Subject Areas on Research
- Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117.
- Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries.
- Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3.
- Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3.