Cyclic AMP-Dependent Protein Kinases
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Subject Areas on Research
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A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus.
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A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans.
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A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination.
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A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension.
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A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
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AMPK and substrate availability regulate creatine transport in cultured cardiomyocytes.
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AQP2 is a substrate for endogenous PP2B activity within an inner medullary AKAP-signaling complex.
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Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases.
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Acceleration of myosin light chain dephosphorylation and relaxation of smooth muscle by telokin. Synergism with cyclic nucleotide-activated kinase.
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Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.
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Acute in vivo genetic rescue demonstrates that phosphorylation of RIM1alpha serine 413 is not required for mossy fiber long-term potentiation.
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Acute regulation of NHE3 by protein kinase A requires a multiprotein signal complex.
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Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C.
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Adenylyl cyclase G, an osmosensor controlling germination of Dictyostelium spores.
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Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade.
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Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C.
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Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration.
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Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy.
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Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities.
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Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients.
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An alanine residue in the M3-M4 linker lines the glycine binding pocket of the N-methyl-D-aspartate receptor.
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Anabolic effects of a G protein-coupled receptor kinase inhibitor expressed in osteoblasts.
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Analysis of the structural properties of cAMP-responsive element-binding protein (CREB) and phosphorylated CREB.
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Androgen receptor activation by G(s) signaling in prostate cancer cells.
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Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons.
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Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway.
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Arc/Arg3.1 translation is controlled by convergent N-methyl-D-aspartate and Gs-coupled receptor signaling pathways.
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Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling.
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Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation.
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Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2.
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Beta-adrenergic axis and heart disease.
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Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization.
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Beta-adrenergic receptor kinase: primary structure delineates a multigene family.
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Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway.
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Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.
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Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms.
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Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels.
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Binding of G protein beta gamma-subunits to pleckstrin homology domains.
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Biochemical and biophysical identification of cystic fibrosis transmembrane conductance regulator chloride channels as components of endocytic clathrin-coated vesicles.
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Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring.
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CAMP-mediated inhibition of the renal brush border membrane Na+-H+ exchanger requires a dissociable phosphoprotein cofactor.
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CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin.
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Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV gene.
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Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure.
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Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.
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Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.
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Cardiac hypertrophy and altered beta-adrenergic signaling in transgenic mice that express the amino terminus of beta-ARK1.
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Cardiac muscarinic potassium channel activity is attenuated by inhibitors of G beta gamma.
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Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells.
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Cellular and functional defects in a mouse model of heart failure.
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Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.
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Central regulation of photosensitive membrane turnover in the lateral eye of Limulus, II: octopamine acts via adenylate cyclase/cAMP-dependent protein kinase to prime the retina for transient rhabdom shedding.
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Cerebellar defects in Ca2+/calmodulin kinase IV-deficient mice.
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Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response.
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Characterization of GRK2-catalyzed phosphorylation of the human substance P receptor in Sf9 membranes.
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Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger.
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Chronic very low dose naltrexone administration attenuates opioid withdrawal expression.
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Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family.
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Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase.
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Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans.
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Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.
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Conserved cAMP signaling cascades regulate fungal development and virulence.
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Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features.
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Constitutively active mutants of the alpha 2-adrenergic receptor.
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Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice.
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Control of the postmating behavioral switch in Drosophila females by internal sensory neurons.
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Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.
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Cryptococcal titan cell formation is regulated by G-protein signaling in response to multiple stimuli.
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Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling.
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Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans.
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Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans.
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Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae.
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DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells.
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Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity.
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Defective beta-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression.
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Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice.
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Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.
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Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms.
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Desensitization of the mouse thromboxane A2 receptor (TP) by G protein-coupled receptor kinases (Grks).
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Determination of the G beta gamma-binding domain of phosducin. A regulatable modulator of G beta gamma signaling.
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Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor.
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Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells.
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Differential myocardial gene expression in the development and rescue of murine heart failure.
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Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases.
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Differential regulation of formyl peptide and platelet-activating factor receptors. Role of phospholipase Cbeta3 phosphorylation by protein kinase A.
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Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins.
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Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.
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Direct regulation of the Na,K pump by signal transduction mechanisms.
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Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.
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Divergence of protein kinase A catalytic subunits in Cryptococcus neoformans and Cryptococcus gattii illustrates evolutionary reconfiguration of a signaling cascade.
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Divergent Roles for cAMP-PKA Signaling in the Regulation of Filamentous Growth in Saccharomyces cerevisiae
and Saccharomyces bayanus
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Domains of the parathyroid hormone (PTH) receptor required for regulation by G protein-coupled receptor kinases (GRKs).
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ETAR and protein kinase A pathway mediate ET-1 sensitization of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.
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Effects of human immunodeficiency virus type 1 on CD4 lymphocyte subset activation.
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Elevated mu-opioid receptor expression in the nucleus of the solitary tract accompanies attenuated withdrawal signs after chronic low dose naltrexone in opiate-dependent rats.
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Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin-producing beta-cell line (INS-1 832/13).
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Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein.
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Enhanced cardiac function in transgenic mice expressing a Ca(2+)-stimulated adenylyl cyclase.
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Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine.
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Environmental and genetic determinants of colony morphology in yeast.
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Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades.
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Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-alphavbeta3 interactions.
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Epitope-specific signaling through CD45 on T lymphocytes leads to cAMP synthesis in monocytes after ICAM-1-dependent cellular interaction.
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Essential role for NHERF in cAMP-mediated inhibition of the Na+-HCO3- co-transporter in BSC-1 cells.
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Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.
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Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice.
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Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice.
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Ezrin Orchestrates Signal Transduction in Airway Cells.
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Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases.
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Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone.
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Forskolin stimulation of water and cation permeability in aquaporin 1 water channels.
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Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling.
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Functional consequences of A1 adenosine-receptor phosphorylation by the beta-adrenergic receptor kinase.
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Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein).
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Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.
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G protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development.
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G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans.
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G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning.
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G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis.
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G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization.
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G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95.
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G protein-coupled receptor kinase function is essential for chemosensation in C. elegans.
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G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation.
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G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR.
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G-protein-coupled receptor function in heart failure.
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G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins.
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Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP.
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Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress.
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Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.
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HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling.
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Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling.
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Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart.
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Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor.
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Improving FRET dynamic range with bright green and red fluorescent proteins.
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In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function.
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In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction.
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Increased renal dopamine and acute renal adaptation to a high-phosphate diet.
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Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells.
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Inhibition of Ca²⁺/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation.
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Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy.
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Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis.
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Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure.
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Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor.
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Inhibition of the beta-adrenergic receptor kinase by polyanions.
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Inhibition of the cAMP/PKA/CREB Pathway Contributes to the Analgesic Effects of Electroacupuncture in the Anterior Cingulate Cortex in a Rat Pain Memory Model.
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Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases.
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Inhibitor-1, a regulator of protein phosphatase 1 function.
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Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule.
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Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2.
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Intracellular signaling in primary sensory neurons and persistent pain.
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Investigation of the basis of virulence in serotype A strains of Cryptococcus neoformans from apparently immunocompetent individuals.
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Involvement of cAMP-dependent protein kinase in mu-opioid modulation of NMDA-mediated synaptic currents.
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Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.
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Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases.
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Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma.
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Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis.
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Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure.
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MRP4-mediated regulation of intracellular cAMP and cGMP levels in trabecular meshwork cells and homeostasis of intraocular pressure.
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Maximal beta3-adrenergic regulation of lipolysis involves Src and epidermal growth factor receptor-dependent ERK1/2 activation.
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Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase.
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Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1.
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Mitochondria, cell death, and B cell tolerance.
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Modeling mutant phenotypes and oscillatory dynamics in the Saccharomyces cerevisiae cAMP-PKA pathway.
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Modes of interactions between signaling pathways.
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Modulation of Xenopus oocyte-expressed phospholemman-induced ion currents by co-expression of protein kinases.
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Modulatory function of CREB.CREM alpha heterodimers depends upon CREM alpha phosphorylation.
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Molecular basis for interactions of G protein betagamma subunits with effectors.
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Molecular beta-adrenergic signaling abnormalities in failing rabbit hearts after infarction.
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Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases.
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Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2.
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Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding.
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Mutations of the serine phosphorylated in the protein phosphatase-1-binding motif in the skeletal muscle glycogen-targeting subunit.
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Myocardial G protein-coupled receptor kinases: implications for heart failure therapy.
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Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice.
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Myocardial overexpression of adrenergic receptors and receptor kinases.
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NHERF and regulation of the renal sodium-hydrogen exchanger NHE3.
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NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes.
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Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion.
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Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression.
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Orphan Adhesion GPCR GPR64/ADGRG2 Is Overexpressed in Parathyroid Tumors and Attenuates Calcium-Sensing Receptor-Mediated Signaling.
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Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells attenuates mitogenic signaling via G protein-coupled and platelet-derived growth factor receptors.
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Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells reduces neointimal hyperplasia.
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Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.
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Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury.
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PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation.
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PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching.
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PKA/AKAP1 and PP2A/Bβ2 regulate neuronal morphogenesis via Drp1 phosphorylation and mitochondrial bioenergetics.
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PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation.
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PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms.
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Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1.
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Pde1 phosphodiesterase modulates cyclic AMP levels through a protein kinase A-mediated negative feedback loop in Cryptococcus neoformans.
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Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies.
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Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex.
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Phosphorylation analysis of G protein-coupled receptor by mass spectrometry: identification of a phosphorylation site in V2 vasopressin receptor.
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Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity.
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Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase.
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Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10).
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Phosphorylation of Aspergillus fumigatus PkaR impacts growth and cell wall integrity through novel mechanisms.
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Phosphorylation of G protein-coupled receptor kinase 1 (GRK1) is regulated by light but independent of phototransduction in rod photoreceptors.
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Phosphorylation of chick heart muscarinic cholinergic receptors by the beta-adrenergic receptor kinase.
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Phosphorylation of telokin by cyclic nucleotide kinases and the identification of in vivo phosphorylation sites in smooth muscle.
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Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress.
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Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na(+)/H(+) exchanger regulatory factor.
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Physiological induction of a beta-adrenergic receptor kinase inhibitor transgene preserves ss-adrenergic responsiveness in pressure-overload cardiac hypertrophy.
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Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid.
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Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction.
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Presynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca2+ entry pathway.
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Properties of secretin receptor internalization differ from those of the beta(2)-adrenergic receptor.
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Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways.
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Protein kinase A operates a molecular switch that governs yeast pseudohyphal differentiation.
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Protein kinase A regulates ATP hydrolysis and dimerization by a CFTR (cystic fibrosis transmembrane conductance regulator) domain.
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Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system.
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Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis.
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Protein phosphatases mediate depotentiation induced by high-intensity theta-burst stimulation.
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Protein phosphorylation is a regulatory mechanism for O6-alkylguanine-DNA alkyltransferase in human brain tumor cells.
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Protein synthesis-dependent potentiation by thyroxine of antiviral activity of interferon-gamma.
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Proteolytic cleavage and PKA phosphorylation of α1C subunit are not required for adrenergic regulation of CaV1.2 in the heart.
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Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2.
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RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation.
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RNA editing induces variation in desensitization and trafficking of 5-hydroxytryptamine 2c receptor isoforms.
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Real-time visualization of the cellular redistribution of G protein-coupled receptor kinase 2 and beta-arrestin 2 during homologous desensitization of the substance P receptor.
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Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases.
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Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems.
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Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice.
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Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4.
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Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization.
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Regulation of G protein-coupled receptors by agonist-dependent phosphorylation.
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Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79.
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Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors.
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Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer.
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Role of VASP phosphorylation for the regulation of microglia chemotaxis via the regulation of focal adhesion formation/maturation.
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Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase.
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Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors.
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Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization.
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Role of beta-arrestins in the intracellular trafficking of G-protein-coupled receptors.
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Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in Dictyostelium.
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Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1.
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Role of the beta-adrenergic receptor kinase in desensitization of the alpha 2-adrenergic receptor.
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Salt stress increases abundance and glycosylation of CFTR localized at apical surfaces of salt gland secretory cells.
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Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold.
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Seven-transmembrane-spanning receptors and heart function.
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Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA.
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Signal transduction cascades regulating fungal development and virulence.
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Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae.
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Signal transduction. Bringing channels closer to the action!
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Signaling pathways mediating beta3-adrenergic receptor-induced production of interleukin-6 in adipocytes.
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Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism.
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Sok2 regulates yeast pseudohyphal differentiation via a transcription factor cascade that regulates cell-cell adhesion.
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Somatostatin induces translocation of the beta-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells.
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Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base.
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Specific agrin isoforms induce cAMP response element binding protein phosphorylation in hippocampal neurons.
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Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors.
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Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa.
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Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF).
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Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.
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Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization.
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Synthetic peptides of the hamster beta 2-adrenoceptor as substrates and inhibitors of the beta-adrenoceptor kinase.
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TRPV1 receptors mediate particulate matter-induced apoptosis.
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Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts.
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Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression.
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Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss.
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Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis.
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Targeting inhibition of GluR1 Ser845 phosphorylation with an RNA aptamer that blocks AMPA receptor trafficking.
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Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins.
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The Cryptococcus neoformans Rim101 transcription factor directly regulates genes required for adaptation to the host.
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The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin.
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The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain.
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The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance.
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The Listeria monocytogenes PASTA Kinase PrkA and Its Substrate YvcK Are Required for Cell Wall Homeostasis, Metabolism, and Virulence.
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The TOR signal transduction cascade controls cellular differentiation in response to nutrients.
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The adrenergic receptors.
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The beta-adrenergic receptor kinase: role in homologous desensitization in S49 lymphoma cells.
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The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis.
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The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.
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The cell and molecular basis of leukocyte common antigen (CD45)-triggered, lymphocyte function-associated antigen-1-/intercellular adhesion molecule-1-dependent, leukocyte adhesion.
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The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung.
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The genetic architecture of biofilm formation in a clinical isolate of Saccharomyces cerevisiae.
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The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells.
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The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms.
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The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2.
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The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels.
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The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition.
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The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.
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The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase.
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The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification.
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The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2.
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Tor and cyclic AMP-protein kinase A: two parallel pathways regulating expression of genes required for cell growth.
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Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts.
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Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans.
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Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling.
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Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor.
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Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PTH(1-34).
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Unveiling Protein Kinase A Targets in Cryptococcus neoformans Capsule Formation.
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Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure.
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alpha-Actinin is a potent regulator of G protein-coupled receptor kinase activity and substrate specificity in vitro.
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beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase.
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beta-Adrenergic receptor kinase. Activity of partial agonists for stimulation of adenylate cyclase correlates with ability to promote receptor phosphorylation.
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beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
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beta-Arrestin: a protein that regulates beta-adrenergic receptor function.
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beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.
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cAMP-dependent protein kinase is necessary for increased NF-E2.DNA complex formation during erythroleukemia cell differentiation.
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cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase.
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miR-33a promotes glioma-initiating cell self-renewal via PKA and NOTCH pathways.
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p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis.
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Keywords of People
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Magwene, Paul Mitaari,
Associate Professor of Biology,
Biology
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Milano, Carmelo Alessio,
Professor of Surgery,
Surgery, Cardiovascular and Thoracic Surgery
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Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology
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Soderling, Scott Haydn,
George Barth Geller Distinguished Professor of Molecular Biology,
Cell Biology
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Zennadi, Rahima,
Associate Professor in Medicine,
Pathology