Receptors, Cytoplasmic and Nuclear

• 

  Subject Areas on Research

  • 9-cis retinoic acid regulation of rat growth hormone gene expression: potential roles of multiple nuclear hormone receptors. 
  • A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. 
  • A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development. 
  • A cell-specific nuclear receptor regulates the steroid hydroxylases. 
  • A futile metabolic cycle activated in adipocytes by antidiabetic agents. 
  • A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase. 
  • A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. 
  • A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. 
  • A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. 
  • A structurally optimized FXR agonist, MET409, reduced liver fat content over 12 weeks in patients with non-alcoholic steatohepatitis. 
  • ALK1 signalling analysis identifies angiogenesis related genes and reveals disparity between TGF-beta and constitutively active receptor induced gene expression. 
  • ATM functions at the peroxisome to induce pexophagy in response to ROS. 
  • Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. 
  • Activation of orphan receptor-mediated transcription by Ca(2+)/calmodulin-dependent protein kinase IV. 
  • Allosteric modulation of nucleoporin assemblies by intrinsically disordered regions. 
  • Alterations in calcium metabolism in murine macrophages by the benzene metabolite 1,4-benzoquinone. 
  • Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins. 
  • Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. 
  • Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes. 
  • Anthrabenzoxocinones from Streptomyces sp. as liver X receptor ligands and antibacterial agents. 
  • Antioxidative, antinitrative, and vasculoprotective effects of a peroxisome proliferator-activated receptor-gamma agonist in hypercholesterolemia. 
  • Apoptotic regulation by the Crk adapter protein mediated by interactions with Wee1 and Crm1/exportin. 
  • Application of random peptide phage display to the study of nuclear hormone receptors. 
  • Biochemical fractionation and assembly of the membrane components that mediate nascent chain targeting and translocation. 
  • Biochemistry of soluble guanylate cyclase. 
  • Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. 
  • Body mass index and obesity- and diabetes-associated genotypes and risk for pancreatic cancer. 
  • CD4+CD45RBHi T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin. 
  • Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. 
  • Chloroquine, quinine and quinidine inhibit calcium release from macrophage intracellular stores by blocking inositol 1,4,5-trisphosphate binding to its receptor. 
  • Cilofexor, a Nonsteroidal FXR Agonist, in Patients With Noncirrhotic NASH: A Phase 2 Randomized Controlled Trial. 
  • Classical nuclear hormone receptor activity as a mediator of complex biological responses: a look at health and disease. 
  • Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy. 
  • Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues. 
  • Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR). 
  • Constitutively active retinoid receptors exhibit interfamily and intrafamily promoter specificity. 
  • Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1. 
  • Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. 
  • Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor). 
  • Cyclosporin A inhibits inositol 1,4,5-trisphosphate binding to its receptors and release of calcium from intracellular stores in peritoneal macrophages. 
  • DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin. 
  • Decreased synthesis of matrix metalloproteinase-7 and adhesion to the extracellular matrix proteins of human colon cancer cells treated with troglitazone. 
  • Development of peptide antagonists that target estrogen receptor beta-coactivator interactions. 
  • Differences in the anatomic distribution of immediate-early gene expression in amygdala and angular bundle kindling development. 
  • Differential responsiveness of MCF-7 human breast cancer cell line stocks to the pineal hormone, melatonin. 
  • Differential transcriptional activation of peroxisome proliferator-activated receptor gamma by omega-3 and omega-6 fatty acids in MCF-7 cells. 
  • Differentiation of human embryonic stem cells along a hepatic lineage. 
  • Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta. 
  • Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs. 
  • Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator. 
  • Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. 
  • Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation. 
  • Dynamic shuttling and intranuclear mobility of nuclear hormone receptors. 
  • Effect of the isoflavone genistein against galactose-induced cataracts in rats. 
  • Emerging roles for nuclear receptors in the pathogenesis of age-related macular degeneration. 
  • Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors. 
  • Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. 
  • Etomoxir-induced PPARalpha-modulated enzymes protect during acute renal failure. 
  • Exposure to the synthetic FXR agonist GW4064 causes alterations in gene expression and sublethal hepatotoxicity in eleutheroembryo medaka (Oryzias latipes). 
  • Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. 
  • Farnesoid-X Receptor (FXR) as a Promising Pharmaceutical Target in Atherosclerosis. 
  • Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. 
  • Functional ecdysone receptor is the product of EcR and Ultraspiracle genes. 
  • Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. 
  • Fxr signaling and microbial metabolism of bile salts in the zebrafish intestine. 
  • Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta -cell. 
  • Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand. 
  • Half-site arrangement of hybrid glucocorticoid and thyroid hormone response elements specifies thyroid hormone receptor complex binding to DNA and transcriptional activity. 
  • Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide. 
  • Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk. 
  • Heterodimerization and deoxyribonucleic acid-binding properties of a retinoid X receptor-related factor. 
  • Homer modulates NFAT-dependent signaling during muscle differentiation. 
  • Human PXR forms a tryptophan zipper-mediated homodimer. 
  • Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. 
  • Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. 
  • Identification of a novel set of genes regulated by a unique liver X receptor-alpha -mediated transcription mechanism. 
  • Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. 
  • Identification of late larval stage developmental checkpoints in Caenorhabditis elegans regulated by insulin/IGF and steroid hormone signaling pathways. 
  • Identification of novel mediators of NF-kappaB through genome-wide survey of monocyte adherence-induced genes. 
  • Impact of obeticholic acid on the lipoprotein profile in patients with non-alcoholic steatohepatitis. 
  • In vitro assessment of human nuclear hormone receptor activity and cytotoxicity of the flame retardant mixture FM 550 and its triarylphosphate and brominated components. 
  • Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding. 
  • Inflammasomes are important mediators of cyclophosphamide-induced bladder inflammation. 
  • Inhibition of the inositol triphosphate receptor increases endotoxin-mediated nitric oxide synthesis in macrophages. 
  • Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B. 
  • International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. 
  • Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis. 
  • Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression. 
  • Involvement of the mt1 melatonin receptor in human breast cancer. 
  • KPT-330 Prevents Aortic Valve Calcification via a Novel C/EBPβ Signaling Pathway. 
  • Kindling and associated mossy fibre sprouting are not affected in mice deficient of NGFI-A/NGFI-B genes. 
  • Knockout of Nr2e3 prevents rod photoreceptor differentiation and leads to selective L-/M-cone photoreceptor degeneration in zebrafish. 
  • LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression. 
  • Leveraging Nuclear Receptors as Targets for Pathological Ocular Vascular Diseases. 
  • Liver X receptors alpha and beta regulate renin expression in vivo. 
  • Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism. 
  • Lymphocyte accumulation in the spleen of retinoic acid receptor-related orphan receptor gamma-deficient mice. 
  • Lymphocyte development and function in the absence of retinoic acid-related orphan receptor alpha. 
  • MCF-7 and T47D human breast cancer cells contain a functional peroxisomal response. 
  • MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. 
  • Mapping of m6A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-Low Induction of Therapy Resistance. 
  • Maternal Diet and Insulin-Like Signaling Control Intergenerational Plasticity of Progeny Size and Starvation Resistance. 
  • Mechanisms of NOD-like receptor-associated inflammasome activation. 
  • Melatonin enhancement of splenocyte proliferation is attenuated by luzindole, a melatonin receptor antagonist. 
  • Melatonin synergizes with retinoic acid in the prevention and regression of breast cancer. 
  • Melatonin: a chemical photoperiodic signal with clinical significance in humans. 
  • Membrane insertion, glycosylation, and oligomerization of inositol trisphosphate receptors in a cell-free translation system. 
  • Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism. 
  • Methylation profiling of paediatric pilocytic astrocytoma reveals variants specifically associated with tumour location and predictive of recurrence. 
  • Microarray analysis of peroxisome proliferator-activated receptor-gamma induced changes in gene expression in macrophages. 
  • Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors. 
  • Minireview: Nuclear receptors, hematopoiesis, and stem cells. 
  • Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1. 
  • Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. 
  • Molecular mechanisms of dominant negative activity by nuclear hormone receptors. 
  • Monitoring changes in gene expression in renal ischemia-reperfusion in the rat. 
  • N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents. 
  • Nascent secretory chain binding and translocation are distinct processes: differentiation by chemical alkylation. 
  • Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response. 
  • Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal. 
  • New strategies in pancreatic cancer: emerging epidemiologic and therapeutic concepts. 
  • Nuclear Receptor Atlases of Choroidal Tissues Reveal Candidate Receptors Associated with Age-Related Macular Degeneration. 
  • Nuclear receptor LXRalpha is involved in cAMP-mediated human renin gene expression. 
  • Nuclear receptors as potential therapeutic targets for age-related macular degeneration. 
  • Nucleotide regulation of soluble guanylate cyclase substrate specificity. 
  • Orphan nuclear receptors in T lymphocyte development. 
  • Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion. 
  • Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice. 
  • P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia. 
  • PPAR alpha ligand protects during cisplatin-induced acute renal failure by preventing inhibition of renal FAO and PDC activity. 
  • Paralogous VDRs in teleosts:transition of nuclear receptor function 
  • Pelger-Huët anomaly in a child with 1q42.3-44 deletion. 
  • Peptide antagonists of the human estrogen receptor. 
  • Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells. 
  • Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): A report from the pediatric preclinical testing program. 
  • Potential therapeutic targets for age-related macular degeneration: The nuclear option. 
  • Probing domain interactions in soluble guanylate cyclase. 
  • Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy. 
  • Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor. 
  • RANK, RANKL, OPG, and M-CSF expression in stromal cells during corneal wound healing. 
  • ROR alpha augments thyroid hormone receptor-mediated transcriptional activation. 
  • RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. 
  • Reconstitution of nuclear protein export in isolated nuclear envelopes. 
  • Regulation of ALK-1 signaling by the nuclear receptor LXRbeta. 
  • Regulation of ribosome detachment from the mammalian endoplasmic reticulum membrane. 
  • Regulation of the ATM-activator protein Aven by CRM1-dependent nuclear export. 
  • Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes. 
  • Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration. 
  • Resistance to thyroid hormone in a patient without thyroid hormone receptor mutations. 
  • Rethinking Nuclear Receptors as Potential Therapeutic Targets for Retinal Diseases. 
  • Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis. 
  • Revealing the macromolecular targets of complex natural products. 
  • Reversing adipocyte differentiation: implications for treatment of obesity. 
  • Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells. 
  • Roles of 3,5,3'-triiodothyronine and deoxyribonucleic acid binding on thyroid hormone receptor complex formation. 
  • Rosiglitazone versus placebo for men with prostate carcinoma and a rising serum prostate-specific antigen level after radical prostatectomy and/or radiation therapy. 
  • SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development. 
  • Selective Autophagy of BES1 Mediated by DSK2 Balances Plant Growth and Survival. 
  • Selinexor for the treatment of patients with previously treated multiple myeloma. 
  • Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. 
  • Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. 
  • Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence. 
  • Soluble guanylate cyclase: a potential therapeutic target for heart failure. 
  • Sry induces cell proliferation in the mouse gonad. 
  • Steroidal and triterpenoidal fungal metabolites as ligands of liver X receptors. 
  • Steroidogenic factor 1 (SF-1) is essential for endocrine development and function. 
  • Steroidogenic factor 1 (SF-1) is essential for ovarian development and function. 
  • Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development. 
  • Steroidogenic factor 1 is the essential transcript of the mouse Ftz-F1 gene. 
  • Steroidogenic factor 1 plays multiple roles in endocrine development and function. 
  • Steroidogenic factor 1: an essential mediator of endocrine development. 
  • Steroidogenic factor-1 is a sphingolipid binding protein. 
  • Structure and regulation of soluble guanylate cyclase. 
  • Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. 
  • Suppressor of fused negatively regulates beta-catenin signaling. 
  • Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists. 
  • Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1. 
  • Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss. 
  • The Nonsteroidal Farnesoid X Receptor Agonist Cilofexor (GS-9674) Improves Markers of Cholestasis and Liver Injury in Patients With Primary Sclerosing Cholangitis. 
  • The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress. 
  • The cell-specific nuclear receptor steroidogenic factor 1 plays multiple roles in reproductive function. 
  • The human constitutive androstane receptor promotes the differentiation and maturation of hepatic-like cells. 
  • The jensen symposium; a tribute to a pioneer in the field of nuclear receptor biology. 
  • The mechanism of action of steroid hormones: a new twist to an old tale. 
  • The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis. 
  • The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. 
  • The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin. 
  • The role of membrane-associated adaptors in T cell receptor signalling. 
  • The role of orphan nuclear receptor in thymocyte differentiation and lymphoid organ development. 
  • The roles of orphan nuclear receptors in the development and function of the immune system. 
  • The roles of steroidogenic factor-1 in reproductive function. 
  • The signal sequence receptor, unlike the signal recognition particle receptor, is not essential for protein translocation. 
  • The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1. 
  • Thymic expression of the transcription factor Nur77 rescues the T cell but not the B cell abnormality of gld/gld mice. 
  • Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3. 
  • Transcriptional regulation of the mouse uncoupling protein-2 gene. Double E-box motif is required for peroxisome proliferator-activated receptor-gamma-dependent activation. 
  • Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro 
  • Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PTH(1-34). 
  • Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells. 
  • Week 4 Liver Fat Reduction on MRI as an Early Predictor of Treatment Response in Participants with Nonalcoholic Steatohepatitis. 
  • XPO1 expression worsens the prognosis of unfavorable DLBCL that can be effectively targeted by selinexor in the absence of mutant p53. 
  • XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A. 
  • dbl-1/TGF-β and daf-12/NHR Signaling Mediate Cell-Nonautonomous Effects of daf-16/FOXO on Starvation-Induced Developmental Arrest 
• 

  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Bilbo, Staci D., Haley Family Professor of Psycology and Neuroscience, Psychology & Neuroscience
  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Hirschey, Matthew, Associate Professor of Medicine, Cell Biology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology