Calcium-Calmodulin-Dependent Protein Kinases
-
Subject Areas on Research
-
5-Oxo-eicosanoids and hematopoietic cytokines cooperate in stimulating neutrophil function and the mitogen-activated protein kinase pathway.
-
5-Oxo-eicosatetraenoate is a broadly active, eosinophil-selective stimulus for human granulocytes.
-
A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans.
-
A novel Ca2+/calmodulin-dependent protein kinase and a male germ cell-specific calmodulin-binding protein are derived from the same gene.
-
A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy.
-
A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.
-
A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR.
-
Aberrant promoter methylation of multiple genes in non-small cell lung cancers.
-
Acetyl-CoA:1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase is directly activated by p38 kinase.
-
Acrylamide increases in vitro calcium and calmodulin-dependent kinase-mediated phosphorylation of rat brain and spinal cord neurofilament proteins.
-
Activation of MAP kinase by a dual specificity Tyr/Thr kinase.
-
Activation of calcium channels by cAMP in STC-1 cells is dependent upon Ca2+ calmodulin-dependent protein kinase II.
-
Activation of orphan receptor-mediated transcription by Ca(2+)/calmodulin-dependent protein kinase IV.
-
Activation of the 9E3/cCAF chemokine by phorbol esters occurs via multiple signal transduction pathways that converge to MEK1/ERK2 and activate the Elk1 transcription factor.
-
Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis.
-
Angiotensin II type 2 receptor mediates programmed cell death.
-
Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis.
-
Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.
-
Biochemical changes in sciatic nerve of hens treated with tri-o-cresyl phosphate: increased phosphorylation of cytoskeletal proteins.
-
Biochemical characterization of the multifunctional Ca2+/calmodulin-dependent protein kinase type IV expressed in insect cells.
-
Ca(2+)/CaM-dependent kinases: from activation to function.
-
Ca(2+)/calmodulin-dependent kinase is essential for both growth and nuclear division in Aspergillus nidulans.
-
Ca(2+)/calmodulin-dependent protein kinase IV is expressed in spermatids and targeted to chromatin and the nuclear matrix.
-
Ca2+/calmodulin-dependent protein kinase II from hen brain. Purification and characterization.
-
Ca2+/calmodulin-dependent protein kinase IV and calcium signaling.
-
Ca2+/calmodulin-dependent protein kinase type IV in dorsal root ganglion: colocalization with peptides, axonal transport and effect of axotomy.
-
CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation.
-
Calcium binding is required for calmodulin function in Aspergillus nidulans.
-
Calcium, calmodulin and cell cycle regulation.
-
Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains.
-
Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression.
-
Calmodulin activation of target enzymes. Consequences of deletions in the central helix.
-
Calmodulin and CaMKII as molecular switches for cardiac ion channels.
-
Calmodulin kinase II chimeras used to investigate the structural requirements for smooth muscle myosin light chain kinase autoinhibition and calmodulin-dependent activation.
-
Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance.
-
Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation.
-
Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV gene.
-
Capillary density of skeletal muscle: a contributing mechanism for exercise intolerance in class II-III chronic heart failure independent of other peripheral alterations.
-
Carbon disulfide inhalation increases Ca2+/calmodulin-dependent kinase phosphorylation of cytoskeletal proteins in the rat central nervous system.
-
Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects.
-
Catalytic activity is required for calcium/calmodulin-dependent protein kinase IV to enter the nucleus.
-
Cerebellar defects in Ca2+/calmodulin kinase IV-deficient mice.
-
Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation.
-
Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I.
-
Chimeric calmodulin-cardiac troponin C proteins differentially activate calmodulin target enzymes.
-
Chronic elevation of calmodulin in the ventricles of transgenic mice increases the autonomous activity of calmodulin-dependent protein kinase II, which regulates atrial natriuretic factor gene expression.
-
Comparison of Ca2+/calmodulin-dependent protein kinase II purified from control and diisopropyl phosphorofluoridate (DFP)-treated hens.
-
Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta.
-
Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions.
-
Cultured human trabecular meshwork cells express functional alpha 2A adrenergic receptors.
-
Cyclic phosphorylation-dephosphorylation of rhodopsin in retina by protein kinase FA (the activator of ATP.Mg-dependent protein phosphatase).
-
Cytoskeletal proteins as targets for organophosphorus compound and aliphatic hexacarbon-induced neurotoxicity.
-
DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells.
-
Defective signaling in a subpopulation of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IV.
-
Defective survival and activation of thymocytes in transgenic mice expressing a catalytically inactive form of Ca2+/calmodulin-dependent protein kinase IV.
-
Defining Ca2+/calmodulin-dependent protein kinase cascades in transcriptional regulation.
-
Differential effects of platelet-derived growth factor isotypes on human smooth muscle cell proliferation and migration are mediated by distinct signaling pathways.
-
Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo.
-
Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins.
-
Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation.
-
Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase.
-
Dual kinase-mediated regulation of PITK by CaMKII and GSK3.
-
Effect of a dominant negative ras on myocardial hypertrophy by using adenoviral-mediated gene transfer.
-
Effects of human immunodeficiency virus type 1 on CD4 lymphocyte subset activation.
-
Enhanced activity and level of protein kinase A in the spinal cord supernatant of diisopropyl phosphorofluoridate (DFP)-treated hens. Distribution of protein kinases and phosphatases in spinal cord subcellular fractions.
-
Enhanced calmodulin binding concurrent with increased kinase-dependent phosphorylation of cytoskeletal proteins following a single subcutaneous injection of diisopropyl phosphorofluoridate in hens.
-
Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase.
-
Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors.
-
Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium.
-
Expression of Ca(2+)/calmodulin-dependent protein kinase IV (caMKIV) messenger RNA during murine embryogenesis.
-
Expression of a constitutive form of calcium/calmodulin dependent protein kinase II leads to arrest of the cell cycle in G2.
-
Expression of a constitutively active Ca2+/calmodulin-dependent kinase in Aspergillus nidulans spores prevents germination and entry into the cell cycle.
-
Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant.
-
Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth.
-
Expression of tumor-suppressor genes interferon regulatory factor 1 and death-associated protein kinase in primitive acute myelogenous leukemia cells.
-
Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases.
-
Female fertility is reduced in mice lacking Ca2+/calmodulin-dependent protein kinase IV.
-
Focus on CaMKII: a molecular switch in the pathophysiology and treatment of mood and anxiety disorders.
-
Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.
-
Functional analysis of a complementary DNA for the 50-kilodalton subunit of calmodulin kinase II.
-
Functional consequences of truncating amino acid side chains located at a calmodulin-peptide interface.
-
G beta gamma interactions with PH domains and Ras-MAPK signaling pathways.
-
G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor.
-
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
-
G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases.
-
G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism.
-
G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors.
-
GABAA alpha 2 mRNA levels are decreased following induction of spontaneous epileptiform discharges in hippocampal-entorhinal cortical slices.
-
Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP.
-
Genome-wide association of pericardial fat identifies a unique locus for ectopic fat.
-
Growth hormone regulates phosphorylation and function of CCAAT/enhancer-binding protein beta by modulating Akt and glycogen synthase kinase-3.
-
HER-2/c-erbB2 is phosphorylated by calmodulin-dependent protein kinase II on a single site in the cytoplasmic tail at threonine-1172.
-
Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase.
-
Identification and characterization of two Ca2+/CaM-dependent protein kinases required for normal nuclear division in Aspergillus nidulans.
-
Identification of calcium-calmodulin multifunctional protein kinase II in rabbit kidney.
-
Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes.
-
Identification of the endogenous smooth muscle myosin phosphatase-associated kinase.
-
In vitro calcium and calmodulin-dependent kinase-mediated phosphorylation of rat brain and spinal cord neurofilament proteins is increased by glycidamide administration.
-
Inhibition of calcium/calmodulin kinase II alpha subunit expression results in epileptiform activity in cultured hippocampal neurons.
-
Intracellular third loop domain of angiotensin II type-2 receptor. Role in mediating signal transduction and cellular function.
-
Involvement of cytoskeletal proteins in the mechanisms of organophosphorus ester-induced delayed neurotoxicity.
-
LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.
-
Limbic epilepsy in transgenic mice carrying a Ca2+/calmodulin-dependent kinase II alpha-subunit mutation.
-
Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia.
-
Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis.
-
Long-lasting reduction of inhibitory function and gamma-aminobutyric acid type A receptor subunit mRNA expression in a model of temporal lobe epilepsy.
-
Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate.
-
MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type.
-
Mapping of calmodulin-binding domain of Ca2+/calmodulin-dependent protein kinase II from rat brain.
-
Mechanisms for regulation of calmodulin kinase IIalpha by Ca(2+)/calmodulin and autophosphorylation of threonine 286.
-
Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2.
-
Methionine to glutamine substitutions in the C-terminal domain of calmodulin impair the activation of three protein kinases.
-
Mitogen-activated protein kinases enhance long-range activation by the beta-globin locus control region.
-
Mitogenic signaling via G protein-coupled receptors.
-
Modes of interactions between signaling pathways.
-
Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons.
-
Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.
-
Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein.
-
Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins.
-
Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II.
-
Molecular signaling mechanisms underlying epileptogenesis.
-
Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase.
-
Multiple Ca(2+)-calmodulin-dependent protein kinase kinases from rat brain. Purification, regulation by Ca(2+)-calmodulin, and partial amino acid sequence.
-
Mutagenic analysis of functional domains of the mos proto-oncogene and identification of the sites important for MAPK activation and DNA binding.
-
Mutational analysis of the autoinhibitory domain of calmodulin kinase II.
-
Neurofilament phosphorylation and [125I]calmodulin binding by Ca2+/calmodulin-dependent protein kinase in the brain subcellular fractions of diisopropyl phosphorofluoridate (DFP)-treated hen.
-
Organization and analysis of the complete rat calmodulin-dependent protein kinase IV gene.
-
Par-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy.
-
Peptide specificity determinants at P-7 and P-6 enhance the catalytic efficiency of Ca2+/calmodulin-dependent protein kinase I in the absence of activation loop phosphorylation.
-
Persistent alterations of calmodulin kinase II activity in chickens after an oral dose of tri-o-cresyl phosphate.
-
Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation.
-
Phosphorylation of caldesmon by mitogen-activated protein kinase with no effect on Ca2+ sensitivity in rabbit smooth muscle.
-
Phosphorylation-dependent control of ZIPK nuclear import is species specific.
-
Physiological roles of the Ca2+/CaM-dependent protein kinase cascade in health and disease.
-
Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases.
-
Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo.
-
Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus.
-
Protein phosphatase 2A: a panoply of enzymes.
-
Proteomic analysis of calcium/calmodulin-dependent protein kinase I and IV in vitro substrates reveals distinct catalytic preferences.
-
Purification of a 12,020-dalton protein that enhances the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase.
-
ROCK1 phosphorylates and activates zipper-interacting protein kinase.
-
Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway.
-
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
-
Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex.
-
Regulation and properties of the rat Ca2+/calmodulin-dependent protein kinase IV gene and its protein products.
-
Regulation of Ca2+/calmodulin-dependent protein kinase II by Ca2+/calmodulin-independent autophosphorylation.
-
Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A.
-
Regulation of cell cycle progression by calcium/calmodulin-dependent pathways.
-
Regulation of cholecystokinin secretion by calcium-dependent calmodulin kinase II: differential effects of phenylalanine and cAMP.
-
Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I.
-
Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes.
-
Regulation of intrasteric inhibition of the multifunctional calcium/calmodulin-dependent protein kinase.
-
Regulation of mitochondrial biogenesis in skeletal muscle by CaMK.
-
Regulation of mitogen-activated protein kinase pathways by catecholamine receptors.
-
Regulatory cascades involving calmodulin-dependent protein kinases.
-
Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK.
-
Requirement for Ca2+/calmodulin-dependent kinase type IV/Gr in setting the thymocyte selection threshold.
-
Role of Ca++/calmodulin binding proteins in Aspergillus nidulans cell cycle regulation.
-
Role of beta-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment.
-
Selective activation and inhibition of calmodulin-dependent enzymes by a calmodulin-like protein found in human epithelial cells.
-
Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain.
-
Serotonin 5-HT1A receptor-mediated Erk activation requires calcium/calmodulin-dependent receptor endocytosis.
-
Smooth muscle cell migration and proliferation are mediated by distinct phases of activation of the intracellular messenger mitogen-activated protein kinase.
-
Smooth muscle myosin phosphatase-associated kinase induces Ca2+ sensitization via myosin phosphatase inhibition.
-
Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides.
-
Spermatogenesis and the regulation of Ca(2+)-calmodulin-dependent protein kinase IV localization are not dependent on calspermin.
-
Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4.
-
Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling.
-
Steering growth cones with a CaMKII/calcineurin switch.
-
Stimulation of mitogen-activated protein kinase by G protein-coupled alpha(2)-adrenergic receptors does not require agonist-elicited endocytosis.
-
Studies of the regulatory mechanism of Ca2+/calmodulin-dependent protein kinase II. Mutation of threonine 286 to alanine and aspartate.
-
Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.
-
T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+.
-
Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis.
-
Tau phosphorylation by diisopropyl phosphorofluoridate (DFP)-treated hen brain supernatant inhibits its binding with microtubules: role of Ca2+/Calmodulin-dependent protein kinase II in tau phosphorylation.
-
Tau proteins-enhanced Ca2+/calmodulin (CaM)-dependent phosphorylation by the brain supernatant of diisopropyl phosphorofluoridate (DFP)-treated hen: tau mutants indicate phosphorylation of more amino acids in tau by CaM kinase II.
-
The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae.
-
The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer.
-
The autonomous activity of calcium/calmodulin-dependent protein kinase IV is required for its role in transcription.
-
The beta3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism.
-
The clash in titin.
-
The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking.
-
The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation.
-
The suppression of testis-brain RNA binding protein and kinesin heavy chain disrupts mRNA sorting in dendrites.
-
VEGF stimulates MAPK through a pathway that is unique for receptor tyrosine kinases.
-
Wnt signalling shows its versatility.
-
X-ray analysis reveals conformational adaptation of the linker in functional calmodulin mutants.
-
Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog.
-
ZAP-70-dependent and -independent activation of Erk in Jurkat T cells. Differences in signaling induced by H2o2 and Cd3 cross-linking.
-
ZIP kinase, a key regulator of myosin protein phosphatase 1.
-
beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor.
-
cDNA cloning and sequencing of Ca2+/calmodulin-dependent protein kinase IIalpha subunit and its mRNA expression in diisopropyl phosphorofluoridate (DFP)-treated hen central nervous system.
-
Keywords of People