Calcium-Calmodulin-Dependent Protein Kinases
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Subject Areas on Research
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5-Oxo-eicosanoids and hematopoietic cytokines cooperate in stimulating neutrophil function and the mitogen-activated protein kinase pathway.
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5-Oxo-eicosatetraenoate is a broadly active, eosinophil-selective stimulus for human granulocytes.
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A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans.
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A novel Ca2+/calmodulin-dependent protein kinase and a male germ cell-specific calmodulin-binding protein are derived from the same gene.
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A requirement for rac1 in the PDGF-stimulated migration of fibroblasts and vascular smooth cells.
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A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy.
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A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.
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A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR.
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Aberrant promoter methylation of multiple genes in non-small cell lung cancers.
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Acetyl-CoA:1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase is directly activated by p38 kinase.
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Acrylamide increases in vitro calcium and calmodulin-dependent kinase-mediated phosphorylation of rat brain and spinal cord neurofilament proteins.
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Activation of MAP kinase by a dual specificity Tyr/Thr kinase.
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Activation of calcium channels by cAMP in STC-1 cells is dependent upon Ca2+ calmodulin-dependent protein kinase II.
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Activation of extracellular signal-regulated kinase in human prostate cancer.
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Activation of mitogen-activated protein kinase by epidermal growth factor in hippocampal neurons and neuronal cell lines.
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Activation of orphan receptor-mediated transcription by Ca(2+)/calmodulin-dependent protein kinase IV.
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Activation of the 9E3/cCAF chemokine by phorbol esters occurs via multiple signal transduction pathways that converge to MEK1/ERK2 and activate the Elk1 transcription factor.
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Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis.
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Angiotensin II type 2 receptor mediates programmed cell death.
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Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis.
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Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.
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Biochemical changes in sciatic nerve of hens treated with tri-o-cresyl phosphate: increased phosphorylation of cytoskeletal proteins.
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Biochemical characterization of the multifunctional Ca2+/calmodulin-dependent protein kinase type IV expressed in insect cells.
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Ca(2+)/CaM-dependent kinases: from activation to function.
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Ca(2+)/calmodulin-dependent kinase is essential for both growth and nuclear division in Aspergillus nidulans.
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Ca(2+)/calmodulin-dependent protein kinase IV is expressed in spermatids and targeted to chromatin and the nuclear matrix.
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Ca2+/calmodulin-dependent protein kinase II from hen brain. Purification and characterization.
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Ca2+/calmodulin-dependent protein kinase IV and calcium signaling.
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Ca2+/calmodulin-dependent protein kinase type IV in dorsal root ganglion: colocalization with peptides, axonal transport and effect of axotomy.
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CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation.
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Calcium binding is required for calmodulin function in Aspergillus nidulans.
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Calcium, calmodulin and cell cycle regulation.
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Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains.
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Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression.
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Calmodulin activation of target enzymes. Consequences of deletions in the central helix.
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Calmodulin and CaMKII as molecular switches for cardiac ion channels.
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Calmodulin kinase II chimeras used to investigate the structural requirements for smooth muscle myosin light chain kinase autoinhibition and calmodulin-dependent activation.
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Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance.
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Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation.
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Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV gene.
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Capillary density of skeletal muscle: a contributing mechanism for exercise intolerance in class II-III chronic heart failure independent of other peripheral alterations.
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Carbon disulfide inhalation increases Ca2+/calmodulin-dependent kinase phosphorylation of cytoskeletal proteins in the rat central nervous system.
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Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects.
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Catalytic activity is required for calcium/calmodulin-dependent protein kinase IV to enter the nucleus.
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Cell type-specific angiotensin II-evoked signal transduction pathways: critical roles of Gbetagamma subunit, Src family, and Ras in cardiac fibroblasts.
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Cerebellar defects in Ca2+/calmodulin kinase IV-deficient mice.
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Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation.
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Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I.
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Chimeric calmodulin-cardiac troponin C proteins differentially activate calmodulin target enzymes.
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Chronic elevation of calmodulin in the ventricles of transgenic mice increases the autonomous activity of calmodulin-dependent protein kinase II, which regulates atrial natriuretic factor gene expression.
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Comparison of Ca2+/calmodulin-dependent protein kinase II purified from control and diisopropyl phosphorofluoridate (DFP)-treated hens.
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Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta.
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Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions.
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Cultured human trabecular meshwork cells express functional alpha 2A adrenergic receptors.
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Cyclic phosphorylation-dephosphorylation of rhodopsin in retina by protein kinase FA (the activator of ATP.Mg-dependent protein phosphatase).
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Cytoskeletal proteins as targets for organophosphorus compound and aliphatic hexacarbon-induced neurotoxicity.
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DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells.
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Defective signaling in a subpopulation of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IV.
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Defective survival and activation of thymocytes in transgenic mice expressing a catalytically inactive form of Ca2+/calmodulin-dependent protein kinase IV.
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Defining Ca2+/calmodulin-dependent protein kinase cascades in transcriptional regulation.
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Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome.
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Differential effects of platelet-derived growth factor isotypes on human smooth muscle cell proliferation and migration are mediated by distinct signaling pathways.
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Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo.
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Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins.
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Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation.
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Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase.
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Dual kinase-mediated regulation of PITK by CaMKII and GSK3.
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Effect of a dominant negative ras on myocardial hypertrophy by using adenoviral-mediated gene transfer.
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Effects of human immunodeficiency virus type 1 on CD4 lymphocyte subset activation.
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Enhanced activity and level of protein kinase A in the spinal cord supernatant of diisopropyl phosphorofluoridate (DFP)-treated hens. Distribution of protein kinases and phosphatases in spinal cord subcellular fractions.
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Enhanced calmodulin binding concurrent with increased kinase-dependent phosphorylation of cytoskeletal proteins following a single subcutaneous injection of diisopropyl phosphorofluoridate in hens.
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Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase.
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Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors.
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Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium.
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Expression of Ca(2+)/calmodulin-dependent protein kinase IV (caMKIV) messenger RNA during murine embryogenesis.
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Expression of a constitutive form of calcium/calmodulin dependent protein kinase II leads to arrest of the cell cycle in G2.
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Expression of a constitutively active Ca2+/calmodulin-dependent kinase in Aspergillus nidulans spores prevents germination and entry into the cell cycle.
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Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant.
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Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth.
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Expression of tumor-suppressor genes interferon regulatory factor 1 and death-associated protein kinase in primitive acute myelogenous leukemia cells.
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Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases.
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Female fertility is reduced in mice lacking Ca2+/calmodulin-dependent protein kinase IV.
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Focus on CaMKII: a molecular switch in the pathophysiology and treatment of mood and anxiety disorders.
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Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.
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Functional analysis of a complementary DNA for the 50-kilodalton subunit of calmodulin kinase II.
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Functional consequences of truncating amino acid side chains located at a calmodulin-peptide interface.
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G beta gamma interactions with PH domains and Ras-MAPK signaling pathways.
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G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor.
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G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
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G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases.
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G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism.
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G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors.
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GABAA alpha 2 mRNA levels are decreased following induction of spontaneous epileptiform discharges in hippocampal-entorhinal cortical slices.
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Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP.
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Genome-wide association of pericardial fat identifies a unique locus for ectopic fat.
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Growth hormone regulates phosphorylation and function of CCAAT/enhancer-binding protein beta by modulating Akt and glycogen synthase kinase-3.
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HER-2/c-erbB2 is phosphorylated by calmodulin-dependent protein kinase II on a single site in the cytoplasmic tail at threonine-1172.
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Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase.
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Identification and characterization of two Ca2+/CaM-dependent protein kinases required for normal nuclear division in Aspergillus nidulans.
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Identification of calcium-calmodulin multifunctional protein kinase II in rabbit kidney.
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Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes.
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Identification of the endogenous smooth muscle myosin phosphatase-associated kinase.
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In vitro calcium and calmodulin-dependent kinase-mediated phosphorylation of rat brain and spinal cord neurofilament proteins is increased by glycidamide administration.
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Inhibition of calcium/calmodulin kinase II alpha subunit expression results in epileptiform activity in cultured hippocampal neurons.
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Intracellular third loop domain of angiotensin II type-2 receptor. Role in mediating signal transduction and cellular function.
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Involvement of cytoskeletal proteins in the mechanisms of organophosphorus ester-induced delayed neurotoxicity.
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LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.
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Limbic epilepsy in transgenic mice carrying a Ca2+/calmodulin-dependent kinase II alpha-subunit mutation.
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Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia.
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Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis.
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Long-lasting reduction of inhibitory function and gamma-aminobutyric acid type A receptor subunit mRNA expression in a model of temporal lobe epilepsy.
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Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate.
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MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type.
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Mapping of calmodulin-binding domain of Ca2+/calmodulin-dependent protein kinase II from rat brain.
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Mechanisms for regulation of calmodulin kinase IIalpha by Ca(2+)/calmodulin and autophosphorylation of threonine 286.
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Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2.
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Methionine to glutamine substitutions in the C-terminal domain of calmodulin impair the activation of three protein kinases.
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Mitogen-activated protein kinases enhance long-range activation by the beta-globin locus control region.
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Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts.
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Mitogenic signaling via G protein-coupled receptors.
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Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons.
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Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.
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Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins.
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Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II.
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Molecular signaling mechanisms underlying epileptogenesis.
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Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase.
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Multiple Ca(2+)-calmodulin-dependent protein kinase kinases from rat brain. Purification, regulation by Ca(2+)-calmodulin, and partial amino acid sequence.
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Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.
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Mutagenic analysis of functional domains of the mos proto-oncogene and identification of the sites important for MAPK activation and DNA binding.
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Mutational analysis of the autoinhibitory domain of calmodulin kinase II.
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Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs.
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Neurofilament phosphorylation and [125I]calmodulin binding by Ca2+/calmodulin-dependent protein kinase in the brain subcellular fractions of diisopropyl phosphorofluoridate (DFP)-treated hen.
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Organization and analysis of the complete rat calmodulin-dependent protein kinase IV gene.
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Par-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy.
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Peptide specificity determinants at P-7 and P-6 enhance the catalytic efficiency of Ca2+/calmodulin-dependent protein kinase I in the absence of activation loop phosphorylation.
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Persistent alterations of calmodulin kinase II activity in chickens after an oral dose of tri-o-cresyl phosphate.
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Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation.
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Phosphorylation of caldesmon by mitogen-activated protein kinase with no effect on Ca2+ sensitivity in rabbit smooth muscle.
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Phosphorylation state, solubility, and activity of calcium/calmodulin-dependent protein kinase II alpha in transient focal ischemia in mouse brain.
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Phosphorylation-dependent control of ZIPK nuclear import is species specific.
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Physiological roles of the Ca2+/CaM-dependent protein kinase cascade in health and disease.
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Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases.
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Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo.
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Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus.
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Protein phosphatase 2A: a panoply of enzymes.
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Proteomic analysis of calcium/calmodulin-dependent protein kinase I and IV in vitro substrates reveals distinct catalytic preferences.
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Purification of a 12,020-dalton protein that enhances the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase.
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ROCK1 phosphorylates and activates zipper-interacting protein kinase.
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Ras enhances Myc protein stability.
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Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway.
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
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Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex.
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Regulation and properties of the rat Ca2+/calmodulin-dependent protein kinase IV gene and its protein products.
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Regulation of Ca2+/calmodulin-dependent protein kinase II by Ca2+/calmodulin-independent autophosphorylation.
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Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A.
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Regulation of cell cycle progression by calcium/calmodulin-dependent pathways.
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Regulation of cholecystokinin secretion by calcium-dependent calmodulin kinase II: differential effects of phenylalanine and cAMP.
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Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I.
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Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes.
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Regulation of intrasteric inhibition of the multifunctional calcium/calmodulin-dependent protein kinase.
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Regulation of mitochondrial biogenesis in skeletal muscle by CaMK.
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Regulation of mitogen-activated protein kinase pathways by catecholamine receptors.
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Regulatory cascades involving calmodulin-dependent protein kinases.
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Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK.
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Requirement for Ca2+/calmodulin-dependent kinase type IV/Gr in setting the thymocyte selection threshold.
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Role of Ca++/calmodulin binding proteins in Aspergillus nidulans cell cycle regulation.
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Role of beta-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment.
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Selective activation and inhibition of calmodulin-dependent enzymes by a calmodulin-like protein found in human epithelial cells.
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Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain.
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Serotonin 5-HT1A receptor-mediated Erk activation requires calcium/calmodulin-dependent receptor endocytosis.
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Shear-induced tyrosine phosphorylation in endothelial cells requires Rac1-dependent production of ROS.
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Signaling specificity: the RTK/RAS/MAP kinase pathway in metazoans.
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Smooth muscle cell migration and proliferation are mediated by distinct phases of activation of the intracellular messenger mitogen-activated protein kinase.
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Smooth muscle myosin phosphatase-associated kinase induces Ca2+ sensitization via myosin phosphatase inhibition.
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Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides.
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Spermatogenesis and the regulation of Ca(2+)-calmodulin-dependent protein kinase IV localization are not dependent on calspermin.
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Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4.
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Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling.
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Staurosporine-induced apoptosis in cardiomyocytes: A potential role of caspase-3.
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Steering growth cones with a CaMKII/calcineurin switch.
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Stimulation of mitogen-activated protein kinase by G protein-coupled alpha(2)-adrenergic receptors does not require agonist-elicited endocytosis.
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Studies of the regulatory mechanism of Ca2+/calmodulin-dependent protein kinase II. Mutation of threonine 286 to alanine and aspartate.
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Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.
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T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+.
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Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis.
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Tau phosphorylation by diisopropyl phosphorofluoridate (DFP)-treated hen brain supernatant inhibits its binding with microtubules: role of Ca2+/Calmodulin-dependent protein kinase II in tau phosphorylation.
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Tau proteins-enhanced Ca2+/calmodulin (CaM)-dependent phosphorylation by the brain supernatant of diisopropyl phosphorofluoridate (DFP)-treated hen: tau mutants indicate phosphorylation of more amino acids in tau by CaM kinase II.
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The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae.
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The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer.
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The autonomous activity of calcium/calmodulin-dependent protein kinase IV is required for its role in transcription.
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The beta3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism.
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The clash in titin.
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The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking.
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The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation.
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The suppression of testis-brain RNA binding protein and kinesin heavy chain disrupts mRNA sorting in dendrites.
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Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand.
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VEGF stimulates MAPK through a pathway that is unique for receptor tyrosine kinases.
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Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism.
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Wnt signalling shows its versatility.
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Wnt signalling shows its versatility.
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X-ray analysis reveals conformational adaptation of the linker in functional calmodulin mutants.
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Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog.
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ZAP-70-dependent and -independent activation of Erk in Jurkat T cells. Differences in signaling induced by H2o2 and Cd3 cross-linking.
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ZIP kinase, a key regulator of myosin protein phosphatase 1.
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beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor.
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cDNA cloning and sequencing of Ca2+/calmodulin-dependent protein kinase IIalpha subunit and its mRNA expression in diisopropyl phosphorofluoridate (DFP)-treated hen central nervous system.
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