assisted laparoscopic radical prostatectomy versus radical retropubic prostatectomy. 
  • ABO blood group influences transfusion and survival after cardiac surgery. 
  • Addressing the question of the effect of RBC storage on clinical outcomes: the Red Cell Storage Duration Study (RECESS) (Section 7). 
  • An Assessment of Bleeding Complications Necessitating Blood Transfusion across Inpatient Plastic Surgery Procedures: A Nationwide Analysis Using the National Surgical Quality Improvement Program Database. 
  • An infant girl with severe autoimmune hemolytic anemia: apparent anti-Vel specificity. 
  • An official American Thoracic Society clinical practice guideline: diagnosis, risk stratification, and management of pulmonary hypertension of sickle cell disease. 
  • Aprotinin use during cardiac surgery: recent alterations and effects on blood product utilization. 
  • Are there clinical benefits with early erythropoietic intervention for chemotherapy-induced anemia? A systematic review. 
  • Association of leukocyte-depleted blood transfusions with infectious complications after cardiac surgery. 
  • Autologous blood procurement in the surgical setting: lessons learned in the last 10 years. 
  • Bivalirudin during cardiopulmonary bypass in patients with previous or acute heparin-induced thrombocytopenia and heparin antibodies: results of the CHOOSE-ON trial. 
  • Blood substitutes: evolution and future applications. 
  • Blood transfusion and infection after cardiac surgery. 
  • Blood transfusions are associated with urinary biomarkers of kidney injury in cardiac surgery. 
  • Blood utilization and hemoglobin levels in cancer patients after label and coverage changes for erythropoiesis-stimulating agents. 
  • CE: A Review of Current Practice in Transfusion Therapy. 
  • Case 13--2014: Management of pulmonary hemorrhage after pulmonary endarterectomy with venovenous extracorporeal membrane oxygenation without systemic anticoagulation. 
  • Cerebral Oxygenation and Transfusion for Severe Anemia: Searching for Functional Outcomes to Guide Transfusion. 
  • Chronic transfusion practices for prevention of primary stroke in children with sickle cell anemia and abnormal TCD velocities. 
  • Clinical Practice Guidelines From the AABB: Red Blood Cell Transfusion Thresholds and Storage. 
  • Clinical studies of erythrocyte outcomes and mortality: size really counts. 
  • Clinical trials evaluating red blood cell transfusion thresholds: An updated systematic review and with additional focus on patients with cardiovascular disease. 
  • Coagulation and fibrinolytic protein kinetics in cardiopulmonary bypass. 
  • Comparison of red cell transfusion and polyethylene glycol-modified adenosine deaminase therapy in an adenosine deaminase-deficient child: measurement of erythrocyte deoxyadenosine triphosphate as a useful tool. 
  • Computerized physician order entry improves compliance with a manual exchange transfusion protocol in the pediatric intensive care unit. 
  • Concepts of blood transfusion in adults. 
  • Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. 
  • Conservative versus liberal red cell transfusion in acute myocardial infarction (the CRIT Randomized Pilot Study). 
  • Definitions of the phenotypic manifestations of sickle cell disease. 
  • Disparity in the management of iron overload between patients with sickle cell disease and thalassemia who received transfusions. 
  • Double-blind, placebo-controlled study of quality of life, hematologic end points, and safety of weekly epoetin alfa in children with cancer receiving myelosuppressive chemotherapy. 
  • Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis. 
  • Economic analysis of an intraoperative cell salvage service. 
  • Effect of liberal blood transfusion on clinical outcomes and cost in spine surgery patients. 
  • Effects of red blood cell (RBC) transfusion on sickle cell disease recipient plasma and RBC metabolism. 
  • Effects of red-cell storage duration on patients undergoing cardiac surgery. 
  • Elective cholecystectomy in children with sickle hemoglobinopathies. Successful outcome using a preoperative transfusion regimen. 
  • Epidural analgesia in hepatic resection. 
  • Erythrocytapheresis can reduce iron overload and prevent the need for chelation therapy in chronically transfused pediatric patients. 
  • Estimation of Achievable Oxygen Consumption Following Transfusion With Rejuvenated Red Blood Cells. 
  • Estimation of economic costs associated with transfusion dependence in adults with MDS. 
  • Etiology and complications of thrombocytopenia in hospitalized medical patients. 
  • Evidence gaps in the management of sickle cell disease: A summary of needed research. 
  • Extended storage of AS-1 and AS-3 leukoreduced red blood cells for 15 days after deglycerolization and resuspension in AS-3 using an automated closed system. 
  • Feeding practices and other risk factors for developing transfusion-associated necrotizing enterocolitis. 
  • Goal-directed intraoperative fluid administration reduces length of hospital stay after major surgery. 
  • Impact of transfusion of autologous 7- versus 42-day-old AS-3 red blood cells on tissue oxygenation and the microcirculation in healthy volunteers. 
  • Inventory management strategies that reduce the age of red blood cell components at the time of transfusion. 
  • Invited commentary. 
  • Iron overload following red blood cell transfusion and its impact on disease severity. 
  • Is preoperative fibrinogen predictive for postoperative bleeding after coronary artery bypass grafting surgery? 
  • Isn't it about time we learned how to use blood transfusion in patients with ischemic heart disease? 
  • Liver cell adenoma: a multicenter analysis of risk factors for rupture and malignancy. 
  • Marrow harvesting from normal donors. 
  • Marrow transplantation for thalassaemia. 
  • Mitral surgery after prior cardiac operation: port-access versus sternotomy or thoracotomy. 
  • Morbidity and mortality in chronically transfused subjects with thalassemia and sickle cell disease: A report from the multi-center study of iron overload. 
  • Mortality benefit with prasugrel in the TRITON-TIMI 38 coronary artery bypass grafting cohort: risk-adjusted retrospective data analysis. 
  • Myelodysplastic syndromes clinical practice guidelines in oncology. 
  • National Benchmarks for Proportions of Patients Receiving Blood Transfusions During Pediatric and Congenital Heart Surgery: An Analysis of the STS Congenital Heart Surgery Database. 
  • Nitric oxide in RBCs. 
  • Packed red blood cells suppress T-cell proliferation through a process involving cell-cell contact. 
  • Patient Blood Management: Recommendations From the 2018 Frankfurt Consensus Conference. 
  • Patterns and outcomes of red blood cell transfusion in patients undergoing percutaneous coronary intervention. 
  • Point-of-care washing of allogeneic red blood cells for the prevention of transfusion-related respiratory complications (WAR-PRC): a protocol for a multicenter randomised clinical trial in patients undergoing cardiac surgery. 
  • Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomized, double-blind trial. 
  • Post-operative pharmacologic thromboprophylaxis after major hepatectomy: does peripheral venous thromboembolism prevention outweigh bleeding risks? 
  • Predictors of massive transfusion with thoracic aortic procedures involving deep hypothermic circulatory arrest. 
  • Preoperative transarterial embolization of spinal column neoplasms. 
  • Prior polyvascular disease: risk factor for adverse ischaemic outcomes in acute coronary syndromes. 
  • Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016. 
  • Prognostic impact of blood transfusion after primary angioplasty for acute myocardial infarction: analysis from the CADILLAC (Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications) Trial. 
  • Proinflammatory, immunomodulating, and prothrombotic properties of anemia and red blood cell transfusions. 
  • Propensity matched comparison of outcomes in older and younger patients after coronary artery bypass graft surgery. 
  • RBC transfusions in paroxysmal nocturnal hemoglobinuria. 
  • Radial versus femoral access, bleeding and ischemic events in patients with non-ST-segment elevation acute coronary syndrome managed with an invasive strategy. 
  • Randomized study of washing 40- to 42-day-stored red blood cells. 
  • Rapid correction of anemia with partial exchange transfusion. 
  • Rapid increases in parasitemia following red cell exchange for malaria. 
  • Recommendations on the Indications for RBC Transfusion for the Critically Ill Child Receiving Support From Extracorporeal Membrane Oxygenation, Ventricular Assist, and Renal Replacement Therapy Devices From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. 
  • Red blood cell phenotype fidelity following glycerol cryopreservation optimized for research purposes. 
  • Red blood cell transfusion: a clinical practice guideline from the AABB*. 
  • Red cell exchange transfusion for babesiosis in Rhode Island. 
  • Red cell transfusion in the newborn. Indications and unique blood banking needs. 
  • Relationship of neonatal treatments with the development of necrotizing enterocolitis in preterm infants. 
  • S-Nitrosohemoglobin Levels and Patient Outcome After Transfusion During Pediatric Bypass Surgery. 
  • Safe application of a restrictive transfusion protocol in moderate-risk patients undergoing cardiac operations. 
  • Safety of selective serotonin reuptake inhibitor use prior to coronary artery bypass grafting. 
  • Secondary surgical-site infection after coronary artery bypass grafting: A multi-institutional prospective cohort study. 
  • The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States. 
  • The Prospective Evaluation of the Net Effect of Red Blood Cell Transfusions in Routine Provision of Palliative Care. 
  • The association between duration of storage of transfused red blood cells and morbidity and mortality after reoperative cardiac surgery. 
  • To transfuse or not to transfuse in upper gastrointestinal hemorrhage? That is the question. 
  • Transfusion and mortality in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. 
  • Transfusion in Ischemic Heart Disease: Correlation, Confounding, and Confusion. 
  • Transfusion of Red Blood Cells Stored More Than 28 Days is Associated With Increased Morbidity Following Spine Surgery. 
  • Transfusion of sickle cells may be a therapeutic option for patients suffering metastatic disease. 
  • Transfusion-related biologic effects and free hemoglobin, heme, and iron. 
  • Transient abnormalities in serum bilirubin and lactate dehydrogenase levels following red blood cell transfusions in adults. 
  • Variation in use of blood transfusion in coronary artery bypass graft surgery. 
  • Weight gain: a response to transfusion in selected preterm infants. 
  • epsilon-Aminocaproic acid plasma levels during cardiopulmonary bypass. 
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  Keywords of People

  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. / Guidant Foundation Professor of Cardiology, Medicine, Clinical Pharmacology
  • Turi, Jennifer Lilly, Associate Professor of Pediatrics, Pediatrics, Critical Care Medicine