Receptors, Adrenergic, beta-2
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Subject Areas on Research
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A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.
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A central role for beta-arrestins and clathrin-coated vesicle-mediated endocytosis in beta2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types.
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A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated.
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A crystal clear view of the beta2-adrenergic receptor.
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A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.
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A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
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A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling.
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Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism.
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Adenovirus-mediated gene transfer of the beta2-adrenergic receptor to donor hearts enhances cardiac function.
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Adjunctive β2-agonists reverse neuromuscular involvement in murine Pompe disease.
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Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature.
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Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer.
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Adrenergic receptor function in panic disorder. II. Neutrophil beta 2 receptors: Gs protein coupling, effects of imipramine treatment and relationship to treatment outcome.
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Adrenergic receptors in premenstrual dysphoric disorder. II. Neutrophil beta2-adrenergic receptors: Gs protein coupling, phase of menstrual cycle and prediction of luteal phase symptom severity.
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Age increases cardiac Galpha(i2) expression, resulting in enhanced coupling to G protein-coupled receptors.
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Agonist-specific regulation of delta-opioid receptor trafficking by G protein-coupled receptor kinase and beta-arrestin.
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Agonist-stimulated beta-adrenergic receptor internalization requires dynamic cytoskeletal actin turnover.
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Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.
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Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes.
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Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.
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Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy.
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Androgen receptor activation by G(s) signaling in prostate cancer cells.
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Anticholinergic vs Long-Acting β-Agonist in Combination With Inhaled Corticosteroids in Black Adults With Asthma: The BELT Randomized Clinical Trial.
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Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling.
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Association of hypertension with beta2- and alpha2c10-adrenergic receptor genotype.
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Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2.
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Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i).
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Beta-2 adrenergic receptor gene (ADRB2) polymorphism and risk for lung adenocarcinoma: a case-control study in a Chinese population.
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Beta-adrenergic receptor polymorphisms and cardiac graft function in potential organ donors.
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Beta-adrenoceptor control of G protein function in the neonate: determinant of desensitization or sensitization.
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Beta-adrenoceptor signaling and its control of cell replication in MDA-MB-231 human breast cancer cells.
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Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor.
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Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.
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Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle.
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Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction.
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Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms.
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Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context.
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Beta2-adrenergic receptor genotype affects the renin-angiotensin-aldosterone system response to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern.
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Beta2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains.
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Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels.
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Binding of the beta2 adrenergic receptor to N-ethylmaleimide-sensitive factor regulates receptor recycling.
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Biopsychosocial Influence on Shoulder Pain: Influence of Genetic and Psychological Combinations on Twelve-Month Postoperative Pain and Disability Outcomes.
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Cardiac function in genetically engineered mice with altered adrenergic receptor signaling.
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Cardiac gene delivery with cardiopulmonary bypass.
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Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors.
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Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice.
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Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1.
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Clinical application of cardiovascular pharmacogenetics.
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Coarse-grained modeling of allosteric regulation in protein receptors.
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Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity.
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Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor.
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Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor.
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Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.
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Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
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Crystallizing thinking about the beta2-adrenergic receptor.
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DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe.
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Design, synthesis, and functional assessment of Cmpd-15 derivatives as negative allosteric modulators for the β2-adrenergic receptor.
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Detergent- and phospholipid-based reconstitution systems have differential effects on constitutive activity of G-protein-coupled receptors.
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Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins.
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Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.
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Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking.
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Dose dependent effects of cardiac beta2 adrenoceptor gene therapy.
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Down-regulation of ADRB2 expression is associated with small cell neuroendocrine prostate cancer and adverse clinical outcomes in castration-resistant prostate cancer.
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Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes.
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Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization.
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Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome.
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Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein.
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Enhanced vasorelaxation by overexpression of beta 2-adrenergic receptors in large arteries.
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Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery.
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Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo.
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Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase.
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Ethnicity, gender, and age effects on adrenoceptors and physiological responses to emotional stress.
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Ex vivo adenovirus-mediated gene transfer to the adult rat heart.
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Functional analysis of myocardial performance in murine hearts overexpressing the human beta 2-adrenergic receptor.
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Further evidence for a role of the ADRB2 gene in risk for posttraumatic stress disorder.
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G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands.
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G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor.
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G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer.
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G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins.
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Genetic association studies; the good, the bad, and the ugly.
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Genetic risk factors for perception of symptoms in GERD: an observational cohort study.
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Genetic variants are not associated with outcome in patients with coronary artery disease and left ventricular dysfunction: results of the Genetic Substudy of the Surgical Treatment for Ischemic Heart Failure (STICH) trials.
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Gi-biased β2AR signaling links GRK2 upregulation to heart failure.
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Hypertension genes and retinal vascular calibre: the Cardiovascular Health Study.
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Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3.
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Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor.
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Immunoaffinity purification of epitope-tagged human beta 2-adrenergic receptor to homogeneity.
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Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor.
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Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor.
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Interactions between social/ behavioral factors and ADRB2 genotypes may be associated with health at advanced ages in China.
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Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate.
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Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance.
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Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol.
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Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice.
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MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors.
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Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.
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Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene.
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Mechanism of intracellular allosteric β2
AR antagonist revealed by X-ray crystal structure.
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Mechanism of β2AR regulation by an intracellular positive allosteric modulator.
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Mechanisms of beta-adrenergic receptor desensitization and resensitization.
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Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.
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Modeling of sequestration and down regulation in cells containing beta2-adrenergic receptors.
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Modulation of the BP response to diet by genes in the renin-angiotensin system and the adrenergic nervous system.
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Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry.
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Multiple ligand-specific conformations of the β2-adrenergic receptor.
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Myocardial overexpression of adrenergic receptors and receptor kinases.
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Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor.
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Neuroinflammation and behavioral abnormalities after neonatal terbutaline treatment in rats: implications for autism.
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Neutrophil beta(2)-adrenoceptor function in major depression: G(s) coupling, effects of imipramine and relationship to treatment outcome.
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Neutrophil beta2-adrenergic receptor coupling efficiency to Gs protein in subjects with post-traumatic stress disorder and normal controls.
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New perspectives regarding β(2) -adrenoceptor ligands in the treatment of asthma.
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Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion.
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Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury.
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Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.
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Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6.
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Perspectives on the genetic basis of opioid-induced hyperalgesia.
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Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex.
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Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets.
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Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors.
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Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress.
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Physiologic and cardiac roles of beta-arrestins.
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Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity.
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Polymorphisms in the ACE and ADRB2 genes and risks of aging-associated phenotypes: the case of myocardial infarction.
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Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes.
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Preliminary evidence of linkage of salt sensitivity in black Americans at the beta 2-adrenergic receptor locus.
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Production of adrenergic receptors in yeast.
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Properties of secretin receptor internalization differ from those of the beta(2)-adrenergic receptor.
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Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism in animal models.
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Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways.
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Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system.
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Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis.
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Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways.
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Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin.
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Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.
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Relationship between the G protein signaling and homologous desensitization of G protein-coupled receptors.
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Role for β-arrestin in mediating paradoxical β2AR and PAR2 signaling in asthma.
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Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization.
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Role of beta-arrestins in the intracellular trafficking of G-protein-coupled receptors.
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Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1.
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Role of β-3 adrenergic receptor polymorphism in overactive bladder.
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S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking.
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Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries.
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Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling.
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Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis.
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Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling.
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Structural and functional interactions between six-transmembrane μ-opioid receptors and β2-adrenoreceptors modulate opioid signaling.
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Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex.
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Sustained stimulation of β2- and β3-adrenergic receptors leads to persistent functional pain and neuroinflammation.
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Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.
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Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization.
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Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach.
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Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins.
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The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor.
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The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange.
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The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.
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The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor.
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The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.
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The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits.
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The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition.
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The real estate of cardiac signaling: location, location, location.
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The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification.
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The third beta is not the charm.
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Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder.
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Unique Positive Cooperativity Between the β-Arrestin-Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor.
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Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial.
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Visualization of arrestin recruitment by a G-protein-coupled receptor.
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beta(2)-Adrenergic receptor and adenylate cyclase gene polymorphisms affect sickle red cell adhesion.
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beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking.
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beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis.
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beta-arrestin-biased agonism at the beta2-adrenergic receptor.
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beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.
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beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis.
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beta2 adrenoceptor gene therapy ameliorates left ventricular dysfunction following cardiac surgery.
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beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.
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beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics.
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β-Adrenergic agonist and antagonist regulation of autophagy in HepG2 cells, primary mouse hepatocytes, and mouse liver.
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β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility.
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β2- and β3-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines.
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β2-Adrenoreceptors of regulatory lymphocytes are essential for vagal neuromodulation of the innate immune system.
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Keywords of People
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Milano, Carmelo Alessio,
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery,
Surgery, Cardiovascular and Thoracic Surgery
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Oas, Terrence Gilbert,
Professor of Biochemistry,
Biochemistry
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Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology