Chloride Channels

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  Subject Areas on Research

  • A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity. 
  • A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation. 
  • A novel chloride channel in Vicia faba guard cell vacuoles activated by the serine/threonine kinase, CDPK. 
  • A novel mutation in the cystic fibrosis gene in patients with pulmonary disease but normal sweat chloride concentrations. 
  • A positive modulator of K Ca 2 and K Ca 3 channels, 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo. 
  • Activation of G551D CFTR channel with MPB-91: regulation by ATPase activity and phosphorylation. 
  • Activation of swelling-activated chloride current by tumor necrosis factor-alpha requires ClC-3-dependent endosomal reactive oxygen production. 
  • Age-related differences in neurosteroid potentiation of muscimol-stimulated 36Cl(-) flux following chronic ethanol treatment. 
  • Alterations in the gamma-aminobutyric acid-gated chloride channel following transient forebrain ischemia in the gerbil. 
  • Analysis of the mouse transcriptome for genes involved in the function of the nervous system. 
  • Autosomal recessive best vitelliform macular dystrophy: report of a family and management of early-onset neovascular complications. 
  • Bidirectional modulation of GABA-gated chloride channels by divalent cations: inhibition by Ca2+ and enhancement by Mg2+. 
  • Biochemical and biophysical identification of cystic fibrosis transmembrane conductance regulator chloride channels as components of endocytic clathrin-coated vesicles. 
  • CFTR as a cAMP-dependent regulator of sodium channels. 
  • Ca++-switch induction of RPE differentiation. 
  • Ca2+-activated Cl- channels at a glance. 
  • Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. 
  • Characterization of the hyperpolarization-activated chloride current in dissociated rat sympathetic neurons. 
  • Chloride channel ClCN7 mutations are responsible for severe recessive, dominant, and intermediate osteopetrosis. 
  • Chloride dependence of hyperpolarization-activated chloride channel gates. 
  • ClC-2 chloride secretion mediates prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum. 
  • Cryptococcus neoformans virulence gene discovery through insertional mutagenesis. 
  • Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3. 
  • Cytoskeletal actin gates a Cl- channel in neocortical astrocytes. 
  • Cytosolic Ca2+ gradients triggering unidirectional fluid secretion from exocrine pancreas. 
  • Enhanced inflow and outflow rates despite lower IOP in bestrophin-2-deficient mice. 
  • Expression of an abundant alternatively spliced form of the cystic fibrosis transmembrane conductance regulator (CFTR) gene is not associated with a cAMP-activated chloride conductance. 
  • Functional repair of a mutant chloride channel using a trans-splicing ribozyme. 
  • Functionally relevant gamma-aminobutyric acidA receptors: equivalence between receptor affinity (Kd) and potency (EC50)? 
  • Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning. 
  • Inhibition of GABA-gated chloride channel function by arachidonic acid. 
  • Inhibition of GABA-gated chloride channels in brain by the arachidonic acid metabolite, thromboxane A2. 
  • Inhibition of the GABA receptor-gated chloride ion channel in brain by noncompetitive inhibitors of the nicotinic receptor-gated cation channel. 
  • Interactions between propofol and lipid mediator receptors: inhibition of lysophosphatidate signaling. 
  • Intrarenal and subcellular localization of rat CLC5. 
  • Ion regulation in the brain: implications for pathophysiology. 
  • Localization of the cystic fibrosis transmembrane conductance regulator in human bile duct epithelial cells. 
  • Lysophosphatidic acid stimulates neurotransmitter-like conductance changes that precede GABA and L-glutamate in early, presumptive cortical neuroblasts. 
  • Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption. 
  • Measurement of chloride movement in neuronal preparations. 
  • Missense mutation (G480C) in the CFTR gene associated with protein mislocalization but normal chloride channel activity. 
  • Modulation of Xenopus oocyte-expressed phospholemman-induced ion currents by co-expression of protein kinases. 
  • Molecular basis of defective anion transport in L cells expressing recombinant forms of CFTR. 
  • Molecular dissection of gating in the ClC-2 chloride channel. 
  • Multiple calcium-mediated effector mechanisms regulate chloride secretory responses in T84-cells. 
  • Polarized expression of cAMP-activated chloride channels in isolated epithelial cells. 
  • Rapid decline of GABAA receptor subunit mRNA expression in hippocampus following transient cerebral ischemia in the gerbil. 
  • Receptor-evoked Cl- current in Xenopus oocytes is mediated through a beta-type phospholipase C. Cloning of a new form of the enzyme. 
  • Regulation of epithelial chloride channels by protein phosphatase. 
  • Regulation of intracellular pH mediates Bax activation in HeLa cells treated with staurosporine or tumor necrosis factor-alpha. 
  • Regulation of membrane chloride currents in rat bile duct epithelial cells. 
  • Regulatory Roles of Anoctamin-6 in Human Trabecular Meshwork Cells. 
  • Salt stress increases abundance and glycosylation of CFTR localized at apical surfaces of salt gland secretory cells. 
  • Structural cues involved in endoplasmic reticulum degradation of G85E and G91R mutant cystic fibrosis transmembrane conductance regulator. 
  • TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. 
  • The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels. 
  • The anion in salt taste: a possible role for paracellular pathways. 
  • The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. 
  • Truncating CLCN1 mutations in myotonia congenita: variable patterns of inheritance. 
  • Ultrastructural localization of variant forms of cystic fibrosis transmembrane conductance regulator in human bronchial epithelial of xenografts. 
  • Whole-cell chloride currents in rat astrocytes accompany changes in cell morphology. 
  • cAMP analogs inhibit gamma-aminobutyric acid-gated chloride flux and activate protein kinase A in brain synaptoneurosomes. 
  • cAMP and forskolin decrease gamma-aminobutyric acid-gated chloride flux in rat brain synaptoneurosomes. 
  • gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. 
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  Keywords of People

  • Yang, Yiping, Professor of Medicine, Immunology