Connexin 43

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  Subject Areas on Research

  • Adrenomedullin improves fertility and promotes pinopodes and cell junctions in the peri-implantation endometrium. 
  • Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. 
  • Cardiac fibroblast paracrine factors alter impulse conduction and ion channel expression of neonatal rat cardiomyocytes. 
  • Changes in anisotropic conduction caused by remodeling cell size and the cellular distribution of gap junctions and Na(+) channels. 
  • Chondrocytes isolated from mature articular cartilage retain the capacity to form functional gap junctions. 
  • Combined PI3K/Akt and Smad2 Activation Promotes Corneal Endothelial Cell Proliferation. 
  • Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: a genome-wide association study of 13,372 participants. 
  • Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice. 
  • Differential expression of hippocampal connexins after acute hypoxia in the developing brain. 
  • Effect of the isoflavone genistein against galactose-induced cataracts in rats. 
  • Engineering prokaryotic channels for control of mammalian tissue excitability. 
  • Gender-specific differences in expression of mRNAs for functional and structural proteins in rat ventricular myocardium. 
  • Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. 
  • Prolonged dark adaptation changes connexin expression in the mouse retina. 
  • Rapid fusion between mesenchymal stem cells and cardiomyocytes yields electrically active, non-contractile hybrid cells. 
  • S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents. 
  • Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes. 
  • Size and ionic currents of unexcitable cells coupled to cardiomyocytes distinctly modulate cardiac action potential shape and pacemaking activity in micropatterned cell pairs. 
  • Structural coupling of cardiomyocytes and noncardiomyocytes: quantitative comparisons using a novel micropatterned cell pair assay. 
  • Tissue engineering of functional cardiac muscle: molecular, structural, and electrophysiological studies. 
  • Tumor-induced loss of mural Connexin 43 gap junction activity promotes endothelial proliferation. 
  • Tyrosine-dependent basolateral targeting of human connexin43-eYFP in Madin-Darby canine kidney cells can be disrupted by the oculodentodigital dysplasia mutation L90V. 
  • Up-regulation of connexin45 in heart failure. 
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  Keywords of People

  • Bursac, Nenad, Professor of Biomedical Engineering, Biomedical Engineering