Erythrocyte Transfusion

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  Subject Areas on Research

  • A Randomized Controlled Trial of Low-Dose Tranexamic Acid versus Placebo to Reduce Red Blood Cell Transfusion During Complex Multilevel Spine Fusion Surgery. 
  • A Regression Model for Prediction of Cesarean-Associated Blood Transfusion. 
  • A clinical prediction tool to estimate the number of units of red blood cells needed in primary elective coronary artery bypass surgery. 
  • A descriptive evaluation of transfusion practices in patients receiving mechanical ventilation. 
  • A novel mouse model of red blood cell storage and posttransfusion in vivo survival. 
  • A phase 2 prospective, randomized, double-blind trial comparing the effects of tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery with cardiopulmonary bypass (CONSERV-2 Trial). 
  • A prospective, double-blind, randomized clinical feasibility trial of controlling the storage age of red blood cells for transfusion in cardiac surgical patients. 
  • A randomized controlled pilot study of VO2 max testing: a potential model for measuring relative in vivo efficacy of different red blood cell products. 
  • A retrospective comparison of anesthetic management of robot-assisted laparoscopic radical prostatectomy versus radical retropubic prostatectomy. 
  • ABO blood group influences transfusion and survival after cardiac surgery. 
  • Addressing the question of the effect of RBC storage on clinical outcomes: the Red Cell Storage Duration Study (RECESS) (Section 7). 
  • An Assessment of Bleeding Complications Necessitating Blood Transfusion across Inpatient Plastic Surgery Procedures: A Nationwide Analysis Using the National Surgical Quality Improvement Program Database. 
  • An official American Thoracic Society clinical practice guideline: diagnosis, risk stratification, and management of pulmonary hypertension of sickle cell disease. 
  • Angiogenin-mediated tRNA cleavage as a novel feature of stored red blood cells. 
  • Aprotinin use during cardiac surgery: recent alterations and effects on blood product utilization. 
  • Are there clinical benefits with early erythropoietic intervention for chemotherapy-induced anemia? A systematic review. 
  • Association of Perioperative Red Blood Cell Transfusions With Venous Thromboembolism in a North American Registry. 
  • Association of leukocyte-depleted blood transfusions with infectious complications after cardiac surgery. 
  • Bedside Allogeneic Erythrocyte Washing with a Cell Saver to Remove Cytokines, Chemokines, and Cell-derived Microvesicles. 
  • Bivalirudin during cardiopulmonary bypass in patients with previous or acute heparin-induced thrombocytopenia and heparin antibodies: results of the CHOOSE-ON trial. 
  • Blood transfusions are associated with urinary biomarkers of kidney injury in cardiac surgery. 
  • Blood utilization and hemoglobin levels in cancer patients after label and coverage changes for erythropoiesis-stimulating agents. 
  • Case 13--2014: Management of pulmonary hemorrhage after pulmonary endarterectomy with venovenous extracorporeal membrane oxygenation without systemic anticoagulation. 
  • Cerebral Oxygenation and Transfusion for Severe Anemia: Searching for Functional Outcomes to Guide Transfusion. 
  • Changes in blood center red blood cell distributions in the era of patient blood management: the trends for collection (TFC) study. 
  • Clinical studies of erythrocyte outcomes and mortality: size really counts. 
  • Clinical trials evaluating red blood cell transfusion thresholds: An updated systematic review and with additional focus on patients with cardiovascular disease. 
  • Coagulation and fibrinolytic protein kinetics in cardiopulmonary bypass. 
  • Comparative changes of pre-operative autologous transfusions and peri-operative cell salvage in the United States. 
  • Comparison of red cell transfusion and polyethylene glycol-modified adenosine deaminase therapy in an adenosine deaminase-deficient child: measurement of erythrocyte deoxyadenosine triphosphate as a useful tool. 
  • Computerized physician order entry improves compliance with a manual exchange transfusion protocol in the pediatric intensive care unit. 
  • Concepts of blood transfusion in adults. 
  • Cryopreserved packed red blood cells in surgical patients: past, present, and future. 
  • Definitions of the phenotypic manifestations of sickle cell disease. 
  • Disparity in the management of iron overload between patients with sickle cell disease and thalassemia who received transfusions. 
  • Do red cell transfusions increase the risk of necrotizing enterocolitis in premature infants? 
  • Donor Iron Deficiency Study (DIDS): protocol of a study to test whether iron deficiency in blood donors affects red blood cell recovery after transfusion. 
  • Donor glucose-6-phosphate dehydrogenase deficiency decreases blood quality for transfusion. 
  • Double-blind, placebo-controlled study of quality of life, hematologic end points, and safety of weekly epoetin alfa in children with cancer receiving myelosuppressive chemotherapy. 
  • Early Blood Transfusions in Sepsis: Unchanged Survival and Increased Costs. 
  • Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis. 
  • Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial. 
  • Effect of Prone Positional Apparatus on the Occurrence of Acute Kidney Injury After Spine Surgery. 
  • Effect of liberal blood transfusion on clinical outcomes and cost in spine surgery patients. 
  • Effects of blood storage age on immune, coagulation, and nitric oxide parameters in transfused patients undergoing cardiac surgery. 
  • Effects of red blood cell (RBC) transfusion on sickle cell disease recipient plasma and RBC metabolism. 
  • Effects of red-cell storage duration on patients undergoing cardiac surgery. 
  • Effects of repleting organic phosphates in banked erythrocytes on plasma metabolites and vasoactive mediators after red cell exchange transfusion in sickle cell disease. 
  • Epidural analgesia in hepatic resection. 
  • Erythrocyte-Derived Microparticles Activate Pulmonary Endothelial Cells in a Murine Model of Transfusion. 
  • Estimation of Achievable Oxygen Consumption Following Transfusion With Rejuvenated Red Blood Cells. 
  • Estimation of economic costs associated with transfusion dependence in adults with MDS. 
  • Etiology and complications of thrombocytopenia in hospitalized medical patients. 
  • Evidence gaps in the management of sickle cell disease: A summary of needed research. 
  • Extended storage of AS-1 and AS-3 leukoreduced red blood cells for 15 days after deglycerolization and resuspension in AS-3 using an automated closed system. 
  • Factors associated with red blood cell, platelet, and plasma transfusions among inpatient hospitalizations: a nationally representative study in the United States. 
  • Feeding practices and other risk factors for developing transfusion-associated necrotizing enterocolitis. 
  • Goal-directed intraoperative fluid administration reduces length of hospital stay after major surgery. 
  • Hematocrit as a predictor of preoperative transfusion-associated complications in spine surgery: A NSQIP study. 
  • Higher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants. 
  • Hospital red blood cell and platelet supply and utilization from March to December of the first year of the COVID-19 pandemic: The BEST collaborative study. 
  • Impact of transfusion of autologous 7- versus 42-day-old AS-3 red blood cells on tissue oxygenation and the microcirculation in healthy volunteers. 
  • Implementation of a pediatric trauma massive transfusion protocol: one institution's experience. 
  • Increased number of coagulation products in relationship to red blood cell products transfused improves mortality in trauma patients. 
  • Interval decline in hemoglobin A is associated with annual clinical event rate in sickle cell anemia patients receiving maintenance apheresis RBC exchange. 
  • Inventory management strategies that reduce the age of red blood cell components at the time of transfusion. 
  • Invited commentary. 
  • Iron overload following red blood cell transfusion and its impact on disease severity. 
  • Is preoperative fibrinogen predictive for postoperative bleeding after coronary artery bypass grafting surgery? 
  • Is there transfusion-related acute renal injury? 
  • Isn't it about time we learned how to use blood transfusion in patients with ischemic heart disease? 
  • Marrow harvesting from normal donors. 
  • Marrow transplantation for thalassaemia. 
  • Massive transfusion in the pediatric population: A systematic review and summary of best-evidence practice strategies. 
  • Metabolic impact of red blood cell exchange with rejuvenated red blood cells in sickle cell patients. 
  • Mitral surgery after prior cardiac operation: port-access versus sternotomy or thoracotomy. 
  • Morbidity and mortality in chronically transfused subjects with thalassemia and sickle cell disease: A report from the multi-center study of iron overload. 
  • Mortality benefit with prasugrel in the TRITON-TIMI 38 coronary artery bypass grafting cohort: risk-adjusted retrospective data analysis. 
  • Myelodysplastic syndromes clinical practice guidelines in oncology. 
  • National Benchmarks for Proportions of Patients Receiving Blood Transfusions During Pediatric and Congenital Heart Surgery: An Analysis of the STS Congenital Heart Surgery Database. 
  • Nitric oxide loading reduces sickle red cell adhesion and vaso-occlusion in vivo. 
  • Packed red blood cells suppress T-cell proliferation through a process involving cell-cell contact. 
  • Patient Blood Management: Recommendations From the 2018 Frankfurt Consensus Conference. 
  • Patterns and outcomes of red blood cell transfusion in patients undergoing percutaneous coronary intervention. 
  • Patterns of phlebotomy blood loss and transfusions in extremely low birth weight infants. 
  • Perioperative Anemia: Prevention, Diagnosis, and Management Throughout the Spectrum of Perioperative Care. 
  • Perioperative Fresh Red Blood Cell Transfusion May Negatively Affect Recipient Survival After Liver Transplantation. 
  • Perioperative Transfusions and Venous Thromboembolism. 
  • Point-of-care washing of allogeneic red blood cells for the prevention of transfusion-related respiratory complications (WAR-PRC): a protocol for a multicenter randomised clinical trial in patients undergoing cardiac surgery. 
  • Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomized, double-blind trial. 
  • Post-operative pharmacologic thromboprophylaxis after major hepatectomy: does peripheral venous thromboembolism prevention outweigh bleeding risks? 
  • Predictors of massive transfusion with thoracic aortic procedures involving deep hypothermic circulatory arrest. 
  • Preoperative transarterial embolization of spinal column neoplasms. 
  • Prior polyvascular disease: risk factor for adverse ischaemic outcomes in acute coronary syndromes. 
  • Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016. 
  • Prognostic impact of blood transfusion after primary angioplasty for acute myocardial infarction: analysis from the CADILLAC (Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications) Trial. 
  • Proinflammatory, immunomodulating, and prothrombotic properties of anemia and red blood cell transfusions. 
  • Prolonged red cell storage before transfusion increases extravascular hemolysis. 
  • Propensity matched comparison of outcomes in older and younger patients after coronary artery bypass graft surgery. 
  • RBC transfusions in paroxysmal nocturnal hemoglobinuria. 
  • Radial versus femoral access, bleeding and ischemic events in patients with non-ST-segment elevation acute coronary syndrome managed with an invasive strategy. 
  • Randomized controlled trial of 7, 28, vs 42 day stored red blood cell transfusion on oxygen delivery (VO2 max) and exercise duration. 
  • Randomized study of washing 40- to 42-day-stored red blood cells. 
  • Rapid increases in parasitemia following red cell exchange for malaria. 
  • Red blood cell alloimmunization mitigation strategies. 
  • Red blood cell phenotype fidelity following glycerol cryopreservation optimized for research purposes. 
  • Red blood cell transfusion threshold and mortality in cardiac intensive care unit patients. 
  • Red cell exchange transfusion for babesiosis in Rhode Island. 
  • Reexamination of the chromium-51-labeled posttransfusion red blood cell recovery method. 
  • Relationship of neonatal treatments with the development of necrotizing enterocolitis in preterm infants. 
  • Restrictive versus liberal red blood cell transfusion for cardiac surgery: a systematic review and meta-analysis of randomized controlled trials. 
  • Retrospective analysis of community hospital red blood cell recovery procedures: improved utilization needed for effectiveness. 
  • Safe application of a restrictive transfusion protocol in moderate-risk patients undergoing cardiac operations. 
  • Safety of selective serotonin reuptake inhibitor use prior to coronary artery bypass grafting. 
  • Secondary surgical-site infection after coronary artery bypass grafting: A multi-institutional prospective cohort study. 
  • Society of Cardiovascular Anesthesiologists Clinical Practice Improvement Advisory for Management of Perioperative Bleeding and Hemostasis in Cardiac Surgery Patients. 
  • Targeting health-related quality of life in patients with myelodysplastic syndromes - Current knowledge and lessons to be learned. 
  • The AABB recommendations for the Choosing Wisely campaign of the American Board of Internal Medicine. 
  • The Association of Increased FFP:RBC Transfusion Ratio to Primary Graft Dysfunction in Bleeding Lung Transplantation Patients. 
  • The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States. 
  • The Prospective Evaluation of the Net Effect of Red Blood Cell Transfusions in Routine Provision of Palliative Care. 
  • The association between duration of storage of transfused red blood cells and morbidity and mortality after reoperative cardiac surgery. 
  • To transfuse or not to transfuse in upper gastrointestinal hemorrhage? That is the question. 
  • Transfusion and mortality in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. 
  • Transfusion of Red Blood Cells Stored More Than 28 Days is Associated With Increased Morbidity Following Spine Surgery. 
  • Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings. 
  • Transfusion-related biologic effects and free hemoglobin, heme, and iron. 
  • Transfusion-transmitted babesiosis: achieving successful mitigation while balancing cost and donor loss. 
  • Transient abnormalities in serum bilirubin and lactate dehydrogenase levels following red blood cell transfusions in adults. 
  • Treatment through a preoperative anemia clinic is associated with a reduction in perioperative red blood cell transfusion in patients undergoing orthopedic and gynecologic surgery. 
  • Trends in antigen-negative red blood cell distributions by racial or ethnic groups in the United States. 
  • Variation in use of blood transfusion in coronary artery bypass graft surgery. 
  • When Therapy Is Confounded With Approach: Retrospective Studies of Transfusion-Related Outcomes After Lung Transplantation. 
  • epsilon-Aminocaproic acid plasma levels during cardiopulmonary bypass. 
  • pH modulation ameliorates the red blood cell storage lesion in a murine model of transfusion. 
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  Keywords of People

  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. Distinguished Professor, Medicine, Clinical Pharmacology