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Subject Areas on Research
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"Model" behavior.
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4D MRI of polycystic kidneys from rapamycin-treated Glis3-deficient mice.
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5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals.
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A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice.
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A CRISPR-Cas system enhances envelope integrity mediating antibiotic resistance and inflammasome evasion.
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A Combination of Ontogeny and CNS Environment Establishes Microglial Identity.
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A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice.
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A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement.
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A Knock-In Tristetraprolin (TTP) Zinc Finger Point Mutation in Mice: Comparison with Complete TTP Deficiency.
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A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia.
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A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome.
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A RIPK3-caspase 8 complex mediates atypical pro-IL-1β processing.
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A Role for Protease Activated Receptor Type 3 (PAR3) in Nociception Demonstrated Through Development of a Novel Peptide Agonist.
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A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome.
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A TRPA1-dependent mechanism for the pungent sensation of weak acids.
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A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory.
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A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels.
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A barrier-type insulator forms a boundary between active and inactive chromatin at the murine TCRβ locus.
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A beta-arrestin 2 signaling complex mediates lithium action on behavior.
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A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.
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A beta-blocker, propranolol, decreases the efficacy from enzyme replacement therapy in Pompe disease.
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A c-Myc and surface CD19 signaling amplification loop promotes B cell lymphoma development and progression in mice.
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A cell-intrinsic role for Mst1 in regulating thymocyte egress.
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A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation.
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A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development.
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A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation.
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A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon.
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A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability.
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A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism.
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A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation.
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A critical role for the autophagy gene Atg5 in T cell survival and proliferation.
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A crucial role of L-selectin in C protein-induced experimental polymyositis in mice.
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A cytokine cocktail directly modulates the phenotype of DC-enriched anti-tumor T cells to convey potent anti-tumor activities in a murine model.
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A functional genomics predictive network model identifies regulators of inflammatory bowel disease.
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A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo.
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A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25.
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A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier.
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A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections.
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A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics.
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A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection.
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A major role for the EP4 receptor in regulation of renin.
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A mechanism-based antioxidant approach for the reduction of skin carcinogenesis.
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A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors.
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A mouse model of adult-onset anaemia due to erythropoietin deficiency.
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A mouse model of familial porphyria cutanea tarda.
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A murine model of hyperdopaminergic state displays altered respiratory control.
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A new activating role for CO in cardiac mitochondrial biogenesis.
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A new model of Epstein-Barr virus infection reveals an important role for early lytic viral protein expression in the development of lymphomas.
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A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism.
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A novel immunomodulatory protein from Poria cocos induces Toll-like receptor 4-dependent activation within mouse peritoneal macrophages.
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A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.
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A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis.
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A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension.
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A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair.
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A protective Hsp70-TLR4 pathway in lethal oxidant lung injury.
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A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery.
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A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation.
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A role for E2F activities in determining the fate of Myc-induced lymphomagenesis.
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A role for MAPK in feedback inhibition of Tcrb recombination.
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A role for TREK1 in generating the slow afterhyperpolarization in developing starburst amacrine cells.
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A role for angiotensin II type 1 receptors on bone marrow-derived cells in the pathogenesis of angiotensin II-dependent hypertension.
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A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes.
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A role for cFLIP in B cell proliferation and stress MAPK regulation.
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A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth.
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A role for the CD38
rs3796863 polymorphism in alcohol and monetary reward: evidence from CD38 knockout mice and alcohol self-administration, [11C]-raclopride binding, and functional MRI in humans.
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A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation.
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A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses.
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A role of matrix metalloproteinase-8 in atherosclerosis.
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A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma.
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A shared vision.
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A spatially and temporally restricted mouse model of soft tissue sarcoma.
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A tenascin knockout with a phenotype.
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A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis.
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A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy.
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A two-phase innate host response to alphavirus infection identified by mRNP-tagging in vivo.
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A validated regulatory network for Th17 cell specification.
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A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation.
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A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression.
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AAV vector-mediated reversal of hypoglycemia in canine and murine glycogen storage disease type Ia.
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AAV9 Edits Muscle Stem Cells in Normal and Dystrophic Adult Mice.
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AAV9 gene replacement therapy for respiratory insufficiency in very-long chain acyl-CoA dehydrogenase deficiency.
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ABCB5 is a limbal stem cell gene required for corneal development and repair.
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ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory.
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ACE and ACE2 activity in diabetic mice.
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ADAM10 is essential for proteolytic activation of Notch during thymocyte development.
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ADAM10-Dependent Signaling Through Notch1 and Notch4 Controls Development of Organ-Specific Vascular Beds.
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ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.
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ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration.
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AMH induces mesonephric cell migration in XX gonads.
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ANGPTL3 Deficiency and Protection Against Coronary Artery Disease.
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APOE genotype-specific differences in human and mouse macrophage nitric oxide production.
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APOE genotype-specific differences in the innate immune response.
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ASL Metabolically Regulates Tyrosine Hydroxylase in the Nucleus Locus Coeruleus.
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AT2 receptor and vascular smooth muscle cell differentiation in vascular development.
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ATM functions at the peroxisome to induce pexophagy in response to ROS.
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ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome.
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Aberrant production of IL-13 by T cells promotes exocrinopathy in Id3 knockout mice.
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Aberrant responses in social interaction of dopamine transporter knockout mice.
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Abi3bp is a multifunctional autocrine/paracrine factor that regulates mesenchymal stem cell biology.
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Abi3bp regulates cardiac progenitor cell proliferation and differentiation.
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Abl family kinases regulate endothelial barrier function in vitro and in mice.
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Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway.
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Abl tyrosine kinases are required for infection by Shigella flexneri.
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Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin.
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Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload.
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Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo.
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Ablation of the leptin receptor in myeloid cells impairs pulmonary clearance of Streptococcus pneumoniae and alveolar macrophage bactericidal function.
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Abnormal cardiac Na(+) channel properties and QT heart rate adaptation in neonatal ankyrin(B) knockout mice.
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Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease.
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Abnormal iron deposition in renal cells in the rat with chronic angiotensin II administration.
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Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after hemarthrosis.
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Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema.
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Abrogation of adenosine A1 receptor signalling improves metabolic regulation in mice by modulating oxidative stress and inflammatory responses.
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Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract.
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Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits.
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Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse.
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Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease.
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Absence of tubuloglomerular feedback responses in AT1A receptor-deficient mice.
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Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.
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Accessory subunit KChIP2 modulates the cardiac L-type calcium current.
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Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity.
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Acquisition of response thresholds for timed performance is regulated by a calcium-responsive transcription factor, CaRF.
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Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy.
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Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice.
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Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells.
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Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside.
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Activation of decidual invariant natural killer T cells promotes lipopolysaccharide-induced preterm birth.
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Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation.
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Activation of toll-like receptor 4 is necessary for trauma hemorrhagic shock-induced gut injury and polymorphonuclear neutrophil priming.
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Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome.
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Activation-induced cytidine deaminase mediates central tolerance in B cells.
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Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain.
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Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice.
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Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9.
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Adam10 is essential for early embryonic cardiovascular development.
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Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism.
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Adaptive mechanisms that preserve cardiac function in mice without myoglobin.
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Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid hormone.
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Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo.
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Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo.
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Adenylate cyclase 7 is implicated in the biology of depression and modulation of affective neural circuitry.
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Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner.
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Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis.
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Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels.
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Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance.
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Adjunctive β2-agonist treatment reduces glycogen independently of receptor-mediated acid α-glucosidase uptake in the limb muscles of mice with Pompe disease.
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Adjunctive β2-agonists reverse neuromuscular involvement in murine Pompe disease.
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Adoptively transferred ex vivo expanded gammadelta-T cells mediate in vivo antitumor activity in preclinical mouse models of breast cancer.
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Adrenoceptors, uncoupling proteins, and energy expenditure.
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Adrenomedullin improves fertility and promotes pinopodes and cell junctions in the peri-implantation endometrium.
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Advanced glycation end-product of low density lipoprotein activates the toll-like 4 receptor pathway implications for diabetic atherosclerosis.
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Age-Dependent Effects of Immunoproteasome Deficiency on Mouse Adenovirus Type 1 Pathogenesis.
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Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice.
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Age-related changes in the cellular composition and epithelial organization of the mouse trachea.
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Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration.
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Aging enhances the basal production of IL-6 and CCL2 in vascular smooth muscle cells.
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Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies.
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Airway smooth muscle relaxation is impaired in mice lacking the p47phox subunit of NAD(P)H oxidase.
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Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism.
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Akt is required for Stat5 activation and mammary differentiation.
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Akt1 and Akt2 promote peripheral B-cell maturation and survival.
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Akt1 deletion prevents lung tumorigenesis by mutant K-ras.
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Aldosterone, ion channels, and sudden death: another piece of the circle?
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Aldosterone-Induced Vascular Remodeling and Endothelial Dysfunction Require Functional Angiotensin Type 1a Receptors.
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Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors.
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Aligning animal models with clinical epilepsy: where to begin?
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Allele-specific regulation of TCR beta variable gene segment chromatin structure.
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Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl.
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Allergic lung responses are increased in prostaglandin H synthase-deficient mice.
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Allogeneic splenocyte transfer and lipopolysaccharide inhalations induce differential T cell expansion and lung injury: a novel model of pulmonary graft-versus-host disease.
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Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism.
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Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance.
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Altered Mitochondrial Homeostasis during Systemic Lupus Erythematosus Impairs Neutrophil Extracellular Trap Formation Rendering Neutrophils Ineffective at Combating Staphylococcus aureus.
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Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes.
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Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities.
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Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.
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Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice.
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Altered immune responses in apolipoprotein E-deficient mice.
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Altered inflammatory responses in leukotriene-deficient mice.
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Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP.
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Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism.
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Altered morphology of hippocampal dentate granule cell presynaptic and postsynaptic terminals following conditional deletion of TrkB.
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Altered regulation of brain-derived neurotrophic factor protein in hippocampus following slice preparation.
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Altered trabecular bone structure and delayed cartilage degeneration in the knees of collagen VI null mice.
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Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1.
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Altered wound healing in mice lacking a functional osteopontin gene (spp1).
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Alveolar proteinosis: a disease of mice and men.
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Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors.
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An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.
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An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments.
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An Endothelial Hsp70-TLR4 Axis Limits Nox3 Expression and Protects Against Oxidant Injury in Lungs.
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An Engineered Metal Sensor Tunes the Kinetics of Synaptic Transmission.
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An FGF-WNT gene regulatory network controls lung mesenchyme development.
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An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis.
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An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice.
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An IL-9-pulmonary macrophage axis defines the allergic lung inflammatory environment.
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An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation.
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An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.
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An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cells.
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An anti-inflammatory role for carbon monoxide and heme oxygenase-1 in chronic Th2-mediated murine colitis.
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An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.
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An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a.
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An engineered vascular endothelial growth factor-activating transcription factor induces therapeutic angiogenesis in ApoE knockout mice with hindlimb ischemia.
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An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.
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An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype.
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An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response.
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An essential role for c-FLIP in the efficient development of mature T lymphocytes.
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An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation.
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An essential role of antibodies in the control of Chikungunya virus infection.
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An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion.
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An increase in the myocardial PCr/ATP ratio in GLUT4 null mice.
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An interferon-β-resistant and NLRP3 inflammasome-independent subtype of EAE with neuronal damage.
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An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells.
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Analysis of the Conditions That Affect the Selective Processing of Endogenous Notch1 by ADAM10 and ADAM17.
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Analysis of the role of E2A-encoded proteins in insulin gene transcription.
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Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch.
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Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity.
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Angiopoietin-1 is required for Schlemm's canal development in mice and humans.
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Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes.
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Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide.
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Angiotensin 1-7 reduces mortality and rupture of intracranial aneurysms in mice.
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Angiotensin AT1B receptor mediates calcium signaling in vascular smooth muscle cells of AT1A receptor-deficient mice.
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Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.
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Angiotensin II mobilizes spleen monocytes to promote the development of abdominal aortic aneurysm in Apoe-/- mice.
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Angiotensin II promotes development of the renal microcirculation through AT1 receptors.
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Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation.
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Angiotensin II stimulates canonical TGF-β signaling pathway through angiotensin type 1 receptor to induce granulation tissue contraction.
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Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells.
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Angiotensin II: an immune costimulator?
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Angiotensin receptors in the kidney and vasculature in hypertension and kidney disease.
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Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages.
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Angiotensinogen gene null-mutant mice lack homeostatic regulation of glomerular filtration and tubular reabsorption.
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Animal models in the research of abdominal aortic aneurysms development.
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Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory.
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Ank3-dependent SVZ niche assembly is required for the continued production of new neurons.
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Ankyrin-B directs membrane tethering of periaxin and is required for maintenance of lens fiber cell hexagonal shape and mechanics.
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Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments.
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Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth.
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AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing.
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AnkyrinG is required to maintain axo-dendritic polarity in vivo.
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Ankyrins.
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Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis.
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Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia.
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Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration.
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Antibody formation and mannose-6-phosphate receptor expression impact the efficacy of muscle-specific transgene expression in murine Pompe disease.
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Antibody is critical for the clearance of murine norovirus infection.
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Antibody-mediated enzyme replacement therapy targeting both lysosomal and cytoplasmic glycogen in Pompe disease.
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Antigen-loaded monocyte administration induces potent therapeutic antitumor T cell responses.
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Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor.
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Anxiety-like behaviors in mice lacking GIT2.
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Apical CLC-2 in retinal pigment epithelium is crucial for survival of the outer retina.
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ApoB-48 and apoB-100 differentially influence the expression of type-III hyperlipoproteinemia in APOE*2 mice.
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ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-beta1-42.
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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
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ApoER2 function in the establishment and maintenance of retinal synaptic connectivity.
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Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis.
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Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade.
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Apolipoprotein E deficiency worsens outcome from global cerebral ischemia in the mouse.
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Apolipoprotein E expression and behavioral toxicity of high charge, high energy (HZE) particle radiation.
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Apolipoprotein E isoform mediated regulation of nitric oxide release.
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Apolipoprotein E modifies the CNS response to injury via a histamine-mediated pathway.
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Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice.
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Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner.
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Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes.
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Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity.
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Apoptotic Debris Accumulates on Hematopoietic Cells and Promotes Disease in Murine and Human Systemic Lupus Erythematosus.
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Aquaporin 9 is the major pathway for glycerol uptake by mouse erythrocytes, with implications for malarial virulence.
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Aquaporin-4-dependent glymphatic solute transport in the rodent brain.
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Arfgef1 haploinsufficiency in mice alters neuronal endosome composition and decreases membrane surface postsynaptic GABAA receptors.
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Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity.
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Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsin.
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Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling.
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Arterial response to shear stress critically depends on endothelial TRPV4 expression.
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Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology.
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Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways.
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Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin.
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Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury.
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Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis.
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Atomic description of the immune complex involved in heparin-induced thrombocytopenia.
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Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice.
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Attenuation of acid induced oesophagitis in VR-1 deficient mice.
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Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice.
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Attrition of memory CD8 T cells during sepsis requires LFA-1.
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Augmented Responses to Ozone in Obese Mice Require IL-17A and Gastrin-Releasing Peptide.
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Autocrine Complement Inhibits IL10-Dependent T-cell-Mediated Antitumor Immunity to Promote Tumor Progression.
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Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity.
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Autophagy is redundant for the host defense against systemic Candida albicans infections.
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Autophagy links inflammasomes to atherosclerotic progression.
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Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes.
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Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder.
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Axin2 regulates chondrocyte maturation and axial skeletal development.
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Axonal Odorant Receptors Mediate Axon Targeting.
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Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system.
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B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation.
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B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin.
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B cell depletion reduces the development of atherosclerosis in mice.
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B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity.
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B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies.
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B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions.
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B-lymphocyte depletion ameliorates Sjögren's syndrome in Id3 knockout mice.
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B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis.
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B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.
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BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells.
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BCL2 inhibits cell adhesion, spreading, and motility by enhancing actin polymerization.
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BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV.
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BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia.
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BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium.
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BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development.
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Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms.
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Balance of Irgm protein activities determines IFN-gamma-induced host defense.
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Bcl-xL is an oncogenic driver in colorectal cancer.
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Behavioral characterization of P311 knockout mice.
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Behavioral phenotyping of transgenic and knockout animals: a cautionary tale.
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Behavioral responses to social stress in noradrenaline transporter knockout mice: effects on social behavior and depression.
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Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice.
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Beta-adrenergic axis and heart disease.
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Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling.
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Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis.
-
Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration.
-
Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle.
-
Beta-caryophyllene enhances wound healing through multiple routes.
-
Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing.
-
Beta1-adrenergic receptors maintain fetal heart rate and survival.
-
Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction.
-
Bezafibrate induces autophagy and improves hepatic lipid metabolism in glycogen storage disease type Ia.
-
Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes.
-
Biochemical and immunological abnormalities in purine nucleoside phosphorylase deficient mice.
-
Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene.
-
Blocking CCR7 at the ocular surface impairs the pathogenic contribution of dendritic cells in allergic conjunctivitis.
-
Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration.
-
Blood pressure homeostasis is maintained by a P311-TGF-β axis.
-
Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis.
-
Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses.
-
Blunted stress responses in delayed type hypersensitivity in mice lacking the neuronal isoform of nitric oxide synthase.
-
Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements.
-
Bmp4 is required for the generation of primordial germ cells in the mouse embryo.
-
Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration.
-
Body weight and fat deposition in prolactin receptor-deficient mice.
-
Bombesin inhibits alveolarization and promotes pulmonary fibrosis in newborn mice.
-
Bone marrow chimeras and c-fms conditional ablation (Mafia) mice reveal an essential role for resident myeloid cells in lipopolysaccharide/TLR4-induced corneal inflammation.
-
Bone marrow dendritic cell-mediated regulation of TLR and B cell receptor signaling in B cells.
-
Bone marrow transplantation augments the effect of brain- and spinal cord-directed adeno-associated virus 2/5 gene therapy by altering inflammation in the murine model of globoid-cell leukodystrophy.
-
Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter.
-
Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis.
-
Both Hematopoietic- and Non-hematopoietic-derived {beta}-arrestin-2 Regulates Murine Allergic Airway Disease.
-
Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission.
-
Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors.
-
Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight.
-
Bronchus-associated lymphoid tissue-resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection.
-
C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration.
-
C-C Motif Chemokine Receptor 7 Exacerbates Hypertension Through Effects on T Lymphocyte Trafficking.
-
C-myc-induced apoptosis in polycystic kidney disease is Bcl-2 and p53 independent.
-
CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice.
-
CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice.
-
CCR2 deficiency, dysregulation of Notch signaling, and spontaneous pulmonary arterial hypertension.
-
CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality.
-
CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells.
-
CD19 can regulate B lymphocyte signal transduction independent of complement activation.
-
CD19 expression in B cells is important for suppression of contact hypersensitivity.
-
CD19 expression in B cells regulates atopic dermatitis in a mouse model.
-
CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19.
-
CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes.
-
CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma.
-
CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction.
-
CD19-specific CAR T Cells that Express a PD-1/CD28 Chimeric Switch-Receptor are Effective in Patients with PD-L1-positive B-Cell Lymphoma.
-
CD21/35 promotes protective immunity to Streptococcus pneumoniae through a complement-independent but CD19-dependent pathway that regulates PD-1 expression.
-
CD22 and CD72 cooperatively contribute to the development of the reverse Arthus reaction model.
-
CD22 expression mediates the regulatory functions of peritoneal B-1a cells during the remission phase of contact hypersensitivity reactions.
-
CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.
-
CD22 serves as a receptor for soluble IgM.
-
CD28 is required for germinal center formation.
-
CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin.
-
CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells.
-
CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury.
-
CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis.
-
CD83 expression influences CD4+ T cell development in the thymus.
-
CD83 expression is a sensitive marker of activation required for B cell and CD4+ T cell longevity in vivo.
-
CD86 (B7-2) can function to drive MHC-restricted antigen-specific CTL responses in vivo.
-
CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression.
-
CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis.
-
CLN3p impacts galactosylceramide transport, raft morphology, and lipid content.
-
CNS myelin wrapping is driven by actin disassembly.
-
CRISPLD2 is a target of progesterone receptor and its expression is decreased in women with endometriosis.
-
CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes.
-
CX3CR1 deficiency impairs dendritic cell accumulation in arterial intima and reduces atherosclerotic burden.
-
CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5.
-
CXCL13/CXCR5 enhances sodium channel Nav1.8 current density via p38 MAP kinase in primary sensory neurons following inflammatory pain.
-
CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis.
-
Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium.
-
CaMKK2 Knockout Bone Marrow Cells Collected/Processed in Low Oxygen (Physioxia) Suggests CaMKK2 as a Hematopoietic Stem to Progenitor Differentiation Fate Determinant.
-
CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer.
-
Calcium/Calmodulin Dependent Protein Kinase Kinase 2 Regulates the Expansion of Tumor-Induced Myeloid-Derived Suppressor Cells.
-
Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration.
-
Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells.
-
Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance.
-
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation.
-
Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway.
-
Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice.
-
Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs.
-
Cardiac function in genetically engineered mice with altered adrenergic receptor signaling.
-
Cardiac micro-computed tomography for morphological and functional phenotyping of muscle LIM protein null mice.
-
Cardiac myocyte p38α kinase regulates angiogenesis via myocyte-endothelial cell cross-talk during stress-induced remodeling in the heart.
-
Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts.
-
Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation.
-
Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors.
-
Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis.
-
Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury.
-
Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.
-
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.
-
Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology.
-
Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure.
-
Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase.
-
Catecholamines act via a beta-adrenergic receptor to maintain fetal heart rate and survival.
-
Cathelicidin-related antimicrobial peptide mediates skeletal muscle degeneration caused by injury and Duchenne muscular dystrophy in mice.
-
Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.
-
Caveolin-1 modulates intraocular pressure: implications for caveolae mechanoprotection in glaucoma.
-
Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.
-
Cell therapy in murine atherosclerosis: in vivo imaging with high-resolution helical SPECT.
-
Cell-autonomous adiposity through increased cell surface GLUT4 due to ankyrin-B deficiency.
-
Cellular FLIP Inhibits Myeloid Cell Activation by Suppressing Selective Innate Signaling.
-
Cellular and functional defects in a mouse model of heart failure.
-
Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies.
-
Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells.
-
Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation.
-
Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen.
-
Cerebellar defects in Ca2+/calmodulin kinase IV-deficient mice.
-
Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD.
-
ChREBP regulates fructose-induced glucose production independently of insulin signaling.
-
Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model.
-
Characterization of Fatty Acid Binding Protein 7 (FABP7) in the Murine Retina.
-
Characterization of NO and cytokine production in immune-activated microglia and peritoneal macrophages derived from a mouse model expressing the human NOS2 gene on a mouse NOS2 knockout background.
-
Characterization of XIAP-deficient mice.
-
Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice.
-
Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models.
-
Characterization of elongation factor-1A (eEF1A-1) and eEF1A-2/S1 protein expression in normal and wasted mice.
-
Characterization of liver GSD IX γ2 pathophysiology in a novel Phkg2-/-
mouse model.
-
Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues.
-
Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and β-arrestin 2 in inflammatory macrophages.
-
Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.
-
Chemiluminescence and the Nox1-Nox2-Nox4 Triple Knockout.
-
Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection.
-
Chikungunya virus neutralization antigens and direct cell-to-cell transmission are revealed by human antibody-escape mutants.
-
Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10.
-
Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor.
-
Chordin and noggin promote organizing centers of forebrain development in the mouse.
-
Chordin is a modifier of tbx1 for the craniofacial malformations of 22q11 deletion syndrome phenotypes in mouse.
-
Chromium(VI) induces p53-dependent apoptosis in diploid human lung and mouse dermal fibroblasts.
-
Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice.
-
Chronic loss of noradrenergic tone produces β-arrestin2-mediated cocaine hypersensitivity and alters cellular D2 responses in the nucleus accumbens.
-
Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy.
-
Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice.
-
Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation.
-
Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis.
-
Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice.
-
Circadian rhythms of activity and drinking in mice lacking angiotensin II 1A receptors.
-
Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder.
-
Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors.
-
Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo.
-
Cis-acting human ApoE tissue expression element is associated with human pattern of intraneuronal ApoE in transgenic mice.
-
Clara cells attenuate the inflammatory response through regulation of macrophage behavior.
-
Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin.
-
Classical Dendritic Cells Mediate Hypertension by Promoting Renal Oxidative Stress and Fluid Retention.
-
Clinical and serologic manifestations of autoimmune disease in MRL-lpr/lpr mice lacking nitric oxide synthase type 2.
-
Clipping of arginine-methylated histone tails by JMJD5 and JMJD7.
-
Cnksr2 Loss in Mice Leads to Increased Neural Activity and Behavioral Phenotypes of Epilepsy-Aphasia Syndrome.
-
Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2.
-
Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool.
-
Collapsing glomerulopathy: an inflammatory podocytopathy?
-
Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer.
-
Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor.
-
Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Activated intrarenal renin-angiotensin system is correlated with high blood pressure in humans.
-
Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10.
-
Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells.
-
Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice.
-
Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis.
-
Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections.
-
Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling.
-
Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2.
-
Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation.
-
Complement component C3d-antigen complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement.
-
Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus.
-
Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis.
-
Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels.
-
Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease.
-
Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies.
-
Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease.
-
Concerted regulation of skeletal muscle contractility by oxygen tension and endogenous nitric oxide.
-
Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.
-
Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model.
-
Conditional deletion of TrkC does not modify limbic epileptogenesis.
-
Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior.
-
Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles.
-
Connexin 36 and rod bipolar cell independent rod pathways drive retinal ganglion cells and optokinetic reflexes.
-
Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis.
-
Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP.
-
Contribution of IL-13 to early exocrinopathy in Id3-/- mice.
-
Contribution of mast cells to bacterial clearance and their proliferation during experimental cystitis induced by type 1 fimbriated E. coli.
-
Contributions of beta2-microglobulin-dependent molecules and lymphocytes to iron regulation: insights from HfeRag1(-/-) and beta2mRag1(-/-) double knock-out mice.
-
Contributions of endothelial and neuronal nitric oxide synthases to cerebrovascular responses to hyperoxia.
-
Control of IFN-alphaA by CD73: implications for mucosal inflammation.
-
Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases).
-
Control of Intestinal Inflammation, Colitis-Associated Tumorigenesis, and Macrophage Polarization by Fibrinogen-Like Protein 2.
-
Control of antiviral innate immune response by protein geranylgeranylation.
-
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
-
Control of muscle formation by the fusogenic micropeptide myomixer.
-
Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3.
-
Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling.
-
Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function.
-
Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing.
-
Conversion of effector CD4+ T cells to a CD8+ MHC II-recognizing lineage.
-
Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3.
-
Copper Chelation Inhibits BRAFV600E-Driven Melanomagenesis and Counters Resistance to BRAFV600E and MEK1/2 Inhibitors.
-
Correction of glycogen storage disease type II by an adeno-associated virus vector containing a muscle-specific promoter.
-
Correction of multiple striated muscles in murine Pompe disease through adeno-associated virus-mediated gene therapy.
-
Cortical glutamic acid decarboxylase 67 deficiency results in lower cannabinoid 1 receptor messenger RNA expression: implications for schizophrenia.
-
Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa.
-
Critical role for mouse marginal zone B cells in PF4/heparin antibody production.
-
Critical role for the alpha-1B adrenergic receptor at the sympathetic neuroeffector junction.
-
Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses.
-
Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity.
-
Critical roles of RasGRP1 for invariant NKT cell development.
-
Cross-talk Between Nitrate-Nitrite-NO and NO Synthase Pathways in Control of Vascular NO Homeostasis.
-
Cryptococcus neoformans is resistant to surfactant protein A mediated host defense mechanisms.
-
Cutting edge: C3d functions as a molecular adjuvant in the absence of CD21/35 expression.
-
Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2.
-
Cutting edge: Role of osteopontin and integrin αv in T cell-mediated anti-inflammatory responses in endotoxemia.
-
Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury.
-
Cutting edge: critical role of intracellular osteopontin in antifungal innate immune responses.
-
Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice.
-
Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning.
-
Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor).
-
Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3.
-
Cytokine expression by invariant natural killer T cells is tightly regulated throughout development and settings of type-2 inflammation.
-
Cytokine-dependent and cytokine-independent roles for Mcl-1: genetic evidence for multiple mechanisms by which Mcl-1 promotes survival in primary T lymphocytes.
-
Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance.
-
Cytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis.
-
Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.
-
DEK is required for homologous recombination repair of DNA breaks.
-
DEK regulates hematopoietic stem engraftment and progenitor cell proliferation.
-
DGK α and ζ Activities Control TH1 and TH17 Cell Differentiation.
-
DVT: a new era in anticoagulant therapy.
-
Decreased Th17 and antigen-specific humoral responses in CX₃ CR1-deficient mice in the collagen-induced arthritis model.
-
Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid.
-
Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen.
-
Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin M.
-
Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media.
-
Defective T cell development and function in the absence of Abelson kinases.
-
Defective antitumor responses in CX3CR1-deficient mice.
-
Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice.
-
Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.
-
Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1-/- renal proximal tubule cells.
-
Defective prolactin signaling impairs pancreatic β-cell development during the perinatal period.
-
Defective signaling in a subpopulation of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IV.
-
Defects of prostate development and reproductive system in the estrogen receptor-alpha null male mice.
-
Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer.
-
Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.
-
Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice.
-
Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice.
-
Deficiency of Mucosal-Associated Invariant T Cells in TCRJα18 Germline Knockout Mice.
-
Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers.
-
Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response.
-
Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.
-
Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism.
-
Deficiency of α-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling.
-
Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1.
-
Definition of a novel cellular constituent of the bone marrow that regulates the response of immature B cells to B cell antigen receptor engagement.
-
Deletion of Atm in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma.
-
Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse.
-
Deletion of GSK3β in D2R-expressing neurons reveals distinct roles for β-arrestin signaling in antipsychotic and lithium action.
-
Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation.
-
Deletion of Melanin Concentrating Hormone Receptor-1 disrupts overeating in the presence of food cues.
-
Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway.
-
Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis.
-
Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription.
-
Deletion of angiotensin II type 2 receptor accelerates adipogenesis in murine mesenchymal stem cells via Wnt10b/beta-catenin signaling.
-
Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice.
-
Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology.
-
Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia.
-
Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate.
-
Deletion of the phosphatase INPP5E in the murine retina impairs photoreceptor axoneme formation and prevents disc morphogenesis.
-
Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding.
-
Dendritic Cells Interpret Haptotactic Chemokine Gradients in a Manner Governed by Signal-to-Noise Ratio and Dependent on GRK6.
-
Dendritic epidermal T cells regulate skin antimicrobial barrier function.
-
Dengue vascular leakage is augmented by mast cell degranulation mediated by immunoglobulin Fcγ receptors.
-
Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2.
-
Desmoplakin controls microvilli length but not cell adhesion or keratin organization in the intestinal epithelium.
-
Desmoplakin: an unexpected regulator of microtubule organization in the epidermis.
-
Detailed analysis of gene expression during development of T cell lineages in the thymus.
-
Determination of an angiotensin II-regulated proteome in primary human kidney cells by stable isotope labeling of amino acids in cell culture (SILAC).
-
Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells.
-
Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity.
-
Developmental defects in mouse embryos lacking N-cadherin.
-
Developmental onset of enduring long-term potentiation in mouse hippocampus.
-
Developmental renin expression in mice with a defective renin-angiotensin system.
-
Diabetes insipidus in uricase-deficient mice: a model for evaluating therapy with poly(ethylene glycol)-modified uricase.
-
Diabetic liver injury from streptozotocin is regulated through the caspase-8 homolog cFLIP involving activation of JNK2 and intrahepatic immunocompetent cells.
-
Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii.
-
Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses.
-
Diet-induced obese mice retain endogenous leptin action.
-
Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis.
-
Dietary ω-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin.
-
Different presynaptic roles of synapsins at excitatory and inhibitory synapses.
-
Differential Immune Microenvironments and Response to Immune Checkpoint Blockade among Molecular Subtypes of Murine Medulloblastoma.
-
Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents.
-
Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells.
-
Differential Roles of Phospholipase D Proteins in FcεRI-Mediated Signaling and Mast Cell Function.
-
Differential TM4SF5-mediated SIRT1 modulation and metabolic signaling in nonalcoholic steatohepatitis progression.
-
Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals.
-
Differential dynamics and activity-dependent regulation of alpha- and beta-neurexins at developing GABAergic synapses.
-
Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells.
-
Differential expression of p63 isoforms in female reproductive organs.
-
Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice.
-
Differential psychostimulant-induced activation of neural circuits in dopamine transporter knockout and wild type mice.
-
Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin.
-
Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases.
-
Differential regulation of the PGC family of genes in a mouse model of Staphylococcus aureus sepsis.
-
Differential requirement for the SAP-Fyn interaction during NK T cell development and function.
-
Differential requirement of RasGRP1 for γδ T cell development and activation.
-
Differential requirements for NAIP5 in activation of the NLRC4 inflammasome.
-
Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants.
-
Direct Actions of AT1 (Type 1 Angiotensin) Receptors in Cardiomyocytes Do Not Contribute to Cardiac Hypertrophy.
-
Discovery of a functionally selective ghrelin receptor (GHSR1a) ligand for modulating brain dopamine.
-
Discovery of biomarker candidates for coronary artery disease from an APOE-knock out mouse model using iTRAQ-based multiplex quantitative proteomics.
-
Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.
-
Display of cell surface sites for fibronectin assembly is modulated by cell adherence to (1)F3 and C-terminal modules of fibronectin.
-
Disrupted Blood-Retina Lysophosphatidylcholine Transport Impairs Photoreceptor Health But Not Visual Signal Transduction.
-
Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice.
-
Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice.
-
Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.
-
Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum.
-
Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction.
-
Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress.
-
Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction.
-
Disruption of diacylglycerol metabolism impairs the induction of T cell anergy.
-
Disruption of mindin exacerbates cardiac hypertrophy and fibrosis.
-
Disruption of the Ang II type 1 receptor promotes longevity in mice.
-
Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice.
-
Disruption of the gene encoding the mitogen-regulated translational modulator PHAS-I in mice.
-
Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells.
-
Disruption of the mouse oestrogen receptor gene: resulting phenotypes and experimental findings.
-
Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production.
-
Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus.
-
Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice.
-
Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons.
-
Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties.
-
Distinct function of estrogen receptor α in smooth muscle and fibroblast cells in prostate development.
-
Distinct gene expression phenotypes of cells lacking Rb and Rb family members.
-
Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm.
-
Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration.
-
Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system.
-
Distribution of, and immune response to, chicken anti-alpha Gal immunoglobulin Y antibodies in wild-type and alpha Gal knockout mice.
-
Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines.
-
Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis.
-
Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms.
-
Dopamine and α-synuclein dysfunction in Smad3 null mice.
-
Dopamine levels modulate the updating of tastant values.
-
Dopaminergic abnormalities in Hdac6-deficient mice.
-
Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons.
-
Dopaminergic control of sleep-wake states.
-
Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity.
-
Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice.
-
Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis.
-
Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction.
-
Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo.
-
Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides.
-
Drebrin attenuates atherosclerosis by limiting smooth muscle cell transdifferentiation.
-
Drebrin regulates angiotensin II-induced aortic remodelling.
-
Dual allosteric modulation of opioid antinociceptive potency by α2A-adrenoceptors.
-
Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes.
-
Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy.
-
Dual-energy computed tomography imaging of atherosclerotic plaques in a mouse model using a liposomal-iodine nanoparticle contrast agent.
-
Dynamic and redundant regulation of LRRK2 and LRRK1 expression.
-
E protein transcription factors are required for the development of CD4(+) lineage T cells.
-
E-cadherin polarity is determined by a multifunction motif mediating lateral membrane retention through ankyrin-G and apical-lateral transcytosis through clathrin.
-
E2-induced degradation of uterine insulin receptor substrate-2: requirement for an IGF-I-stimulated, proteasome-dependent pathway.
-
E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression.
-
E2A promotes the survival of precursor and mature B lymphocytes.
-
EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts.
-
ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.
-
ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo.
-
ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation.
-
EXT1 regulates chondrocyte proliferation and differentiation during endochondral bone development.
-
Early B-cell activation after West Nile virus infection requires alpha/beta interferon but not antigen receptor signaling.
-
Early Endometriosis in Females Is Directed by Immune-Mediated Estrogen Receptor α and IL-6 Cross-Talk.
-
Early adaptive chromatin remodeling events precede pathologic phenotypes and are reinforced in the failing heart.
-
Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during NAFLD progression.
-
Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
-
Early, sustained efficacy of adeno-associated virus vector-mediated gene therapy in glycogen storage disease type Ia.
-
Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema.
-
Effect of bimatoprost on intraocular pressure in prostaglandin FP receptor knockout mice.
-
Effector T Cell Egress via Afferent Lymph Modulates Local Tissue Inflammation.
-
Effects of Combined Tristetraprolin/Tumor Necrosis Factor Receptor Deficiency on the Splenic Transcriptome.
-
Effects of HSP70.1/3 gene knockout on acute respiratory distress syndrome and the inflammatory response following sepsis.
-
Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice.
-
Effects of candesartan on angiotensin II-induced renal vasoconstriction in rats and mice.
-
Effects of castration and chronic steroid treatments on hypothalamic gonadotropin-releasing hormone content and pituitary gonadotropins in male wild-type and estrogen receptor-alpha knockout mice.
-
Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage.
-
Effects of lactogen resistance and GH deficiency on mouse metabolism: pancreatic hormones, adipocytokines, and expression of adiponectin and insulin receptors.
-
Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice.
-
Effects of neuronal PIK3C3/Vps34 deletion on autophagy and beyond.
-
Effects of tumor microenvironment heterogeneity on nanoparticle disposition and efficacy in breast cancer tumor models.
-
Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice.
-
Efficacious Androgen Hormone Administration in Combination with Adeno-Associated Virus Vector-Mediated Gene Therapy in Female Mice with Pompe Disease.
-
Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer.
-
Efficacy of an adeno-associated virus 8-pseudotyped vector in glycogen storage disease type II.
-
Efficacy of helper-dependent adenovirus vector-mediated gene therapy in murine glycogen storage disease type Ia.
-
Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein mindin.
-
Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin.
-
Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2.
-
Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration.
-
Ena/VASP proteins regulate activated T-cell trafficking by promoting diapedesis during transendothelial migration.
-
EndoU is a novel regulator of AICD during peripheral B cell selection.
-
Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis.
-
Endogenous S-nitrosothiols protect against myocardial injury.
-
Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production.
-
Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival.
-
Endogenous glucocorticoids prevent gastric metaplasia by suppressing spontaneous inflammation.
-
Endoglin deficiency impairs stroke recovery.
-
Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development.
-
Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis.
-
Endothelial CD74 mediates macrophage migration inhibitory factor protection in hyperoxic lung injury.
-
Endothelial MKK3 is a critical mediator of lethal murine endotoxemia and acute lung injury.
-
Endothelial PINK1 mediates the protective effects of NLRP3 deficiency during lethal oxidant injury.
-
Endothelial STAT3 is essential for the protective effects of HO-1 in oxidant-induced lung injury.
-
Endothelial Stanniocalcin 1 Maintains Mitochondrial Bioenergetics and Prevents Oxidant-Induced Lung Injury via Toll-Like Receptor 4.
-
Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity.
-
Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia.
-
Endothelial cell Pannexin1 modulates severity of ischemic stroke by regulating cerebral inflammation and myogenic tone.
-
Endothelial cell-secreted MIF reduces pericyte contractility and enhances neutrophil extravasation.
-
Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome.
-
Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1.
-
Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a.
-
Endothelial uncoupling protein 2 regulates mitophagy and pulmonary hypertension during intermittent hypoxia.
-
Energy metabolism in uncoupling protein 3 gene knockout mice.
-
Engineering human pluripotent stem cells into a functional skeletal muscle tissue.
-
Enhanced Glucose Control Following Vertical Sleeve Gastrectomy Does Not Require a β-Cell Glucagon-Like Peptide 1 Receptor.
-
Enhanced T cell responses due to diacylglycerol kinase zeta deficiency.
-
Enhanced Uterine Contractility and Stillbirth in Mice Lacking G Protein-Coupled Receptor Kinase 6 (GRK6): Implications for Oxytocin Receptor Desensitization.
-
Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes.
-
Enhanced central response to dehydration in mice lacking angiotensin AT(1a) receptors.
-
Enhanced efficacy from gene therapy in Pompe disease using coreceptor blockade.
-
Enhanced efficacy of an AAV vector encoding chimeric, highly secreted acid alpha-glucosidase in glycogen storage disease type II.
-
Enhanced efficacy of enzyme replacement therapy in Pompe disease through mannose-6-phosphate receptor expression in skeletal muscle.
-
Enhanced gene expression of systemically administered plasmid DNA in the liver with therapeutic ultrasound and microbubbles.
-
Enhanced inflow and outflow rates despite lower IOP in bestrophin-2-deficient mice.
-
Enhanced morphine analgesia in mice lacking beta-arrestin 2.
-
Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice.
-
Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2.
-
Environmental Factors Modify the Severity of Acute DSS Colitis in Caspase-11-Deficient Mice.
-
Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice.
-
Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice.
-
Eosinophils alter colonic epithelial barrier function: role for major basic protein.
-
Epidermal growth factor regulates hematopoietic regeneration after radiation injury.
-
Epigenetic dysregulation of Oxtr in Tet1-deficient mice has implications for neuropsychiatric disorders.
-
Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells.
-
Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine.
-
Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis.
-
Epstein-Barr Viruses (EBVs) Deficient in EBV-Encoded RNAs Have Higher Levels of Latent Membrane Protein 2 RNA Expression in Lymphoblastoid Cell Lines and Efficiently Establish Persistent Infections in Humanized Mice.
-
Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart.
-
Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages.
-
Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation.
-
Essential role of AT1A receptor in the development of 2K1C hypertension.
-
Essential role of LAT in T cell development.
-
Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia.
-
Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling.
-
Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock.
-
Estradiol replacement enhances cocaine-stimulated locomotion in female C57BL/6 mice through estrogen receptor alpha.
-
Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERα signaling on astrocytes but not through ERβ signaling on astrocytes or neurons.
-
Estrogen metabolism within the lung and its modulation by tobacco smoke.
-
Estrogen receptor beta protects against in vivo injury in RPE cells.
-
Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy.
-
Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors.
-
Ethanol contributes to neurogenic pancreatitis by activation of TRPV1.
-
Ethanol metabolism modifies hepatic protein acylation in mice.
-
Ethylenecarbodiimide-fixed donor splenocyte infusions differentially target direct and indirect pathways of allorecognition for induction of transplant tolerance.
-
Etomoxir-induced PPARalpha-modulated enzymes protect during acute renal failure.
-
EuroPhenome: a repository for high-throughput mouse phenotyping data.
-
Evaluation of antihypertensive drugs in combination with enzyme replacement therapy in mice with Pompe disease.
-
Evasion of immune responses to introduced human acid alpha-glucosidase by liver-restricted expression in glycogen storage disease type II.
-
Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis.
-
Evolution of the tenascin family--implications for function of the C-terminal fibrinogen-like domain.
-
Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D.
-
Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections.
-
Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21.
-
Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.
-
Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies.
-
Exposure of mice to topical bovine thrombin induces systemic autoimmunity.
-
Expression and modulation of RPE cell membrane complement regulatory proteins.
-
Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice.
-
Expression of stimulator of Fe transport is not enhanced in Hfe knockout mice.
-
Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth.
-
Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders.
-
Expression of the apolipoprotein E gene does not affect motor recovery after sensorimotor cortex injury in the mouse.
-
Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion.
-
Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1.
-
Extracellular superoxide dismutase deficiency worsens outcome from focal cerebral ischemia in the mouse.
-
Extracellular superoxide dismutase regulates cardiac function and fibrosis.
-
Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration.
-
Extrarenal Signs of Proximal Renal Tubular Acidosis Persist in Nonacidemic Nbce1b/c-Null Mice.
-
Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure.
-
Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis.
-
FGF21-FGFR1 Coordinates Phospholipid Homeostasis, Lipid Droplet Function, and ER Stress in Obesity.
-
FGF23 induces left ventricular hypertrophy.
-
FGF23/FGFR4-mediated left ventricular hypertrophy is reversible.
-
FGF9 promotes survival of germ cells in the fetal testis.
-
FGFR4 does not contribute to progression of chronic kidney disease.
-
FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes.
-
FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506.
-
FOXO protects against age-progressive axonal degeneration.
-
FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation.
-
Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI.
-
Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2.
-
Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease.
-
Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta.
-
Fenofibrate rapidly decreases hepatic lipid and glycogen storage in neonatal mice with glycogen storage disease type Ia.
-
Ferric citrate reduces fibroblast growth factor 23 levels and improves renal and cardiac function in a mouse model of chronic kidney disease.
-
Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium.
-
Fgf8 is required for anterior heart field development.
-
Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination.
-
Fibroblast growth factor 21 mediates specific glucagon actions.
-
Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone.
-
Fibronectin Extra Domain A Promotes Liver Sinusoid Repair following Hepatectomy.
-
Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing.
-
Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus.
-
Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53.
-
Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis
-
Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis.
-
Food reward in the absence of taste receptor signaling.
-
Formation of Rathke's pouch requires dual induction from the diencephalon.
-
Formin-like 1 mediates effector T cell trafficking to inflammatory sites to enable T cell-mediated autoimmunity.
-
Formyl peptide receptor 2 determines sex-specific differences in the progression of nonalcoholic fatty liver disease and steatohepatitis.
-
FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain.
-
FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes.
-
Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.
-
Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation.
-
Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways.
-
Fully deleted adenovirus persistently expressing GAA accomplishes long-term skeletal muscle glycogen correction in tolerant and nontolerant GSD-II mice.
-
Function of tau protein in adult newborn neurons.
-
Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1.
-
Functional and molecular adaptations in skeletal muscle of myoglobin-mutant mice.
-
Functional characteristics and survival requirements of memory CD4+ T lymphocytes in vivo.
-
Functional complementation between FADD and RIP1 in embryos and lymphocytes.
-
G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.
-
G protein G(alpha)o is essential for vomeronasal function and aggressive behavior in mice.
-
G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization.
-
G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses.
-
G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors.
-
G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency.
-
G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal.
-
G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis.
-
G-protein-coupled receptor function in heart failure.
-
GABA signaling promotes synapse elimination and axon pruning in developing cortical inhibitory interneurons.
-
GATA2 regulates body water homeostasis through maintaining aquaporin 2 expression in renal collecting ducts.
-
GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst.
-
GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination.
-
GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans.
-
GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice.
-
GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy.
-
GMab-1, a high-affinity anti-3'-isoLM1/3',6'-isoLD1 IgG monoclonal antibody, raised in lacto-series ganglioside-defective knockout mice.
-
GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo.
-
GPR158 in the Visual System: Homeostatic Role in Regulation of Intraocular Pressure.
-
GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain.
-
Galectin-1 is essential for the induction of MOG35-55 -based intravenous tolerance in experimental autoimmune encephalomyelitis.
-
Galphaz negatively regulates insulin secretion and glucose clearance.
-
Gap Junctions Contribute to Differential Light Adaptation across Direction-Selective Retinal Ganglion Cells.
-
Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor.
-
Gene Expression Profiling of Cutaneous Injured and Non-Injured Nociceptors in SNI Animal Model of Neuropathic Pain.
-
Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300.
-
Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP.
-
Gene expression profiles linked to AT1 angiotensin receptors in the kidney.
-
Gene expression profiling of familial and sporadic interstitial pneumonia.
-
Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation.
-
Gene-targeting studies of the renin-angiotensin system: mechanisms of hypertension and cardiovascular disease.
-
Generation and behavioral characterization of beta-catenin forebrain-specific conditional knock-out mice.
-
Generation and characterization of Tmeff2 mutant mice.
-
Generation and characterization of a complete null estrogen receptor alpha mouse using Cre/LoxP technology.
-
Generation of a Listeria vaccine strain by enhanced caspase-1 activation.
-
Generation of a Magoh conditional allele in mice.
-
Genes that modify the hemochromatosis phenotype in mice.
-
Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension.
-
Genetic Deletion of β-Arrestin-2 and the Mitigation of Established Airway Hyperresponsiveness in a Murine Asthma Model.
-
Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress.
-
Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function.
-
Genetic background influences cardiac phenotype in murine chronic kidney disease.
-
Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells.
-
Genetic deletion of Rgs12 in mice affects serotonin transporter expression and function in vivo and ex vivo.
-
Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor).
-
Genetic deletion of the Tas2r143/Tas2r135/Tas2r126 cluster reveals that TAS2Rs may not mediate bitter tastant-induced bronchodilation.
-
Genetic dissection of rod and cone pathways in the dark-adapted mouse retina.
-
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.
-
Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing γδ T cells.
-
Genetic modifiers of the Kv beta2-null phenotype in mice.
-
Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1.
-
Genetic variation in SP-A2 leads to differential binding to Mycoplasma pneumoniae membranes and regulation of host responses.
-
Genetically induced microtubule disruption in the mouse intestine impairs intracellular organization and transport.
-
Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males.
-
Genome-wide identification of calcium-response factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways.
-
Genomic abnormalities of the murine model of Fabry disease after disease-related perturbation, a systems biology approach.
-
Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells.
-
Gestational, pathologic and biochemical differences between very long-chain acyl-CoA dehydrogenase deficiency and long-chain acyl-CoA dehydrogenase deficiency in the mouse.
-
Ghrelin enhances olfactory sensitivity and exploratory sniffing in rodents and humans.
-
Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires βarrestin-2.
-
Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling.
-
Gipr is essential for adrenocortical steroidogenesis; however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(-/-) mice.
-
Glial ankyrins facilitate paranodal axoglial junction assembly.
-
Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease.
-
Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis.
-
Glucagon lowers glycemia when β-cells are active.
-
Glutamine attenuation of cell death and inducible nitric oxide synthase expression following inflammatory cytokine-induced injury is dependent on heat shock factor-1 expression.
-
Glutamine's protection against cellular injury is dependent on heat shock factor-1.
-
Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression.
-
Glutamine-mediated attenuation of cellular metabolic dysfunction and cell death after injury is dependent on heat shock factor-1 expression.
-
Glutamine-mediated dual regulation of heat shock transcription factor-1 activation and expression.
-
Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo.
-
Glutathione peroxidase-deficient smooth muscle cells cause paracrine activation of normal smooth muscle cells via cyclophilin A.
-
Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation.
-
Glycogen accumulation in smooth muscle of a Pompe disease mouse model.
-
Glymphatic fluid transport controls paravascular clearance of AAV vectors from the brain.
-
Gp91phox contributes to NADPH oxidase activity in aortic fibroblasts but not smooth muscle cells.
-
Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.
-
Gradated assembly of multiple proteins into supramolecular nanomaterials.
-
Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN).
-
Granulocytes act as a niche for Mycobacterium tuberculosis growth.
-
Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells.
-
Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation.
-
Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.
-
Guanylate cyclase 1 relies on rhodopsin for intracellular stability and ciliary trafficking.
-
Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂.
-
Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway.
-
Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling.
-
H(2)O(2)-induced O(2) production by a non-phagocytic NAD(P)H oxidase causes oxidant injury.
-
H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection.
-
HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG-I.
-
HDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes.
-
HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase.
-
HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism.
-
Haem oxygenase-1 prevents cell death by regulating cellular iron.
-
Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4.
-
Have gene knockouts caused evolutionary reversals in the mammalian first arch?
-
Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis.
-
Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells.
-
Helicobacter infection decreases reproductive performance of IL10-deficient mice.
-
Helicobacter pylori-induced Th17 responses modulate Th1 cell responses, benefit bacterial growth, and contribute to pathology in mice.
-
Helicobacter typhlonius and Helicobacter rodentium differentially affect the severity of colon inflammation and inflammation-associated neoplasia in IL10-deficient mice.
-
Hematopoietic Wnts Modulate Endochondral Ossification During Fracture Healing.
-
Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression.
-
Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production.
-
Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression.
-
Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis.
-
Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1.
-
Heparin binding EGF is necessary for vasospastic response to endothelin.
-
Hepatic SRC-1 activity orchestrates transcriptional circuitries of amino acid pathways with potential relevance for human metabolic pathogenesis.
-
Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa).
-
Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO.
-
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH.
-
Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice.
-
Hepatorenal correction in murine glycogen storage disease type I with a double-stranded adeno-associated virus vector.
-
Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice.
-
High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease.
-
High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice.
-
High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7's induction of DNA damage response, an activity mediated by E7's inactivation of pocket proteins.
-
High-Resolution Mapping of Chromatin Conformation in Cardiac Myocytes Reveals Structural Remodeling of the Epigenome in Heart Failure.
-
High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice.
-
Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis.
-
Homer modulates NFAT-dependent signaling during muscle differentiation.
-
Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.
-
Hormone signaling and fatty liver in females: analysis of estrogen receptor α mutant mice.
-
How vinculin regulates force transmission.
-
Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior.
-
Humoral autoimmunity in mice overexpressing B cell surface CD19: vital role for MHC class II.
-
Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence.
-
Humoral immune responses in L-selectin-deficient mice.
-
Hyaluronan contributes to bronchiolitis obliterans syndrome and stimulates lung allograft rejection through activation of innate immunity.
-
Hydrostatic isolated limb perfusion with adeno-associated virus vectors enhances correction of skeletal muscle in Pompe disease.
-
Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells.
-
Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling.
-
Hyperexpression of Foxp3 and IDO during acute rejection of islet allografts.
-
Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2.
-
Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A.
-
Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4.
-
Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice.
-
Hypothalamic CaMKK2 contributes to the regulation of energy balance.
-
Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.
-
Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium.
-
Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores.
-
IFN-gamma dictates allograft fate via opposing effects on the graft and on recipient CD8 T cell responses.
-
IKKα negatively regulates ASC-dependent inflammasome activation.
-
IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage.
-
IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.
-
IL-13 and IL-1beta promote lung fibroblast growth through coordinated up-regulation of PDGF-AA and PDGF-Ralpha.
-
IL-15 regulates homeostasis and terminal maturation of NKT cells.
-
IL-17 Production of Neutrophils Enhances Antibacteria Ability but Promotes Arthritis Development During Mycobacterium tuberculosis Infection.
-
IL-17 contributes to neutrophil recruitment but not to control of viral replication during acute mouse adenovirus type 1 respiratory infection.
-
IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia.
-
IL-1β, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis.
-
IL-1β-dependent activation of dendritic epidermal T cells in contact hypersensitivity.
-
IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus.
-
IL-27 Facilitates Skin Wound Healing through Induction of Epidermal Proliferation and Host Defense.
-
IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjögren's syndrome-like disease of the nonobese diabetic mouse.
-
IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival.
-
IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland.
-
IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins.
-
IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria.
-
Id Proteins Suppress E2A-Driven Invariant Natural Killer T Cell Development prior to TCR Selection.
-
Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts.
-
Id2 Collaborates with Id3 To Suppress Invariant NKT and Innate-like Tumors.
-
Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity.
-
Id3 and Id2 act as a dual safety mechanism in regulating the development and population size of innate-like γδ T cells.
-
Id3 restricts the developmental potential of gamma delta lineage during thymopoiesis.
-
Identification and characterization of novel candidate compounds targeting 6- and 7-transmembrane μ-opioid receptor isoforms.
-
Identification of CD146 as a marker enriched for tumor-propagating capacity reveals targetable pathways in primary human sarcoma.
-
Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system.
-
Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells.
-
Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages.
-
Identification of potential cytokine pathways for therapeutic intervention in murine primary biliary cirrhosis.
-
Identification of specific EP receptors responsible for the hemodynamic effects of PGE2.
-
Identifying genetic determinants of inflammatory pain in mice using a large-scale gene-targeted screen.
-
IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF.
-
Immunodominant liver-specific expression suppresses transgene-directed immune responses in murine pompe disease.
-
Immunoglobulin-like domain containing receptor 1 mediates fat-stimulated cholecystokinin secretion.
-
Immunological disruption of antiangiogenic signals by recruited allospecific T cells leads to corneal allograft rejection.
-
Impact of surfactant protein D, interleukin-5, and eosinophilia on Cryptococcosis.
-
Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse.
-
Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells.
-
Impaired fear response in mice lacking GIT1.
-
Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene.
-
Impaired insulin secretion and enhanced insulin sensitivity in cholecystokinin-deficient mice.
-
Impaired liver regeneration in inducible nitric oxide synthasedeficient mice.
-
Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47).
-
Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss.
-
Impaired photoreceptor protein transport and synaptic transmission in a mouse model of Bardet-Biedl syndrome.
-
Impaired social recognition memory in recombination activating gene 1-deficient mice.
-
Impairment of the blood-nerve and blood-brain barriers in apolipoprotein e knockout mice.
-
Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo.
-
Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy.
-
Improved efficacy of gene therapy approaches for Pompe disease using a new, immune-deficient GSD-II mouse model.
-
Improved survival and reduced phenotypic severity following AAV9/MECP2 gene transfer to neonatal and juvenile male Mecp2 knockout mice.
-
In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides.
-
In vivo and in vitro propagation of intraductal papillary mucinous neoplasms.
-
In vivo expansion, persistence, and function of peptide vaccine-induced CD8 T cells occur independently of CD4 T cells.
-
Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection.
-
Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation.
-
Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss.
-
Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice.
-
Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans.
-
Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6.
-
Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP.
-
Increased immunogenicity of a DNA-launched Venezuelan equine encephalitis virus-based replicon DNA vaccine.
-
Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice.
-
Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration.
-
Increased skin carcinogenesis in caspase-activated DNase knockout mice.
-
Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet.
-
Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation.
-
Increased vasoconstrictor response of the mouse lacking angiotensin II type 2 receptor.
-
Increasing O-GlcNAcylation is neuroprotective in young and aged brains after ischemic stroke.
-
Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development.
-
Induced sensitization of tumor stroma leads to eradication of established cancer by T cells.
-
Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload.
-
Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: selection against membrane proximal external region-associated autoreactivity limits T-dependent responses.
-
Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning.
-
Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production.
-
Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression.
-
Inflammation influences vascular remodeling through AT2 receptor expression and signaling.
-
Inflammation-Dependent IL18 Signaling Restricts Hepatocellular Carcinoma Growth by Enhancing the Accumulation and Activity of Tumor-Infiltrating Lymphocytes.
-
Inflammation-associated repression of vasodilator-stimulated phosphoprotein (VASP) reduces alveolar-capillary barrier function during acute lung injury.
-
Influence of CD4 T cells and the source of major histocompatibility complex class II-restricted peptides on cytotoxic T-cell priming by dendritic cells.
-
Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis.
-
Inhibition of Ca²⁺/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation.
-
Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat-Fed Diabetic Mice.
-
Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis.
-
Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis.
-
Inhibition of adenosine-1 receptor-mediated preglomerular vasoconstriction in AT1A receptor-deficient mice.
-
Inhibition of iNOS attenuates skeletal muscle reperfusion injury in extracellular superoxide dismutase knockout mice.
-
Inhibition of inflammatory CCR2 signaling promotes aged muscle regeneration and strength recovery after injury.
-
Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.
-
Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice.
-
Inhibition of p38 Mitogen-Activated Protein Kinase Enhances the Apoptosis Induced by Oxidized Low-Density Lipoprotein in Endothelial Progenitor Cells.
-
Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure.
-
Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.
-
Initial sequencing and comparative analysis of the mouse genome.
-
Innate PI3K p110δ regulates Th1/Th17 development and microbiota-dependent colitis.
-
Innate immune activation potentiates alloimmune lung disease independent of chemokine (C-X-C motif) receptor 3.
-
Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome.
-
Inner ear abnormalities in a Kcnq1 (Kvlqt1) knockout mouse: a model of Jervell and Lange-Nielsen syndrome.
-
Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers.
-
Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling.
-
Insights from molecular signature of in vivo cardiac c-Kit(+) cells following cardiac injury and β-catenin inhibition.
-
Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77.
-
Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase.
-
Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers.
-
Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes.
-
Integrin beta 1 regulates phagosome maturation in macrophages through Rac expression.
-
Integrin-β1 is required for the renal cystogenesis caused by ciliary defects.
-
Interaction of CRF and kappa opioid systems on GABAergic neurotransmission in the mouse central amygdala.
-
Intercellular adhesion molecule-1 and L-selectin regulate bleomycin-induced lung fibrosis.
-
Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice.
-
Intercellular growth factor signaling and the development of mouse tracheal submucosal glands.
-
Interferon-dependent immunoproteasome activity during mouse adenovirus type 1 infection.
-
Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome.
-
Interleukin 1 receptor (IL-1R1) activation exacerbates toxin-induced acute kidney injury.
-
Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis.
-
Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron.
-
Interleukin-1 receptor activation aggravates autosomal dominant polycystic kidney disease by modulating regulated necrosis.
-
Interleukin-17A Contributes to the Control of Streptococcus pyogenes Colonization and Inflammation of the Female Genital Tract.
-
Interleukin-6 as a photoreceptor neuroprotectant in an experimental model of retinal detachment.
-
Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent.
-
Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.
-
Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition.
-
Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis.
-
Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.
-
Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis.
-
Intestinal alkaline phosphatase prevents metabolic syndrome in mice.
-
Intestinal alkaline phosphatase promotes gut bacterial growth by reducing the concentration of luminal nucleotide triphosphates.
-
Intestinal, but not hepatic, ChREBP is required for fructose tolerance.
-
Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis.
-
Intracellular cholesterol biosynthesis in enchondroma and chondrosarcoma.
-
Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity.
-
Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.
-
Intraislet Ghrelin Signaling Does Not Regulate Insulin Secretion From Adult Mice.
-
Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice.
-
Intrinsic Antiviral Activity of Optineurin Prevents Hyperproliferation of a Primary Herpes Simplex Virus Type 2 Infection.
-
Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche.
-
Involvement of P311 in the affective, but not in the sensory component of pain.
-
Involvement of Sensory Neurone-TRPV4 in Acute and Chronic Itch Behaviours.
-
Involvement of Transient Receptor Potential Cation Channel Member A1 activation in the irritation and pain response elicited by skin-lightening reagent hydroquinone.
-
Irgm1 (LRG-47), a regulator of cell-autonomous immunity, does not localize to mycobacterial or listerial phagosomes in IFN-γ-induced mouse cells.
-
Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling.
-
Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium.
-
Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation.
-
Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels.
-
Iron metabolism in mice with partial frataxin deficiency.
-
Isoform-Specific Effects of Wild-Type Ras Genes on Carcinogen-Induced Lung Tumorigenesis in Mice.
-
Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation.
-
Isolation of oligodendrocyte-like cells from human umbilical cord blood.
-
Isoprenylcysteine carboxyl methyltransferase deficiency in mice.
-
JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain.
-
JNK1 is required to preserve cardiac function in the early response to pressure overload.
-
JunB Controls Intestinal Effector Programs in Regulatory T Cells.
-
JunB promotes Th17 cell identity and restrains alternative CD4+ T-cell programs during inflammation.
-
KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.
-
KIF18B is a cell type-specific regulator of spindle orientation in the epidermis.
-
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.
-
KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance.
-
Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells.
-
Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions.
-
Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1.
-
Kindling and associated mossy fibre sprouting are not affected in mice deficient of NGFI-A/NGFI-B genes.
-
Klf15 orchestrates circadian nitrogen homeostasis.
-
Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development.
-
Knockout mice as experimental models of virulence.
-
Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice.
-
Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity.
-
Kruppel-like factor 15 is critical for vascular inflammation.
-
Kruppel-like factor 15 is required for the cardiac adaptive response to fasting.
-
L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes.
-
L-selectin and intercellular adhesion molecule-1 regulate the development of Concanavalin A-induced liver injury.
-
L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice.
-
L-selectin is not required for T cell-mediated autoimmune diabetes.
-
L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity.
-
L-selectin shedding does not regulate constitutive T cell trafficking but controls the migration pathways of antigen-activated T lymphocytes.
-
LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells.
-
LAB: a new membrane-associated adaptor molecule in B cell activation.
-
LKB1 reduces ROS-mediated cell damage via activation of p38.
-
LRRK2 inhibition attenuates microglial inflammatory responses.
-
LRRK2 secretion in exosomes is regulated by 14-3-3.
-
LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1.
-
LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target.
-
Lack of annexin 1 results in an increase in corticotroph number in male but not female mice.
-
Lack of galectin-1 or galectin-3 alters B cell deletion and anergy in an autoantibody transgene model.
-
Lack of nitric oxide synthases increases lipoprotein immune complex deposition in the aorta and elevates plasma sphingolipid levels in lupus.
-
Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis.
-
Lack of the P2X7 receptor protects against AMD-like defects and microparticle accumulation in a chronic oxidative stress-induced mouse model of AMD.
-
Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity.
-
Leptin metabolically licenses T cells for activation to link nutrition and immunity.
-
Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathways.
-
Leukocyte iNOS is required for inflammation and pathological remodeling in ischemic heart failure.
-
Leukocyte rolling velocities and migration are optimized by cooperative L-selectin and intercellular adhesion molecule-1 functions.
-
Leukocyte-derived IL-10 reduces subepithelial fibrosis associated with chronically inhaled endotoxin.
-
Life without myoglobin.
-
Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.
-
Limited effects of Muc1 deficiency on mouse adenovirus type 1 respiratory infection.
-
Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-Mediated Enhancement of Anabolic Synthesis.
-
Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element.
-
Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses.
-
Lipopolysaccharide Potentiates Insulin-Driven Hypoglycemic Shock.
-
Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis.
-
Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype.
-
Liver X receptors alpha and beta regulate renin expression in vivo.
-
Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism.
-
Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes.
-
Liver-specific deletion of augmenter of liver regeneration accelerates development of steatohepatitis and hepatocellular carcinoma in mice.
-
Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice.
-
Liver-specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy.
-
Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition.
-
LncRNA VINAS regulates atherosclerosis by modulating NF-κB and MAPK signaling.
-
Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity.
-
Local induction of bladder Th1 responses to combat urinary tract infections.
-
Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant.
-
Long-range function of secreted small nucleolar RNAs that direct 2'-O-methylation.
-
Long-term correction of glycogen storage disease type II with a hybrid Ad-AAV vector.
-
Long-term efficacy after [E1-, polymerase-] adenovirus-mediated transfer of human acid-alpha-glucosidase gene into glycogen storage disease type II knockout mice.
-
Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model.
-
Longitudinal study of differential protein expression in an Alzheimer's mouse model lacking inducible nitric oxide synthase.
-
Longitudinal study of urinary excretion of phosphate, calcium, and uric acid in mutant NHERF-1 null mice.
-
Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration.
-
Loss of BMI1 in mature olfactory sensory neurons leads to increased olfactory basal cell proliferation.
-
Loss of Bladder Epithelium Induced by Cytolytic Mast Cell Granules.
-
Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy.
-
Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall.
-
Loss of Diacylglycerol Kinase α Enhances Macrophage Responsiveness.
-
Loss of LDAH associated with prostate cancer and hearing loss.
-
Loss of MPZL3 function causes seborrhoeic dermatitis-like phenotype in mice.
-
Loss of NR1 subunit of NMDARs in primary sensory neurons leads to hyperexcitability and pain hypersensitivity: involvement of Ca(2+)-activated small conductance potassium channels.
-
Loss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determination.
-
Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response.
-
Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.
-
Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4.
-
Loss of deacetylation activity of Hdac6 affects emotional behavior in mice.
-
Loss of epithelial oestrogen receptor α inhibits oestrogen-stimulated prostate proliferation and squamous metaplasia via in vivo tissue selective knockout models.
-
Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds.
-
Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease.
-
Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems.
-
Loss of the perforin cytotoxic pathway predisposes mice to experimental cytomegalovirus retinitis.
-
Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation.
-
Lung effector memory and activated CD4+ T cells display enhanced proliferation in surfactant protein A-deficient mice during allergen-mediated inflammation.
-
Lung inflammation stalls Th17-cell migration en route to the central nervous system during the development of experimental autoimmune encephalomyelitis.
-
Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds.
-
Ly49-dependent NK cell licensing and effector inhibition involve the same interaction site on MHC ligands.
-
Lymphocyte accumulation in the spleen of retinoic acid receptor-related orphan receptor gamma-deficient mice.
-
Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen.
-
Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.
-
MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart.
-
MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation.
-
MEKK3 is essential for lymphopenia-induced T cell proliferation and survival.
-
MKK3 deletion improves mitochondrial quality.
-
MKK3 influences mitophagy and is involved in cigarette smoke-induced inflammation.
-
MKK3 mediates inflammatory response through modulation of mitochondrial function.
-
ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse.
-
MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate.
-
Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice.
-
Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease.
-
Macrophage polarization is linked to Ca2+-independent phospholipase A2β-derived lipids and cross-cell signaling in mice.
-
Macrophage-Derived MicroRNA-21 Drives Overwhelming Glycolytic and Inflammatory Response during Sepsis via Repression of the PGE2/IL-10 Axis.
-
Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing.
-
Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart.
-
Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation.
-
Magnetic resonance imaging at microscopic resolution reveals subtle morphological changes in a mouse model of dopaminergic hyperfunction.
-
Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption.
-
Male mice deficient in microsomal epoxide hydrolase are not susceptible to benzene-induced toxicity.
-
Male-to-female sex reversal in mice lacking fibroblast growth factor 9.
-
Manganese superoxide dismutase is a mitochondrial fidelity protein that protects Polγ against UV-induced inactivation.
-
Manganese superoxide dismutase-mediated inside-out signaling in HaCaT human keratinocytes and SKH-1 mouse skin.
-
Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent.
-
Mast cell TNF receptors regulate responses to Mycoplasma pneumoniae in surfactant protein A (SP-A)-/- mice.
-
Mast cell function is not altered by Coronin-1A deficiency.
-
Mast cell stabilization improves survival by preventing apoptosis in sepsis.
-
Mast cells are critical for protection against peptic ulcers induced by the NSAID piroxicam.
-
Mast cells in tumor microenvironment promotes the in vivo growth of pancreatic ductal adenocarcinoma.
-
Maternal Immunity and Vaccination Influence Disease Severity in Progeny in a Novel Mast Cell-Deficient Mouse Model of Severe Dengue.
-
Maximal adjuvant activity of nasally delivered IL-1α requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production.
-
Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2.
-
Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.
-
MeCP2 reinforces STAT3 signaling and the generation of effector CD4+ T cells by promoting miR-124-mediated suppression of SOCS5.
-
Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by light.
-
Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function.
-
Mekk3 is essential for early embryonic cardiovascular development.
-
Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat.
-
Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants.
-
Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism.
-
MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair After Myocardial Ischemia Reperfusion Injury.
-
Mercury-induced cognitive impairment in metallothionein-1/2 null mice.
-
Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype.
-
Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis.
-
Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle.
-
Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation.
-
Metabolism and vascular fatty acid transport.
-
Metabolism of chloroform by cytochrome P450 2E1 is required for induction of toxicity in the liver, kidney, and nose of male mice.
-
Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase-deficient fetal thymic organ cultures.
-
Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function.
-
Metallothionein expression and neurocognitive function in mice.
-
Metallothionein in the central nervous system: Roles in protection, regeneration and cognition.
-
Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.
-
Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development.
-
Methods to Investigate the Roles for β-Arrestin-2 in Allergic Inflammatory Airway Disease.
-
Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens.
-
Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth.
-
Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia.
-
Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord.
-
Mice deficient in inducible nitric oxide synthase are susceptible to experimental autoimmune uveoretinitis.
-
Mice heterozygous for a null mutation of CPE show reduced expression of carboxypeptidase e mRNA and enzyme activity but normal physiology, behavior, and levels of neuropeptides.
-
Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity.
-
Mice lacking proSAAS display alterations in emotion, consummatory behavior and circadian entrainment.
-
Mice lacking synapsin III show abnormalities in explicit memory and conditioned fear.
-
Mice lacking the dopamine transporter display altered regulation of distal colonic motility.
-
Mice lacking the norepinephrine transporter are supersensitive to psychostimulants.
-
Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome.
-
Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis.
-
Mice with a deletion in the gene for CCAAT/enhancer-binding protein beta are protected against diet-induced obesity.
-
Mice without myoglobin.
-
Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis.
-
MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice.
-
MicroRNA-31 negatively regulates peripherally derived regulatory T-cell generation by repressing retinoic acid-inducible protein 3.
-
Microarray analysis of knockout mice identifies cyclin D2 as a possible mediator for the action of thyroid hormone during the postnatal development of the cerebellum.
-
Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome.
-
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model.
-
Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.
-
Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks.
-
Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease.
-
Minimal phenotype of mice homozygous for a null mutation in the forkhead/winged helix gene, Mf2.
-
Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development.
-
Minimum Effective Dose to Achieve Biochemical Correction with Adeno-Associated Virus Vector-Mediated Gene Therapy in Mice with Pompe Disease.
-
Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy.
-
Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
-
Mitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient mice.
-
Mitochondrial dysfunction in ataxia-telangiectasia.
-
Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs.
-
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.
-
Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis.
-
Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expression.
-
Mitral cells in the olfactory bulb are mainly excited through a multistep signaling path.
-
Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes.
-
Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis.
-
Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1.
-
Models of dopaminergic and serotonergic signaling.
-
Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene.
-
Modifier locus on mouse chromosome 3 for renal vascular pathology in AT1A receptor-deficiency.
-
Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli.
-
Modulation of experimental arthritis by vagal sensory and central brain stimulation.
-
Modulation of in vivo cardiac function by myocyte-specific nitric oxide synthase-3.
-
Modulation of intestinal sulfur assimilation metabolism regulates iron homeostasis.
-
Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice.
-
Modulation of taste responsiveness by the satiation hormone peptide YY.
-
Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation.
-
Molecular manipulations of extracellular superoxide dismutase: functional importance for learning.
-
Morphine side effects in beta-arrestin 2 knockout mice.
-
Morphogenesis and Compartmentalization of the Intestinal Crypt.
-
Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs.
-
Morphologic phenotyping with MR microscopy: the visible mouse.
-
Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism.
-
Mouse Cntnap2 and Human CNTNAP2 ASD Alleles Cell Autonomously Regulate PV+ Cortical Interneurons.
-
Mouse keratin 4 is necessary for internal epithelial integrity.
-
Mouse model of Timothy syndrome recapitulates triad of autistic traits.
-
Mouse model of glycogen storage disease type III.
-
Mouse models for studying genetic influences on factors determining smoking cessation success in humans.
-
Mouse models of diabetic nephropathy.
-
Mouse retinal pigmented epithelial cell lines retain their phenotypic characteristics after transfection with human papilloma virus: a new tool to further the study of RPE biology.
-
Mst1/Mst2 regulate development and function of regulatory T cells through modulation of Foxo1/Foxo3 stability in autoimmune disease.
-
Msx Homeobox Genes Act Downstream of BMP2 to Regulate Endometrial Decidualization in Mice and in Humans.
-
Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence.
-
Mu-opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: lack of ethanol interactions.
-
MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet.
-
Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4.
-
Multifaceted Changes in Synaptic Composition and Astrocytic Involvement in a Mouse Model of Fragile X Syndrome.
-
Multiple constraints at the level of TCRalpha rearrangement impact Valpha14i NKT cell development.
-
Multiple gamma c-dependent cytokines regulate T-cell development.
-
Multiple innate inflammatory responses induced after systemic adenovirus vector delivery depend on a functional complement system.
-
Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis.
-
Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release.
-
Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro B cells.
-
Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness.
-
Multivariate MR biomarkers better predict cognitive dysfunction in mouse models of Alzheimer's disease.
-
Munc13-1 is required for presynaptic long-term potentiation.
-
Murine Glucocorticoid Receptors Orchestrate B Cell Migration Selectively between Bone Marrow and Blood.
-
Murine cytomegalovirus retinitis during retrovirus-induced immunodeficiency (MAIDS) in mice: interleukin-2 immunotherapy correlates with increased intraocular levels of perforin mRNA.
-
Murine female reproductive tract intraepithelial lymphocytes display selection characteristics distinct from both peripheral and other mucosal T cells.
-
Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract.
-
Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis.
-
Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging.
-
Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.
-
Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment.
-
Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice.
-
Muscle Krüppel-like factor 15 regulates lipid flux and systemic metabolic homeostasis.
-
Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet.
-
Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility.
-
Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization.
-
Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch.
-
Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.
-
Mutations in TFAM, encoding mitochondrial transcription factor A, cause neonatal liver failure associated with mtDNA depletion.
-
Mutations in topoisomerase IIβ result in a B cell immunodeficiency.
-
Myc requires distinct E2F activities to induce S phase and apoptosis.
-
Mycobacterium bovis bacille Calmette-Guérin infection in the CNS suppresses experimental autoimmune encephalomyelitis and Th17 responses in an IFN-gamma-independent manner.
-
Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration.
-
Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1.
-
Myeloid-Specific Deletion of Mcl-1 Yields Severely Neutropenic Mice That Survive and Breed in Homozygous Form.
-
Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis.
-
Myeloperoxidase is increased in human cerebral aneurysms and increases formation and rupture of cerebral aneurysms in mice.
-
Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations.
-
Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF.
-
N-cadherin functions as a growth suppressor in a model of K-ras-induced PanIN.
-
N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity.
-
N-formyl peptide receptors internalize but do not recycle in the absence of arrestins.
-
N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias.
-
NAD(P)H quinone oxidoreductase 1 is essential for ozone-induced oxidative stress in mice and humans.
-
NAD(P)H quinone oxidoreductase 1 regulates neutrophil elastase-induced mucous cell metaplasia.
-
NAD+ modulates p53 DNA binding specificity and function.
-
NCKAP1 Disruptive Variants Lead to a Neurodevelopmental Disorder with Core Features of Autism.
-
NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity.
-
NF-κB activation persists into the remodeling phase of tendon healing and promotes myofibroblast survival.
-
NFIL3-deficient mice develop microbiota-dependent, IL-12/23-driven spontaneous colitis.
-
NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes.
-
NK cell recruitment limits tissue damage during an enteric helminth infection.
-
NLRC3 negatively regulates CD4+ T cells and impacts protective immunity during Mycobacterium tuberculosis infection.
-
NLRP3 Promotes Diabetic Bladder Dysfunction and Changes in Symptom-Specific Bladder Innervation.
-
NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis.
-
NO and superoxide: opposite ends of the seesaw in cardiac contractility.
-
NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease.
-
NOS2 regulation of NF-kappaB by S-nitrosylation of p65.
-
NOX2 protects against prolonged inflammation, lung injury, and mortality following systemic insults.
-
NPAS3 is a trachealess homolog critical for lung development and homeostasis.
-
Nasal vaccination with troponin reduces troponin specific T-cell responses and improves heart function in myocardial ischemia-reperfusion injury.
-
Natural IgM Switches the Function of Lipopolysaccharide-Activated Murine Bone Marrow-Derived Dendritic Cells to a Regulatory Dendritic Cell That Suppresses Innate Inflammation.
-
Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume.
-
Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways.
-
Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunity.
-
Near-infrared spectrometry of abdominal aortic aneurysm in the ApoE-/- mouse.
-
Necroptosis-independent signaling by the RIP kinases in inflammation.
-
Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1.
-
Negative regulation of lymphocyte activation by the adaptor protein LAX.
-
Neonatal co-infection with helicobacter species markedly accelerates the development of inflammation-associated colonic neoplasia in IL-10(-/-) mice.
-
Nervous system defects of AnkyrinB (-/-) mice suggest functional overlap between the cell adhesion molecule L1 and 440-kD AnkyrinB in premyelinated axons.
-
Neural circuit repair by low-intensity magnetic stimulation requires cellular magnetoreceptors and specific stimulation patterns.
-
Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice.
-
Neurodevelopmental mutation of giant ankyrin-G disrupts a core mechanism for axon initial segment assembly.
-
Neuroendocrine effects of dehydration in mice lacking the angiotensin AT1a receptor.
-
Neuroimmune perspectives in sepsis.
-
Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis.
-
Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice.
-
Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect.
-
Neuronal IL-4Rα modulates neuronal apoptosis and cell viability during the acute phases of cerebral ischemia.
-
Neuronal ceroid lipofuscinosis: a common pathway?
-
Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance.
-
Neuropathology in respiratory-related motoneurons in young Pompe (Gaa(-/-)) mice.
-
Neuroprotection mediated through estrogen receptor-alpha in astrocytes.
-
Neurosteroid transport by the organic solute transporter OSTα-OSTβ.
-
Neurotrophin-3 signaling maintains maturational homeostasis between neuronal populations in the olfactory epithelium.
-
Neutrophil L-Plastin Controls Ocular Paucibacteriality and Susceptibility to Keratitis.
-
Neutrophil accumulation and NET release contribute to thrombosis in HIT.
-
New insights into adenosine-receptor-mediated immunosuppression and the role of adenosine in causing the immunodeficiency associated with adenosine deaminase deficiency.
-
New mass spectrometric assay for angiotensin-converting enzyme 2 activity.
-
New tools for studying microglia in the mouse and human CNS.
-
Newborn, carrier, and early childhood screening recommendations for fragile X.
-
Nicotine activates TRPM5-dependent and independent taste pathways.
-
Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation.
-
Nicotinic alpha7- or beta2-containing receptor knockout: effects on radial-arm maze learning and long-term nicotine consumption in mice.
-
Nitric oxide as an inflammatory mediator in autoimmune MRL-lpr/lpr mice.
-
Nitric oxide mediates relative airway hyporesponsiveness to lipopolysaccharide in surfactant protein A-deficient mice.
-
Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases.
-
Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia.
-
Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice.
-
Nitric oxide-mediated intracellular growth restriction of pathogenic Rhodococcus equi can be prevented by iron.
-
Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors.
-
Nogo receptor 1 is expressed by nearly all retinal ganglion cells.
-
Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis.
-
Noradrenergic control of cortico-striato-thalamic and mesolimbic cross-structural synchrony.
-
Norepinephrine induces hepatic fibrogenesis in leptin deficient ob/ob mice.
-
Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis.
-
Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism.
-
Novel role for surfactant protein A in gastrointestinal graft-versus-host disease.
-
Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes.
-
Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma.
-
Novelty seeking and stereotypic activation of behavior in mice with disruption of the Dat1 gene.
-
Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration.
-
Nox2 NADPH oxidase is dispensable for platelet activation or arterial thrombosis in mice.
-
Nox4 NADPH oxidase contributes to smooth muscle cell phenotypes associated with unstable atherosclerotic plaques.
-
Nrf2-mediated protection against 6-hydroxydopamine.
-
Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis.
-
Nuclear phosphatase PPM1G in cellular survival and neural development.
-
Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes.
-
Nuclear receptors as potential therapeutic targets for age-related macular degeneration.
-
Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice.
-
OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection.
-
Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications.
-
Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation.
-
Odorant receptors govern the formation of a precise topographic map.
-
Oestrogen receptors enhance dopamine neurone survival in rat midbrain.
-
Of cardiovascular illness and diversity of biological response.
-
Of mice, birds, and men: the mouse ultrasonic song system has some features similar to humans and song-learning birds.
-
Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice.
-
On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy.
-
Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis.
-
One tissue, two fates: molecular genetic events that underlie testis versus ovary development.
-
Opposing action of conantokin-G on synaptically and extrasynaptically-activated NMDA receptors.
-
Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts.
-
Opposing actions of renal tubular- and myeloid-derived porcupine in obstruction-induced kidney fibrosis.
-
Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling.
-
Optimal processing of photoreceptor signals is required to maximize behavioural sensitivity.
-
Oral L-arginine stimulates GLP-1 secretion to improve glucose tolerance in male mice.
-
Oral feeding with pig peripheral lymphocytes decreases the xenogeneic delayed type hypersensitivity reaction in galactosyltransferase knockout mice.
-
Oral immunogenicity of the plant proteinase bromelain.
-
Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation.
-
Orphan nuclear receptors in T lymphocyte development.
-
Osteoclast differentiation and function in aquaglyceroporin AQP9-null mice.
-
Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages.
-
Osteopontin deficiency ameliorates Alport pathology by preventing tubular metabolic deficits.
-
Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells.
-
Osteopontin mediates Stat1 degradation to inhibit iNOS transcription in a cecal ligation and puncture model of sepsis.
-
Overload-induced skeletal muscle extracellular matrix remodelling and myofibre growth in mice lacking IL-6.
-
Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice.
-
Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway.
-
Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease.
-
Oxygen seizure latency and peroxynitrite formation in mice lacking neuronal or endothelial nitric oxide synthases.
-
Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2.
-
Ozone inhalation promotes CX3CR1-dependent maturation of resident lung macrophages that limit oxidative stress and inflammation.
-
P-glycoprotein is a major determinant of norbuprenorphine brain exposure and antinociception.
-
PAD4 is not essential for disease in the K/BxN murine autoantibody-mediated model of arthritis.
-
PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection.
-
PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity.
-
PAX9 regulates squamous cell differentiation and carcinogenesis in the oro-oesophageal epithelium.
-
PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia.
-
PD-1 blockade inhibits osteoclast formation and murine bone cancer pain.
-
PD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue.
-
PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis.
-
PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1.
-
PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo.
-
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum.
-
PECAM-1 dampens cytokine levels during LPS-induced endotoxemia by regulating leukocyte trafficking.
-
PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis.
-
PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types.
-
PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons.
-
PINK1 mediates the protective effects of thyroid hormone T3 in hyperoxia-induced lung injury.
-
PKM1 Exerts Critical Roles in Cardiac Remodeling Under Pressure Overload in the Heart.
-
PLEKHG5 deficiency leads to an intermediate form of autosomal-recessive Charcot-Marie-Tooth disease.
-
PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.
-
PPAR alpha ligand protects during cisplatin-induced acute renal failure by preventing inhibition of renal FAO and PDC activity.
-
PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling.
-
PRCD is essential for high-fidelity photoreceptor disc formation.
-
PTH receptor signaling in osteoblasts regulates endochondral vascularization in maintenance of postnatal growth plate.
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PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer.
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PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms.
-
PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy.
-
Packaging of an AAV vector encoding human acid alpha-glucosidase for gene therapy in glycogen storage disease type II with a modified hybrid adenovirus-AAV vector.
-
Palmitoylation of the immunity related GTPase, Irgm1: impact on membrane localization and ability to promote mitochondrial fission.
-
Pannexin 1 channels control the hemodynamic response to hypoxia by regulating O2-sensitive extracellular ATP in blood.
-
Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma.
-
Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin.
-
Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1.
-
Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP.
-
Pathogenesis of growth failure and partial reversal with gene therapy in murine and canine Glycogen Storage Disease type Ia.
-
Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity.
-
Pathophysiology of SPINK mutations in pancreatic development and disease.
-
Pattern recognition molecule mindin promotes intranasal clearance of influenza viruses.
-
Perforin knockout mice, but not mice with MAIDS, show protection against experimental cytomegalovirus retinitis after adoptive transfer of immune cells with a functional perforin cytotoxic pathway.
-
Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers.
-
Peripheral nerve and neuromuscular junction pathology in Pompe disease.
-
Peripheral sensory nerve defects in apolipoprotein E knockout mice.
-
Peripheral serotonin causes dengue virus-induced thrombocytopenia through 5HT2 receptors.
-
Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2.
-
Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-γ+CD4+ T cell numbers during colitis development in mice.
-
Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia.
-
Peroxynitrite formation and decreased catalase activity in autoimmune MRL-lpr/lpr mice.
-
Persistent expression of MNF identifies myogenic stem cells in postnatal muscles.
-
Persistent hyperdopaminergia decreases the peak frequency of hippocampal theta oscillations during quiet waking and REM sleep.
-
Persisting neurobehavioral effects of developmental copper exposure in wildtype and metallothionein 1 and 2 knockout mice.
-
Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy.
-
Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model.
-
Pharmacometabolomic signature of ataxia SCA1 mouse model and lithium effects.
-
Phenotypic characterization of murine models of cerebral cavernous malformations.
-
Phenotypic differences between mice deficient in XIAP and SAP, two factors targeted in X-linked lymphoproliferative syndrome (XLP).
-
Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouse.
-
Phosducin regulates the expression of transducin betagamma subunits in rod photoreceptors and does not contribute to phototransduction adaptation.
-
Phosducin regulates transmission at the photoreceptor-to-ON-bipolar cell synapse.
-
Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging.
-
Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins.
-
Phosphodiesterase 4 Inhibitors Attenuate the Asthma Phenotype Produced by β2-Adrenoceptor Agonists in Phenylethanolamine N-Methyltransferase-Knockout Mice.
-
Phospholipase D in TCR-Mediated Signaling and T Cell Activation.
-
Phosphorylation at tyrosine 262 promotes GADD34 protein turnover.
-
Phosphorylation of G protein-coupled receptor kinase 1 (GRK1) is regulated by light but independent of phototransduction in rod photoreceptors.
-
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.
-
Photon-counting cine-cardiac CT in the mouse.
-
Photoreceptor discs form through peripherin-dependent suppression of ciliary ectosome release.
-
Photoreceptors in a mouse model of Leigh syndrome are capable of normal light-evoked signaling.
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Physiologic Consequences of Caveolin-1 Ablation in Conventional Outflow Endothelia.
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Physiological roles of the GIP receptor in murine brown adipose tissue.
-
Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis.
-
Pik3c3 deletion in pyramidal neurons results in loss of synapses, extensive gliosis and progressive neurodegeneration.
-
Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis.
-
Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans.
-
Plasminogen activator inhibitor-1 (PAI-1) modifies the formation of aggressive fibromatosis (desmoid tumor).
-
Plasminogen alleles influence susceptibility to invasive aspergillosis.
-
Plasticity and behavior: new genetic techniques to address multiple forms and functions.
-
Plasticity of renal erythropoietin-producing cells governs fibrosis.
-
Platelet-derived growth factor (PDGF) regulates Slingshot phosphatase activity via Nox1-dependent auto-dephosphorylation of serine 834 in vascular smooth muscle cells.
-
Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell-bound CD154.
-
Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches.
-
Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche.
-
Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation.
-
Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease.
-
Polysaccharides PS-G and protein LZ-8 from Reishi (Ganoderma lucidum) exhibit diverse functions in regulating murine macrophages and T lymphocytes.
-
Postnatal TrkB ablation in corticolimbic interneurons induces social dominance in male mice.
-
Postsynaptic Mechanisms Render Syn I/II/III Mice Highly Responsive to Psychostimulants.
-
Posttranslational regulation of TCR Valpha allelic exclusion during T cell differentiation.
-
Potential role of Hedgehog signaling and microRNA-29 in liver fibrosis of IKKβ-deficient mouse.
-
Precise regulation of porcupine activity is required for physiological Wnt signaling.
-
Pregnenolone rescues schizophrenia-like behavior in dopamine transporter knockout mice.
-
Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver.
-
Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases.
-
Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection.
-
Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2.
-
Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice.
-
Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors.
-
Presynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca2+ entry pathway.
-
Prevention of the polycystic ovarian phenotype and characterization of ovulatory capacity in the estrogen receptor-alpha knockout mouse.
-
Pro- and antiatherogenic effects of a dominant-negative P465L mutation of peroxisome proliferator-activated receptor-γ in apolipoprotein E-Null mice.
-
ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine.
-
Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor SR-BI/apolipoprotein E double knockout mouse.
-
Progenitor cell dose determines the pace and completeness of engraftment in a xenograft model for cord blood transplantation.
-
Progressive improvement in wound healing with increased therapy in haemophilia B mice.
-
Progressive optic atrophy in a retinal ganglion cell-specific mouse model of complex I deficiency.
-
Proinflammatory actions of thromboxane receptors to enhance cellular immune responses.
-
Prolactin receptor signal transduction pathways and actions determined in prolactin receptor knockout mice.
-
Prolactin receptor signaling is essential for perinatal brown adipocyte function: a role for insulin-like growth factor-2.
-
Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance.
-
Prolonged survival of class II transactivator-deficient cardiac allografts.
-
Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination.
-
Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism in animal models.
-
Prostacyclin protects against elevated blood pressure and cardiac fibrosis.
-
Prostaglandin E2 Production and T Cell Function in Mouse Adenovirus Type 1 Infection following Allogeneic Bone Marrow Transplantation.
-
Prostaglandin E2 production during neonatal respiratory infection with mouse adenovirus type 1.
-
Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice.
-
Protease-activated receptor-2 signaling triggers dendritic cell development.
-
Proteasome overload is a common stress factor in multiple forms of inherited retinal degeneration.
-
Protection from experimental asthma by an endogenous bronchodilator.
-
Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4.
-
Protective immunity in recurrent Staphylococcus aureus infection reflects localized immune signatures and macrophage-conferred memory.
-
Protective role of transient pore openings in calcium handling by cardiac mitochondria.
-
Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.
-
Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells.
-
Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation.
-
Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity.
-
Proteomic identification of specific oxidized proteins in ApoE-knockout mice: relevance to Alzheimer's disease.
-
Prothymosin-alpha inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction.
-
Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways.
-
Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism.
-
Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes.
-
R-spondin1 tips the balance in sex determination.
-
R9AP targeting to rod outer segments is independent of rhodopsin and is guided by the SNARE homology domain.
-
RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure.
-
RBPJ mediates uterine repair in the mouse and is reduced in women with recurrent pregnancy loss.
-
RGS2-deficient mice exhibit decreased intraocular pressure and increased retinal ganglion cell survival.
-
RGS2: a "turn-off" in hypertension.
-
RGS9 knockout causes a short delay in light responses of ON-bipolar cells.
-
RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression.
-
ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm.
-
RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2.
-
Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival.
-
Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo.
-
Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
-
Rapamycin does not control hemophagocytic lymphohistiocytosis in LCMV-infected perforin-deficient mice.
-
Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing.
-
Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction.
-
RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer.
-
Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium.
-
Reactive oxygen species induce antibiotic tolerance during systemic Staphylococcus aureus infection.
-
Receptor tyrosine kinase MerTK suppresses an allogenic type I IFN response to promote transplant tolerance.
-
Receptors and signaling mechanisms required for prostaglandin E2-mediated regulation of mast cell degranulation and IL-6 production.
-
Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse.
-
Recipient Myd88 Deficiency Promotes Spontaneous Resolution of Kidney Allograft Rejection.
-
Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.
-
Recruited exudative macrophages selectively produce CXCL10 after noninfectious lung injury.
-
Recurrent GNAQ mutation encoding T96S in natural killer/T cell lymphoma.
-
Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.
-
Reduced arsenic clearance and increased toxicity in aquaglyceroporin-9-null mice.
-
Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice.
-
Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II.
-
Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.
-
Reduced prostate branching morphogenesis in stromal fibroblast, but not in epithelial, estrogen receptor α knockout mice.
-
Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice.
-
Reduction of Autophagic Accumulation in Pompe Disease Mouse Model Following Gene Therapy.
-
Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice.
-
Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo.
-
Regional absence of mitochondria causing energy depletion in the myocardium of muscle LIM protein knockout mice.
-
Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase.
-
Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage.
-
Regulation of Intrinsic and Bystander T Follicular Helper Cell Differentiation and Autoimmunity by Tsc1.
-
Regulation of RasGRP1 function in T cell development and activation by its unique tail domain.
-
Regulation of T cell receptor beta allelic exclusion at a level beyond accessibility.
-
Regulation of T-cell survival and mitochondrial homeostasis by TSC1.
-
Regulation of TCR delta and alpha repertoires by local and long-distance control of variable gene segment chromatin structure.
-
Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility.
-
Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation.
-
Regulation of blood pressure by the type 1A angiotensin II receptor gene.
-
Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A.
-
Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction.
-
Regulation of humoral immune responses by CD21/CD35.
-
Regulation of inflammation by β-arrestins: Not just receptor tales.
-
Regulation of iron absorption in Hfe mutant mice.
-
Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis.
-
Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation.
-
Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL.
-
Regulation of sodium balance and blood pressure by the AT(1A) receptor for angiotensin II.
-
Regulation of steady-state neutrophil homeostasis by macrophages.
-
Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination.
-
Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein.
-
Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2.
-
Regulation of transcription factor NFAT by ADP-ribosylation.
-
Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis.
-
Regulator of G protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor.
-
Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice.
-
Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis.
-
Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity.
-
Regulatory T cell ablation causes acute T cell lymphopenia.
-
Regulatory T cells decrease invariant natural killer T cell-mediated pregnancy loss in mice.
-
Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis.
-
Relation of addiction genes to hypothalamic gene changes subserving genesis and gratification of a classic instinct, sodium appetite.
-
Relative contributions of rod and cone bipolar cell inputs to AII amacrine cell light responses in the mouse retina.
-
Relative contributions of selectins and intercellular adhesion molecule-1 to tissue injury induced by immune complex deposition.
-
Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery.
-
Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition.
-
Renal actions of RGS2 control blood pressure.
-
Renal function in the AT1A receptor knockout mouse during normal and volume-expanded conditions.
-
Renal growth and development in mice lacking AT1A receptors for angiotensin II.
-
Renal segmental microvascular responses to ANG II in AT1A receptor null mice.
-
Renal vascular reactivity in mice: AngII-induced vasoconstriction in AT1A receptor null mice.
-
Reperfusion injury in skeletal muscle is reduced in inducible nitric oxide synthase knockout mice.
-
Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor.
-
Requirement for Ca2+/calmodulin-dependent kinase type IV/Gr in setting the thymocyte selection threshold.
-
Requirements for T lymphocyte migration in explanted lymph nodes.
-
Rescue of Pompe disease in mice by AAV-mediated liver delivery of secretable acid α-glucosidase.
-
Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family.
-
Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels.
-
Resistance to hypertension mediated by intercalated cells of the collecting duct.
-
Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1.
-
Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions.
-
Restoring hemostatic thrombin generation at the time of cutaneous wounding does not normalize healing in hemophilia B.
-
Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia.
-
Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice.
-
Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways.
-
Resveratrol and endometrium: a closer look at an active ingredient of red wine using in vivo and in vitro models.
-
Retinal pigment epithelial cells induce foxp3(+) regulatory T cells via membrane-bound TGF-β.
-
Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis.
-
Retrovirus-elicited interleukin-12 and tumour necrosis factor-alpha as inducers of interferon-gamma-mediated pathology in mouse AIDS.
-
Review: Collectins link innate and adaptive immunity in allergic airway disease.
-
Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.
-
Robust adenoviral and adeno-associated viral gene transfer to the in vivo murine heart: application to study of phospholamban physiology.
-
Role for the target enzyme in deactivation of photoreceptor G protein in vivo.
-
Role for thromboxane receptors in angiotensin-II-induced hypertension.
-
Role of CCR5 in the pathogenesis of IL-13-induced inflammation and remodeling.
-
Role of Caspases and Gasdermin A during HSV-1 Infection in Mice.
-
Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease.
-
Role of EP(2) and EP(3) PGE(2) receptors in control of murine renal hemodynamics.
-
Role of Fn14 in acute alcoholic steatohepatitis in mice.
-
Role of LAT in the granule-mediated cytotoxicity of CD8 T cells.
-
Role of TRPV ion channels in sensory transduction of osmotic stimuli in mammals.
-
Role of Transient Receptor Potential Vanilloid 4 in Neutrophil Activation and Acute Lung Injury.
-
Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal.
-
Role of complement receptors 1 and 2 (CD35 and CD21), C3, C4, and C5 in survival by mice of Staphylococcus aureus bacteremia.
-
Role of estrogen receptor signaling required for endometriosis-like lesion establishment in a mouse model.
-
Role of interleukin-1beta in postoperative cognitive dysfunction.
-
Role of metabolic activation and the TRPA1 receptor in the sensory irritation response to styrene and naphthalene.
-
Role of microsomal prostaglandin E synthase 1 in the kidney.
-
Role of prostacyclin in the cardiovascular response to thromboxane A2.
-
Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity.
-
Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men.
-
Role of the endocannabinoid system in management of patients with type 2 diabetes mellitus and cardiovascular risk factors.
-
Role of transcription factor NFAT in glucose and insulin homeostasis.
-
Role of tumor suppressor TSC1 in regulating antigen-specific primary and memory CD8 T cell responses to bacterial infection.
-
Roles of estrogen in the formation of intracranial aneurysms in ovariectomized female mice.
-
Roles of organizer factors and BMP antagonism in mammalian forebrain establishment.
-
Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency.
-
Rpl13a small nucleolar RNAs regulate systemic glucose metabolism.
-
Ryk controls remapping of motor cortex during functional recovery after spinal cord injury.
-
S-Nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase
-
S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection.
-
SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells.
-
SEMA3A signaling controls layer-specific interneuron branching in the cerebellum.
-
SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons.
-
SIRT1 plays an important role in implantation and decidualization during mouse early pregnancy.
-
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.
-
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
-
SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.
-
SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.
-
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.
-
SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site.
-
SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model.
-
SMPDL3b modulates insulin receptor signaling in diabetic kidney disease.
-
SP-A preserves airway homeostasis during Mycoplasma pneumoniae infection in mice.
-
SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart.
-
STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection.
-
STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration.
-
STAT3-enhancing germline mutations contribute to tumor-extrinsic immune evasion.
-
STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib.
-
STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice.
-
STIM1-Ca2+ signaling in coronary sinus cardiomyocytes contributes to interatrial conduction.
-
STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.
-
SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease.
-
SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development.
-
SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice.
-
SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice.
-
Salmeterol enhances the cardiac response to gene therapy in Pompe disease.
-
Salmeterol with Liver Depot Gene Therapy Enhances the Skeletal Muscle Response in Murine Pompe Disease.
-
Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines.
-
Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity.
-
Satb1 Overexpression Drives Tumor-Promoting Activities in Cancer-Associated Dendritic Cells.
-
Scara5 is a ferritin receptor mediating non-transferrin iron delivery.
-
Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity.
-
Secondary allergic T cell responses are regulated by dendritic cell-derived thrombospondin-1 in the setting of allergic eye disease.
-
Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling.
-
Secreted osteopontin from CD4+ T cells limits acute graft-versus-host disease.
-
Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival.
-
Selective role for TRPV4 ion channels in visceral sensory pathways.
-
Self-assembled peptide nanofibers raising durable antibody responses against a malaria epitope.
-
Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic.
-
Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism.
-
Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels.
-
Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity.
-
Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes.
-
Serum cholesterol levels and tumor growth in a PTEN-null transgenic mouse model of prostate cancer.
-
Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins.
-
Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106.
-
Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background.
-
Sex-Specific Mechanisms of Resistance Vessel Endothelial Dysfunction Induced by Cardiometabolic Risk Factors.
-
Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9.
-
Signals from dying hepatocytes trigger growth of liver progenitors.
-
Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation.
-
Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site.
-
Sirtuin 5 is required for mouse survival in response to cardiac pressure overload.
-
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production.
-
Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis.
-
Skeletal muscle mass recovery from atrophy in IL-6 knockout mice.
-
Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin.
-
Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair.
-
Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice.
-
Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice.
-
Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction.
-
Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain.
-
Smoothelin-like 1 deletion enhances myogenic reactivity of mesenteric arteries with alterations in PKC and myosin phosphatase signaling.
-
Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase.
-
Sodium channels and mammalian sensory mechanotransduction.
-
Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney.
-
Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport.
-
Somatic Liver Knockout (SLiK): A Quick and Efficient Way to Generate Liver-Specific Knockout Mice Using Multiplex CRISPR/Cas9 Gene Editing.
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Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate.
-
Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination.
-
Sonic hedgehog is required for cardiac outflow tract and neural crest cell development.
-
Sour taste responses in mice lacking PKD channels.
-
Sox2 regulates cholinergic amacrine cell positioning and dendritic stratification in the retina.
-
Sox6 as a new modulator of renin expression in the kidney.
-
Spatial organization of bacterial flora in normal and inflamed intestine: a fluorescence in situ hybridization study in mice.
-
Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function.
-
Spermatogenesis and the regulation of Ca(2+)-calmodulin-dependent protein kinase IV localization are not dependent on calspermin.
-
Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4.
-
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease.
-
Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1.
-
Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine.
-
Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors.
-
Splenectomy and partial splenectomy improve hematopoietic stem cell engraftment in hypersplenic mice.
-
Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis.
-
Spontaneous Differentiation of T Follicular Helper Cells in LATY136F Mutant Mice.
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Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure-Lowering Effects of Latanoprost.
-
Stanniocalcin-1 is a Modifier of Oxygen-Induced Retinopathy Severity.
-
Starch Binding Domain-containing Protein 1 Plays a Dominant Role in Glycogen Transport to Lysosomes in Liver.
-
Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems.
-
Stbd1 is highly elevated in skeletal muscle of Pompe disease mice but suppression of its expression does not affect lysosomal glycogen accumulation.
-
Steroid hormones drive cancer development.
-
Steroidogenic factor 1 (SF-1) is essential for endocrine development and function.
-
Steroidogenic factor 1 (SF-1) is essential for ovarian development and function.
-
Steroidogenic factor 1 is the essential transcript of the mouse Ftz-F1 gene.
-
Steroidogenic factor 1 plays multiple roles in endocrine development and function.
-
Steroidogenic factor 1: an essential mediator of endocrine development.
-
Stimulating Type 1 Angiotensin Receptors on T Lymphocytes Attenuates Renal Fibrosis.
-
Stimulation of Respiratory Motor Output and Ventilation in a Murine Model of Pompe Disease by Ampakines.
-
Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension.
-
Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53.
-
Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival.
-
Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts.
-
Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones.
-
Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis.
-
Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors.
-
Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D₂ receptor agonists.
-
Studies on the adapter molecule LAT.
-
Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3).
-
Substance P receptor mediated maintenance of chronic inflammation in EAE.
-
Subtype specific estrogen receptor action protects against changes in MMP-2 activation in mouse retinal pigmented epithelial cells.
-
Sulfation of glycosaminoglycans depends on the catalytic activity of lithium-inhibited phosphatase BPNT2 in vitro.
-
Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia.
-
Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis.
-
Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization.
-
Suppression of aberrant choroidal neovascularization through activation of the aryl hydrocarbon receptor.
-
Surfactant protein A integrates activation signal strength to differentially modulate T cell proliferation.
-
Surfactant protein A modulates induction of regulatory T cells via TGF-β.
-
Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair.
-
Surfactant protein D facilitates Cryptococcus neoformans infection.
-
Surfactant protein D increases phagocytosis of hypocapsular Cryptococcus neoformans by murine macrophages and enhances fungal survival.
-
Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma.
-
Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis.
-
Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis.
-
Susceptibility to vascular neoplasms but no increased susceptibility to renal carcinogenesis in Vhl knockout mice.
-
Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis.
-
Synapsins differentially control dopamine and serotonin release.
-
Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance.
-
Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways.
-
Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment.
-
Syncoilin isoform organization and differential expression in murine striated muscle.
-
Syncoilin modulates peripherin filament networks and is necessary for large-calibre motor neurons.
-
Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.
-
Synergistic Efficacy from Gene Therapy with Coreceptor Blockade and a β2-Agonist in Murine Pompe Disease.
-
Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta.
-
Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass.
-
Systemic correction of the muscle disorder glycogen storage disease type II after hepatic targeting of a modified adenovirus vector encoding human acid-alpha-glucosidase.
-
Systems biology of vaccination for seasonal influenza in humans.
-
T cell engagement of cross-presenting microglia protects the brain from a nasal virus infection.
-
T-bet-dependent expression of osteopontin contributes to T cell polarization.
-
T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells.
-
TASK-1 and TASK-3 channels modulate pressure overload-induced cardiac remodeling and dysfunction.
-
TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Nonfunctioning Pituitary Adenomas in Mice.
-
TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation.
-
TERC is not a major gene in human neural tube defects.
-
TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures.
-
TGFβ/Smad3 signal pathway is not required for epidermal Langerhans cell development.
-
TLR adaptor MyD88 is essential for pathogen control during oral toxoplasma gondii infection but not adaptive immunity induced by a vaccine strain of the parasite.
-
TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk.
-
TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and neuroinflammation.
-
TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice.
-
TLR4 signaling attenuates ongoing allergic inflammation.
-
TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury.
-
TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation.
-
TNF is required for the induction but not the maintenance of compression-induced BME signals in murine tail vertebrae: limitations of anti-TNF therapy for degenerative disc disease.
-
TNF-α contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2.
-
TNF-α in T lymphocytes attenuates renal injury and fibrosis during nephrotoxic nephritis.
-
TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation.
-
TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis.
-
TRPA1 is a major oxidant sensor in murine airway sensory neurons.
-
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents.
-
TRPA1 mediates the noxious effects of natural sesquiterpene deterrents.
-
TRPC1 channels are critical for hypertrophic signaling in the heart.
-
TRPC6 enhances angiotensin II-induced albuminuria.
-
TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain.
-
TRPV1 receptors mediate particulate matter-induced apoptosis.
-
TRPV4 Is Required for Hypoxic Pulmonary Vasoconstriction.
-
TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension.
-
TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation.
-
TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells.
-
TRPV4 channels augment macrophage activation and ventilator-induced lung injury.
-
TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses.
-
TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs.
-
TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure.
-
TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation.
-
TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons.
-
TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice.
-
Targeted HAS2 Expression Lessens Airway Responsiveness in Chronic Murine Allergic Airway Disease.
-
Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance.
-
Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation.
-
Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice.
-
Targeted disruption of the estrogen receptor-alpha gene in female mice: characterization of ovarian responses and phenotype in the adult.
-
Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis.
-
Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting.
-
Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia.
-
Targeted gene disruption in endocrine research--the case of glucagon-like peptide-1 and neuroendocrine function.
-
Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function.
-
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development.
-
Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells.
-
Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle.
-
Targeted proteomic profiling of renal Na(+) transporter and channel abundances in angiotensin II type 1a receptor knockout mice.
-
Targeting CXCR4-dependent immunosuppressive Ly6Clow monocytes improves antiangiogenic therapy in colorectal cancer.
-
Targeting Endoglin-Expressing Regulatory T Cells in the Tumor Microenvironment Enhances the Effect of PD1 Checkpoint Inhibitor Immunotherapy.
-
Targeting High Mobility Group Box-1 (HMGB1) Promotes Cell Death in Myelodysplastic Syndrome.
-
Targeting PIM Kinase with PD1 Inhibition Improves Immunotherapeutic Antitumor T-cell Response.
-
Targeting VE-PTP phosphatase protects the kidney from diabetic injury.
-
Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.
-
Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease.
-
Targeting proximal tubule mitochondrial dysfunction attenuates the renal disease of methylmalonic acidemia.
-
Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms.
-
Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma.
-
Taste perception: how to make a gourmet mouse.
-
Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression.
-
Tau is essential to beta -amyloid-induced neurotoxicity.
-
Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.
-
Tau--an inhibitor of deacetylase HDAC6 function.
-
Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits.
-
Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub.
-
Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire.
-
Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney.
-
Temporal modulation of collective cell behavior controls vascular network topology.
-
Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy.
-
Tenascin knockout mice: barrels, boundary molecules, and glial scars.
-
Tenascin-C knockout mouse has no detectable tenascin-C protein.
-
Tetraspanin CD37 protects against the development of B cell lymphoma.
-
Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout mice.
-
Th1-Dependent Cryptococcus-Associated Immune Reconstitution Inflammatory Syndrome Model With Brain Damage.
-
Th17 Immunity in the Colon Is Controlled by Two Novel Subsets of Colon-Specific Mononuclear Phagocytes.
-
Thalamic relay of spontaneous retinal activity prior to vision.
-
The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia.
-
The Arp2/3 Complex Is Essential for Distinct Stages of Spine Synapse Maturation, Including Synapse Unsilencing.
-
The BMP antagonists Chordin and Noggin have essential but redundant roles in mouse mandibular outgrowth.
-
The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system.
-
The Cell-Intrinsic Circadian Clock Is Dispensable for Lymphocyte Differentiation and Function.
-
The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy.
-
The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.
-
The E2F1-3 transcription factors are essential for cellular proliferation.
-
The Enigma of CRB1 and CRB1 Retinopathies.
-
The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies.
-
The GARP Domain of the Rod CNG Channel's β1-Subunit Contains Distinct Sites for Outer Segment Targeting and Connecting to the Photoreceptor Disk Rim.
-
The GS Protein-coupled A2a Adenosine Receptor Controls T Cell Help in the Germinal Center.
-
The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia.
-
The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity.
-
The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment.
-
The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion.
-
The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages.
-
The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection.
-
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer.
-
The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.
-
The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis.
-
The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons.
-
The PD-1 Regulatory Axis Inhibits T Cell-Independent B Cell Memory Generation and Reactivation.
-
The Phagocyte Oxidase Controls Tolerance to Mycobacterium tuberculosis Infection.
-
The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis.
-
The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation.
-
The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections.
-
The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses.
-
The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.
-
The Role of Elevated Branched-Chain Amino Acids in the Effects of Vertical Sleeve Gastrectomy to Reduce Weight and Improve Glucose Regulation.
-
The Ubiquitin-Modifying Enzyme A20 Terminates C-Type Lectin Receptor Signals and Is a Suppressor of Host Defense against Systemic Fungal Infection.
-
The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling.
-
The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.
-
The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor.
-
The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety.
-
The anorectic effect of GLP-1 in rats is nutrient dependent.
-
The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel.
-
The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes.
-
The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages.
-
The autophagy gene ATG5 plays an essential role in B lymphocyte development.
-
The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development.
-
The bi-modal effects of estradiol on gonadotropin synthesis and secretion in female mice are dependent on estrogen receptor-alpha.
-
The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis.
-
The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice.
-
The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19.
-
The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival.
-
The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition.
-
The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons.
-
The capsaicin receptor participates in artificial sweetener aversion.
-
The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits.
-
The central effectors of cell death in the immune system.
-
The chromatin-binding protein Smyd1 restricts adult mammalian heart growth.
-
The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression.
-
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.
-
The contribution of type I interferon signaling to immunity induced by alphavirus replicon vaccines.
-
The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression.
-
The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding.
-
The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis.
-
The death-inducing activity of RIPK1 is regulated by the pH environment.
-
The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling.
-
The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals.
-
The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity.
-
The dopamine metabolite 3-methoxytyramine is a neuromodulator.
-
The double-stranded RNA-activated protein kinase mediates viral-induced encephalitis.
-
The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer.
-
The effect of inflammatory cell-derived MCP-1 loss on neuronal survival during chronic neuroinflammation.
-
The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis.
-
The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage.
-
The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens.
-
The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense.
-
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.
-
The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus.
-
The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation.
-
The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation.
-
The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.
-
The helix-loop-helix gene E2A is required for B cell formation.
-
The host defense peptide cathelicidin is required for NK cell-mediated suppression of tumor growth.
-
The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background.
-
The importance of LAT in the activation, homeostasis, and regulatory function of T cells.
-
The importance of the Erk pathway in the development of linker for activation of T cells-mediated autoimmunity.
-
The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB.
-
The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy.
-
The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB.
-
The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy.
-
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis.
-
The liver kinase B1 is a central regulator of T cell development, activation, and metabolism.
-
The long isoform of cellular FLIP is essential for T lymphocyte proliferation through an NF-kappaB-independent pathway.
-
The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy.
-
The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis.
-
The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice.
-
The lung is protected from spontaneous inflammation by autophagy in myeloid cells.
-
The m6A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis.
-
The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation.
-
The mammalian twisted gastrulation gene functions in foregut and craniofacial development.
-
The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via μ- and κ-opioid receptors.
-
The naturally occurring luteinizing hormone surge is diminished in mice lacking estrogen receptor Beta in the ovary.
-
The necroptosis adaptor RIPK3 promotes injury-induced cytokine expression and tissue repair.
-
The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus.
-
The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration.
-
The oral iron chelator deferiprone protects against systemic iron overload-induced retinal degeneration in hepcidin knockout mice.
-
The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation.
-
The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice.
-
The physiology of urinary concentration: an update.
-
The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18.
-
The posterior cricoarytenoid muscle is spared from MuRF1-mediated muscle atrophy in mice with acute lung injury.
-
The prolyl isomerase Pin1 modulates development of CD8+ cDC in mice.
-
The relationship between slow photoresponse recovery rate and temporal resolution of vision.
-
The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development.
-
The requirement of linker for activation of T cells in the primary and memory responses of CD8 T cells.
-
The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis.
-
The role of Meteorin-like in skeletal development and bone fracture healing.
-
The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes.
-
The role of Ras guanine nucleotide releasing protein 4 in Fc epsilonRI-mediated signaling, mast cell function, and T cell development.
-
The role of Smad3 in mediating mouse hepatic stellate cell activation.
-
The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice.
-
The role of complement dysregulation in AMD mouse models.
-
The role of diacylglycerol kinase ζ and phosphatidic acid in the mechanical activation of mammalian target of rapamycin (mTOR) signaling and skeletal muscle hypertrophy.
-
The role of hyaluronan degradation products as innate alloimmune agonists.
-
The role of the LAT-PLC-gamma1 interaction in T regulatory cell function.
-
The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury.
-
The role of the forkhead transcription factor, Foxc1, in the development of the mouse lacrimal gland.
-
The role of the macrophage scavenger receptor in immune stimulation by bacterial DNA and synthetic oligonucleotides.
-
The role of the transcription factor ETV5 in insulin exocytosis.
-
The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets.
-
The role of β cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs.
-
The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome.
-
The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches.
-
The roles of steroidogenic factor-1 in reproductive function.
-
The scaffold-dependent function of RIPK1 in dendritic cells promotes injury-induced colitis.
-
The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment.
-
The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells.
-
The transcription factor interferon regulatory factor-1 mediates liver damage during ischemia-reperfusion injury.
-
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment.
-
The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression.
-
The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction.
-
The tyrosine receptor kinase B ligand, neurotrophin-4, is not required for either epileptogenesis or tyrosine receptor kinase B activation in the kindling model.
-
The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.
-
The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination.
-
The upstream enhancer elements of the G6PC promoter are critical for optimal G6PC expression in murine glycogen storage disease type Ia.
-
The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression.
-
The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility.
-
Therapeutic Benefit of Autophagy Modulation in Pompe Disease.
-
Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome.
-
Three-dimensional tissue-engineered human skeletal muscle model of Pompe disease.
-
Thrittene, homologous with somatostatin-28((1-13)), is a novel peptide in mammalian gut and circulation.
-
Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes.
-
Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia.
-
Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke.
-
Thromboxane A2 induces airway constriction through an M3 muscarinic acetylcholine receptor-dependent mechanism.
-
Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection.
-
Thromboxane receptor signalling in renal ischemia reperfusion injury.
-
Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death.
-
Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development.
-
Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.
-
Thyroid hormone action at the cellular, genomic and target gene levels.
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Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function.
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Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function.
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Tight regulation of diacylglycerol-mediated signaling is critical for proper invariant NKT cell development.
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Time-restricted feeding mitigates obesity through adipocyte thermogenesis.
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Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist.
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Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice.
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Tissue-specific and nutrient regulation of the branched-chain α-keto acid dehydrogenase phosphatase, protein phosphatase 2Cm (PP2Cm).
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Tissue-specific inactivation of murine M6P/IGF2R.
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Toll-like receptor 2-dependent and -independent activation of macrophages by group B streptococci.
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Toll-like receptor 4 contributes to chronic itch, alloknesis, and spinal astrocyte activation in male mice.
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Toll-like receptor 4 deficiency causes pulmonary emphysema.
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Toll-like receptor 7 mediates pruritus.
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Tollip SNP rs5743899 modulates human airway epithelial responses to rhinovirus infection.
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Topographic specificity within membranes of a single muscle detected in vitro.
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Toward a mouse model of diabetic nephropathy: is endothelial nitric oxide synthase the missing link?
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Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Orchestrate Chronic Infection and GRA12 Underpins Resistance to Host Gamma Interferon.
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Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney Development.
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Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression.
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Transcription factor short stature homeobox 2 is required for proper development of tropomyosin-related kinase B-expressing mechanosensory neurons.
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Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation.
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Transcriptional control of preadipocyte determination by Zfp423.
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Transcriptional regulation of the mouse presenilin-1 gene.
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Transducin gamma-subunit sets expression levels of alpha- and beta-subunits and is crucial for rod viability.
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Transducin translocation in rods is triggered by saturation of the GTPase-activating complex.
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Transducin β-Subunit Can Interact with Multiple G-Protein γ-Subunits to Enable Light Detection by Rod Photoreceptors.
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Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element.
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Transgelin-2 as a therapeutic target for asthmatic pulmonary resistance.
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Transgenic animals in integrative biology: approaches and interpretations of outcome.
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Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype.
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Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol.
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Transient Receptor Potential Vanilloid 4 Channel Deficiency Aggravates Tubular Damage after Acute Renal Ischaemia Reperfusion.
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Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch.
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Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism.
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Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice.
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Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission.
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Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia.
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Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury.
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Transient receptor potential vanilloid channels functioning in transduction of osmotic stimuli.
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Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms.
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Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire.
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Treatment with a laminin-derived peptide suppresses lupus nephritis.
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Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease.
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Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli.
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Troponin T3 expression in skeletal and smooth muscle is required for growth and postnatal survival: characterization of Tnnt3(tm2a(KOMP)Wtsi) mice.
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Tuberous sclerosis 1 promotes invariant NKT cell anergy and inhibits invariant NKT cell-mediated antitumor immunity.
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Tumor Subtype Determines Therapeutic Response to Chimeric Polypeptide Nanoparticle-based Chemotherapy in Pten-deleted Mouse Models of Sarcoma.
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Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline.
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Tumor necrosis factor-α produced in the kidney contributes to angiotensin II-dependent hypertension.
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Tumor suppressor TSC1 is critical for T-cell anergy.
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Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma.
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Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning.
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Twist1 in T Lymphocytes Augments Kidney Fibrosis after Ureteral Obstruction.
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Type 1 Angiotensin Receptors on CD11c-Expressing Cells Protect Against Hypertension by Regulating Dendritic Cell-Mediated T Cell Activation.
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Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis.
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Type I IFN Receptor Signaling on B Cells Promotes Antibody Responses to Polysaccharide Antigens.
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Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury.
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Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage.
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Tyrosine phosphorylation-independent regulation of lipopolysaccharide-mediated response by the transmembrane adaptor protein LAB.
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U1 RNA induces innate immunity signaling.
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U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia.
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UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis.
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USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis.
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UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent manner.
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Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion.
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Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins.
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Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation.
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Ubiquitination of Innate Immune Regulator TRAF3 Orchestrates Expulsion of Intracellular Bacteria by Exocyst Complex.
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Ubiquitination regulates the neuroprotective function of the deubiquitinase ataxin-3 in vivo.
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Ultrastructural abnormalities in CA1 hippocampus caused by deletion of the actin regulator WAVE-1.
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Ultraviolet light exposure suppresses contact hypersensitivity by abrogating endothelial intercellular adhesion molecule-1 up-regulation at the elicitation site.
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Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).
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Understanding the mechanism of bias signaling of the insulin-like growth factor 1 receptor: Effects of LL37 and HASF.
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Unexpected anti-alpha GalNAc antibodies in alpha-galactosyl transferase-deficient mice: complex relationship between genotype and the natural antibody repertoire.
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Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation.
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Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells.
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Unmasking Proteolytic Activity for Adult Visual Cortex Plasticity by the Removal of Lynx1.
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Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy.
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Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension.
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Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons.
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Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion.
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Urinary concentrating function in mice lacking EP3receptors for prostaglandin E2.
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Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice.
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Use of genetically modified mouse models for evaluation of carcinogenic risk: considerations for the laboratory animal scientist.
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VEGF inhibition and renal thrombotic microangiopathy.
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VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch.
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Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages.
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Variable Extent of Lineage-Specificity and Developmental Stage-Specificity of Cohesin and CCCTC-Binding Factor Binding Within the Immunoglobulin and T Cell Receptor Loci.
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Variation in interferon sensitivity and induction among strains of eastern equine encephalitis virus.
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Vascular Endothelial Growth Factor Receptor 3 Regulates Endothelial Function Through β-Arrestin 1.
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Vascular control of kidney epithelial transporters.
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Vascular endothelial growth factor signaling is necessary for expansion of medullary microvessels during postnatal kidney development.
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Vascular morphogenesis: tales of two syndromes.
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Vasoconstrictor responses in thromboxane receptor knockout mice: tubuloglomerular feedback and ureteral obstruction.
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Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB.
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Vesicular zinc promotes presynaptic and inhibits postsynaptic long-term potentiation of mossy fiber-CA3 synapse.
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Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling.
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Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo.
-
Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation.
-
WNK1 regulates uterine homeostasis and its ability to support pregnancy.
-
WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory.
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Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity.
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What can knockout mice contribute to an understanding of hypertension?
-
What's new and what's next for gene therapy in Pompe disease?
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Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations.
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Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells.
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Wound healing in haemophilia--breaking the vicious cycle.
-
XIAP regulates cytosol-specific innate immunity to Listeria infection.
-
Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53.
-
Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis.
-
ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation.
-
Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program.
-
Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse.
-
[Degeneration of growth cones in a culture of embryonic neurons of mouse with presenilin 1 gene knockout].
-
[Potential role of presenilin 1 in regulation of synaptic function].
-
beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation.
-
beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking.
-
beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.
-
beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.
-
beta-Catenin protects the epidermis from mechanical stresses.
-
beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.
-
beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics.
-
c-FLIP protects T lymphocytes from apoptosis in the intrinsic pathway.
-
cAMP-Response Element-Binding 3-Like Protein 1 (CREB3L1) is Required for Decidualization and its Expression is Decreased in Women with Endometriosis.
-
cFLIP regulates skin homeostasis and protects against TNF-induced keratinocyte apoptosis.
-
gammadelta T cells are a component of early immunity against preerythrocytic malaria parasites.
-
iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.
-
mTOR Activation Initiates Renal Cell Carcinoma Development by Coordinating ERK and p38MAPK.
-
mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis.
-
mTOR is critical for intestinal T-cell homeostasis and resistance to Citrobacter rodentium.
-
mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice.
-
mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development.
-
meaRtools: An R package for the analysis of neuronal networks recorded on microelectrode arrays.
-
miR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammation.
-
miR-21 depletion in macrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy.
-
miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis.
-
miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus.
-
microRNA-142 guards against autoimmunity by controlling Treg cell homeostasis and function.
-
p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes.
-
p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia.
-
p38 Mitogen-activated protein kinase regulates chamber-specific perinatal growth in heart.
-
p38α MAPK Regulates Lineage Commitment and OPG Synthesis of Bone Marrow Stromal Cells to Prevent Bone Loss under Physiological and Pathological Conditions.
-
p38γ activity is required for maintenance of slow skeletal muscle size.
-
p53-dependent control of transactivation of the Pen2 promoter by presenilins.
-
p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.
-
ΔN-TRPV1: A Molecular Co-detector of Body Temperature and Osmotic Stress.
-
α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin.
-
α7-Nicotinic receptors and cognition.
-
α7-cholinergic receptor mediates vagal induction of splenic norepinephrine.
-
αB-crystallin: a novel regulator of breast cancer metastasis to the brain.
-
β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility.
-
β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel.
-
β-Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway.
-
β-Arrestin-2-Dependent Signaling Promotes CCR4-mediated Chemotaxis of Murine T-Helper Type 2 Cells.
-
β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury.
-
β-Arrestin2 mediates progression of murine primary myelofibrosis.
-
β-Arrestin2 mediates the initiation and progression of myeloid leukemia.
-
β-Catenin modulation in neurofibromatosis type 1 bone repair: therapeutic implications.
-
β-Catenin-regulated myeloid cell adhesion and migration determine wound healing.
-
β-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation.
-
β-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice.
-
β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.
-
β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix.
-
β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain.
-
β-arrestin1-biased β1-adrenergic receptor signaling regulates microRNA processing.
-
β1-integrin-matrix interactions modulate cerebral microvessel endothelial cell tight junction expression and permeability.
-
β2-Adrenoceptor agonists are required for development of the asthma phenotype in a murine model.
-
β2-Adrenoreceptors of regulatory lymphocytes are essential for vagal neuromodulation of the innate immune system.
-
βII-spectrin promotes mouse brain connectivity through stabilizing axonal plasma membranes and enabling axonal organelle transport.
-
κ-Opioid receptors in the central amygdala regulate ethanol actions at presynaptic GABAergic sites.
-
Keywords of People
-
-
Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
-
Bowes Rickman, Catherine,
George and Geneva Boguslavsky Distinguished Professor of Eye Research,
Cell Biology
-
Calakos, Nicole,
Lincoln Financial Group Distinguished Professor of Neurobiology,
Duke Science & Society
-
Chen, Jun,
Professor of Medicine,
Duke Cancer Institute
-
Choi, Steven Sok,
Associate Professor of Medicine,
Medicine, Gastroenterology
-
Cianciolo, George James,
Associate Professor Emeritus of Pathology,
Pathology
-
Ciofani, Maria,
Associate Professor of Immunology,
Cell Biology
-
Erickson, Harold Paul,
Professor Emeritus of Cell Biology,
Cell Biology
-
Farsiu, Sina,
Professor in the Department of Biomedical Engineering,
Electrical and Computer Engineering
-
Freemark, Michael Scott,
Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine,
Pediatrics, Endocrinology
-
Gunn, Michael Dee,
Professor of Medicine,
Immunology
-
Hirschey, Matthew,
Associate Professor of Medicine,
Cell Biology
-
Hogan, Brigid L. M.,
Research Professor of Cell Biology,
Cell Biology
-
Johnson, G. Allan,
Charles E. Putman University Distinguished Professor of Radiology,
Biomedical Engineering
-
Kelsoe, Garnett H.,
James B. Duke Distinguished Professor of Immunology,
Immunology
-
Krangel, Michael S.,
George Barth Geller Distinguished Professor of Immunology,
Immunology
-
Laskowitz, Daniel Todd,
Professor of Neurology,
Duke Science & Society
-
McDonnell, Donald Patrick,
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine,
Cell Biology
-
McLendon, Roger Edwin,
Professor of Pathology,
Pathology
-
Nicolelis, Miguel Angelo L.,
Duke School of Medicine Distinguished Professor in Neuroscience,
Neurobiology
-
Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology
-
Schmehl, Meredith,
Student,
Neurobiology
-
Shinohara, Mari L.,
Associate Professor of Immunology,
Cell Biology
-
Soderling, Scott Haydn,
George Barth Geller Distinguished Professor of Molecular Biology,
Cell Biology
-
Sparks, Matthew A.,
Associate Professor of Medicine,
Medicine, Nephrology
-
Sunday, Mary Elizabeth Anne,
Professor of Pathology,
Cell Biology
-
Taylor, Gregory Alan,
Professor in Medicine,
Immunology
-
Zhong, Xiaoping,
Professor of Pediatrics,
Immunology