Receptors, Adrenergic, beta-2

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  Subject Areas on Research

  • A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. 
  • A central role for beta-arrestins and clathrin-coated vesicle-mediated endocytosis in beta2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types. 
  • A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated. 
  • A crystal clear view of the beta2-adrenergic receptor. 
  • A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration. 
  • A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. 
  • A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. 
  • Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism. 
  • Adenovirus-mediated gene transfer of the beta2-adrenergic receptor to donor hearts enhances cardiac function. 
  • Adjunctive β2-agonists reverse neuromuscular involvement in murine Pompe disease. 
  • Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature. 
  • Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer. 
  • Adrenergic receptor function in panic disorder. II. Neutrophil beta 2 receptors: Gs protein coupling, effects of imipramine treatment and relationship to treatment outcome. 
  • Adrenergic receptors in premenstrual dysphoric disorder. II. Neutrophil beta2-adrenergic receptors: Gs protein coupling, phase of menstrual cycle and prediction of luteal phase symptom severity. 
  • Age increases cardiac Galpha(i2) expression, resulting in enhanced coupling to G protein-coupled receptors. 
  • Agonist-specific regulation of delta-opioid receptor trafficking by G protein-coupled receptor kinase and beta-arrestin. 
  • Agonist-stimulated beta-adrenergic receptor internalization requires dynamic cytoskeletal actin turnover. 
  • Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library. 
  • Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes. 
  • Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. 
  • Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. 
  • Androgen receptor activation by G(s) signaling in prostate cancer cells. 
  • Anticholinergic vs Long-Acting β-Agonist in Combination With Inhaled Corticosteroids in Black Adults With Asthma: The BELT Randomized Clinical Trial. 
  • Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling. 
  • Association of hypertension with beta2- and alpha2c10-adrenergic receptor genotype. 
  • Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2. 
  • Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i). 
  • Beta-2 adrenergic receptor gene (ADRB2) polymorphism and risk for lung adenocarcinoma: a case-control study in a Chinese population. 
  • Beta-adrenergic receptor polymorphisms and cardiac graft function in potential organ donors. 
  • Beta-adrenoceptor control of G protein function in the neonate: determinant of desensitization or sensitization. 
  • Beta-adrenoceptor signaling and its control of cell replication in MDA-MB-231 human breast cancer cells. 
  • Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor. 
  • Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. 
  • Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle. 
  • Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction. 
  • Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms. 
  • Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context. 
  • Beta2-adrenergic receptor genotype affects the renin-angiotensin-aldosterone system response to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern. 
  • Beta2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains. 
  • Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels. 
  • Binding of the beta2 adrenergic receptor to N-ethylmaleimide-sensitive factor regulates receptor recycling. 
  • Biopsychosocial Influence on Shoulder Pain: Influence of Genetic and Psychological Combinations on Twelve-Month Postoperative Pain and Disability Outcomes. 
  • Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. 
  • Cardiac gene delivery with cardiopulmonary bypass. 
  • Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. 
  • Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice. 
  • Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1. 
  • Clinical application of cardiovascular pharmacogenetics. 
  • Coarse-grained modeling of allosteric regulation in protein receptors. 
  • Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity. 
  • Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor. 
  • Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor. 
  • Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. 
  • Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. 
  • Crystallizing thinking about the beta2-adrenergic receptor. 
  • DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe. 
  • Design, synthesis, and functional assessment of Cmpd-15 derivatives as negative allosteric modulators for the β2-adrenergic receptor. 
  • Detergent- and phospholipid-based reconstitution systems have differential effects on constitutive activity of G-protein-coupled receptors. 
  • Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins. 
  • Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin. 
  • Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking. 
  • Dose dependent effects of cardiac beta2 adrenoceptor gene therapy. 
  • Down-regulation of ADRB2 expression is associated with small cell neuroendocrine prostate cancer and adverse clinical outcomes in castration-resistant prostate cancer. 
  • Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. 
  • Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization. 
  • Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. 
  • Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein. 
  • Enhanced vasorelaxation by overexpression of beta 2-adrenergic receptors in large arteries. 
  • Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery. 
  • Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo. 
  • Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. 
  • Ethnicity, gender, and age effects on adrenoceptors and physiological responses to emotional stress. 
  • Ex vivo adenovirus-mediated gene transfer to the adult rat heart. 
  • Functional analysis of myocardial performance in murine hearts overexpressing the human beta 2-adrenergic receptor. 
  • Further evidence for a role of the ADRB2 gene in risk for posttraumatic stress disorder. 
  • G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands. 
  • G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor. 
  • G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. 
  • G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins. 
  • Genetic association studies; the good, the bad, and the ugly. 
  • Genetic risk factors for perception of symptoms in GERD: an observational cohort study. 
  • Genetic variants are not associated with outcome in patients with coronary artery disease and left ventricular dysfunction: results of the Genetic Substudy of the Surgical Treatment for Ischemic Heart Failure (STICH) trials. 
  • Hypertension genes and retinal vascular calibre: the Cardiovascular Health Study. 
  • Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3. 
  • Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor. 
  • Immunoaffinity purification of epitope-tagged human beta 2-adrenergic receptor to homogeneity. 
  • Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor. 
  • Interactions between social/ behavioral factors and ADRB2 genotypes may be associated with health at advanced ages in China. 
  • Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate. 
  • Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance. 
  • Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol. 
  • Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice. 
  • MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors. 
  • Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9. 
  • Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene. 
  • Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure. 
  • Mechanism of β2AR regulation by an intracellular positive allosteric modulator. 
  • Mechanisms of beta-adrenergic receptor desensitization and resensitization. 
  • Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration. 
  • Modeling of sequestration and down regulation in cells containing beta2-adrenergic receptors. 
  • Modulation of the BP response to diet by genes in the renin-angiotensin system and the adrenergic nervous system. 
  • Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry. 
  • Multiple ligand-specific conformations of the β2-adrenergic receptor. 
  • Myocardial overexpression of adrenergic receptors and receptor kinases. 
  • Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. 
  • Neuroinflammation and behavioral abnormalities after neonatal terbutaline treatment in rats: implications for autism. 
  • Neutrophil beta(2)-adrenoceptor function in major depression: G(s) coupling, effects of imipramine and relationship to treatment outcome. 
  • Neutrophil beta2-adrenergic receptor coupling efficiency to Gs protein in subjects with post-traumatic stress disorder and normal controls. 
  • New perspectives regarding β(2) -adrenoceptor ligands in the treatment of asthma. 
  • Nitric oxide regulates endocytosis by S-nitrosylation of dynamin. 
  • Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion. 
  • Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury. 
  • Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL. 
  • Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6. 
  • Perspectives on the genetic basis of opioid-induced hyperalgesia. 
  • Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. 
  • Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets. 
  • Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors. 
  • Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress. 
  • Physiologic and cardiac roles of beta-arrestins. 
  • Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity. 
  • Polymorphisms in the ACE and ADRB2 genes and risks of aging-associated phenotypes: the case of myocardial infarction. 
  • Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes. 
  • Preliminary evidence of linkage of salt sensitivity in black Americans at the beta 2-adrenergic receptor locus. 
  • Production of adrenergic receptors in yeast. 
  • Properties of secretin receptor internalization differ from those of the beta(2)-adrenergic receptor. 
  • Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism in animal models. 
  • Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways. 
  • Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system. 
  • Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis. 
  • Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways. 
  • Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. 
  • Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies. 
  • Relationship between the G protein signaling and homologous desensitization of G protein-coupled receptors. 
  • Role for β-arrestin in mediating paradoxical β2AR and PAR2 signaling in asthma. 
  • Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. 
  • Role of beta-arrestins in the intracellular trafficking of G-protein-coupled receptors. 
  • Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1. 
  • Role of β-3 adrenergic receptor polymorphism in overactive bladder. 
  • S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking. 
  • Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries. 
  • Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling. 
  • Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis. 
  • Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling. 
  • Structural and functional interactions between six-transmembrane μ-opioid receptors and β2-adrenoreceptors modulate opioid signaling. 
  • Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex. 
  • Sustained stimulation of β2- and β3-adrenergic receptors leads to persistent functional pain and neuroinflammation. 
  • Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. 
  • Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization. 
  • Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach. 
  • Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. 
  • The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. 
  • The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. 
  • The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. 
  • The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor. 
  • The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. 
  • The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits. 
  • The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition. 
  • The real estate of cardiac signaling: location, location, location. 
  • The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification. 
  • The third beta is not the charm. 
  • Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. 
  • Unique Positive Cooperativity Between the β-Arrestin-Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor. 
  • Visualization of arrestin recruitment by a G-protein-coupled receptor. 
  • beta(2)-Adrenergic receptor and adenylate cyclase gene polymorphisms affect sickle red cell adhesion. 
  • beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. 
  • beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis. 
  • beta-arrestin-biased agonism at the beta2-adrenergic receptor. 
  • beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. 
  • beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. 
  • beta2 adrenoceptor gene therapy ameliorates left ventricular dysfunction following cardiac surgery. 
  • beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. 
  • beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics. 
  • β-Adrenergic agonist and antagonist regulation of autophagy in HepG2 cells, primary mouse hepatocytes, and mouse liver. 
  • β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility. 
  • β2- and β3-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines. 
  • β2-Adrenoreceptors of regulatory lymphocytes are essential for vagal neuromodulation of the innate immune system. 
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  Keywords of People

  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Oas, Terrence Gilbert, Professor of Biochemistry, Biochemistry
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology