Receptors, Metabotropic Glutamate

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  Subject Areas on Research

  • Activation of metabotropic glutamate receptor 7 in spinal cord inhibits pain and hyperalgesia in a novel formalin model in sheep. 
  • Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury. 
  • Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. 
  • Cerebral 5-HT2A receptor binding, but not mGluR2, is increased in tryptophan hydroxylase 2 decrease-of-function mice. 
  • Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate. 
  • Differential expression of glutamate receptors in avian neural pathways for learned vocalization. 
  • Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration. 
  • Functional reconstitution of purified metabotropic glutamate receptor expressed in the fly eye. 
  • Glutamate receptor involvement in dentate granule cell epileptiform activity evoked by mossy fiber stimulation. 
  • Glutamate-binding affinity of Drosophila metabotropic glutamate receptor is modulated by association with lipid rafts. 
  • Homer: a protein that selectively binds metabotropic glutamate receptors. 
  • Hyperpolarization induces a long-term increase in the spontaneous firing rate of cerebellar Golgi cells. 
  • Long-term plasticity mediated by mGluR1 at a retinal reciprocal synapse. 
  • Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. 
  • NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. 
  • Neuroprotective effects of group III mGluR in traumatic neuronal injury. 
  • Opposite modulation of capsaicin-evoked substance P release by glutamate receptors. 
  • Pharmacological characterization and immunoaffinity purification of metabotropic glutamate receptor from Drosophila overexpressed in Sf9 cells. 
  • Regulation of synaptic strength by protein phosphatase 1. 
  • Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity. 
  • Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses. 
  • Short-term frequency-dependent plasticity at recurrent mossy fiber synapses of the epileptic brain. 
  • Synaptic plasticity in drug reward circuitry. 
  • The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism. 
  • The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 inhibits inflammatory pain-induced and incision-induced hypersensitivity in rat. 
  • Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. 
  • mGluR modulation of post-traumatic neuronal death: role of NMDA receptors. 
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  Keywords of People

  • Calakos, Nicole, Lincoln Financial Group Distinguished Professor of Neurobiology, Duke Science & Society
  • Gunn, Michael Dee, Professor of Medicine, Immunology