Antigens, CD28
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Subject Areas on Research
- A critical precursor frequency of donor-reactive CD4+ T cell help is required for CD8+ T cell-mediated CD28/CD154-independent rejection.
- Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma.
- An expanded role of the tumor suppressor TSC1 in T cell tolerance.
- Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes.
- Biologics in organ transplantation.
- CD28 costimulatory signal induces protein arginine methylation in T cells.
- CD28 is required for germinal center formation.
- CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation.
- CD28 ligation induces tyrosine phosphorylation of Pyk2 but not Fak in Jurkat T cells.
- CD28 negative T cells: is their loss our gain?
- CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model.
- CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis.
- CTLA4Ig: bridging the basic immunology with clinical application.
- CX(3)CR1 drives cytotoxic CD4(+)CD28(-) T cells into the brain of multiple sclerosis patients.
- Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients.
- Circulating CD8+CD28- suppressor T cells tied to poorer prognosis among metastatic breast cancer patients receiving adoptive T-cell therapy: A cohort study.
- Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells.
- Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice.
- Costimulation blockade: towards clinical application.
- Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.
- Electron transport complex I is required for CD8+ T cell function.
- Elevated level of peripheral CD8(+)CD28(-) T lymphocytes are an independent predictor of progression-free survival in patients with metastatic breast cancer during the course of chemotherapy.
- Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells.
- Evaluation of CD86/CD28 and CD40/CD154 pathways in regulating monocyte-derived CD80 expression during their interaction with allogeneic endothelium.
- FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506.
- Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.
- IFN-α inhibits telomerase in human CD8⁺ T cells by both hTERT downregulation and induction of p38 MAPK signaling.
- Immunologic characterization of CD7-deficient mice.
- Interleukin-7 permits Th1/Tc1 maturation and promotes ex vivo expansion of cord blood T cells: a critical step toward adoptive immunotherapy after cord blood transplantation.
- Involvement of linker for activation of T cells in the costimulatory signaling pathways.
- In Vivo Expansion and Antitumor Activity of Coinfused CD28- and 4-1BB-Engineered CAR-T Cells in Patients with B Cell Leukemia.
- K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation.
- Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression.
- Negative regulation of TCR signaling by linker for activation of X cells via phosphotyrosine-dependent and -independent mechanisms.
- Notch 1 signaling regulates peripheral T cell activation.
- PD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue.
- Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells.
- Postdepletion Lymphocyte Reconstitution During Belatacept and Rapamycin Treatment in Kidney Transplant Recipients.
- Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506.
- Premature cell senescence and T cell receptor-independent activation of CD8+ T cells in juvenile idiopathic arthritis.
- Preventing Lck Activation in CAR T Cells Confers Treg Resistance but Requires 4-1BB Signaling for Them to Persist and Treat Solid Tumors in Nonlymphodepleted Hosts.
- Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases.
- Secondary lymphoid tissue and costimulation-blockade resistant rejection: A nonhuman primate renal transplant study.
- Selective targeting of human alloresponsive CD8+ effector memory T cells based on CD2 expression.
- T Cell Receptor-Independent, CD31/IL-17A-Driven Inflammatory Axis Shapes Synovitis in Juvenile Idiopathic Arthritis.
- T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+.
- T cell-mediated elimination of B7.2 transgenic B cells.
- The CD28 signaling pathway regulates glucose metabolism.
- The calm after the cytokine storm: lessons from the TGN1412 trial.
- Tolerance: is it achievable in pediatric solid organ transplantation?
- Tumor suppressor TSC1 is critical for T-cell anergy.
- Viral-induced CD28 loss evokes costimulation independent alloimmunity.
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Keywords of People
- Zhong, Xiaoping, Professor of Pediatrics, Immunology