Subject Areas on Research
- A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.
- A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation.
- A novel chloride channel in Vicia faba guard cell vacuoles activated by the serine/threonine kinase, CDPK.
- A positive modulator of K Ca 2 and K Ca 3 channels, 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo.
- A3 adenosine and CB1 receptors activate a PKC-sensitive Cl- current in human nonpigmented ciliary epithelial cells via a G beta gamma-coupled MAPK signaling pathway.
- Activation of G551D CFTR channel with MPB-91: regulation by ATPase activity and phosphorylation.
- Activation of swelling-activated chloride current by tumor necrosis factor-alpha requires ClC-3-dependent endosomal reactive oxygen production.
- Age-related differences in neurosteroid potentiation of muscimol-stimulated 36Cl(-) flux following chronic ethanol treatment.
- Alterations in the gamma-aminobutyric acid-gated chloride channel following transient forebrain ischemia in the gerbil.
- An Additional Ca2+ Binding Site Allosterically Controls TMEM16A Activation.
- Analysis of the mouse transcriptome for genes involved in the function of the nervous system.
- Apical CLC-2 in retinal pigment epithelium is crucial for survival of the outer retina.
- Bidirectional modulation of GABA-gated chloride channels by divalent cations: inhibition by Ca2+ and enhancement by Mg2+.
- Biochemical and biophysical identification of cystic fibrosis transmembrane conductance regulator chloride channels as components of endocytic clathrin-coated vesicles.
- CFTR as a cAMP-dependent regulator of sodium channels.
- Ca++-switch induction of RPE differentiation.
- Ca2+-activated Cl- channels at a glance.
- Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.
- Characterization of the hyperpolarization-activated chloride current in dissociated rat sympathetic neurons.
- Chloride channel ClCN7 mutations are responsible for severe recessive, dominant, and intermediate osteopetrosis.
- Chloride dependence of hyperpolarization-activated chloride channel gates.
- Cryptococcus neoformans virulence gene discovery through insertional mutagenesis.
- Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3.
- Cytoskeletal actin gates a Cl- channel in neocortical astrocytes.
- Enhanced inflow and outflow rates despite lower IOP in bestrophin-2-deficient mice.
- Expression of an abundant alternatively spliced form of the cystic fibrosis transmembrane conductance regulator (CFTR) gene is not associated with a cAMP-activated chloride conductance.
- Functional repair of a mutant chloride channel using a trans-splicing ribozyme.
- Functionally relevant gamma-aminobutyric acidA receptors: equivalence between receptor affinity (Kd) and potency (EC50)?
- Hyposmotic activation of ICl,swell in rabbit nonpigmented ciliary epithelial cells involves increased ClC-3 trafficking to the plasma membrane.
- Hyposmotically activated chloride channels in cultured rabbit non-pigmented ciliary epithelial cells.
- Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning.
- Inhibition of GABA-gated chloride channel function by arachidonic acid.
- Inhibition of GABA-gated chloride channels in brain by the arachidonic acid metabolite, thromboxane A2.
- Inhibition of the GABA receptor-gated chloride ion channel in brain by noncompetitive inhibitors of the nicotinic receptor-gated cation channel.
- Interactions between propofol and lipid mediator receptors: inhibition of lysophosphatidate signaling.
- Intrarenal and subcellular localization of rat CLC5.
- Localization of the cystic fibrosis transmembrane conductance regulator in human bile duct epithelial cells.
- Lubiprostone protects esophageal mucosa from acid injury in porcine esophagus.
- Lysophosphatidic acid stimulates neurotransmitter-like conductance changes that precede GABA and L-glutamate in early, presumptive cortical neuroblasts.
- Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption.
- Measurement of chloride movement in neuronal preparations.
- Missense mutation (G480C) in the CFTR gene associated with protein mislocalization but normal chloride channel activity.
- Modulation of Xenopus oocyte-expressed phospholemman-induced ion currents by co-expression of protein kinases.
- Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A.
- Molecular basis of defective anion transport in L cells expressing recombinant forms of CFTR.
- Molecular dissection of gating in the ClC-2 chloride channel.
- Multiple calcium-mediated effector mechanisms regulate chloride secretory responses in T84-cells.
- Polarized expression of cAMP-activated chloride channels in isolated epithelial cells.
- Protein tyrosine kinase and protein phosphatase signaling pathways regulate volume-sensitive chloride currents in a nonpigmented ciliary epithelial cell line.
- Rapid decline of GABAA receptor subunit mRNA expression in hippocampus following transient cerebral ischemia in the gerbil.
- Regulation of epithelial chloride channels by protein phosphatase.
- Regulation of membrane chloride currents in rat bile duct epithelial cells.
- Regulatory Roles of Anoctamin-6 in Human Trabecular Meshwork Cells.
- Salt stress increases abundance and glycosylation of CFTR localized at apical surfaces of salt gland secretory cells.
- Structural cues involved in endoplasmic reticulum degradation of G85E and G91R mutant cystic fibrosis transmembrane conductance regulator.
- Structure-Function of TMEM16 Ion Channels and Lipid Scramblases.
- TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation.
- The anion in salt taste: a possible role for paracellular pathways.
- The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons.
- Truncating CLCN1 mutations in myotonia congenita: variable patterns of inheritance.
- Use of non-mammalian alternative models for neurotoxicological study.
- Whole-cell chloride currents in rat astrocytes accompany changes in cell morphology.
- cAMP analogs inhibit gamma-aminobutyric acid-gated chloride flux and activate protein kinase A in brain synaptoneurosomes.
- cAMP and forskolin decrease gamma-aminobutyric acid-gated chloride flux in rat brain synaptoneurosomes.
- gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia.