Sodium-Hydrogen Antiporter
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Subject Areas on Research
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A C-terminal PDZ motif in NHE3 binds NHERF-1 and enhances cAMP inhibition of sodium-hydrogen exchange.
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A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.
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AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure.
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Acute regulation of NHE3 by protein kinase A requires a multiprotein signal complex.
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Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid hormone.
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Administration of atrial natriuretic factor inhibits sodium-coupled transport in proximal tubules.
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Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene.
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Assembly of signaling complexes by the sodium-hydrogen exchanger regulatory factor family of PDZ-containing proteins.
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Association of plasminogen with dipeptidyl peptidase IV and Na+/H+ exchanger isoform NHE3 regulates invasion of human 1-LN prostate tumor cells.
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CAMP-mediated inhibition of the renal brush border membrane Na+-H+ exchanger requires a dissociable phosphoprotein cofactor.
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Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger.
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Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport.
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Cyclosporine A inhibits Ca2+-dependent stimulation of the Na+/H+ antiport in human T cells.
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Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice.
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Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media.
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Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice.
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Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1-/- renal proximal tubule cells.
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Differential renal distribution of NHERF isoforms and their colocalization with NHE3, ezrin, and ROMK.
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Dipeptidyl peptidase IV (DPP IV/CD26) is a cell-surface plasminogen receptor.
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Dynamics of PTH-induced disassembly of Npt2a/NHERF-1 complexes in living OK cells.
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Effect of limited trypsin digestion on the renal Na+-H+ exchanger and its regulation by cAMP-dependent protein kinase.
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Effect of potent redox-modulating manganese porphyrin, MnTM-2-PyP, on the Na(+)/H(+) exchangers NHE-1 and NHE-3 in the diabetic rat.
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Efficacy of zoniporide, an Na/H exchange ion inhibitor, for reducing perioperative cardiovascular events in vascular surgery patients.
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Epilepsy genetics: an abundance of riches for biologists.
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Essential role for NHERF in cAMP-mediated inhibition of the Na+-HCO3- co-transporter in BSC-1 cells.
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Exercise alters the regulation of myocardial Na(+)/H(+) exchanger-1 activity.
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Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation.
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Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells.
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Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone.
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G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction.
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Gallbladder Na+/H+ exchange activity is up-regulated prior to cholesterol crystal formation.
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Genetic variants in SLC9A9 are associated with measures of attention-deficit/hyperactivity disorder symptoms in families.
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Human trabecular meshwork cell volume regulation.
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Identification of a putative Na(+)-H+ exchanger regulatory cofactor in rabbit renal BBM.
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Identification of the human NHE-1 form of Na(+)-H+ exchanger in rabbit renal brush border membranes.
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Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells.
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Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate.
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Ion fluxes and differentiation in transformed cell lines.
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Isolation and characterization of renal cortical membranes using an aqueous two-phase partition technique.
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Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse.
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Longitudinal study of urinary excretion of phosphate, calcium, and uric acid in mutant NHERF-1 null mice.
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Maleylated-BSA induces hydrolysis of PIP2, fluxes of Ca2+, NF-kappaB binding, and transcription of the TNF-alpha gene in murine macrophages.
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Modeling oxygen consumption in the proximal tubule: effects of NHE and SGLT2 inhibition.
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Molecular cloning of the cDNA and promoter sequences for the mouse sodium-hydrogen exchanger regulatory factor.
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Myocardial Na+/H+ exchanger-1 (NHE1) content is decreased by exercise training.
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N-terminal PDZ domain is required for NHERF dimerization.
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NHERF and regulation of the renal sodium-hydrogen exchanger NHE3.
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NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3.
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NHERF-1 is required for renal adaptation to a low-phosphate diet.
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NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes.
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NHERF1/EBP50 is an organizer of polarity structures and a diagnostic marker in ependymoma.
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NHERF: targeting and trafficking membrane proteins.
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Nitric oxide enhances salt secretion and Na(+) sequestration in a mangrove plant, Avicennia marina, through increasing the expression of H(+)-ATPase and Na(+)/H(+) antiporter under high salinity.
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PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP.
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Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1.
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Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange.
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Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets.
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Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na(+)/H(+) exchanger regulatory factor.
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Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity.
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Protein kinase C activates the renal apical membrane Na+/H+ exchanger.
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Protein kinase C-alpha regulation of gallbladder Na+ transport becomes progressively more dysfunctional during gallstone formation.
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Reconstitution of cAMP-dependent protein kinase regulated renal Na+-H+ exchanger.
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Regulation of ion transport by the NHERF family of PDZ proteins.
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Regulation of reconstituted renal Na+/H+ exchanger by calcium-dependent protein kinases.
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Regulation of renal Na(+)-H+ exchanger by cAMP-dependent protein kinase.
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Regulation of the Na/H exchanger regulatory factor in OK cells.
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Regulation of the renal Na(+)-H+ exchanger by calcium calmodulin-dependent multifunctional protein kinase II.
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Regulation of the renal Na+-H+ exchanger by protein phosphorylation.
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Regulation of the renal brush border membrane Na(+)-H+ exchanger.
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Role of NHERF and scaffolding proteins in proximal tubule transport.
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Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA.
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Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney.
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Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport.
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Solubilization and reconstitution of renal brush border Na+-H+ exchanger.
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Solute transport and oxygen consumption along the nephrons: effects of Na+ transport inhibitors.
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Stimulation of the T3-T cell receptor-associated Ca2+ influx enhances the activity of the Na+/H+ exchanger in a leukemic human T cell line.
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Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF).
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Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting.
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The Na-H exchanger regulatory factor.
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The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases.
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The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange.
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The role of NHERF-1 in the regulation of renal proximal tubule sodium-hydrogen exchanger 3 and sodium-dependent phosphate cotransporter 2a.
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The role of ion fluxes in hematopoietic cell differentiation.
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Trypsin digestion increases Na(+)-H+ exchange rates in native rabbit brush border membrane.
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Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice.
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cAMP-associated inhibition of Na+-H+ exchanger in rabbit kidney brush-border membranes.
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cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor.
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