Pyramidal Cells

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  Subject Areas on Research

  • A circuit for motor cortical modulation of auditory cortical activity. 
  • Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits. 
  • Absence of histological lesions in primate models of ECT and magnetic seizure therapy. 
  • Aging impairs axonal sprouting response of dentate granule cells following target loss and partial deafferentation. 
  • Alterations in trk A, trk B and trk C receptor immunoreactivities in parietal cortex and cerebellum in Alzheimer's disease. 
  • Altered morphology of hippocampal dentate granule cell presynaptic and postsynaptic terminals following conditional deletion of TrkB. 
  • An on-line archive of reconstructed hippocampal neurons. 
  • Apolipoprotein E genotype and Lewy body disease. 
  • Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. 
  • Autocrine BDNF-TrkB signalling within a single dendritic spine. 
  • Balanced synaptic impact via distance-dependent synapse distribution and complementary expression of AMPARs and NMDARs in hippocampal dendrites. 
  • Benzodiazepines protect hippocampal neurons from degeneration after transient cerebral ischemia: an ultrastructural study. 
  • Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals. 
  • Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. 
  • Chemical two-photon uncaging: a novel approach to mapping glutamate receptors. 
  • Chloride-cotransport blockade desynchronizes neuronal discharge in the "epileptic" hippocampal slice. 
  • Complementary modulation of somatic inhibition by opioids and cannabinoids. 
  • Conditional immortalization of neuronal cells from postmitotic cultures and adult CNS. 
  • Contributions of mossy fiber and CA1 pyramidal cell sprouting to dentate granule cell hyperexcitability in kainic acid-treated hippocampal slice cultures. 
  • Correlation of hippocampal neuronal density and FDG-PET in mesial temporal lobe epilepsy. 
  • Dendrites of classes of hippocampal neurons differ in structural complexity and branching patterns. 
  • Dendritic architecture of the von Economo neurons. 
  • Dendritic properties of hippocampal CA1 pyramidal neurons in the rat: intracellular staining in vivo and in vitro. 
  • Denervation-induced dendritic alterations in CA1 pyramidal cells following kainic acid hippocampal lesions in rats. 
  • Depressed responses to applied and synaptically-released GABA in CA1 pyramidal cells, but not in CA1 interneurons, after transient forebrain ischemia. 
  • Developmental differences in the sensitivity of spontaneous and miniature IPSCs to ethanol. 
  • Developmental sensitivity of hippocampal interneurons to ethanol: involvement of the hyperpolarization-activated current, Ih. 
  • Dietary prenatal choline supplementation alters postnatal hippocampal structure and function. 
  • Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents. 
  • Differential effect of ethanol on NMDA EPSCs in pyramidal cells in the posterior cingulate cortex of juvenile and adult rats. 
  • Differential expression of GABA and glutamate-receptor subunits and enzymes involved in GABA metabolism between electrophysiologically identified hippocampal CA1 pyramidal cells and interneurons. 
  • Differential sensitivity of hippocampal interneurons to ethanol in adolescent and adult rats. 
  • Differential sensitivity to intracellular pH among high- and low-threshold Ca2+ currents in isolated rat CA1 neurons. 
  • Differing mechanisms for glutamate receptor aggregation on dendritic spines and shafts in cultured hippocampal neurons. 
  • Dissociation of synchronization and excitability in furosemide blockade of epileptiform activity. 
  • Distinct timing in the activity of cannabinoid-sensitive and cannabinoid-insensitive basket cells. 
  • Distribution of functional glutamate and GABA receptors on hippocampal pyramidal cells and interneurons. 
  • Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease. 
  • Dynamics of networks of randomly connected excitatory and inhibitory spiking neurons. 
  • Dynamics of sparsely connected networks of excitatory and inhibitory spiking neurons. 
  • Effect of transient cerebral ischemia on gamma-aminobutyric acidA receptor alpha 1-subunit-immunoreactive interneurons in the gerbil CA1 hippocampus. 
  • Effects of the selective norepinephrine reuptake inhibitor reboxetine on norepinephrine and serotonin transmission in the rat hippocampus. 
  • Electrophysiological correlates to the intrinsic optical signal in the rat neocortical slice. 
  • Endogenous opioids regulate long-term potentiation of synaptic inhibition in the dentate gyrus of rat hippocampus. 
  • Ethanol inhibition of AMPA and kainate receptor-mediated depolarizations of hippocampal area CA1. 
  • Excitatory synaptic site heterogeneity during paired pulse plasticity in CA1 pyramidal cells in rat hippocampus in vitro. 
  • Functional mapping and Ca2+ regulation of nicotinic acetylcholine receptor channels in rat hippocampal CA1 neurons. 
  • Gain modulation by nicotine in macaque v1. 
  • General anesthetic exposure in adolescent rats causes persistent maladaptations in cognitive and affective behaviors and neuroplasticity. 
  • Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors. 
  • Glutamic acid decarboxylase-67-positive hippocampal interneurons undergo a permanent reduction in number following kainic acid-induced degeneration of ca3 pyramidal neurons. 
  • Heptanol but not fluoroacetate prevents the propagation of spreading depression in rat hippocampal slices. 
  • Hub GABA neurons mediate gamma-frequency oscillations at ictal-like event onset in the immature hippocampus. 
  • Hyperexcitability in CA1 of the rat hippocampal slice following hypoxia or adenosine. 
  • Hypotonic exposure enhances synaptic transmission and triggers spreading depression in rat hippocampal tissue slices. 
  • Imaging synaptic inhibition in transgenic mice expressing the chloride indicator, Clomeleon. 
  • Immunohistochemical analysis of Disc1 expression in the developing and adult hippocampus. 
  • Impaired firing and sodium channel function in CA1 hippocampal interneurons after transient cerebral ischemia. 
  • In vitro modulation of endogenous rhythms by AC electric fields: Syncing with clinical brain stimulation. 
  • In vivo and in vitro analyses of amygdalar function reveal a role for copper. 
  • Increased expression of p130 in Alzheimer disease. 
  • Increased neuronal damage and apoE immunoreactivity in human apolipoprotein E, E4 isoform-specific, transgenic mice after global cerebral ischaemia. 
  • Increased tonic activation of rat forebrain 5-HT(1A) receptors by lithium addition to antidepressant treatments. 
  • Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton. 
  • Inhibition of major cationic inward currents prevents spreading depression-like hypoxic depolarization in rat hippocampal tissue slices. 
  • Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases. 
  • Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis. 
  • Intracerebroventricular kainic acid administration in adult rat alters hippocampal calbindin and non-phosphorylated neurofilament expression. 
  • Intraventricular infusion of apolipoprotein E ameliorates acute neuronal damage after global cerebral ischemia in mice. 
  • Intrinsically determined cell death of developing cortical interneurons. 
  • Ischemic injury and extracellular amino acid accumulation in hippocampal area CA1 are not dependent upon an intact septo-hippocampal pathway. 
  • Kindling reduces sensitivity of CA3 hippocampal pyramidal cells to competitive NMDA receptor antagonists. 
  • Localization of brain-derived neurotrophic factor to distinct terminals of mossy fiber axons implies regulation of both excitation and feedforward inhibition of CA3 pyramidal cells. 
  • Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex. 
  • Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall. 
  • Low external NaCl concentration and low osmolarity enhance voltage-gated Ca currents but depress K currents in freshly isolated rat hippocampal neurons. 
  • Maternal Loss of Ube3a Impairs Experience-Driven Dendritic Spine Maintenance in the Developing Visual Cortex. 
  • Mechanisms of increased hippocampal excitability in the Mashl+/- mouse model of Na+ /K+ -ATPase dysfunction. 
  • Membrane currents in CA1 pyramidal cells during spreading depression (SD) and SD-like hypoxic depolarization. 
  • Memory retention is modulated by acute estradiol and progesterone replacement. 
  • Modulation of NMDA and AMPA-mediated synaptic transmission by CB1 receptors in frontal cortical pyramidal cells. 
  • NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: a potential mechanism of neurotoxicity. 
  • Neurotrophin regulation of cortical dendritic growth requires activity. 
  • Opposing roles for endogenous BDNF and NT-3 in regulating cortical dendritic growth. 
  • Optical imaging of hippocampal neurons with a chloride-sensitive dye: early effects of in vitro ischemia. 
  • Optical imaging of intracellular chloride in living brain slices. 
  • Optical imaging reveals elevated intracellular chloride in hippocampal pyramidal neurons after oxidative stress. 
  • Persistent activity and the single-cell frequency-current curve in a cortical network model. 
  • Pik3c3 deletion in pyramidal neurons results in loss of synapses, extensive gliosis and progressive neurodegeneration. 
  • Polyamines antagonize N-methyl-D-aspartate-evoked depolarizations, but reduce Mg2+ block. 
  • Prenatal nicotine exposure evokes alterations of cell structure in hippocampus and somatosensory cortex. 
  • Presynaptic calcium dynamics and transmitter release evoked by single action potentials at mammalian central synapses. 
  • Prominent reduction in pyramidal neurons density in the orbitofrontal cortex of elderly depressed patients. 
  • Rapid Golgi analysis method for efficient and unbiased classification of dendritic spines. 
  • Recurrent circuitry dynamically shapes the activation of piriform cortex. 
  • Regulation of synaptic strength by protein phosphatase 1. 
  • Seizure-like afterdischarges simulated in a model neuron. 
  • Seizures, cell death, and mossy fiber sprouting in kainic acid-treated organotypic hippocampal cultures. 
  • Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. 
  • Simulated seizures and spreading depression in a neuron model incorporating interstitial space and ion concentrations. 
  • Simulation of transcranial magnetic stimulation in head model with morphologically-realistic cortical neurons. 
  • Spatiotemporal coupling between hippocampal acetylcholine release and theta oscillations in vivo. 
  • Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine. 
  • Strong single-fiber sensory inputs to olfactory cortex: implications for olfactory coding. 
  • Structural plasticity of dentate granule cell mossy fibers during the development of limbic epilepsy. 
  • Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex. 
  • Synapse-specific downregulation of NMDA receptors by early experience: a critical period for plasticity of sensory input to olfactory cortex. 
  • Synaptic mechanisms and network dynamics underlying spatial working memory in a cortical network model. 
  • Synaptic plasticity in morphologically identified CA1 stratum radiatum interneurons and giant projection cells. 
  • The Angelman syndrome protein Ube3a is required for polarized dendrite morphogenesis in pyramidal neurons. 
  • The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability. 
  • The cellular and synaptic location of activated TrkB in mouse hippocampus during limbic epileptogenesis. 
  • The extent and mechanism of the loss of function caused by strongly hypotonic solutions in rat hippocampal slices. 
  • The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1. 
  • The novel micro-opioid receptor antagonist, [N-allyl-Dmt(1)]endomorphin-2, attenuates the enhancement of GABAergic neurotransmission by ethanol. 
  • The suppression of testis-brain RNA binding protein and kinesin heavy chain disrupts mRNA sorting in dendrites. 
  • Toward a Neurocentric View of Learning. 
  • Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth. 
  • Two mechanisms that raise free intracellular calcium in rat hippocampal neurons during hypoosmotic and low NaCl treatment. 
  • What determines the frequency of fast network oscillations with irregular neural discharges? I. Synaptic dynamics and excitation-inhibition balance. 
  • Zinc modulation of GABAA receptor-mediated chloride flux in rat hippocampal slices. 
  • Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse. 
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  Keywords of People

  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering