Receptors, Retinoic Acid

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  Subject Areas on Research

  • 9-cis retinoic acid regulation of rat growth hormone gene expression: potential roles of multiple nuclear hormone receptors. 
  • A retrovirus carrying the promyelocyte-retinoic acid receptor PML-RARalpha fusion gene transforms haematopoietic progenitors in vitro and induces acute leukaemias. 
  • Aberrant promoter methylation of multiple genes in non-small cell lung cancers. 
  • Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. 
  • Agents under investigation for the treatment and prevention of neutropenia. 
  • All-trans-retinoic acid mediates G1 arrest but not apoptosis of normal human mammary epithelial cells. 
  • Alterations in microRNA expression in stress-induced cellular senescence. 
  • Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2. 
  • Axon guidance pathways served as common targets for human speech/language evolution and related disorders. 
  • Characterization and tissue expression of multiple triiodothyronine receptor-auxiliary proteins and their relationship to the retinoid X-receptors. 
  • Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid. 
  • Constitutively active retinoid receptors exhibit interfamily and intrafamily promoter specificity. 
  • CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis. 
  • Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins. 
  • Disruption of Nuclear Receptor Signaling Alters Triphenyl Phosphate-Induced Cardiotoxicity in Zebrafish Embryos. 
  • Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation. 
  • Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation. 
  • Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation. 
  • Dynamic shuttling and intranuclear mobility of nuclear hormone receptors. 
  • Expression of retinoic acid receptor beta mediates retinoic acid-induced growth arrest and apoptosis in breast cancer cells. 
  • Functional ecdysone receptor is the product of EcR and Ultraspiracle genes. 
  • G-CSF induces a potentially tolerant gene and immunophenotype profile in T cells in vivo. 
  • Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. 
  • Genomic landscapes of breast fibroepithelial tumors. 
  • Half-site arrangement of hybrid glucocorticoid and thyroid hormone response elements specifies thyroid hormone receptor complex binding to DNA and transcriptional activity. 
  • Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein. 
  • Heterodimerization and deoxyribonucleic acid-binding properties of a retinoid X receptor-related factor. 
  • Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response. 
  • Human lung cancer cell lines exhibit resistance to retinoic acid treatment. 
  • Human trabecular meshwork cells as a thyroid hormone target tissue: presence of functional thyroid hormone receptors. 
  • Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response. 
  • Identification and characterization of a functional zebrafish smrt corepressor (ncor2). 
  • Identification of differentially methylated genes in normal prostate tissues from African American and Caucasian men. 
  • Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas. 
  • In vitro transcriptional studies of the roles of the thyroid hormone (T3) response elements and minimal promoters in T3-stimulated gene transcription. 
  • Inhibition of 1,25-dihydroxyvitamin D3-dependent transcription by synthetic LXXLL peptide antagonists that target the activation domains of the vitamin D and retinoid X receptors. 
  • Inhibition of retinoic acid receptor function in normal human mammary epithelial cells results in increased cellular proliferation and inhibits the formation of a polarized epithelium in vitro. 
  • Intracellular innate immune cascades and interferon defenses that control hepatitis C virus. 
  • Intracellular proteolytic cleavage of 9-cis-retinoic acid receptor alpha by cathepsin L-type protease is a potential mechanism for modulating thyroid hormone action. 
  • Isoform-specific induction of a retinoid-responsive antigen after biolistic transfection of chimaeric retinoic acid/thyroid hormone receptors into a regenerating limb. 
  • Isoform-specific retinoid-X receptor (RXR) antibodies detect differential expression of RXR proteins in the pituitary gland. 
  • Isolation and functional analysis of the mouse RXRgamma1 gene promoter in anterior pituitary cells. 
  • Lymphocyte accumulation in the spleen of retinoic acid receptor-related orphan receptor gamma-deficient mice. 
  • Mapping of the mouse Rar loci encoding retinoic acid receptors RAR alpha, RAR beta and RAR gamma. 
  • Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors RXR alpha, RXR beta, and RXR gamma. 
  • Melatonin synergizes with retinoic acid in the prevention and regression of breast cancer. 
  • Multimeric complexes of the PML-retinoic acid receptor alpha fusion protein in acute promyelocytic leukemia cells and interference with retinoid and peroxisome-proliferator signaling pathways. 
  • Multiple constraints at the level of TCRalpha rearrangement impact Valpha14i NKT cell development. 
  • New bedfellows in the mammalian sex-determination affair. 
  • Orphan nuclear receptors in T lymphocyte development. 
  • Overexpression of wild-type retinoic acid receptor alpha (RARalpha) recapitulates retinoic acid-sensitive transformation of primary myeloid progenitors by acute promyelocytic leukemia RARalpha-fusion genes. 
  • Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. 
  • Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture. 
  • Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR. 
  • RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. 
  • RXR is an essential component of the oncogenic PML/RARA complex in vivo. 
  • Redundant genes? 
  • Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes. 
  • Regulation of CD8(+) T cell functions by RARgamma. 
  • Regulation of CD8+ T lymphocyte effector function and macrophage inflammatory cytokine production by retinoic acid receptor gamma. 
  • Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes. 
  • Retinoic acid receptor alpha function in vertebrate limb skeletogenesis: a modulator of chondrogenesis. 
  • Retinoic acid receptor alpha in acute promyelocytic leukemia. 
  • Retinoic acid receptor beta2 inhibition of metastasis in mouse mammary gland xenografts. 
  • Retinoic acid receptor expression vector inhibits differentiation of F9 embryonal carcinoma cells. 
  • Retinoic acid receptor-beta2 promoter methylation in random periareolar fine needle aspiration. 
  • Retinoic acid receptors: transcription factors modulating gene regulation, development, and differentiation. 
  • Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells. 
  • Retinoid signaling and the generation of regional and cellular diversity in the embryonic mouse spinal cord. 
  • Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis. 
  • Retinoids and mouse embryonic development. 
  • Retinoids and retinoic acid receptors regulate growth arrest and apoptosis in human mammary epithelial cells and modulate expression of CBP/p300. 
  • Roles of 3,5,3'-triiodothyronine and deoxyribonucleic acid binding on thyroid hormone receptor complex formation. 
  • Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORgamma. 
  • Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development. 
  • Synthetic LXXLL peptide antagonize 1,25-dihydroxyvitamin D3-dependent transcription. 
  • The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. 
  • The mouse retinoid-X receptor-gamma gene: genomic organization and evidence for functional isoforms. 
  • The negative side of retinoic acid receptors. 
  • The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. 
  • The role of orphan nuclear receptor in thymocyte differentiation and lymphoid organ development. 
  • The roles of orphan nuclear receptors in the development and function of the immune system. 
  • The t(15;17) translocation in acute promyelocytic leukemia. 
  • The t(15;17) translocation in acute promyelocytic leukemia. 
  • The transcriptional integrator CREB-binding protein mediates positive cross talk between nuclear hormone receptors and the hematopoietic bZip protein p45/NF-E2. 
  • Thyroid hormone response elements differentially modulate the interactions of thyroid hormone receptors with two receptor binding domains in the steroid receptor coactivator-1. 
  • Transgenic indicator mice for studying activated retinoic acid receptors during development. 
  • Transgenic mice expressing a constitutively active retinoic acid receptor in the lens exhibit ocular defects. 
  • Triiodothyronine (T3) differentially affects T3-receptor/retinoic acid receptor and T3-receptor/retinoid X receptor heterodimer binding to DNA. 
  • Triphenyl phosphate-induced developmental toxicity in zebrafish: potential role of the retinoic acid receptor. 
  • Vitamin D receptors repress basal transcription and exert dominant negative activity on triiodothyronine-mediated transcriptional activity. 
  • WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cells. 
  • WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cells. 
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  Keywords of People

  • McDonnell, Donald Patrick, Chair, Department of Pharmacology & Cancer Biology, Duke Innovation & Entrepreneurship