Genes, Reporter

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  Subject Areas on Research

  • A CDC6 protein-binding peptide selected using a bacterial two-hybrid-like system is a cell cycle inhibitor. 
  • A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor. 
  • A Fluorescent Cell-Based System for Imaging Zika Virus Infection in Real-Time. 
  • A Genetic Porcine Model of Cancer. 
  • A bistable Rb-E2F switch underlies the restriction point. 
  • A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. 
  • A combinatorial network of evolutionarily conserved myelin basic protein regulatory sequences confers distinct glial-specific phenotypes. 
  • A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter. 
  • A comprehensive structure-function analysis of Arabidopsis SNI1 defines essential regions and transcriptional repressor activity. 
  • A family of hierarchically self-assembling linear-dendritic hybrid polymers for highly efficient targeted gene delivery. 
  • A functional variant (-1304T>G) in the MKK4 promoter contributes to a decreased risk of lung cancer by increasing the promoter activity. 
  • A method to measure myocardial calcium handling in adult Drosophila. 
  • A mutation in Arabidopsis that leads to constitutive expression of systemic acquired resistance. 
  • A novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cells. 
  • A novel functional variant (-842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity. 
  • A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression. 
  • A physical interaction network of dengue virus and human proteins. 
  • A protocol for imaging alternative splicing regulation in vivo using fluorescence reporters in transgenic mice. 
  • A quantitative method for measuring gene expression magnitude and volume delivered by gene therapy vectors. 
  • A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans. 
  • A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. 
  • A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression. 
  • A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans. 
  • A transcriptional role for C/EBP beta in the neuronal response to axonal injury. 
  • A transforming growth factor beta type I receptor that signals to activate gene expression. 
  • A transgenic toolkit for visualizing and perturbing microtubules reveals unexpected functions in the epidermis. 
  • A tyrosine hydroxylase-yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene. 
  • A unique role for Fyn in CNS myelination. 
  • ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat. 
  • Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance. 
  • Activation of Human Peroxisome Proliferator-Activated Nuclear Receptors (PPARγ1) by Semi-Volatile Compounds (SVOCs) and Chemical Mixtures in Indoor Dust. 
  • Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway. 
  • Activation of the 9E3/cCAF chemokine by phorbol esters occurs via multiple signal transduction pathways that converge to MEK1/ERK2 and activate the Elk1 transcription factor. 
  • Active immunotherapy with transiently transfected cytokine-secreting tumor cells inhibits breast cancer metastases in tumor-bearing animals. 
  • Activity of a Py-Im polyamide targeted to the estrogen response element. 
  • Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostate tumors reveals unexpected epithelial mesenchymal plasticity. 
  • An analysis of single nucleotide polymorphisms of 125 DNA repair genes in the Texas genome-wide association study of lung cancer with a replication for the XRCC4 SNPs. 
  • An auxin-dependent distal organizer of pattern and polarity in the Arabidopsis root. 
  • Analysis of allosteric signal transduction mechanisms in an engineered fluorescent maltose biosensor. 
  • Analysis of microsatellite mutations in the mitochondrial DNA of Saccharomyces cerevisiae. 
  • AnkyrinG is required to maintain axo-dendritic polarity in vivo. 
  • Application of optical imaging and spectroscopy to radiation biology. 
  • Applications of gene fusions to green fluorescent protein and flow cytometry to the study of bacterial gene expression in host cells. 
  • Aryl hydrocarbon receptor activation in genital tubercle, palate, and other embryonic tissues in 2,3,7, 8-tetrachlorodibenzo-p-dioxin-responsive lacZ mice. 
  • Assembly dynamics of FtsZ rings in Bacillus subtilis and Escherichia coli and effects of FtsZ-regulating proteins. 
  • Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer. 
  • Autofeedback suppression of growth hormone (GH) secretion in transgenic mice expressing a human GH reporter targeted by tyrosine hydroxylase 5'-flanking sequences to the hypothalamus. 
  • Bacterial genetics by flow cytometry: rapid isolation of Salmonella typhimurium acid-inducible promoters by differential fluorescence induction. 
  • Bioelectronic measurement and feedback control of molecules in living cells. 
  • Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs. 
  • Bioluminescence imaging to track bacterial dissemination of Yersinia pestis using different routes of infection in mice. 
  • Bmp4 is required for the generation of primordial germ cells in the mouse embryo. 
  • CBP/p300 induction is required for retinoic acid sensitivity in human mammary cells. 
  • CCAAT/enhancer-binding protein alpha is required for transcription of the beta 3-adrenergic receptor gene during adipogenesis. 
  • CTLA-4-Mediated inhibition of early events of T cell proliferation. 
  • Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans. 
  • Casein kinase Iepsilon plays a functional role in the transforming growth factor-beta signaling pathway. 
  • Caspase 3 promotes surviving melanoma tumor cell growth after cytotoxic therapy. 
  • Changes in gravitational force induce alterations in gene expression that can be monitored in the live, developing zebrafish heart. 
  • Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo. 
  • Characterization of lung inflammation and its impact on macrophage function in aging. 
  • Characterization of murine BATF: a negative regulator of activator protein-1 activity in the thymus. 
  • Characterization of the rat type III hexokinase gene promoter. A functional octamer 1 motif is critical for basal promoter activity. 
  • Charge-reversal amphiphiles for gene delivery. 
  • Chondrogenic Differentiation Processes in Human Bone-Marrow Aspirates Seeded in Three-Dimensional-Woven Poly(ɛ-Caprolactone) Scaffolds Enhanced by Recombinant Adeno-Associated Virus-Mediated SOX9 Gene Transfer. 
  • Chronic oxidative DNA damage due to DNA repair defects causes chromosomal instability in Saccharomyces cerevisiae. 
  • Co-transactivation of the 3' erythropoietin hypoxia inducible enhancer by the HIF-1 protein. 
  • Common commercial and consumer products contain activators of the aryl hydrocarbon (dioxin) receptor. 
  • Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity. 
  • Conditional gene silencing in mammalian cells mediated by a stress-inducible promoter. 
  • Conservation of Endo16 expression in sea urchins despite evolutionary divergence in both cis and trans-acting components of transcriptional regulation. 
  • Construction and detection of fluorescent, germline transgenic zebrafish. 
  • Context dependence of meiotic recombination hotspots in yeast: the relationship between recombination activity of a reporter construct and base composition. 
  • Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades. 
  • Cryptococcus neoformans differential gene expression detected in vitro and in vivo with green fluorescent protein. 
  • Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. 
  • Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation. 
  • Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. 
  • Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation. 
  • Definition of the interferon-alpha receptor-binding domain on the TYK2 kinase. 
  • Derivatives of plant phenolic compound affect the type III secretion system of Pseudomonas aeruginosa via a GacS-GacA two-component signal transduction system. 
  • Design, expression, and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration. 
  • Development and use of SIV-based Integrase defective lentiviral vector for immunization. 
  • Development of a modified positive selection medium that allows to isolate Aspergillus oryzae strains cured of the integrated niaD-based plasmid. 
  • Development of a novel screen for protease inhibitors. 
  • Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics. 
  • Dhh1 regulates the G1/S-checkpoint following DNA damage or BRCA1 expression in yeast. 
  • Differential CD4/CCR5 utilization, gp120 conformation, and neutralization sensitivity between envelopes from a microglia-adapted human immunodeficiency virus type 1 and its parental isolate. 
  • Differential expression of intracellular and secreted osteopontin isoforms by murine macrophages in response to toll-like receptor agonists. 
  • Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues. 
  • Differential microRNA regulation of HLA-C expression and its association with HIV control. 
  • Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins. 
  • Differentiation of a catecholaminergic CNS cell line modifies tyrosine hydroxylase transcriptional regulation. 
  • Dioxin induces transcription of fos and jun genes by Ah receptor-dependent and -independent pathways. 
  • Direct GR Binding Sites Potentiate Clusters of TF Binding across the Human Genome. 
  • Directed evolution of the surface chemistry of the reporter enzyme beta-glucuronidase. 
  • Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair. 
  • Distinct cell-specific expression patterns of early and late gibberellin biosynthetic genes during Arabidopsis seed germination. 
  • Distinctive gene transduction efficiencies of commonly used viral vectors in the retina. 
  • Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control. 
  • Drosophila genome-wide RNAi screens: are they delivering the promise? 
  • DsbB is required for the pathogenesis process of Xanthomonas campestris pv. campestris. 
  • Dual-Affinity Re-Targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells. 
  • ETS transcription factors regulate an enhancer activity in the third intron of TNF-alpha. 
  • Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system. 
  • Effective tumor therapy with plasmid-encoded cytokines combined with in vivo electroporation. 
  • Effects of rate, volume, and dose of intratumoral infusion on virus dissemination in local gene delivery. 
  • Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells. 
  • Efficacy of multiple administrations of a recombinant adenovirus expressing wild-type p53 in an immune-competent mouse tumor model. 
  • Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology. 
  • Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells. 
  • Enhancement of rAAV2-mediated transgene expression in retina cells in vitro and in vivo by coadministration of low-dose chemotherapeutic drugs. 
  • Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. 
  • Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6. 
  • Establishment of Expression in the SHORTROOT-SCARECROW Transcriptional Cascade through Opposing Activities of Both Activators and Repressors. 
  • Estrogen and thyroid hormone interaction on regulation of gene expression. 
  • Evaluating neutralizing antibodies against HIV, SIV, and SHIV in luciferase reporter gene assays. 
  • Expression of exogenous protein in the egg white of transgenic chickens. 
  • Expression of penicillin G acylase from the cloned pac gene of Escherichia coli ATCC11105. Effects of pacR and temperature. 
  • Expression of the 71 kDa dystrophin isoform (Dp71) evaluated by gene targeting. 
  • Expression of the human poliovirus receptor/CD155 gene during development of the central nervous system: implications for the pathogenesis of poliomyelitis. 
  • Expression of the type III TGF-beta receptor is negatively regulated by TGF-beta. 
  • Faithful expression of GFP from the PLCbeta2 promoter in a functional class of taste receptor cells. 
  • Fate Mapping In Vivo to Distinguish Bona Fide Microglia Versus Recruited Monocyte-Derived Macrophages in Retinal Disease. 
  • Fgf8 is required for anterior heart field development. 
  • Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production. Modulation by potassium channel blockade. 
  • Fluorescence in situ hybridization method for measuring transfection efficiency. 
  • Focal expression of mutant huntingtin in the songbird basal ganglia disrupts cortico-basal ganglia networks and vocal sequences. 
  • Forces drive basement membrane invasion in Caenorhabditis elegans. 
  • Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes. 
  • Formulation of chitosan-DNA nanoparticles with poly(propyl acrylic acid) enhances gene expression. 
  • Formulations which increase the size of lipoplexes prevent serum-associated inhibition of transfection. 
  • FtsZ from divergent foreign bacteria can function for cell division in Escherichia coli. 
  • Function of nuclear factor kappaB in pancreatic cancer metastasis. 
  • Functional analysis of intra-allelic variation at NACP-Rep1 in the alpha-synuclein gene. 
  • Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. 
  • G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. 
  • Gamma-globin gene promoter elements required for interaction with globin enhancers. 
  • Gene expression markers for Caenorhabditis elegans vulval cells. 
  • Genome rearrangements caused by interstitial telomeric sequences in yeast. 
  • Genome-wide identification of regulatory elements in Sertoli cells. 
  • Genomic deletions and point mutations induced in Saccharomyces cerevisiae by the trinucleotide repeats (GAA·TTC) associated with Friedreich's ataxia. 
  • Genotypic effect of the -565C>T polymorphism in the ABCA1 gene promoter on ABCA1 expression and severity of atherosclerosis. 
  • Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas. 
  • Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. 
  • Gq signaling causes glomerular injury by activating TRPC6. 
  • Graft-extrinsic cells predominate in vein graft arterialization. 
  • Green fluorescent protein as a tag for molecular motor proteins. 
  • Green fluorescent protein marks skeletal muscle in murine cell lines and zebrafish. 
  • Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing. 
  • Guanine analogues enhance antisense oligonucleotide-induced exon skipping in dystrophin gene in vitro and in vivo. 
  • Heat-induced gene expression as a novel targeted cancer gene therapy strategy. 
  • Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. 
  • High-throughput RNA interference screens in Drosophila tissue culture cells. 
  • Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1. 
  • Human topoisomerase I promotes HIV-1 proviral DNA synthesis: implications for the species specificity and cellular tropism of HIV-1 infection. 
  • Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK-dependent pathway. 
  • Hypoxia reprograms calcium signaling and regulates myoglobin expression. 
  • Identification and functional characterization of JWA polymorphisms and their association with risk of gastric cancer and esophageal squamous cell carcinoma in a Chinese population. 
  • Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. 
  • Identification of ENV determinants in V3 that influence the molecular anatomy of CCR5 utilization. 
  • Identification of an enhancer element in the estrogen receptor upstream region: implications for regulation of ER transcription in breast cancer. 
  • Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation. 
  • Identification of host-induced pathogen genes by differential fluorescence induction reporter systems. 
  • Identification of regulators of germ stem cell enwrapment by its niche in C. elegans. 
  • Identification of six new susceptibility loci for invasive epithelial ovarian cancer. 
  • Imaging cyclic AMP changes in pancreatic islets of transgenic reporter mice. 
  • Imaging molecular pathways: reporter genes. 
  • Immunology of gene therapy with adenoviral vectors in mouse skeletal muscle. 
  • In Vivo Determination of Mitochondrial Function Using Luciferase-Expressing Caenorhabditis elegans: Contribution of Oxidative Phosphorylation, Glycolysis, and Fatty Acid Oxidation to Toxicant-Induced Dysfunction. 
  • In vitro assays fail to predict in vivo effects of regulatory polymorphisms. 
  • In vivo bioluminescent imaging of influenza a virus infection and characterization of novel cross-protective monoclonal antibodies. 
  • In vivo protein expression and immune responses generated by DNA vaccines expressing mycobacterial antigens fused with a reporter protein. 
  • In vivo regulation of hTERT expression and telomerase activity by androgen. 
  • Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. 
  • Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis. 
  • Inhibition of retinoic acid receptor function in normal human mammary epithelial cells results in increased cellular proliferation and inhibits the formation of a polarized epithelium in vitro. 
  • Interactions of estrogen- and thyroid hormone receptors on a progesterone receptor estrogen response element (ERE) sequence: a comparison with the vitellogenin A2 consensus ERE. 
  • Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy. 
  • Intravital fluorescence facilitates measurement of multiple physiologic functions and gene expression in tumors of live animals. 
  • Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset. 
  • Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus. 
  • Isolation and characterization of effector-loop mutants of CDC42 in yeast. 
  • Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy. 
  • Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator. 
  • Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts. 
  • Ligand-induced recruitment of a histone deacetylase in the negative-feedback regulation of the thyrotropin beta gene. 
  • Ligand-specific dynamics of the androgen receptor at its response element in living cells. 
  • Light-inducible gene regulation with engineered zinc finger proteins. 
  • Localization and function of ADP ribosylation factor A in Aspergillus nidulans. 
  • Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. 
  • MAZ elements alter transcription elongation and silencing of the fibroblast growth factor receptor 2 exon IIIb. 
  • MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. 
  • Macrophage-derived Hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni. 
  • Manipulation of OCT4 levels in human embryonic stem cells results in induction of differential cell types. 
  • Marking and quantifying IL-17A-producing cells in vivo. 
  • Measuring HIV neutralization in a luciferase reporter gene assay. 
  • Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation. 
  • Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development. 
  • Methylation of TFPI-2 gene is not the sole cause of its silencing. 
  • MicroRNA-24 regulates the processing of latent TGFβ1 during cyclic mechanical stress in human trabecular meshwork cells through direct targeting of FURIN. 
  • MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. 
  • Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tract. 
  • Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas. 
  • Molecular and genetic approaches for the analysis of C. elegans neuronal development. 
  • Mucosal healing and fibrosis after acute or chronic inflammation in wild type FVB-N mice and C57BL6 procollagen α1(I)-promoter-GFP reporter mice. 
  • Multimodal regulation of E2F1 gene expression by progestins. 
  • Multiprotein HIV type 1 clade B DNA and MVA vaccines: construction, expression, and immunogenicity in rodents of the MVA component. 
  • Mutagenesis by AID, a molecule critical to immunoglobulin hypermutation, is not caused by an alteration of the precursor nucleotide pool. 
  • Mutational fingerprints of aging. 
  • Myc cooperates with β-catenin to drive gene expression in nephron progenitor cells. 
  • N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma. 
  • N-myc regulates parkin expression. 
  • NanoCluster Beacons as reporter probes in rolling circle enhanced enzyme activity detection. 
  • Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers. 
  • Newspapers and newspaper ink contain agonists for the ah receptor. 
  • Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation. 
  • Noncoding deletions reveal a gene that is critical for intestinal function. 
  • Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo. 
  • Noninvasive imaging of cationic lipid-mediated delivery of optical and PET reporter genes in living mice. 
  • Noninvasive visualization of retinoblastoma growth and metastasis via bioluminescence imaging. 
  • Novel Sfp1 transcriptional regulation of Saccharomyces cerevisiae gene expression changes during spaceflight. 
  • Novel luciferase-based reporter system to monitor activation of ErbB2/Her2/neu pathway noninvasively during radiotherapy. 
  • Novel transcriptional activities of vitamin E: inhibition of cholesterol biosynthesis. 
  • Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis. 
  • Nucleotide excision repair as a marker for susceptibility to tobacco-related cancers: a review of molecular epidemiological studies. 
  • Oct4 RNA interference induces trophectoderm differentiation in mouse embryonic stem cells. 
  • Optimized regimen for expression of heat-inducible Cre in mice. 
  • Oscillating gene expression determines competence for periodic Arabidopsis root branching. 
  • Osteopontin is a negative feedback regulator of nitric oxide synthesis in murine macrophages. 
  • Oxidative stress increases hepatocyte iNOS gene transcription and promoter activity. 
  • PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. 
  • Pairing of competitive and topologically distinct regulatory modules enhances patterned gene expression. 
  • Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway. 
  • Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2. 
  • Perivascular mural cells of the mouse choroid demonstrate morphological diversity that is correlated to vasoregulatory function. 
  • Photoacoustic imaging using genetically encoded reporters: a review. 
  • Photoacoustic microscopy of tyrosinase reporter gene in vivo. 
  • Pim-1 kinase inhibits the activation of reporter gene expression in Elk-1 and c-Fos reporting systems but not the endogenous gene expression: an artifact of the reporter gene assay by transient co-transfection. 
  • Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. 
  • Polymorphism in the serotonin transporter gene and response to treatment in African American cocaine and alcohol-abusing individuals. 
  • Posttranscriptional regulation of protein expression in human epithelial carcinoma cells by adenine-uridine-rich elements in the 3'-untranslated region of tumor necrosis factor-alpha messenger RNA. 
  • Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line. 
  • Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET. 
  • Principles and applications of a Tat-based assay for analyzing specific RNA-protein interactions in mammalian cells. 
  • Probing bacterial gene expression within host cells. 
  • Progesterone receptor interacting coregulatory proteins and cross talk with cell signaling pathways. 
  • Promoter logic. 
  • Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription. 
  • Pseudotyped viruses permit rapid detection of neutralizing antibodies in human and equine serum against Venezuelan equine encephalitis virus. 
  • RNA-Seq and ChIP-Seq reveal SQSTM1/p62 as a key mediator of JunB suppression of NF-κB-dependent inflammation. 
  • Rapid assessment of repair of ultraviolet DNA damage with a modified host-cell reactivation assay using a luciferase reporter gene and correlation with polymorphisms of DNA repair genes in normal human lymphocytes. 
  • Rapid selection of tetracycline-controlled inducible cell lines using a green fluorescent-transactivator fusion protein. 
  • Recruitment of host progenitor cells in rat liver transplants. 
  • Reduced DNA repair capacity in lung cancer patients. 
  • Regeneration Genetics. 
  • Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. 
  • Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. 
  • Regulation of casein kinase I epsilon activity by Wnt signaling. 
  • Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum. 
  • RelB cellular regulation and transcriptional activity are regulated by p100. 
  • Replication-Competent Influenza B Reporter Viruses as Tools for Screening Antivirals and Antibodies. 
  • Retention of pendrin in the endoplasmic reticulum is a major mechanism for Pendred syndrome. 
  • Retinoic acid-mediated gene expression in transgenic reporter zebrafish. 
  • Retinoid regulation of the zebrafish cyp26a1 promoter. 
  • Ribotrap : targeted purification of RNA-specific RNPs from cell lysates through immunoaffinity precipitation to identify regulatory proteins and RNAs. 
  • Role for ETS domain transcription factors Pea3/Erm in mouse lung development. 
  • Role for hedgehog signaling in hepatic stellate cell activation and viability. 
  • Runx2/Cbfa1 stimulates transdifferentiation of primary skeletal myoblasts into a mineralizing osteoblastic phenotype. 
  • SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. 
  • Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro. 
  • Scanning Quadrupole Data-Independent Acquisition, Part B: Application to the Analysis of the Calcineurin-Interacting Proteins during Treatment of Aspergillus fumigatus with Azole and Echinocandin Antifungal Drugs. 
  • Seeing into cells. The promise of in vivo molecular imaging in oncology. 
  • Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORgamma. 
  • Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes. 
  • Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis. 
  • Sequence requirements for micro RNA processing and function in human cells. 
  • Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. 
  • Snare protein expression and adenoviral transfection of amphicrine AR42J. 
  • Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. 
  • Split luciferase complementation assay for the analysis of G protein-coupled receptor ligand response in Saccharomyces cerevisiae. 
  • Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. 
  • Study of Cryptococcus neoformans actin gene regulation with a beta-galactosidase-actin fusion. 
  • Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function. 
  • Suppression of neuronal hyperexcitability and associated delayed neuronal death by adenoviral expression of GABA(C) receptors. 
  • Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells. 
  • Suppressor and activator functions mediated by a repeated heptad sequence in the liver fatty acid-binding protein gene (Fabpl). Effects on renal, small intestinal, and colonic epithelial cell gene expression in transgenic mice. 
  • Sustained gene expression in retrovirally transduced, engrafting human hematopoietic stem cells and their lympho-myeloid progeny. 
  • Synergistic enhancement of both initiation and elongation by acidic transcription activation domains. 
  • Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging. 
  • Systemic dissemination of viral vectors during intratumoral injection. 
  • TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase signaling effectors. 
  • Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts. 
  • Targeted gene transfer to Schlemm's canal by retroperfusion. 
  • Targeted skipping of human dystrophin exons in transgenic mouse model systemically for antisense drug development. 
  • The Arabidopsis copper transporter COPT1 functions in root elongation and pollen development. 
  • The effect of surface agitation on ultrasound-mediated gene transfer in vitro. 
  • The epsilon subunit of DNA polymerase III Is involved in the nalidixic acid-induced SOS response in Escherichia coli. 
  • The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo. 
  • The human D1A dopamine receptor gene promoter directs expression of a reporter gene to the central nervous system in transgenic mice. 
  • The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter. 
  • The human gene for the type III isozyme of hexokinase: structure, basal promoter, and evolution. 
  • The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks. 
  • The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions. 
  • The role of Alzheimer's disease-related presenilin 1 in intercellular adhesion. 
  • The suppression of testis-brain RNA binding protein and kinesin heavy chain disrupts mRNA sorting in dendrites. 
  • The uses of green fluorescent protein in prokaryotes. 
  • Tissue-engineered 3-dimensional (3D) microenvironment enhances the direct reprogramming of fibroblasts into cardiomyocytes by microRNAs. 
  • Towards resolving the transcription factor network controlling myelin gene expression. 
  • Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn. 
  • Transcriptional and posttranscriptional regulation of transcription factor expression in Arabidopsis roots. 
  • Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation. 
  • Transcriptional regulation of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa: dissection of key promoter elements. 
  • Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers. 
  • Transduction of renal cells in vitro and in vivo by adeno-associated virus gene therapy vectors. 
  • Transfer of CD8+ T cell memory using Bcl-2 as a marker. 
  • Transgene expression in the brain stem effected by intramuscular injection of polyethylenimine/DNA complexes. 
  • Transient requirement for ganglion cells during assembly of retinal synaptic layers. 
  • Transsynaptic Tracing from Peripheral Targets with Pseudorabies Virus Followed by Cholera Toxin and Biotinylated Dextran Amines Double Labeling. 
  • Two closely related human nuclear export factors utilize entirely distinct export pathways. 
  • Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro. 
  • Two forms of mitochondrial DNA ligase III are produced in Xenopus laevis oocytes. 
  • Unmasking Proteolytic Activity for Adult Visual Cortex Plasticity by the Removal of Lynx1. 
  • Use of Hes1-GFP reporter mice to assess activity of the Hes1 promoter in bone cells under chronic inflammation. 
  • Use of bacterial quorum-sensing components to regulate gene expression in plants. 
  • Use of viral systems to study miRNA-mediated regulation of gene expression in human cells. 
  • Utility of the secreted placental alkaline phosphatase reporter enzyme. 
  • Utilization of a mammalian cell-based RNA binding assay to characterize the RNA binding properties of picornavirus 3C proteinases. 
  • Variation in efficiency of DNA mismatch repair at different sites in the yeast genome. 
  • Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis. 
  • Widespread expression of netrin-1 by neurons and oligodendrocytes in the adult mammalian spinal cord. 
  • Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog. 
  • Zebrafish assays of ciliopathies. 
  • [Using Hsp70 promoter to regulate target gene expression in tumor]. 
  • beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation. 
  • beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. 
  • c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts. 
  • cis-acting DNA from fission yeast centromeres mediates histone H3 methylation and recruitment of silencing factors and cohesin to an ectopic site. 
  • neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. 
  • p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene. 
  • p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1. 
  • β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium. 
• 

  Keywords of People

  • Baugh, L. Ryan, Associate Professor of Biology, Biology
  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Chitneni, Satish K., Associate Professor in Radiology, Radiology
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
  • Luftig, Micah Alan, Associate Professor of Molecular Genetics and Microbiology, Immunology
  • McDonnell, Donald Patrick, Chair, Department of Pharmacology & Cancer Biology, Duke Innovation & Entrepreneurship
  • Milano, Carmelo Alessio, Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Tsalik, Ephraim, Associate Professor of Medicine, Molecular Genetics and Microbiology
  • Velkey, John Matthew, Assistant Professor of the Practice of Medical Education in the Department of Cell Biology, Cell Biology
  • Wray, Gregory Allan, Professor of Biology, Duke Innovation & Entrepreneurship
  • Yan, Hai, Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine, Pathology
  • Zhong, Pei, Professor in the Department of Mechanical Enginnering and Materials Science, Mechanical Engineering and Materials Science