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Subject Areas on Research
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A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas.
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A randomized, double-blind comparison of the NK1 antagonist, aprepitant, versus ondansetron for the prevention of postoperative nausea and vomiting.
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Attenuation of acid induced oesophagitis in VR-1 deficient mice.
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Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis.
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Characterization of GRK2-catalyzed phosphorylation of the human substance P receptor in Sf9 membranes.
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Characterization of differences between rapid agonist-dependent phosphorylation and phorbol ester-mediated phosphorylation of human substance P receptor in intact cells.
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Developmental expression of neurokinin A and functional neurokinin-2 receptors in lung.
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Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis.
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Differential expression of two isoforms of the neurokinin-1 (substance P) receptor in vivo.
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Ethnomedicinally selected plants as sources of potential analgesic compounds: indication of in vitro biological activity in receptor binding assays.
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Extrinsic surgical denervation ameliorates TNBS-induced colitis in rats.
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Human substance P receptor expressed in Chinese hamster ovary cells directly activates G(alpha q/11), G(alpha s), G(alpha o).
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Human substance P receptor expressed in Sf9 cells couples with multiple endogenous G proteins.
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Human substance P receptor lacking the C-terminal domain remains competent to desensitize and internalize.
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Human substance P receptor undergoes agonist-dependent phosphorylation by G protein-coupled receptor kinase 5 in vitro.
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Increased substance P receptor expression by blood vessels and lymphoid aggregates in Clostridium difficile-induced pseudomembranous colitis.
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Localization of substance P NK-1 receptors in rat tongue.
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Mild Traumatic Brain Injury in Mice Beneficially Alters Lung NK1R and Structural Protein Expression to Enhance Survival after Pseudomonas aeruginosa Infection.
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Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*.
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NK-1 receptor gene expression is related to pain in chronic pancreatitis.
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Neurokinin subtype receptors mediating substance P contraction in immature rabbit airways.
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Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis.
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Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesia.
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Neuromodulation mediated by neurokinin-1 subtype receptors in adult rabbit airways.
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Nuclear factor kappa B mediates lipopolysaccharide-induced inflammation in the urinary bladder.
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Oncogenic and metastatic properties of preprotachykinin-I and neurokinin-1 genes.
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Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo.
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Real-time visualization of the cellular redistribution of G protein-coupled receptor kinase 2 and beta-arrestin 2 during homologous desensitization of the substance P receptor.
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Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease.
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Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation.
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Rolapitant for the prevention of postoperative nausea and vomiting: a prospective, double-blinded, placebo-controlled randomized trial.
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Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta.
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Sprouting of substance P-expressing primary afferent central terminals and spinal micturition reflex NK1 receptor dependence after spinal cord injury.
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Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum.
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Substance P and substance K receptor binding sites in the human gastrointestinal tract: localization by autoradiography.
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Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors.
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Substance P dependence of endosomal fusion during bladder inflammation.
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Substance P receptor mediated maintenance of chronic inflammation in EAE.
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Substance P receptors on canine chief cells: localization, characterization, and function.
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Synthesis and NK(1)/NK(2) binding activities of a series of diacyl-substituted 2-arylpiperazines.
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The dynamics of bone marrow stromal cells in the proliferation of multipotent hematopoietic progenitors by substance P: an understanding of the effects of a neurotransmitter on the differentiating hematopoietic stem cell.
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The localization of sensory nerve fibers and receptor binding sites for sensory neuropeptides in canine mesenteric lymph nodes.
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The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2.