Sodium-Hydrogen Antiporter

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  Subject Areas on Research

  • A C-terminal PDZ motif in NHE3 binds NHERF-1 and enhances cAMP inhibition of sodium-hydrogen exchange. 
  • A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. 
  • AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. 
  • Acute regulation of NHE3 by protein kinase A requires a multiprotein signal complex. 
  • Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid hormone. 
  • Administration of atrial natriuretic factor inhibits sodium-coupled transport in proximal tubules. 
  • Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene. 
  • Assembly of signaling complexes by the sodium-hydrogen exchanger regulatory factor family of PDZ-containing proteins. 
  • Association of plasminogen with dipeptidyl peptidase IV and Na+/H+ exchanger isoform NHE3 regulates invasion of human 1-LN prostate tumor cells. 
  • CAMP-mediated inhibition of the renal brush border membrane Na+-H+ exchanger requires a dissociable phosphoprotein cofactor. 
  • Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger. 
  • Comparative changes in the blood-brain barrier and cerebral infarction of SHR and WKY rats. 
  • Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport. 
  • Cyclosporine A inhibits Ca2+-dependent stimulation of the Na+/H+ antiport in human T cells. 
  • Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice. 
  • Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media. 
  • Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. 
  • Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1-/- renal proximal tubule cells. 
  • Differential renal distribution of NHERF isoforms and their colocalization with NHE3, ezrin, and ROMK. 
  • Dipeptidyl peptidase IV (DPP IV/CD26) is a cell-surface plasminogen receptor. 
  • Dynamics of PTH-induced disassembly of Npt2a/NHERF-1 complexes in living OK cells. 
  • Effect of limited trypsin digestion on the renal Na+-H+ exchanger and its regulation by cAMP-dependent protein kinase. 
  • Effect of potent redox-modulating manganese porphyrin, MnTM-2-PyP, on the Na(+)/H(+) exchangers NHE-1 and NHE-3 in the diabetic rat. 
  • Efficacy of zoniporide, an Na/H exchange ion inhibitor, for reducing perioperative cardiovascular events in vascular surgery patients. 
  • Epilepsy genetics: an abundance of riches for biologists. 
  • Essential role for NHERF in cAMP-mediated inhibition of the Na+-HCO3- co-transporter in BSC-1 cells. 
  • Exercise alters the regulation of myocardial Na(+)/H(+) exchanger-1 activity. 
  • Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation. 
  • Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells. 
  • Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone. 
  • G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction. 
  • Gallbladder Na+/H+ exchange activity is up-regulated prior to cholesterol crystal formation. 
  • Genetic variants in SLC9A9 are associated with measures of attention-deficit/hyperactivity disorder symptoms in families. 
  • Human trabecular meshwork cell volume regulation. 
  • Identification of a putative Na(+)-H+ exchanger regulatory cofactor in rabbit renal BBM. 
  • Identification of the human NHE-1 form of Na(+)-H+ exchanger in rabbit renal brush border membranes. 
  • Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells. 
  • Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate. 
  • Ion fluxes and differentiation in transformed cell lines. 
  • Isolation and characterization of renal cortical membranes using an aqueous two-phase partition technique. 
  • Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse. 
  • Longitudinal study of urinary excretion of phosphate, calcium, and uric acid in mutant NHERF-1 null mice. 
  • Maleylated-BSA induces hydrolysis of PIP2, fluxes of Ca2+, NF-kappaB binding, and transcription of the TNF-alpha gene in murine macrophages. 
  • Molecular cloning of the cDNA and promoter sequences for the mouse sodium-hydrogen exchanger regulatory factor. 
  • Myocardial Na+/H+ exchanger-1 (NHE1) content is decreased by exercise training. 
  • N-terminal PDZ domain is required for NHERF dimerization. 
  • NHERF and regulation of the renal sodium-hydrogen exchanger NHE3. 
  • NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3. 
  • NHERF-1 is required for renal adaptation to a low-phosphate diet. 
  • NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes. 
  • NHERF1/EBP50 is an organizer of polarity structures and a diagnostic marker in ependymoma. 
  • NHERF: targeting and trafficking membrane proteins. 
  • Nitric oxide enhances salt secretion and Na+ sequestration in a mangrove plant, Avicennia marina, through increasing the expression of H+-ATPase and Na+/H+ antiporter under high salinity 
  • PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP. 
  • Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1. 
  • Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange. 
  • Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets. 
  • Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na(+)/H(+) exchanger regulatory factor. 
  • Plant cell-surface GIPC sphingolipids sense salt to trigger Ca²⁺ influx. 
  • Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity. 
  • Protein kinase C activates the renal apical membrane Na+/H+ exchanger. 
  • Protein kinase C-alpha regulation of gallbladder Na+ transport becomes progressively more dysfunctional during gallstone formation. 
  • Reconstitution of cAMP-dependent protein kinase regulated renal Na+-H+ exchanger. 
  • Regulation of ion transport by the NHERF family of PDZ proteins. 
  • Regulation of reconstituted renal Na+/H+ exchanger by calcium-dependent protein kinases. 
  • Regulation of renal Na(+)-H+ exchanger by cAMP-dependent protein kinase. 
  • Regulation of the Na/H exchanger regulatory factor in OK cells. 
  • Regulation of the renal Na(+)-H+ exchanger by calcium calmodulin-dependent multifunctional protein kinase II. 
  • Regulation of the renal Na+-H+ exchanger by protein phosphorylation. 
  • Regulation of the renal brush border membrane Na(+)-H+ exchanger. 
  • Role of NHERF and scaffolding proteins in proximal tubule transport. 
  • Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA. 
  • Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney. 
  • Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport. 
  • Solubilization and reconstitution of renal brush border Na+-H+ exchanger. 
  • Stimulation of the T3-T cell receptor-associated Ca2+ influx enhances the activity of the Na+/H+ exchanger in a leukemic human T cell line. 
  • Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF). 
  • Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. 
  • The Na-H exchanger regulatory factor. 
  • The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases. 
  • The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. 
  • The role of NHERF-1 in the regulation of renal proximal tubule sodium-hydrogen exchanger 3 and sodium-dependent phosphate cotransporter 2a. 
  • The role of ion fluxes in hematopoietic cell differentiation. 
  • Trypsin digestion increases Na(+)-H+ exchange rates in native rabbit brush border membrane. 
  • Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice. 
  • cAMP-associated inhibition of Na+-H+ exchanger in rabbit kidney brush-border membranes. 
  • cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor. 
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  Keywords of People

  • Sparks, Matthew A., Associate Professor of Medicine, Medicine, Nephrology