Receptors, Adrenergic, alpha-2

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  Subject Areas on Research

  • Adrenergic receptor genotypes influence postoperative outcomes in infants in the Single-Ventricle Reconstruction Trial. 
  • Alpha-2 adrenergic receptors and attention-deficit/hyperactivity disorder. 
  • Alpha-2 adrenergic receptors stimulate actin organization in developing fetal rat cardiac myocytes. 
  • Alpha2-adrenergic receptors in human dorsal root ganglia: predominance of alpha2b and alpha2c subtype mRNAs. 
  • Association of hypertension with beta2- and alpha2c10-adrenergic receptor genotype. 
  • Beta-adrenoceptor modulation of transiently overexpressed alpha 2-adrenoceptors in brain and peripheral tissues: cellular mechanisms underlying the developmental toxicity of terbutaline. 
  • Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. 
  • Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms. 
  • Cultured human trabecular meshwork cells express functional alpha 2A adrenergic receptors. 
  • Differential desensitization and phosphorylation of three cloned and transfected alpha 2-adrenergic receptor subtypes. 
  • Distribution of alpha 2-adrenergic receptor subtype gene expression in rat brain. 
  • Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy. 
  • Expression of alpha(2)-adrenergic receptor subtypes in prenatal rat spinal cord. 
  • G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein. 
  • Genetic variant rs3750625 in the 3'UTR of ADRA2A affects stress-dependent acute pain severity after trauma and alters a microRNA-34a regulatory site. 
  • Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion. 
  • Identification of a naturally occurring 21 bp deletion in alpha 2c noradrenergic receptor gene and cognitive correlates to antipsychotic treatment. 
  • Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol. 
  • Magnitude of abdominal incision affects the duration of postoperative ileus in rats. 
  • Norepinephrine transporter knockout-induced up-regulation of brain alpha2A/C-adrenergic receptors. 
  • Potentiated opioid analgesia in norepinephrine transporter knock-out mice. 
  • Prenatal dexamethasone exposure causes loss of neonatal hypoxia tolerance: cellular mechanisms. 
  • Production of adrenergic receptors in yeast. 
  • Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch. 
  • Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. 
  • Stimulation of mitogen-activated protein kinase by G protein-coupled alpha(2)-adrenergic receptors does not require agonist-elicited endocytosis. 
  • The alpha 1C-adrenoceptor in human prostate: cloning, functional expression, and localization to specific prostatic cell types. 
  • The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety. 
  • The α₂-adrenergic antagonist idazoxan counteracts prepulse inhibition deficits caused by amphetamine or dizocilpine in rats. 
  • Transiently overexpressed alpha2-adrenoceptors and their control of DNA synthesis in the developing brain. 
  • Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: implications for the action of selective serotonin reuptake inhibitors. 
  • alpha 2-Adrenergic receptors in human spinal cord: specific localized expression of mRNA encoding alpha 2-adrenergic receptor subtypes at four distinct levels. 
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  Keywords of People

  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. / Guidant Foundation Professor of Cardiology, Medicine, Clinical Pharmacology
  • Svetkey, Laura Pat, Professor of Medicine, Medicine