Phosphotransferases (Alcohol Group Acceptor)
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Subject Areas on Research
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A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol.
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A PCR-based strategy to generate integrative targeting alleles with large regions of homology.
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A high-performance liquid chromatographic method to measure sphingosine 1-phosphate and related compounds from sphingosine kinase assays and other biological samples.
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A member of a family of sulfate-activating enzymes causes murine brachymorphism.
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A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster.
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A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.
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A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control.
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A role for rat inositol polyphosphate kinases rIPK2 and rIPK1 in inositol pentakisphosphate and inositol hexakisphosphate production in rat-1 cells.
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A single-center experience with ganciclovir-resistant cytomegalovirus in lung transplant recipients: treatment and outcome.
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A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cells.
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Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival.
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Activity and stability of recombinant bifunctional rearranged and monofunctional domains of ATP-sulfurylase and adenosine 5'-phosphosulfate kinase.
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Alteration of lithium pharmacology through manipulation of phosphoadenosine phosphate metabolism.
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Alterations in an inositol phosphate code through synergistic activation of a G protein and inositol phosphate kinases.
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Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism.
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An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production.
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Analysis of sphingoid bases and sphingoid base 1-phosphates by high-performance liquid chromatography.
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BMI1 enhancer polymorphism underlies chromosome 10p12.31 association with childhood acute lymphoblastic leukemia.
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Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor.
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Biochemical and functional characterization of inositol 1,3,4,5, 6-pentakisphosphate 2-kinases.
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CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish.
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CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis.
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Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis.
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Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates.
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Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.
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Clinical heterogeneity of mitochondrial NAD kinase deficiency caused by a NADK2 start loss variant.
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Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception.
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Control of the innate immune response by the mevalonate pathway.
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Deep brain stimulation as a mode of treatment of early onset pantothenate kinase-associated neurodegeneration.
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Deletion and site-directed mutagenesis of the ATP-binding motif (P-loop) in the bifunctional murine ATP-sulfurylase/adenosine 5'-phosphosulfate kinase enzyme.
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Dominant selection system for use in Cryptococcus neoformans.
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EJ-Ras inhibits phospholipase C gamma 1 but not actin polymerization induced by platelet-derived growth factor-BB via phosphatidylinositol 3-kinase.
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Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae.
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Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells.
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FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity.
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Fragments of ATM which have dominant-negative or complementing activity.
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Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif.
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Fungal homoserine kinase (thr1Delta) mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation.
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G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
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GATA3 risk alleles are associated with ancestral components in Hispanic children with ALL.
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Generation of phytate-free seeds in Arabidopsis through disruption of inositol polyphosphate kinases.
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Genetic variation in the one-carbon transfer pathway and ovarian cancer risk.
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Genomic characterization of POS5, the Saccharomyces cerevisiae mitochondrial NADH kinase.
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Homoserine toxicity in Saccharomyces cerevisiae and Candida albicans homoserine kinase (thr1Delta) mutants.
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Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases.
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Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.
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Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling.
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Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila.
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Inositol phosphate multikinase dependent transcriptional control.
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Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.
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Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22.
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Isolation of suppressor mutants of phosphatidylinositol 3-phosphate 5-kinase deficient cells in Schizosaccharomyces pombe.
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Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis.
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MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.
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Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast.
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Mechanistic characterization of the tetraacyldisaccharide-1-phosphate 4'-kinase LpxK involved in lipid A biosynthesis.
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Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia.
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Modulation of inositol phospholipid metabolism by polyamines.
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Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases.
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Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiae.
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Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin.
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NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling.
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Novel childhood ALL susceptibility locus BMI1-PIP4K2A is specifically associated with the hyperdiploid subtype.
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Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.
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Nutrient signaling through TOR kinases controls gene expression and cellular differentiation in fungi.
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Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity.
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Overexpression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production.
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PIP5K1α inhibition as a therapeutic strategy for prostate cancer.
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PIP5K1α promotes myogenic differentiation via AKT activation and calcium release.
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Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway.
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Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast.
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Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR.
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Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells.
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Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway.
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Regulation of nuclear processes by inositol polyphosphates.
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Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.
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Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication.
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Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes.
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SPHK1 Is a Novel Target of Metformin in Ovarian Cancer.
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Structural basis of lipid binding for the membrane-embedded tetraacyldisaccharide-1-phosphate 4'-kinase LpxK.
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Structural studies and protein engineering of inositol phosphate multikinase.
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Sulfate activation and transport in mammals: system components and mechanisms.
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TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk.
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TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase signaling effectors.
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TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.
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TRPC1 channels are critical for hypertrophic signaling in the heart.
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Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.
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The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.
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The isolation and characterization of cDNA encoding the mouse bifunctional ATP sulfurylase-adenosine 5'-phosphosulfate kinase.
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The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation.
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Threonine biosynthetic genes are essential in Cryptococcus neoformans.
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Tor and cyclic AMP-protein kinase A: two parallel pathways regulating expression of genes required for cell growth.
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Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model.
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p53 and ATM: cell cycle, cell death, and cancer.
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Keywords of People