Receptors, Odorant

• 

  Subject Areas on Research

  • A Scalable, Multiplexed Assay for Decoding GPCR-Ligand Interactions with RNA Sequencing. 
  • A dual-target molecular mechanism of pyrethrum repellency against mosquitoes. 
  • Activation state of the M3 muscarinic acetylcholine receptor modulates mammalian odorant receptor signaling. 
  • Agonists of G-Protein-Coupled Odorant Receptors Are Predicted from Chemical Features. 
  • Aldehyde recognition and discrimination by mammalian odorant receptors via functional group-specific hydration chemistry. 
  • An odorant receptor that senses four classes of musk compounds. 
  • An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. 
  • Ant Olfaction: Smells Like an Insect, Develops Like a Mammal. 
  • Assaying surface expression of chemosensory receptors in heterologous cells. 
  • Axonal Odorant Receptors Mediate Axon Targeting. 
  • Behavioral and physiological responses of Drosophila melanogaster and D. suzukii to volatiles from plant essential oils. 
  • Carbon chain shape selectivity by the mouse olfactory receptor OR-I7. 
  • Combinatorial rules of precursor specification underlying olfactory neuron diversity. 
  • Common promoter elements in odorant and vomeronasal receptor genes. 
  • Concentration-Dependent Recruitment of Mammalian Odorant Receptors. 
  • Conserved Residues Control Activation of Mammalian G Protein-Coupled Odorant Receptors. 
  • Crucial role of copper in detection of metal-coordinating odorants. 
  • Decoding the olfactory map through targeted transcriptomics links murine olfactory receptors to glomeruli. 
  • Discovery of novel ligands for mouse olfactory receptor MOR42-3 using an in silico screening approach and in vitro validation. 
  • Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates. 
  • Evaluating cell-surface expression and measuring activation of mammalian odorant receptors in heterologous cells. 
  • Expression of olfactory signaling genes in the eye. 
  • Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. 
  • Formation of precise connections in the olfactory bulb occurs in the absence of odorant-evoked neuronal activity. 
  • Functional analysis of a mammalian odorant receptor subfamily. 
  • Functional evolution of mammalian odorant receptors. 
  • Functional expression of Mammalian odorant receptors. 
  • G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. 
  • General olfactory sensitivity database (GOSdb): candidate genes and their genomic variations. 
  • Genetic elucidation of human hyperosmia to isovaleric acid. 
  • Genetic variation across the human olfactory receptor repertoire alters odor perception. 
  • Genetic variation in a human odorant receptor alters odour perception. 
  • Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol. 
  • Genetic variation of an odorant receptor OR7D4 and sensory perception of cooked meat containing androstenone. 
  • Global Survey of Variation in a Human Olfactory Receptor Gene Reveals Signatures of Non-Neutral Evolution. 
  • High-Throughput Odorant Receptor Deorphanization Via Phospho-S6 Ribosomal Protein Immunoprecipitation and mRNA Profiling. 
  • Hot Spot Mutagenesis Improves the Functional Expression of Unique Mammalian Odorant Receptors. 
  • Human olfactory receptor responses to odorants. 
  • Identification and Characterization of Proteins That Are Involved in RTP1S-Dependent Transport of Olfactory Receptors. 
  • Identification of multiple odorant receptors essential for pyrethrum repellency in Drosophila melanogaster. 
  • Implausibility of the vibrational theory of olfaction. 
  • Improving the odorant sensitivity of olfactory receptor-expressing yeast with accessory proteins. 
  • In vivo identification of eugenol-responsive and muscone-responsive mouse odorant receptors. 
  • Interactions among key residues regulate mammalian odorant receptor trafficking. 
  • Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay. 
  • Machine Learning Assisted Approach for Finding Novel High Activity Agonists of Human Ectopic Olfactory Receptors. 
  • Mammalian class I odorant receptors exhibit a conserved vestibular-binding pocket. 
  • Mammalian odorant receptors: functional evolution and variation. 
  • Mechanisms of olfactory receptor neuron specification in Drosophila. 
  • Mice with a "monoclonal nose": perturbations in an olfactory map impair odor discrimination. 
  • Modification of the response of olfactory receptors to acetophenone by CYP1a2. 
  • Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures. 
  • Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds. 
  • Molecular profiling of activated olfactory neurons identifies odorant receptors for odors in vivo. 
  • Molecular recognition of ketamine by a subset of olfactory G protein-coupled receptors. 
  • Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment. 
  • Next-generation sequencing of the human olfactory receptors. 
  • Numerical Models and In Vitro Assays to Study Odorant Receptors. 
  • Odor coding by a Mammalian receptor repertoire. 
  • Odorant Receptor 7D4 Activation Dynamics. 
  • Odorant receptors and desensitization proteins colocalize in mammalian sperm. 
  • Odorant receptors govern the formation of a precise topographic map. 
  • Olfactory Receptor Subgenomes Linked with Broad Ecological Adaptations in Sauropsida. 
  • Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production. 
  • Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice. 
  • Olfactory receptor gene expression in tiger salamander olfactory epithelium. 
  • Olfactory receptors in macrophages and inflammation. 
  • Olfactory recognition and discrimination in Caenorhabditis elegans. 
  • PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer. 
  • QM/MM model of the mouse olfactory receptor MOR244-3 validated by site-directed mutagenesis experiments. 
  • Quantitative expression profile of PSGR in prostate cancer. 
  • RAMP like proteins : RTP and REEP family of proteins. 
  • RTP family members induce functional expression of mammalian odorant receptors. 
  • Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase. 
  • Receptor-transporting protein 1 short (RTP1S) mediates translocation and activation of odorant receptors by acting through multiple steps. 
  • Receptors, circuits, and behaviors: new directions in chemical senses. 
  • Reply to Turin et al.: Vibrational theory of olfaction is implausible. 
  • Responsiveness of G protein-coupled odorant receptors is partially attributed to the activation mechanism. 
  • SR1, a mouse odorant receptor with an unusually broad response profile. 
  • Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic. 
  • Sequence coevolution and structure stabilization modulate olfactory receptor expression. 
  • Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. 
  • Structural basis of odorant recognition by a human odorant receptor. 
  • Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors. 
  • Synergism of accessory factors in functional expression of mammalian odorant receptors. 
  • The N-terminal region of RTP1S plays important roles in dimer formation and odorant receptor-trafficking. 
  • The human olfactory transcriptome. 
  • The missense of smell: functional variability in the human odorant receptor repertoire. 
  • The molecular basis for ligand specificity in a mouse olfactory receptor: a network of functionally important residues. 
  • The molecular biology of olfactory perception. 
  • The role of metals in mammalian olfaction of low molecular weight organosulfur compounds. 
  • The utility of PacBio circular consensus sequencing for characterizing complex gene families in non-model organisms. 
  • Trafficking of mammalian chemosensory receptors by receptor-transporting proteins. 
  • Transcriptional profiling of olfactory system development identifies distal antenna as a regulator of subset of neuronal fates. 
  • Transfluthrin enhances odorant receptor-mediated spatial repellency in Aedes aegypti. 
  • Vapor detection and discrimination with a panel of odorant receptors. 
  • Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated. 
  • Visualizing an olfactory sensory map.