Machado-Joseph Disease

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  Subject Areas on Research

  • Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117. 
  • Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. 
  • Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3. 
  • Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3.