Acid Anhydride Hydrolases
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Subject Areas on Research
- 5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer.
- Aberrant FHIT mRNA transcripts are present in malignant and normal haematopoiesis, but absence of FHIT protein is restricted to leukaemia.
- Abnormal Fhit expression in malignant and premalignant lesions of the cervix.
- Association between germline variation in the FHIT gene and prostate cancer in Caucasians and African Americans.
- Attempted replication of 50 reported asthma risk genes identifies a SNP in RAD50 as associated with childhood atopic asthma.
- BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.
- Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.
- FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations.
- Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma.
- Genomic FHIT analysis in RER+ and RER- adenocarcinomas of the pancreas.
- Heat induces gene amplification in cancer cells.
- Implication of mitochondrial involvement in apoptotic activity of fragile histidine triad gene: application of synchronous luminescence spectroscopy.
- Loss of Fhit expression in non-small-cell lung cancer: correlation with molecular genetic abnormalities and clinicopathological features.
- Microarray sampling-platform fabrication using bubble-jet technology for a biochip system.
- Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair.
- Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines.
- Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks.
- Simultaneous detection of the tumor suppressor FHIT gene and protein using the multi-functional biochip.
- Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11.
- Surgical treatment of malignant esophageal tumors in PUMC Hospital.
- The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.
- [Surgical treatment of malignant esophageal tumors in PUMC Hospital].
- p53: a two-faced cancer gene.