Long-Term Potentiation

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  Subject Areas on Research

  • A unified model of the presynaptic and postsynaptic changes during LTP at CA1 synapses. 
  • Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits. 
  • Actin-associated neurabin-protein phosphatase-1 complex regulates hippocampal plasticity. 
  • Acute and Long-Term Effects of Brief Sevoflurane Anesthesia During the Early Postnatal Period in Rats. 
  • Acute in vivo genetic rescue demonstrates that phosphorylation of RIM1alpha serine 413 is not required for mossy fiber long-term potentiation. 
  • Adolescent intermittent alcohol exposure: persistence of structural and functional hippocampal abnormalities into adulthood. 
  • Age and dose-dependent effects of ethanol on the induction of hippocampal long-term potentiation. 
  • Age-dependent inhibition of long-term potentiation by ethanol in immature versus mature hippocampus. 
  • Ampakine CX717 potentiates intermittent hypoxia-induced hypoglossal long-term facilitation. 
  • Amyloid precursor protein and amyloid beta-peptide bind to ATP synthase and regulate its activity at the surface of neural cells. 
  • Amyloid-beta1-42 reduces neuronal excitability in mouse dentate gyrus. 
  • ApoE isoform affects LTP in human targeted replacement mice. 
  • ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-beta1-42. 
  • Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline. 
  • Autocrine BDNF-TrkB signalling within a single dendritic spine. 
  • Biochemical principles underlying the stable maintenance of LTP by the CaMKII/NMDAR complex. 
  • Blockade of nicotinic acetylcholine receptors suppresses hippocampal long-term potentiation in wild-type but not ApoE4 targeted replacement mice. 
  • Burst-Dependent Bidirectional Plasticity in the Cerebellum Is Driven by Presynaptic NMDA Receptors. 
  • Calcium-based plasticity model explains sensitivity of synaptic changes to spike pattern, rate, and dendritic location. 
  • Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway. 
  • Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus. 
  • Central sensitization and LTP: do pain and memory share similar mechanisms? 
  • Cerebellar LTD: a molecular mechanism of behavioral learning? 
  • Cerebellar learning using perturbations. 
  • Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation. 
  • Chronic IL-1beta signaling potentiates voltage-dependent sodium currents in trigeminal nociceptive neurons. 
  • Deconstructing behavioral neuropharmacology with cellular specificity. 
  • Depression of LTP in rat dentate gyrus by naloxone is reversed by GABAA blockade. 
  • Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome. 
  • Development of intrinsic and synaptic properties in a forebrain nucleus essential to avian song learning. 
  • Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum. 
  • Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis. 
  • Dynamic changes in single unit activity and γ oscillations in a thalamocortical circuit during rapid instrumental learning. 
  • Effects of relative hypoglycemia on LTP and NADH imaging in rat hippocampal slices. 
  • Endogenous opioids regulate long-term potentiation of synaptic inhibition in the dentate gyrus of rat hippocampus. 
  • Estradiol enhances long term potentiation in hippocampal slices from aged apoE4-TR mice. 
  • Excitatory amino acid receptors and epilepsy. 
  • Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion. 
  • Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP. 
  • Genetics of Angelman syndrome. 
  • Hippocampal function during adolescence: a unique target of ethanol effects. 
  • Hippocampal long-term potentiation and spatial learning in the rat: effects of GABAB receptor blockade. 
  • Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. 
  • Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity. 
  • Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. 
  • In vivo and in vitro analyses of amygdalar function reveal a role for copper. 
  • Induction and reversal of long-term potentiation by low- and high-intensity theta pattern stimulation. 
  • Induction and reversal of long-term potentiation by low- and high-intensity theta pattern stimulation. 
  • Induction of hippocampal long-term potentiation during waking leads to increased extrahippocampal zif-268 expression during ensuing rapid-eye-movement sleep. 
  • Initiation, synchronization, and spread of epileptic discharges. Introduction. 
  • Isolated Primary Blast Inhibits Long-Term Potentiation in Organotypic Hippocampal Slice Cultures. 
  • LTP in the mouse nucleus accumbens is developmentally regulated. 
  • Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts. 
  • Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate. 
  • Long-term potentiation requires activation of calcium-independent phospholipase A2. 
  • Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall. 
  • Mechanisms of CaMKII action in long-term potentiation. 
  • Medial septal benzodiazepine receptors modulate hippocampal evoked responses and long-term potentiation. 
  • Model of global spontaneous activity and local structured activity during delay periods in the cerebral cortex. 
  • Motor learning and memory in the vestibulo-ocular reflex: the dark side. 
  • Munc13-1 is required for presynaptic long-term potentiation. 
  • Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. 
  • NGF is essential for hippocampal plasticity and learning. 
  • Neural basis for motor learning in the vestibuloocular reflex of primates. I. Changes in the responses of brain stem neurons. 
  • Neural basis for motor learning in the vestibuloocular reflex of primates. II. Changes in the responses of horizontal gaze velocity Purkinje cells in the cerebellar flocculus and ventral paraflocculus. 
  • Neural basis for motor learning in the vestibuloocular reflex of primates. III. Computational and behavioral analysis of the sites of learning. 
  • Neural recordings and behavioral observations in the monkey vestibulo-ocular reflex constrain the cellular mechanisms for cerebellum-dependent behavioral learning. 
  • Paired-pulse potentiation of alpha7-containing nAChRs in rat hippocampal CA1 stratum radiatum interneurones. 
  • Physiological roles of the Ca2+/CaM-dependent protein kinase cascade in health and disease. 
  • Plasticity and behavior: new genetic techniques to address multiple forms and functions. 
  • Post-ictal depression transiently inhibits induction of LTP in area CA1 of the rat hippocampal slice. 
  • Power spectral analysis of hypoglossal nerve activity during intermittent hypoxia-induced long-term facilitation in mice. 
  • Prenatal dietary choline supplementation decreases the threshold for induction of long-term potentiation in young adult rats. 
  • Presynaptic and postsynaptic roles of NO, cGK, and RhoA in long-lasting potentiation and aggregation of synaptic proteins. 
  • Primary Blast Exposure Increases Hippocampal Vulnerability to Subsequent Exposure: Reducing Long-Term Potentiation. 
  • Proline-induced potentiation of glutamate transmission. 
  • Rapid increase in clusters of presynaptic proteins at onset of long-lasting potentiation. 
  • Regional-specific effects of ovarian hormone loss on synaptic plasticity in adult human APOE targeted replacement mice. 
  • Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. 
  • Regulation of synaptic strength by protein phosphatase 1. 
  • Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. 
  • Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity. 
  • STDP in a bistable synapse model based on CaMKII and associated signaling pathways. 
  • Seizure-like activity disrupts LTP in vitro. 
  • Spinal CCL2 Promotes Central Sensitization, Long-Term Potentiation, and Inflammatory Pain via CCR2: Further Insights into Molecular, Synaptic, and Cellular Mechanisms. 
  • Synapse-specific downregulation of NMDA receptors by early experience: a critical period for plasticity of sensory input to olfactory cortex. 
  • Synaptic plasticity in drug reward circuitry. 
  • Synaptic plasticity in morphologically identified CA1 stratum radiatum interneurons and giant projection cells. 
  • Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation. 
  • The cellular and synaptic location of activated TrkB in mouse hippocampus during limbic epileptogenesis. 
  • The effects of NR2 subunit-dependent NMDA receptor kinetics on synaptic transmission and CaMKII activation. 
  • Toward a Neurocentric View of Learning. 
  • Vagus nerve stimulation potentiates hippocampal LTP in freely-moving rats. 
  • Vesicular zinc promotes presynaptic and inhibits postsynaptic long-term potentiation of mossy fiber-CA3 synapse. 
  • cAMP response element-binding protein 1 feedback loop is necessary for consolidation of long-term synaptic facilitation in Aplysia. 
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  Keywords of People

  • Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering