Mice, Knockout

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  Subject Areas on Research

  • "Model" behavior. 
  • 4D MRI of polycystic kidneys from rapamycin-treated Glis3-deficient mice. 
  • 5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals. 
  • A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice. 
  • A CRISPR-Cas system enhances envelope integrity mediating antibiotic resistance and inflammasome evasion. 
  • A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice. 
  • A Knock-In Tristetraprolin (TTP) Zinc Finger Point Mutation in Mice: Comparison with Complete TTP Deficiency. 
  • A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia. 
  • A RIPK3-caspase 8 complex mediates atypical pro-IL-1β processing. 
  • A Role for Protease Activated Receptor Type 3 (PAR3) in Nociception Demonstrated Through Development of a Novel Peptide Agonist. 
  • A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome. 
  • A TRPA1-dependent mechanism for the pungent sensation of weak acids. 
  • A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory. 
  • A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels. 
  • A barrier-type insulator forms a boundary between active and inactive chromatin at the murine TCRβ locus. 
  • A beta-arrestin 2 signaling complex mediates lithium action on behavior. 
  • A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. 
  • A beta-blocker, propranolol, decreases the efficacy from enzyme replacement therapy in Pompe disease. 
  • A c-Myc and surface CD19 signaling amplification loop promotes B cell lymphoma development and progression in mice. 
  • A cell-intrinsic role for Mst1 in regulating thymocyte egress. 
  • A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. 
  • A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development. 
  • A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation. 
  • A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. 
  • A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability. 
  • A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism. 
  • A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation. 
  • A critical role for the autophagy gene Atg5 in T cell survival and proliferation. 
  • A crucial role of L-selectin in C protein-induced experimental polymyositis in mice. 
  • A cytokine cocktail directly modulates the phenotype of DC-enriched anti-tumor T cells to convey potent anti-tumor activities in a murine model. 
  • A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells. 
  • A functional genomics predictive network model identifies regulators of inflammatory bowel disease. 
  • A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo. 
  • A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25. 
  • A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier. 
  • A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections. 
  • A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics. 
  • A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection. 
  • A major role for the EP4 receptor in regulation of renin. 
  • A mechanism-based antioxidant approach for the reduction of skin carcinogenesis. 
  • A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors. 
  • A mouse model of adult-onset anaemia due to erythropoietin deficiency. 
  • A murine model of hyperdopaminergic state displays altered respiratory control. 
  • A new activating role for CO in cardiac mitochondrial biogenesis. 
  • A new model of Epstein-Barr virus infection reveals an important role for early lytic viral protein expression in the development of lymphomas. 
  • A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. 
  • A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. 
  • A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis. 
  • A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension. 
  • A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair. 
  • A protective Hsp70-TLR4 pathway in lethal oxidant lung injury. 
  • A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. 
  • A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation. 
  • A role for E2F activities in determining the fate of Myc-induced lymphomagenesis. 
  • A role for MAPK in feedback inhibition of Tcrb recombination. 
  • A role for TREK1 in generating the slow afterhyperpolarization in developing starburst amacrine cells. 
  • A role for angiotensin II type 1 receptors on bone marrow-derived cells in the pathogenesis of angiotensin II-dependent hypertension. 
  • A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes. 
  • A role for cFLIP in B cell proliferation and stress MAPK regulation. 
  • A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth. 
  • A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation. 
  • A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. 
  • A role of matrix metalloproteinase-8 in atherosclerosis. 
  • A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. 
  • A shared vision. 
  • A spatially and temporally restricted mouse model of soft tissue sarcoma. 
  • A tenascin knockout with a phenotype. 
  • A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis. 
  • A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy. 
  • A two-phase innate host response to alphavirus infection identified by mRNP-tagging in vivo. 
  • A validated regulatory network for Th17 cell specification. 
  • A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation. 
  • A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression. 
  • AAV vector-mediated reversal of hypoglycemia in canine and murine glycogen storage disease type Ia. 
  • AAV9 Edits Muscle Stem Cells in Normal and Dystrophic Adult Mice. 
  • AAV9 gene replacement therapy for respiratory insufficiency in very-long chain acyl-CoA dehydrogenase deficiency. 
  • ABCB5 is a limbal stem cell gene required for corneal development and repair. 
  • ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory. 
  • ACE and ACE2 activity in diabetic mice. 
  • ADAM10 is essential for proteolytic activation of Notch during thymocyte development. 
  • ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression. 
  • ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration. 
  • AMH induces mesonephric cell migration in XX gonads. 
  • ANGPTL3 Deficiency and Protection Against Coronary Artery Disease. 
  • APOE genotype-specific differences in human and mouse macrophage nitric oxide production. 
  • APOE genotype-specific differences in the innate immune response. 
  • AT2 receptor and vascular smooth muscle cell differentiation in vascular development. 
  • ATM functions at the peroxisome to induce pexophagy in response to ROS. 
  • ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. 
  • Aberrant production of IL-13 by T cells promotes exocrinopathy in Id3 knockout mice. 
  • Aberrant responses in social interaction of dopamine transporter knockout mice. 
  • Abi3bp is a multifunctional autocrine/paracrine factor that regulates mesenchymal stem cell biology. 
  • Abi3bp regulates cardiac progenitor cell proliferation and differentiation. 
  • Abl family kinases regulate endothelial barrier function in vitro and in mice. 
  • Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway. 
  • Abl tyrosine kinases are required for infection by Shigella flexneri. 
  • Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin. 
  • Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload. 
  • Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo. 
  • Abnormal cardiac Na(+) channel properties and QT heart rate adaptation in neonatal ankyrin(B) knockout mice. 
  • Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease. 
  • Abnormal iron deposition in renal cells in the rat with chronic angiotensin II administration. 
  • Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after hemarthrosis. 
  • Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema. 
  • Abrogation of adenosine A1 receptor signalling improves metabolic regulation in mice by modulating oxidative stress and inflammatory responses. 
  • Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract. 
  • Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits. 
  • Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse. 
  • Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. 
  • Absence of tubuloglomerular feedback responses in AT1A receptor-deficient mice. 
  • Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. 
  • Accessory subunit KChIP2 modulates the cardiac L-type calcium current. 
  • Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity. 
  • Acquisition of response thresholds for timed performance is regulated by a calcium-responsive transcription factor, CaRF. 
  • Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy. 
  • Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice. 
  • Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells. 
  • Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside. 
  • Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation. 
  • Activation of toll-like receptor 4 is necessary for trauma hemorrhagic shock-induced gut injury and polymorphonuclear neutrophil priming. 
  • Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome. 
  • Activation-induced cytidine deaminase mediates central tolerance in B cells. 
  • Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain. 
  • Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9. 
  • Adam10 is essential for early embryonic cardiovascular development. 
  • Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism. 
  • Adaptive mechanisms that preserve cardiac function in mice without myoglobin. 
  • Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid hormone. 
  • Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo. 
  • Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo. 
  • Adenylate cyclase 7 is implicated in the biology of depression and modulation of affective neural circuitry. 
  • Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner. 
  • Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis. 
  • Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. 
  • Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance. 
  • Adjunctive β2-agonist treatment reduces glycogen independently of receptor-mediated acid α-glucosidase uptake in the limb muscles of mice with Pompe disease. 
  • Adjunctive β2-agonists reverse neuromuscular involvement in murine Pompe disease. 
  • Adoptively transferred ex vivo expanded gammadelta-T cells mediate in vivo antitumor activity in preclinical mouse models of breast cancer. 
  • Adrenoceptors, uncoupling proteins, and energy expenditure. 
  • Advanced glycation end-product of low density lipoprotein activates the toll-like 4 receptor pathway implications for diabetic atherosclerosis. 
  • Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice. 
  • Age-related changes in the cellular composition and epithelial organization of the mouse trachea. 
  • Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration. 
  • Aging enhances the basal production of IL-6 and CCL2 in vascular smooth muscle cells. 
  • Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies. 
  • Airway smooth muscle relaxation is impaired in mice lacking the p47phox subunit of NAD(P)H oxidase. 
  • Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism. 
  • Akt1 and Akt2 promote peripheral B-cell maturation and survival. 
  • Akt1 deletion prevents lung tumorigenesis by mutant K-ras. 
  • Aldosterone, ion channels, and sudden death: another piece of the circle? 
  • Aldosterone-Induced Vascular Remodeling and Endothelial Dysfunction Require Functional Angiotensin Type 1a Receptors. 
  • Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors. 
  • Aligning animal models with clinical epilepsy: where to begin? 
  • Allele-specific regulation of TCR beta variable gene segment chromatin structure. 
  • Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl. 
  • Allergic lung responses are increased in prostaglandin H synthase-deficient mice. 
  • Allogeneic splenocyte transfer and lipopolysaccharide inhalations induce differential T cell expansion and lung injury: a novel model of pulmonary graft-versus-host disease. 
  • Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism. 
  • Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance. 
  • Altered Mitochondrial Homeostasis during Systemic Lupus Erythematosus Impairs Neutrophil Extracellular Trap Formation Rendering Neutrophils Ineffective at Combating Staphylococcus aureus. 
  • Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes. 
  • Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. 
  • Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3. 
  • Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. 
  • Altered immune responses in apolipoprotein E-deficient mice. 
  • Altered inflammatory responses in leukotriene-deficient mice. 
  • Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism. 
  • Altered morphology of hippocampal dentate granule cell presynaptic and postsynaptic terminals following conditional deletion of TrkB. 
  • Altered regulation of brain-derived neurotrophic factor protein in hippocampus following slice preparation. 
  • Altered trabecular bone structure and delayed cartilage degeneration in the knees of collagen VI null mice. 
  • Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. 
  • Altered wound healing in mice lacking a functional osteopontin gene (spp1). 
  • Alveolar proteinosis: a disease of mice and men. 
  • Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors. 
  • An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. 
  • An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments. 
  • An Endothelial Hsp70-TLR4 Axis Limits Nox3 Expression and Protects Against Oxidant Injury in Lungs. 
  • An Engineered Metal Sensor Tunes the Kinetics of Synaptic Transmission. 
  • An FGF-WNT gene regulatory network controls lung mesenchyme development. 
  • An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis. 
  • An IL-9-pulmonary macrophage axis defines the allergic lung inflammatory environment. 
  • An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation. 
  • An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer. 
  • An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cells. 
  • An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development. 
  • An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. 
  • An engineered vascular endothelial growth factor-activating transcription factor induces therapeutic angiogenesis in ApoE knockout mice with hindlimb ischemia. 
  • An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis. 
  • An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. 
  • An essential role for c-FLIP in the efficient development of mature T lymphocytes. 
  • An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation. 
  • An interferon-β-resistant and NLRP3 inflammasome-independent subtype of EAE with neuronal damage. 
  • An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells. 
  • Analysis of human innate immune responses to PRINT fabricated nanoparticles with cross validation using a humanized mouse model. 
  • Analysis of the role of E2A-encoded proteins in insulin gene transcription. 
  • Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch. 
  • Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity. 
  • Angiopoietin-1 is required for Schlemm's canal development in mice and humans. 
  • Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes. 
  • Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide. 
  • Angiotensin 1-7 reduces mortality and rupture of intracranial aneurysms in mice. 
  • Angiotensin AT1B receptor mediates calcium signaling in vascular smooth muscle cells of AT1A receptor-deficient mice. 
  • Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. 
  • Angiotensin II mobilizes spleen monocytes to promote the development of abdominal aortic aneurysm in Apoe-/- mice. 
  • Angiotensin II promotes development of the renal microcirculation through AT1 receptors. 
  • Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation. 
  • Angiotensin II stimulates canonical TGF-β signaling pathway through angiotensin type 1 receptor to induce granulation tissue contraction. 
  • Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells. 
  • Angiotensin II: an immune costimulator? 
  • Angiotensin receptors in the kidney and vasculature in hypertension and kidney disease. 
  • Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages. 
  • Angiotensinogen gene null-mutant mice lack homeostatic regulation of glomerular filtration and tubular reabsorption. 
  • Animal models in the research of abdominal aortic aneurysms development. 
  • Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory. 
  • Ank3-dependent SVZ niche assembly is required for the continued production of new neurons. 
  • Ankyrin-B directs membrane tethering of periaxin and is required for maintenance of lens fiber cell hexagonal shape and mechanics. 
  • Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. 
  • Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth. 
  • AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing. 
  • AnkyrinG is required to maintain axo-dendritic polarity in vivo. 
  • Ankyrins. 
  • Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis. 
  • Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia. 
  • Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration. 
  • Antibody formation and mannose-6-phosphate receptor expression impact the efficacy of muscle-specific transgene expression in murine Pompe disease. 
  • Antibody is critical for the clearance of murine norovirus infection. 
  • Antibody-mediated enzyme replacement therapy targeting both lysosomal and cytoplasmic glycogen in Pompe disease. 
  • Antigen-loaded monocyte administration induces potent therapeutic antitumor T cell responses. 
  • Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor. 
  • Anxiety-like behaviors in mice lacking GIT2. 
  • Apical CLC-2 in retinal pigment epithelium is crucial for survival of the outer retina. 
  • ApoB-48 and apoB-100 differentially influence the expression of type-III hyperlipoproteinemia in APOE*2 mice. 
  • ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-beta1-42. 
  • ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. 
  • ApoER2 function in the establishment and maintenance of retinal synaptic connectivity. 
  • Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis. 
  • Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade. 
  • Apolipoprotein E deficiency worsens outcome from global cerebral ischemia in the mouse. 
  • Apolipoprotein E expression and behavioral toxicity of high charge, high energy (HZE) particle radiation. 
  • Apolipoprotein E isoform mediated regulation of nitric oxide release. 
  • Apolipoprotein E modifies the CNS response to injury via a histamine-mediated pathway. 
  • Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice. 
  • Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner. 
  • Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes. 
  • Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity. 
  • Apoptotic Debris Accumulates on Hematopoietic Cells and Promotes Disease in Murine and Human Systemic Lupus Erythematosus. 
  • Aquaporin 9 is the major pathway for glycerol uptake by mouse erythrocytes, with implications for malarial virulence. 
  • Aquaporin-4-dependent glymphatic solute transport in the rodent brain. 
  • Arfgef1 haploinsufficiency in mice alters neuronal endosome composition and decreases membrane surface postsynaptic GABAA receptors. 
  • Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. 
  • Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsin. 
  • Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling. 
  • Arterial response to shear stress critically depends on endothelial TRPV4 expression. 
  • Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology. 
  • Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways. 
  • Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. 
  • Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. 
  • Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. 
  • Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis. 
  • Atomic description of the immune complex involved in heparin-induced thrombocytopenia. 
  • Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. 
  • Attenuation of acid induced oesophagitis in VR-1 deficient mice. 
  • Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice. 
  • Augmented Responses to Ozone in Obese Mice Require IL-17A and Gastrin-Releasing Peptide. 
  • Autocrine Complement Inhibits IL10-Dependent T-cell-Mediated Antitumor Immunity to Promote Tumor Progression. 
  • Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. 
  • Autophagy is redundant for the host defense against systemic Candida albicans infections. 
  • Autophagy links inflammasomes to atherosclerotic progression. 
  • Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. 
  • Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder. 
  • Axin2 regulates chondrocyte maturation and axial skeletal development. 
  • Axonal Odorant Receptors Mediate Axon Targeting. 
  • Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system. 
  • B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation. 
  • B cell depletion reduces the development of atherosclerosis in mice. 
  • B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. 
  • B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. 
  • B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions. 
  • B-lymphocyte depletion ameliorates Sjögren's syndrome in Id3 knockout mice. 
  • B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis. 
  • B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. 
  • BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells. 
  • BCL2 inhibits cell adhesion, spreading, and motility by enhancing actin polymerization. 
  • BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV. 
  • BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia. 
  • BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium. 
  • BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. 
  • Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms. 
  • Balance of Irgm protein activities determines IFN-gamma-induced host defense. 
  • Bcl-xL is an oncogenic driver in colorectal cancer. 
  • Behavioral characterization of P311 knockout mice. 
  • Behavioral responses to social stress in noradrenaline transporter knockout mice: effects on social behavior and depression. 
  • Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. 
  • Beta-adrenergic axis and heart disease. 
  • Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. 
  • Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis. 
  • Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration. 
  • Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle. 
  • Beta-caryophyllene enhances wound healing through multiple routes. 
  • Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing. 
  • Beta1-adrenergic receptors maintain fetal heart rate and survival. 
  • Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction. 
  • Bezafibrate induces autophagy and improves hepatic lipid metabolism in glycogen storage disease type Ia. 
  • Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes. 
  • Biochemical and immunological abnormalities in purine nucleoside phosphorylase deficient mice. 
  • Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene. 
  • Blocking CCR7 at the ocular surface impairs the pathogenic contribution of dendritic cells in allergic conjunctivitis. 
  • Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration. 
  • Blood pressure homeostasis is maintained by a P311-TGF-β axis. 
  • Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. 
  • Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses. 
  • Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. 
  • Bmp4 is required for the generation of primordial germ cells in the mouse embryo. 
  • Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration. 
  • Body weight and fat deposition in prolactin receptor-deficient mice. 
  • Bombesin inhibits alveolarization and promotes pulmonary fibrosis in newborn mice. 
  • Bone marrow chimeras and c-fms conditional ablation (Mafia) mice reveal an essential role for resident myeloid cells in lipopolysaccharide/TLR4-induced corneal inflammation. 
  • Bone marrow dendritic cell-mediated regulation of TLR and B cell receptor signaling in B cells. 
  • Bone marrow transplantation augments the effect of brain- and spinal cord-directed adeno-associated virus 2/5 gene therapy by altering inflammation in the murine model of globoid-cell leukodystrophy. 
  • Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter. 
  • Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. 
  • Both Hematopoietic- and Non-hematopoietic-derived {beta}-arrestin-2 Regulates Murine Allergic Airway Disease. 
  • Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission. 
  • Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors. 
  • Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight. 
  • Bronchus-associated lymphoid tissue-resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection. 
  • C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration. 
  • C-C Motif Chemokine Receptor 7 Exacerbates Hypertension Through Effects on T Lymphocyte Trafficking. 
  • C-myc-induced apoptosis in polycystic kidney disease is Bcl-2 and p53 independent. 
  • CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice. 
  • CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice. 
  • CCR2 deficiency, dysregulation of Notch signaling, and spontaneous pulmonary arterial hypertension. 
  • CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality. 
  • CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. 
  • CD19 can regulate B lymphocyte signal transduction independent of complement activation. 
  • CD19 expression in B cells is important for suppression of contact hypersensitivity. 
  • CD19 expression in B cells regulates atopic dermatitis in a mouse model. 
  • CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19. 
  • CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes. 
  • CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma. 
  • CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction. 
  • CD19-specific CAR T Cells that Express a PD-1/CD28 Chimeric Switch-Receptor are Effective in Patients with PD-L1-positive B-Cell Lymphoma. 
  • CD21/35 promotes protective immunity to Streptococcus pneumoniae through a complement-independent but CD19-dependent pathway that regulates PD-1 expression. 
  • CD22 and CD72 cooperatively contribute to the development of the reverse Arthus reaction model. 
  • CD22 expression mediates the regulatory functions of peritoneal B-1a cells during the remission phase of contact hypersensitivity reactions. 
  • CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux. 
  • CD22 serves as a receptor for soluble IgM. 
  • CD28 is required for germinal center formation. 
  • CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin. 
  • CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. 
  • CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis. 
  • CD83 expression influences CD4+ T cell development in the thymus. 
  • CD83 expression is a sensitive marker of activation required for B cell and CD4+ T cell longevity in vivo. 
  • CD86 (B7-2) can function to drive MHC-restricted antigen-specific CTL responses in vivo. 
  • CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression. 
  • CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. 
  • CLN3p impacts galactosylceramide transport, raft morphology, and lipid content. 
  • CNS myelin wrapping is driven by actin disassembly. 
  • CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes. 
  • CX3CR1 deficiency impairs dendritic cell accumulation in arterial intima and reduces atherosclerotic burden. 
  • CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5. 
  • CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis. 
  • Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium. 
  • CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer. 
  • Calcium/Calmodulin Dependent Protein Kinase Kinase 2 Regulates the Expansion of Tumor-Induced Myeloid-Derived Suppressor Cells. 
  • Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration. 
  • Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells. 
  • Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance. 
  • Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. 
  • Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway. 
  • Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice. 
  • Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs. 
  • Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. 
  • Cardiac micro-computed tomography for morphological and functional phenotyping of muscle LIM protein null mice. 
  • Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts. 
  • Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation. 
  • Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors. 
  • Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis. 
  • Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury. 
  • Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease. 
  • Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. 
  • Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. 
  • Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure. 
  • Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. 
  • Catecholamines act via a beta-adrenergic receptor to maintain fetal heart rate and survival. 
  • Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4. 
  • Caveolin-1 modulates intraocular pressure: implications for caveolae mechanoprotection in glaucoma. 
  • Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. 
  • Cell therapy in murine atherosclerosis: in vivo imaging with high-resolution helical SPECT. 
  • Cell-autonomous adiposity through increased cell surface GLUT4 due to ankyrin-B deficiency. 
  • Cellular FLIP Inhibits Myeloid Cell Activation by Suppressing Selective Innate Signaling. 
  • Cellular and functional defects in a mouse model of heart failure. 
  • Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies. 
  • Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells. 
  • Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation. 
  • Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen. 
  • Cerebellar defects in Ca2+/calmodulin kinase IV-deficient mice. 
  • Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. 
  • ChREBP regulates fructose-induced glucose production independently of insulin signaling. 
  • Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model. 
  • Characterization of Fatty Acid Binding Protein 7 (FABP7) in the Murine Retina. 
  • Characterization of NO and cytokine production in immune-activated microglia and peritoneal macrophages derived from a mouse model expressing the human NOS2 gene on a mouse NOS2 knockout background. 
  • Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. 
  • Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models. 
  • Characterization of elongation factor-1A (eEF1A-1) and eEF1A-2/S1 protein expression in normal and wasted mice. 
  • Characterization of liver GSD IX γ2 pathophysiology in a novel Phkg2-/- mouse model. 
  • Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues. 
  • Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and β-arrestin 2 in inflammatory macrophages. 
  • Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis. 
  • Chemiluminescence and the Nox1-Nox2-Nox4 Triple Knockout. 
  • Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection. 
  • Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10. 
  • Chordin and noggin promote organizing centers of forebrain development in the mouse. 
  • Chordin is a modifier of tbx1 for the craniofacial malformations of 22q11 deletion syndrome phenotypes in mouse. 
  • Chromium(VI) induces p53-dependent apoptosis in diploid human lung and mouse dermal fibroblasts. 
  • Chronic loss of noradrenergic tone produces β-arrestin2-mediated cocaine hypersensitivity and alters cellular D2 responses in the nucleus accumbens. 
  • Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice. 
  • Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation. 
  • Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis. 
  • Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. 
  • Circadian rhythms of activity and drinking in mice lacking angiotensin II 1A receptors. 
  • Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder. 
  • Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors. 
  • Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo. 
  • Cis-acting human ApoE tissue expression element is associated with human pattern of intraneuronal ApoE in transgenic mice. 
  • Clara cells attenuate the inflammatory response through regulation of macrophage behavior. 
  • Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. 
  • Classical Dendritic Cells Mediate Hypertension by Promoting Renal Oxidative Stress and Fluid Retention. 
  • Clinical and serologic manifestations of autoimmune disease in MRL-lpr/lpr mice lacking nitric oxide synthase type 2. 
  • Clipping of arginine-methylated histone tails by JMJD5 and JMJD7. 
  • Cnksr2 Loss in Mice Leads to Increased Neural Activity and Behavioral Phenotypes of Epilepsy-Aphasia Syndrome. 
  • Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. 
  • Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool. 
  • Collapsing glomerulopathy: an inflammatory podocytopathy? 
  • Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer. 
  • Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor. 
  • Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Activated intrarenal renin-angiotensin system is correlated with high blood pressure in humans. 
  • Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10. 
  • Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells. 
  • Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice. 
  • Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis. 
  • Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections. 
  • Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling. 
  • Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. 
  • Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation. 
  • Complement component C3d-antigen complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement. 
  • Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis. 
  • Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. 
  • Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease. 
  • Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies. 
  • Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease. 
  • Concerted regulation of skeletal muscle contractility by oxygen tension and endogenous nitric oxide. 
  • Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer. 
  • Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model. 
  • Conditional deletion of TrkC does not modify limbic epileptogenesis. 
  • Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior. 
  • Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles. 
  • Connexin 36 and rod bipolar cell independent rod pathways drive retinal ganglion cells and optokinetic reflexes. 
  • Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP. 
  • Contribution of IL-13 to early exocrinopathy in Id3-/- mice. 
  • Contribution of mast cells to bacterial clearance and their proliferation during experimental cystitis induced by type 1 fimbriated E. coli. 
  • Contributions of endothelial and neuronal nitric oxide synthases to cerebrovascular responses to hyperoxia. 
  • Control of IFN-alphaA by CD73: implications for mucosal inflammation. 
  • Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases). 
  • Control of Intestinal Inflammation, Colitis-Associated Tumorigenesis, and Macrophage Polarization by Fibrinogen-Like Protein 2. 
  • Control of antiviral innate immune response by protein geranylgeranylation. 
  • Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. 
  • Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3. 
  • Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling. 
  • Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function. 
  • Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing. 
  • Conversion of effector CD4+ T cells to a CD8+ MHC II-recognizing lineage. 
  • Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. 
  • Copper Chelation Inhibits BRAFV600E-Driven Melanomagenesis and Counters Resistance to BRAFV600E and MEK1/2 Inhibitors. 
  • Correction of glycogen storage disease type II by an adeno-associated virus vector containing a muscle-specific promoter. 
  • Correction of multiple striated muscles in murine Pompe disease through adeno-associated virus-mediated gene therapy. 
  • Cortical glutamic acid decarboxylase 67 deficiency results in lower cannabinoid 1 receptor messenger RNA expression: implications for schizophrenia. 
  • Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa. 
  • Critical role for mouse marginal zone B cells in PF4/heparin antibody production. 
  • Critical role for the alpha-1B adrenergic receptor at the sympathetic neuroeffector junction. 
  • Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. 
  • Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity. 
  • Critical roles of RasGRP1 for invariant NKT cell development. 
  • Cross-talk Between Nitrate-Nitrite-NO and NO Synthase Pathways in Control of Vascular NO Homeostasis. 
  • Cryptococcus neoformans is resistant to surfactant protein A mediated host defense mechanisms. 
  • Cutting edge: C3d functions as a molecular adjuvant in the absence of CD21/35 expression. 
  • Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2. 
  • Cutting edge: Role of osteopontin and integrin αv in T cell-mediated anti-inflammatory responses in endotoxemia. 
  • Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. 
  • Cutting edge: critical role of intracellular osteopontin in antifungal innate immune responses. 
  • Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning. 
  • Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor). 
  • Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3. 
  • Cytokine expression by invariant natural killer T cells is tightly regulated throughout development and settings of type-2 inflammation. 
  • Cytokine-dependent and cytokine-independent roles for Mcl-1: genetic evidence for multiple mechanisms by which Mcl-1 promotes survival in primary T lymphocytes. 
  • Cytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis. 
  • Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28. 
  • DGK α and ζ Activities Control TH1 and TH17 Cell Differentiation. 
  • DVT: a new era in anticoagulant therapy. 
  • Decreased Th17 and antigen-specific humoral responses in CX₃ CR1-deficient mice in the collagen-induced arthritis model. 
  • Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid. 
  • Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen. 
  • Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin M. 
  • Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media. 
  • Defective T cell development and function in the absence of Abelson kinases. 
  • Defective antitumor responses in CX3CR1-deficient mice. 
  • Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. 
  • Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. 
  • Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1-/- renal proximal tubule cells. 
  • Defective prolactin signaling impairs pancreatic β-cell development during the perinatal period. 
  • Defective signaling in a subpopulation of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IV. 
  • Defects of prostate development and reproductive system in the estrogen receptor-alpha null male mice. 
  • Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer. 
  • Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. 
  • Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice. 
  • Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice. 
  • Deficiency of Mucosal-Associated Invariant T Cells in TCRJα18 Germline Knockout Mice. 
  • Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers. 
  • Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response. 
  • Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. 
  • Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism. 
  • Deficiency of α-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling. 
  • Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1. 
  • Definition of a novel cellular constituent of the bone marrow that regulates the response of immature B cells to B cell antigen receptor engagement. 
  • Deletion of Atm in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma. 
  • Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse. 
  • Deletion of GSK3β in D2R-expressing neurons reveals distinct roles for β-arrestin signaling in antipsychotic and lithium action. 
  • Deletion of Melanin Concentrating Hormone Receptor-1 disrupts overeating in the presence of food cues. 
  • Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. 
  • Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription. 
  • Deletion of angiotensin II type 2 receptor accelerates adipogenesis in murine mesenchymal stem cells via Wnt10b/beta-catenin signaling. 
  • Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. 
  • Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. 
  • Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia. 
  • Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate. 
  • Deletion of the phosphatase INPP5E in the murine retina impairs photoreceptor axoneme formation and prevents disc morphogenesis. 
  • Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. 
  • Dendritic Cells Interpret Haptotactic Chemokine Gradients in a Manner Governed by Signal-to-Noise Ratio and Dependent on GRK6. 
  • Dendritic cell immunoreceptor regulates Chikungunya virus pathogenesis in mice. 
  • Dendritic epidermal T cells regulate skin antimicrobial barrier function. 
  • Dengue vascular leakage is augmented by mast cell degranulation mediated by immunoglobulin Fcγ receptors. 
  • Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. 
  • Desmoplakin controls microvilli length but not cell adhesion or keratin organization in the intestinal epithelium. 
  • Desmoplakin: an unexpected regulator of microtubule organization in the epidermis. 
  • Detailed analysis of gene expression during development of T cell lineages in the thymus. 
  • Determination of an angiotensin II-regulated proteome in primary human kidney cells by stable isotope labeling of amino acids in cell culture (SILAC). 
  • Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells. 
  • Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity. 
  • Developmental defects in mouse embryos lacking N-cadherin. 
  • Developmental onset of enduring long-term potentiation in mouse hippocampus. 
  • Developmental renin expression in mice with a defective renin-angiotensin system. 
  • Diabetes insipidus in uricase-deficient mice: a model for evaluating therapy with poly(ethylene glycol)-modified uricase. 
  • Diabetic liver injury from streptozotocin is regulated through the caspase-8 homolog cFLIP involving activation of JNK2 and intrahepatic immunocompetent cells. 
  • Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii. 
  • Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses. 
  • Diet-induced obese mice retain endogenous leptin action. 
  • Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis. 
  • Different presynaptic roles of synapsins at excitatory and inhibitory synapses. 
  • Differential Immune Microenvironments and Response to Immune Checkpoint Blockade among Molecular Subtypes of Murine Medulloblastoma. 
  • Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents. 
  • Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells. 
  • Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals. 
  • Differential dynamics and activity-dependent regulation of alpha- and beta-neurexins at developing GABAergic synapses. 
  • Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. 
  • Differential expression of p63 isoforms in female reproductive organs. 
  • Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. 
  • Differential psychostimulant-induced activation of neural circuits in dopamine transporter knockout and wild type mice. 
  • Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. 
  • Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases. 
  • Differential regulation of the PGC family of genes in a mouse model of Staphylococcus aureus sepsis. 
  • Differential requirement for the SAP-Fyn interaction during NK T cell development and function. 
  • Differential requirement of RasGRP1 for γδ T cell development and activation. 
  • Differential requirements for NAIP5 in activation of the NLRC4 inflammasome. 
  • Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants. 
  • Direct Actions of AT1 (Type 1 Angiotensin) Receptors in Cardiomyocytes Do Not Contribute to Cardiac Hypertrophy. 
  • Discovery of a functionally selective ghrelin receptor (GHSR1a) ligand for modulating brain dopamine. 
  • Discovery of biomarker candidates for coronary artery disease from an APOE-knock out mouse model using iTRAQ-based multiplex quantitative proteomics. 
  • Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators. 
  • Display of cell surface sites for fibronectin assembly is modulated by cell adherence to (1)F3 and C-terminal modules of fibronectin. 
  • Disrupted Blood-Retina Lysophosphatidylcholine Transport Impairs Photoreceptor Health But Not Visual Signal Transduction. 
  • Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice. 
  • Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice. 
  • Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. 
  • Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum. 
  • Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction. 
  • Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress. 
  • Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction. 
  • Disruption of diacylglycerol metabolism impairs the induction of T cell anergy. 
  • Disruption of mindin exacerbates cardiac hypertrophy and fibrosis. 
  • Disruption of the Ang II type 1 receptor promotes longevity in mice. 
  • Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice. 
  • Disruption of the gene encoding the mitogen-regulated translational modulator PHAS-I in mice. 
  • Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells. 
  • Disruption of the mouse oestrogen receptor gene: resulting phenotypes and experimental findings. 
  • Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. 
  • Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus. 
  • Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice. 
  • Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons. 
  • Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties. 
  • Distinct function of estrogen receptor α in smooth muscle and fibroblast cells in prostate development. 
  • Distinct gene expression phenotypes of cells lacking Rb and Rb family members. 
  • Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. 
  • Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration. 
  • Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. 
  • Distribution of, and immune response to, chicken anti-alpha Gal immunoglobulin Y antibodies in wild-type and alpha Gal knockout mice. 
  • Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines. 
  • Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis. 
  • Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms. 
  • Dopamine and α-synuclein dysfunction in Smad3 null mice. 
  • Dopamine levels modulate the updating of tastant values. 
  • Dopaminergic abnormalities in Hdac6-deficient mice. 
  • Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. 
  • Dopaminergic control of sleep-wake states. 
  • Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity. 
  • Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. 
  • Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction. 
  • Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo. 
  • Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides. 
  • Drebrin attenuates atherosclerosis by limiting smooth muscle cell transdifferentiation. 
  • Drebrin regulates angiotensin II-induced aortic remodelling. 
  • Dual allosteric modulation of opioid antinociceptive potency by α2A-adrenoceptors. 
  • Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. 
  • Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy. 
  • Dual-energy computed tomography imaging of atherosclerotic plaques in a mouse model using a liposomal-iodine nanoparticle contrast agent. 
  • Dynamic and redundant regulation of LRRK2 and LRRK1 expression. 
  • E protein transcription factors are required for the development of CD4(+) lineage T cells. 
  • E-cadherin polarity is determined by a multifunction motif mediating lateral membrane retention through ankyrin-G and apical-lateral transcytosis through clathrin. 
  • E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression. 
  • E2A promotes the survival of precursor and mature B lymphocytes. 
  • EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts. 
  • ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. 
  • ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation. 
  • EXT1 regulates chondrocyte proliferation and differentiation during endochondral bone development. 
  • Early B-cell activation after West Nile virus infection requires alpha/beta interferon but not antigen receptor signaling. 
  • Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during NAFLD progression. 
  • Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. 
  • Early, sustained efficacy of adeno-associated virus vector-mediated gene therapy in glycogen storage disease type Ia. 
  • Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema. 
  • Effect of bimatoprost on intraocular pressure in prostaglandin FP receptor knockout mice. 
  • Effector T Cell Egress via Afferent Lymph Modulates Local Tissue Inflammation. 
  • Effects of Combined Tristetraprolin/Tumor Necrosis Factor Receptor Deficiency on the Splenic Transcriptome. 
  • Effects of HSP70.1/3 gene knockout on acute respiratory distress syndrome and the inflammatory response following sepsis. 
  • Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice. 
  • Effects of candesartan on angiotensin II-induced renal vasoconstriction in rats and mice. 
  • Effects of castration and chronic steroid treatments on hypothalamic gonadotropin-releasing hormone content and pituitary gonadotropins in male wild-type and estrogen receptor-alpha knockout mice. 
  • Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage. 
  • Effects of lactogen resistance and GH deficiency on mouse metabolism: pancreatic hormones, adipocytokines, and expression of adiponectin and insulin receptors. 
  • Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice. 
  • Effects of neuronal PIK3C3/Vps34 deletion on autophagy and beyond. 
  • Effects of tumor microenvironment heterogeneity on nanoparticle disposition and efficacy in breast cancer tumor models. 
  • Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice. 
  • Efficacious Androgen Hormone Administration in Combination with Adeno-Associated Virus Vector-Mediated Gene Therapy in Female Mice with Pompe Disease. 
  • Efficacy of an adeno-associated virus 8-pseudotyped vector in glycogen storage disease type II. 
  • Efficacy of helper-dependent adenovirus vector-mediated gene therapy in murine glycogen storage disease type Ia. 
  • Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein mindin. 
  • Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin. 
  • Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2. 
  • Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration. 
  • EndoU is a novel regulator of AICD during peripheral B cell selection. 
  • Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis. 
  • Endogenous S-nitrosothiols protect against myocardial injury. 
  • Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production. 
  • Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival. 
  • Endogenous glucocorticoids prevent gastric metaplasia by suppressing spontaneous inflammation. 
  • Endoglin deficiency impairs stroke recovery. 
  • Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. 
  • Endothelial CD74 mediates macrophage migration inhibitory factor protection in hyperoxic lung injury. 
  • Endothelial MKK3 is a critical mediator of lethal murine endotoxemia and acute lung injury. 
  • Endothelial PINK1 mediates the protective effects of NLRP3 deficiency during lethal oxidant injury. 
  • Endothelial STAT3 is essential for the protective effects of HO-1 in oxidant-induced lung injury. 
  • Endothelial Stanniocalcin 1 Maintains Mitochondrial Bioenergetics and Prevents Oxidant-Induced Lung Injury via Toll-Like Receptor 4. 
  • Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity. 
  • Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia. 
  • Endothelial cell Pannexin1 modulates severity of ischemic stroke by regulating cerebral inflammation and myogenic tone. 
  • Endothelial cell-secreted MIF reduces pericyte contractility and enhances neutrophil extravasation. 
  • Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. 
  • Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a. 
  • Endothelial uncoupling protein 2 regulates mitophagy and pulmonary hypertension during intermittent hypoxia. 
  • Energy metabolism in uncoupling protein 3 gene knockout mice. 
  • Engineering human pluripotent stem cells into a functional skeletal muscle tissue. 
  • Enhanced Glucose Control Following Vertical Sleeve Gastrectomy Does Not Require a β-Cell Glucagon-Like Peptide 1 Receptor. 
  • Enhanced T cell responses due to diacylglycerol kinase zeta deficiency. 
  • Enhanced Uterine Contractility and Stillbirth in Mice Lacking G Protein-Coupled Receptor Kinase 6 (GRK6): Implications for Oxytocin Receptor Desensitization. 
  • Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes. 
  • Enhanced central response to dehydration in mice lacking angiotensin AT(1a) receptors. 
  • Enhanced efficacy from gene therapy in Pompe disease using coreceptor blockade. 
  • Enhanced efficacy of an AAV vector encoding chimeric, highly secreted acid alpha-glucosidase in glycogen storage disease type II. 
  • Enhanced efficacy of enzyme replacement therapy in Pompe disease through mannose-6-phosphate receptor expression in skeletal muscle. 
  • Enhanced gene expression of systemically administered plasmid DNA in the liver with therapeutic ultrasound and microbubbles. 
  • Enhanced inflow and outflow rates despite lower IOP in bestrophin-2-deficient mice. 
  • Enhanced morphine analgesia in mice lacking beta-arrestin 2. 
  • Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice. 
  • Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2. 
  • Environmental Factors Modify the Severity of Acute DSS Colitis in Caspase-11-Deficient Mice. 
  • Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice. 
  • Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice. 
  • Eosinophils alter colonic epithelial barrier function: role for major basic protein. 
  • Epidermal growth factor regulates hematopoietic regeneration after radiation injury. 
  • Epigenetic dysregulation of Oxtr in Tet1-deficient mice has implications for neuropsychiatric disorders. 
  • Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. 
  • Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine. 
  • Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis. 
  • Epstein-Barr Viruses (EBVs) Deficient in EBV-Encoded RNAs Have Higher Levels of Latent Membrane Protein 2 RNA Expression in Lymphoblastoid Cell Lines and Efficiently Establish Persistent Infections in Humanized Mice. 
  • Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart. 
  • Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages. 
  • Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation. 
  • Essential role of AT1A receptor in the development of 2K1C hypertension. 
  • Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia. 
  • Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. 
  • Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. 
  • Estradiol replacement enhances cocaine-stimulated locomotion in female C57BL/6 mice through estrogen receptor alpha. 
  • Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERα signaling on astrocytes but not through ERβ signaling on astrocytes or neurons. 
  • Estrogen metabolism within the lung and its modulation by tobacco smoke. 
  • Estrogen receptor beta protects against in vivo injury in RPE cells. 
  • Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy. 
  • Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors. 
  • Ethanol contributes to neurogenic pancreatitis by activation of TRPV1. 
  • Ethanol metabolism modifies hepatic protein acylation in mice. 
  • Ethylenecarbodiimide-fixed donor splenocyte infusions differentially target direct and indirect pathways of allorecognition for induction of transplant tolerance. 
  • Etomoxir-induced PPARalpha-modulated enzymes protect during acute renal failure. 
  • EuroPhenome: a repository for high-throughput mouse phenotyping data. 
  • Evaluation of antihypertensive drugs in combination with enzyme replacement therapy in mice with Pompe disease. 
  • Evasion of immune responses to introduced human acid alpha-glucosidase by liver-restricted expression in glycogen storage disease type II. 
  • Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis. 
  • Evolution of the tenascin family--implications for function of the C-terminal fibrinogen-like domain. 
  • Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D. 
  • Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections. 
  • Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21. 
  • Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. 
  • Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies. 
  • Exposure of mice to topical bovine thrombin induces systemic autoimmunity. 
  • Expression and modulation of RPE cell membrane complement regulatory proteins. 
  • Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice. 
  • Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth. 
  • Expression of the apolipoprotein E gene does not affect motor recovery after sensorimotor cortex injury in the mouse. 
  • Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion. 
  • Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1. 
  • Extracellular superoxide dismutase deficiency worsens outcome from focal cerebral ischemia in the mouse. 
  • Extracellular superoxide dismutase regulates cardiac function and fibrosis. 
  • Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration. 
  • Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure. 
  • Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. 
  • FGF21-FGFR1 Coordinates Phospholipid Homeostasis, Lipid Droplet Function, and ER Stress in Obesity. 
  • FGF23 induces left ventricular hypertrophy. 
  • FGF23/FGFR4-mediated left ventricular hypertrophy is reversible. 
  • FGF9 promotes survival of germ cells in the fetal testis. 
  • FGFR4 does not contribute to progression of chronic kidney disease. 
  • FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes. 
  • FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506. 
  • FOXO protects against age-progressive axonal degeneration. 
  • Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2. 
  • Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. 
  • Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. 
  • Fenofibrate rapidly decreases hepatic lipid and glycogen storage in neonatal mice with glycogen storage disease type Ia. 
  • Ferric citrate reduces fibroblast growth factor 23 levels and improves renal and cardiac function in a mouse model of chronic kidney disease. 
  • Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium. 
  • Fgf8 is required for anterior heart field development. 
  • Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. 
  • Fibroblast growth factor 21 mediates specific glucagon actions. 
  • Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone. 
  • Fibronectin Extra Domain A Promotes Liver Sinusoid Repair following Hepatectomy. 
  • Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing. 
  • Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. 
  • Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. 
  • Food reward in the absence of taste receptor signaling. 
  • Formation of Rathke's pouch requires dual induction from the diencephalon. 
  • Formyl peptide receptor 2 determines sex-specific differences in the progression of nonalcoholic fatty liver disease and steatohepatitis. 
  • FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain. 
  • FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes. 
  • Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation. 
  • Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways. 
  • Fully deleted adenovirus persistently expressing GAA accomplishes long-term skeletal muscle glycogen correction in tolerant and nontolerant GSD-II mice. 
  • Function of tau protein in adult newborn neurons. 
  • Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1. 
  • Functional and molecular adaptations in skeletal muscle of myoglobin-mutant mice. 
  • Functional characteristics and survival requirements of memory CD4+ T lymphocytes in vivo. 
  • Functional complementation between FADD and RIP1 in embryos and lymphocytes. 
  • G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. 
  • G protein G(alpha)o is essential for vomeronasal function and aggressive behavior in mice. 
  • G protein-coupled receptor kinase 2 promotes flaviviridae entry and replication. 
  • G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. 
  • G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses. 
  • G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors. 
  • G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency. 
  • G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal. 
  • G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis. 
  • G-protein-coupled receptor function in heart failure. 
  • GABA signaling promotes synapse elimination and axon pruning in developing cortical inhibitory interneurons. 
  • GATA2 regulates body water homeostasis through maintaining aquaporin 2 expression in renal collecting ducts. 
  • GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst. 
  • GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. 
  • GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans. 
  • GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice. 
  • GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy. 
  • GMab-1, a high-affinity anti-3'-isoLM1/3',6'-isoLD1 IgG monoclonal antibody, raised in lacto-series ganglioside-defective knockout mice. 
  • GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo. 
  • GPR158 in the Visual System: Homeostatic Role in Regulation of Intraocular Pressure. 
  • GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain. 
  • Galphaz negatively regulates insulin secretion and glucose clearance. 
  • Gap Junctions Contribute to Differential Light Adaptation across Direction-Selective Retinal Ganglion Cells. 
  • Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor. 
  • Gene Expression Profiling of Cutaneous Injured and Non-Injured Nociceptors in SNI Animal Model of Neuropathic Pain. 
  • Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. 
  • Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. 
  • Gene expression profiles linked to AT1 angiotensin receptors in the kidney. 
  • Gene expression profiling of familial and sporadic interstitial pneumonia. 
  • Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. 
  • Gene-targeting studies of the renin-angiotensin system: mechanisms of hypertension and cardiovascular disease. 
  • Generation and characterization of Tmeff2 mutant mice. 
  • Generation and characterization of a complete null estrogen receptor alpha mouse using Cre/LoxP technology. 
  • Generation of a Listeria vaccine strain by enhanced caspase-1 activation. 
  • Generation of a Magoh conditional allele in mice. 
  • Genes that modify the hemochromatosis phenotype in mice. 
  • Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension. 
  • Genetic Deletion of β-Arrestin-2 and the Mitigation of Established Airway Hyperresponsiveness in a Murine Asthma Model. 
  • Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. 
  • Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function. 
  • Genetic background influences cardiac phenotype in murine chronic kidney disease. 
  • Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells. 
  • Genetic deletion of Rgs12 in mice affects serotonin transporter expression and function in vivo and ex vivo. 
  • Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor). 
  • Genetic deletion of the Tas2r143/Tas2r135/Tas2r126 cluster reveals that TAS2Rs may not mediate bitter tastant-induced bronchodilation. 
  • Genetic dissection of rod and cone pathways in the dark-adapted mouse retina. 
  • Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes. 
  • Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing γδ T cells. 
  • Genetic modifiers of the Kv beta2-null phenotype in mice. 
  • Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1. 
  • Genetically induced microtubule disruption in the mouse intestine impairs intracellular organization and transport. 
  • Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males. 
  • Genome-wide identification of calcium-response factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways. 
  • Genomic abnormalities of the murine model of Fabry disease after disease-related perturbation, a systems biology approach. 
  • Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells. 
  • Gestational, pathologic and biochemical differences between very long-chain acyl-CoA dehydrogenase deficiency and long-chain acyl-CoA dehydrogenase deficiency in the mouse. 
  • Ghrelin enhances olfactory sensitivity and exploratory sniffing in rodents and humans. 
  • Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires βarrestin-2. 
  • Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling. 
  • Gipr is essential for adrenocortical steroidogenesis; however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(-/-) mice. 
  • Glial ankyrins facilitate paranodal axoglial junction assembly. 
  • Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts. 
  • Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease. 
  • Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis. 
  • Glucagon lowers glycemia when β-cells are active. 
  • Glutamine attenuation of cell death and inducible nitric oxide synthase expression following inflammatory cytokine-induced injury is dependent on heat shock factor-1 expression. 
  • Glutamine's protection against cellular injury is dependent on heat shock factor-1. 
  • Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression. 
  • Glutamine-mediated attenuation of cellular metabolic dysfunction and cell death after injury is dependent on heat shock factor-1 expression. 
  • Glutamine-mediated dual regulation of heat shock transcription factor-1 activation and expression. 
  • Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo. 
  • Glutathione peroxidase-deficient smooth muscle cells cause paracrine activation of normal smooth muscle cells via cyclophilin A. 
  • Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation. 
  • Glycogen accumulation in smooth muscle of a Pompe disease mouse model. 
  • Glymphatic fluid transport controls paravascular clearance of AAV vectors from the brain. 
  • Gp91phox contributes to NADPH oxidase activity in aortic fibroblasts but not smooth muscle cells. 
  • Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility. 
  • Gradated assembly of multiple proteins into supramolecular nanomaterials. 
  • Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). 
  • Granulocytes act as a niche for Mycobacterium tuberculosis growth. 
  • Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation. 
  • Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages. 
  • Guanylate cyclase 1 relies on rhodopsin for intracellular stability and ciliary trafficking. 
  • Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling. 
  • H(2)O(2)-induced O(2) production by a non-phagocytic NAD(P)H oxidase causes oxidant injury. 
  • H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection. 
  • HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG-I. 
  • HDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes. 
  • HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase. 
  • HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism. 
  • Haem oxygenase-1 prevents cell death by regulating cellular iron. 
  • Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. 
  • Have gene knockouts caused evolutionary reversals in the mammalian first arch? 
  • Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis. 
  • Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells. 
  • Helicobacter infection decreases reproductive performance of IL10-deficient mice. 
  • Helicobacter typhlonius and Helicobacter rodentium differentially affect the severity of colon inflammation and inflammation-associated neoplasia in IL10-deficient mice. 
  • Hematopoietic Wnts Modulate Endochondral Ossification During Fracture Healing. 
  • Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production. 
  • Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression. 
  • Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis. 
  • Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. 
  • Heparin binding EGF is necessary for vasospastic response to endothelin. 
  • Hepatic SRC-1 activity orchestrates transcriptional circuitries of amino acid pathways with potential relevance for human metabolic pathogenesis. 
  • Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa). 
  • Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO. 
  • Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH. 
  • Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice. 
  • Hepatorenal correction in murine glycogen storage disease type I with a double-stranded adeno-associated virus vector. 
  • High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease. 
  • High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice. 
  • High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7's induction of DNA damage response, an activity mediated by E7's inactivation of pocket proteins. 
  • High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice. 
  • Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. 
  • Homer modulates NFAT-dependent signaling during muscle differentiation. 
  • Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2. 
  • Hormone signaling and fatty liver in females: analysis of estrogen receptor α mutant mice. 
  • How vinculin regulates force transmission. 
  • Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior. 
  • Humoral autoimmunity in mice overexpressing B cell surface CD19: vital role for MHC class II. 
  • Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence. 
  • Humoral immune responses in L-selectin-deficient mice. 
  • Hyaluronan contributes to bronchiolitis obliterans syndrome and stimulates lung allograft rejection through activation of innate immunity. 
  • Hydrostatic isolated limb perfusion with adeno-associated virus vectors enhances correction of skeletal muscle in Pompe disease. 
  • Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells. 
  • Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling. 
  • Hyperexpression of Foxp3 and IDO during acute rejection of islet allografts. 
  • Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2. 
  • Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. 
  • Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4. 
  • Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice. 
  • Hypothalamic CaMKK2 contributes to the regulation of energy balance. 
  • Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes. 
  • Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium. 
  • Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores. 
  • IFN-gamma dictates allograft fate via opposing effects on the graft and on recipient CD8 T cell responses. 
  • IKKα negatively regulates ASC-dependent inflammasome activation. 
  • IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage. 
  • IL-13 and IL-1beta promote lung fibroblast growth through coordinated up-regulation of PDGF-AA and PDGF-Ralpha. 
  • IL-15 regulates homeostasis and terminal maturation of NKT cells. 
  • IL-17 Production of Neutrophils Enhances Antibacteria Ability but Promotes Arthritis Development During Mycobacterium tuberculosis Infection. 
  • IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia. 
  • IL-1β, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis. 
  • IL-1β-dependent activation of dendritic epidermal T cells in contact hypersensitivity. 
  • IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus. 
  • IL-27 Facilitates Skin Wound Healing through Induction of Epidermal Proliferation and Host Defense. 
  • IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjögren's syndrome-like disease of the nonobese diabetic mouse. 
  • IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. 
  • IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins. 
  • IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria. 
  • Id Proteins Suppress E2A-Driven Invariant Natural Killer T Cell Development prior to TCR Selection. 
  • Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. 
  • Id2 Collaborates with Id3 To Suppress Invariant NKT and Innate-like Tumors. 
  • Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity. 
  • Id3 and Id2 act as a dual safety mechanism in regulating the development and population size of innate-like γδ T cells. 
  • Id3 restricts the developmental potential of gamma delta lineage during thymopoiesis. 
  • Identification of CD146 as a marker enriched for tumor-propagating capacity reveals targetable pathways in primary human sarcoma. 
  • Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system. 
  • Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages. 
  • Identification of potential cytokine pathways for therapeutic intervention in murine primary biliary cirrhosis. 
  • Identification of specific EP receptors responsible for the hemodynamic effects of PGE2. 
  • Identifying genetic determinants of inflammatory pain in mice using a large-scale gene-targeted screen. 
  • IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF. 
  • Immunodominant liver-specific expression suppresses transgene-directed immune responses in murine pompe disease. 
  • Immunoglobulin-like domain containing receptor 1 mediates fat-stimulated cholecystokinin secretion. 
  • Immunological disruption of antiangiogenic signals by recruited allospecific T cells leads to corneal allograft rejection. 
  • Impact of surfactant protein D, interleukin-5, and eosinophilia on Cryptococcosis. 
  • Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse. 
  • Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells. 
  • Impaired fear response in mice lacking GIT1. 
  • Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene. 
  • Impaired insulin secretion and enhanced insulin sensitivity in cholecystokinin-deficient mice. 
  • Impaired liver regeneration in inducible nitric oxide synthasedeficient mice. 
  • Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47). 
  • Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss. 
  • Impaired photoreceptor protein transport and synaptic transmission in a mouse model of Bardet-Biedl syndrome. 
  • Impaired social recognition memory in recombination activating gene 1-deficient mice. 
  • Impairment of the blood-nerve and blood-brain barriers in apolipoprotein e knockout mice. 
  • Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. 
  • Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy. 
  • Improved efficacy of gene therapy approaches for Pompe disease using a new, immune-deficient GSD-II mouse model. 
  • Improved survival and reduced phenotypic severity following AAV9/MECP2 gene transfer to neonatal and juvenile male Mecp2 knockout mice. 
  • In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides. 
  • In vivo and in vitro propagation of intraductal papillary mucinous neoplasms. 
  • In vivo expansion, persistence, and function of peptide vaccine-induced CD8 T cells occur independently of CD4 T cells. 
  • Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. 
  • Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation. 
  • Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss. 
  • Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice. 
  • Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans. 
  • Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6. 
  • Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP. 
  • Increased immunogenicity of a DNA-launched Venezuelan equine encephalitis virus-based replicon DNA vaccine. 
  • Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration. 
  • Increased skin carcinogenesis in caspase-activated DNase knockout mice. 
  • Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet. 
  • Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation. 
  • Increased vasoconstrictor response of the mouse lacking angiotensin II type 2 receptor. 
  • Increasing O-GlcNAcylation is neuroprotective in young and aged brains after ischemic stroke. 
  • Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development. 
  • Induced sensitization of tumor stroma leads to eradication of established cancer by T cells. 
  • Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload. 
  • Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: selection against membrane proximal external region-associated autoreactivity limits T-dependent responses. 
  • Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning. 
  • Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production. 
  • Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression. 
  • Inflammation influences vascular remodeling through AT2 receptor expression and signaling. 
  • Inflammation-Dependent IL18 Signaling Restricts Hepatocellular Carcinoma Growth by Enhancing the Accumulation and Activity of Tumor-Infiltrating Lymphocytes. 
  • Inflammation-associated repression of vasodilator-stimulated phosphoprotein (VASP) reduces alveolar-capillary barrier function during acute lung injury. 
  • Influence of CD4 T cells and the source of major histocompatibility complex class II-restricted peptides on cytotoxic T-cell priming by dendritic cells. 
  • Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis. 
  • Inhibition of Ca²⁺/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation. 
  • Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat-Fed Diabetic Mice. 
  • Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis. 
  • Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis. 
  • Inhibition of adenosine-1 receptor-mediated preglomerular vasoconstriction in AT1A receptor-deficient mice. 
  • Inhibition of iNOS attenuates skeletal muscle reperfusion injury in extracellular superoxide dismutase knockout mice. 
  • Inhibition of inflammatory CCR2 signaling promotes aged muscle regeneration and strength recovery after injury. 
  • Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade. 
  • Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. 
  • Inhibition of p38 Mitogen-Activated Protein Kinase Enhances the Apoptosis Induced by Oxidized Low-Density Lipoprotein in Endothelial Progenitor Cells. 
  • Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure. 
  • Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma. 
  • Initial sequencing and comparative analysis of the mouse genome. 
  • Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis. 
  • Innate immune activation potentiates alloimmune lung disease independent of chemokine (C-X-C motif) receptor 3. 
  • Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. 
  • Inner ear abnormalities in a Kcnq1 (Kvlqt1) knockout mouse: a model of Jervell and Lange-Nielsen syndrome. 
  • Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers. 
  • Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling. 
  • Insights from molecular signature of in vivo cardiac c-Kit(+) cells following cardiac injury and β-catenin inhibition. 
  • Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77. 
  • Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase. 
  • Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers. 
  • Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes. 
  • Integrin beta 1 regulates phagosome maturation in macrophages through Rac expression. 
  • Integrin-β1 is required for the renal cystogenesis caused by ciliary defects. 
  • Interaction of CRF and kappa opioid systems on GABAergic neurotransmission in the mouse central amygdala. 
  • Intercellular adhesion molecule-1 and L-selectin regulate bleomycin-induced lung fibrosis. 
  • Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice. 
  • Intercellular growth factor signaling and the development of mouse tracheal submucosal glands. 
  • Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome. 
  • Interleukin 1 receptor (IL-1R1) activation exacerbates toxin-induced acute kidney injury. 
  • Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis. 
  • Interleukin 21 (IL-21) regulates chronic allograft vasculopathy (CAV) in murine heart allograft rejection. 
  • Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron. 
  • Interleukin-1 receptor activation aggravates autosomal dominant polycystic kidney disease by modulating regulated necrosis. 
  • Interleukin-6 as a photoreceptor neuroprotectant in an experimental model of retinal detachment. 
  • Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent. 
  • Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells. 
  • Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition. 
  • Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis. 
  • Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation. 
  • Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis. 
  • Intestinal alkaline phosphatase prevents metabolic syndrome in mice. 
  • Intestinal alkaline phosphatase promotes gut bacterial growth by reducing the concentration of luminal nucleotide triphosphates. 
  • Intestinal, but not hepatic, ChREBP is required for fructose tolerance. 
  • Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis. 
  • Intracellular cholesterol biosynthesis in enchondroma and chondrosarcoma. 
  • Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models. 
  • Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice. 
  • Intrinsic Antiviral Activity of Optineurin Prevents Hyperproliferation of a Primary Herpes Simplex Virus Type 2 Infection. 
  • Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche. 
  • Involvement of P311 in the affective, but not in the sensory component of pain. 
  • Involvement of Sensory Neurone-TRPV4 in Acute and Chronic Itch Behaviours. 
  • Involvement of Transient Receptor Potential Cation Channel Member A1 activation in the irritation and pain response elicited by skin-lightening reagent hydroquinone. 
  • Irgm1 (LRG-47), a regulator of cell-autonomous immunity, does not localize to mycobacterial or listerial phagosomes in IFN-γ-induced mouse cells. 
  • Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. 
  • Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium. 
  • Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation. 
  • Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels. 
  • Isoform-Specific Effects of Wild-Type Ras Genes on Carcinogen-Induced Lung Tumorigenesis in Mice. 
  • Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. 
  • Isolation of oligodendrocyte-like cells from human umbilical cord blood. 
  • Isoprenylcysteine carboxyl methyltransferase deficiency in mice. 
  • JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. 
  • JNK1 is required to preserve cardiac function in the early response to pressure overload. 
  • JunB Controls Intestinal Effector Programs in Regulatory T Cells. 
  • JunB promotes Th17 cell identity and restrains alternative CD4+ T-cell programs during inflammation. 
  • KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. 
  • KIF18B is a cell type-specific regulator of spindle orientation in the epidermis. 
  • KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference. 
  • Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells. 
  • Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions. 
  • Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1. 
  • Kindling and associated mossy fibre sprouting are not affected in mice deficient of NGFI-A/NGFI-B genes. 
  • Knockout mice as experimental models of virulence. 
  • Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice. 
  • Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity. 
  • Kruppel-like factor 15 is critical for vascular inflammation. 
  • Kruppel-like factor 15 is required for the cardiac adaptive response to fasting. 
  • L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes. 
  • L-selectin and intercellular adhesion molecule-1 regulate the development of Concanavalin A-induced liver injury. 
  • L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice. 
  • L-selectin is not required for T cell-mediated autoimmune diabetes. 
  • L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity. 
  • L-selectin shedding does not regulate constitutive T cell trafficking but controls the migration pathways of antigen-activated T lymphocytes. 
  • LKB1 reduces ROS-mediated cell damage via activation of p38. 
  • LRRK2 inhibition attenuates microglial inflammatory responses. 
  • LRRK2 secretion in exosomes is regulated by 14-3-3. 
  • LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1. 
  • Lack of annexin 1 results in an increase in corticotroph number in male but not female mice. 
  • Lack of galectin-1 or galectin-3 alters B cell deletion and anergy in an autoantibody transgene model. 
  • Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis. 
  • Lack of the P2X7 receptor protects against AMD-like defects and microparticle accumulation in a chronic oxidative stress-induced mouse model of AMD. 
  • Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity. 
  • Leptin metabolically licenses T cells for activation to link nutrition and immunity. 
  • Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathways. 
  • Leukocyte iNOS is required for inflammation and pathological remodeling in ischemic heart failure. 
  • Leukocyte rolling velocities and migration are optimized by cooperative L-selectin and intercellular adhesion molecule-1 functions. 
  • Leukocyte-derived IL-10 reduces subepithelial fibrosis associated with chronically inhaled endotoxin. 
  • Life without myoglobin. 
  • Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects. 
  • Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-Mediated Enhancement of Anabolic Synthesis. 
  • Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element. 
  • Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses. 
  • Lipopolysaccharide Potentiates Insulin-Driven Hypoglycemic Shock. 
  • Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis. 
  • Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype. 
  • Liver X receptors alpha and beta regulate renin expression in vivo. 
  • Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism. 
  • Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes. 
  • Liver-specific deletion of augmenter of liver regeneration accelerates development of steatohepatitis and hepatocellular carcinoma in mice. 
  • Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice. 
  • Liver-specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy. 
  • Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition. 
  • LncRNA VINAS regulates atherosclerosis by modulating NF-κB and MAPK signaling. 
  • Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity. 
  • Local induction of bladder Th1 responses to combat urinary tract infections. 
  • Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant. 
  • Long-range function of secreted small nucleolar RNAs that direct 2'-O-methylation. 
  • Long-term correction of glycogen storage disease type II with a hybrid Ad-AAV vector. 
  • Long-term efficacy after [E1-, polymerase-] adenovirus-mediated transfer of human acid-alpha-glucosidase gene into glycogen storage disease type II knockout mice. 
  • Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model. 
  • Longitudinal study of differential protein expression in an Alzheimer's mouse model lacking inducible nitric oxide synthase. 
  • Longitudinal study of urinary excretion of phosphate, calcium, and uric acid in mutant NHERF-1 null mice. 
  • Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration. 
  • Loss of BMI1 in mature olfactory sensory neurons leads to increased olfactory basal cell proliferation. 
  • Loss of Bladder Epithelium Induced by Cytolytic Mast Cell Granules. 
  • Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall. 
  • Loss of Diacylglycerol Kinase α Enhances Macrophage Responsiveness. 
  • Loss of LDAH associated with prostate cancer and hearing loss. 
  • Loss of MPZL3 function causes seborrhoeic dermatitis-like phenotype in mice. 
  • Loss of NR1 subunit of NMDARs in primary sensory neurons leads to hyperexcitability and pain hypersensitivity: involvement of Ca(2+)-activated small conductance potassium channels. 
  • Loss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determination. 
  • Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. 
  • Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4. 
  • Loss of deacetylation activity of Hdac6 affects emotional behavior in mice. 
  • Loss of epithelial oestrogen receptor α inhibits oestrogen-stimulated prostate proliferation and squamous metaplasia via in vivo tissue selective knockout models. 
  • Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds. 
  • Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease. 
  • Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway. 
  • Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems. 
  • Loss of the perforin cytotoxic pathway predisposes mice to experimental cytomegalovirus retinitis. 
  • Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation. 
  • Lung effector memory and activated CD4+ T cells display enhanced proliferation in surfactant protein A-deficient mice during allergen-mediated inflammation. 
  • Lung inflammation stalls Th17-cell migration en route to the central nervous system during the development of experimental autoimmune encephalomyelitis. 
  • Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds. 
  • Ly49-dependent NK cell licensing and effector inhibition involve the same interaction site on MHC ligands. 
  • Lymphocyte accumulation in the spleen of retinoic acid receptor-related orphan receptor gamma-deficient mice. 
  • Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. 
  • MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. 
  • MEKK3 is essential for lymphopenia-induced T cell proliferation and survival. 
  • MKK3 deletion improves mitochondrial quality. 
  • MKK3 influences mitophagy and is involved in cigarette smoke-induced inflammation. 
  • MKK3 mediates inflammatory response through modulation of mitochondrial function. 
  • ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse. 
  • Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease. 
  • Macrophage-Derived MicroRNA-21 Drives Overwhelming Glycolytic and Inflammatory Response during Sepsis via Repression of the PGE2/IL-10 Axis. 
  • Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing. 
  • Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart. 
  • Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation. 
  • Magnetic resonance imaging at microscopic resolution reveals subtle morphological changes in a mouse model of dopaminergic hyperfunction. 
  • Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption. 
  • Male mice deficient in microsomal epoxide hydrolase are not susceptible to benzene-induced toxicity. 
  • Male-to-female sex reversal in mice lacking fibroblast growth factor 9. 
  • Manganese superoxide dismutase is a mitochondrial fidelity protein that protects Polγ against UV-induced inactivation. 
  • Manganese superoxide dismutase-mediated inside-out signaling in HaCaT human keratinocytes and SKH-1 mouse skin. 
  • Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent. 
  • Mast cell TNF receptors regulate responses to Mycoplasma pneumoniae in surfactant protein A (SP-A)-/- mice. 
  • Mast cell function is not altered by Coronin-1A deficiency. 
  • Mast cell stabilization improves survival by preventing apoptosis in sepsis. 
  • Mast cells are critical for protection against peptic ulcers induced by the NSAID piroxicam. 
  • Mast cells in tumor microenvironment promotes the in vivo growth of pancreatic ductal adenocarcinoma. 
  • Maternal Immunity and Vaccination Influence Disease Severity in Progeny in a Novel Mast Cell-Deficient Mouse Model of Severe Dengue. 
  • Maximal adjuvant activity of nasally delivered IL-1α requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production. 
  • Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2. 
  • Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling. 
  • MeCP2 reinforces STAT3 signaling and the generation of effector CD4+ T cells by promoting miR-124-mediated suppression of SOCS5. 
  • Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by light. 
  • Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function. 
  • Mekk3 is essential for early embryonic cardiovascular development. 
  • Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. 
  • Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. 
  • Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism. 
  • MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair After Myocardial Ischemia Reperfusion Injury. 
  • Mercury-induced cognitive impairment in metallothionein-1/2 null mice. 
  • Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype. 
  • Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis. 
  • Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle. 
  • Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. 
  • Metabolism and vascular fatty acid transport. 
  • Metabolism of chloroform by cytochrome P450 2E1 is required for induction of toxicity in the liver, kidney, and nose of male mice. 
  • Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase-deficient fetal thymic organ cultures. 
  • Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function. 
  • Metallothionein expression and neurocognitive function in mice. 
  • Metallothionein in the central nervous system: Roles in protection, regeneration and cognition. 
  • Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism. 
  • Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development. 
  • Methods to Investigate the Roles for β-Arrestin-2 in Allergic Inflammatory Airway Disease. 
  • Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. 
  • Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth. 
  • Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia. 
  • Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord. 
  • Mice deficient in inducible nitric oxide synthase are susceptible to experimental autoimmune uveoretinitis. 
  • Mice heterozygous for a null mutation of CPE show reduced expression of carboxypeptidase e mRNA and enzyme activity but normal physiology, behavior, and levels of neuropeptides. 
  • Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity. 
  • Mice lacking synapsin III show abnormalities in explicit memory and conditioned fear. 
  • Mice lacking the dopamine transporter display altered regulation of distal colonic motility. 
  • Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. 
  • Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome. 
  • Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. 
  • Mice with a deletion in the gene for CCAAT/enhancer-binding protein beta are protected against diet-induced obesity. 
  • Mice without myoglobin. 
  • Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis. 
  • MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice. 
  • MicroRNA-31 negatively regulates peripherally derived regulatory T-cell generation by repressing retinoic acid-inducible protein 3. 
  • Microarray analysis of knockout mice identifies cyclin D2 as a possible mediator for the action of thyroid hormone during the postnatal development of the cerebellum. 
  • Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. 
  • Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model. 
  • Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons. 
  • Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks. 
  • Minimal phenotype of mice homozygous for a null mutation in the forkhead/winged helix gene, Mf2. 
  • Minimum Effective Dose to Achieve Biochemical Correction with Adeno-Associated Virus Vector-Mediated Gene Therapy in Mice with Pompe Disease. 
  • Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy. 
  • Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice. 
  • Mitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient mice. 
  • Mitochondrial dysfunction in ataxia-telangiectasia. 
  • Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs. 
  • Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. 
  • Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. 
  • Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expression. 
  • Mitral cells in the olfactory bulb are mainly excited through a multistep signaling path. 
  • Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. 
  • Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis. 
  • Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1. 
  • Models of dopaminergic and serotonergic signaling. 
  • Modifier locus on mouse chromosome 3 for renal vascular pathology in AT1A receptor-deficiency. 
  • Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli. 
  • Modulation of experimental arthritis by vagal sensory and central brain stimulation. 
  • Modulation of intestinal sulfur assimilation metabolism regulates iron homeostasis. 
  • Modulation of taste responsiveness by the satiation hormone peptide YY. 
  • Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation. 
  • Molecular manipulations of extracellular superoxide dismutase: functional importance for learning. 
  • Morphine side effects in beta-arrestin 2 knockout mice. 
  • Morphogenesis and Compartmentalization of the Intestinal Crypt. 
  • Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. 
  • Morphologic phenotyping with MR microscopy: the visible mouse. 
  • Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism. 
  • Mouse keratin 4 is necessary for internal epithelial integrity. 
  • Mouse model of Timothy syndrome recapitulates triad of autistic traits. 
  • Mouse model of glycogen storage disease type III. 
  • Mouse models for studying genetic influences on factors determining smoking cessation success in humans. 
  • Mouse models of diabetic nephropathy. 
  • Mouse retinal pigmented epithelial cell lines retain their phenotypic characteristics after transfection with human papilloma virus: a new tool to further the study of RPE biology. 
  • Mst1/Mst2 regulate development and function of regulatory T cells through modulation of Foxo1/Foxo3 stability in autoimmune disease. 
  • Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. 
  • Mu-opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: lack of ethanol interactions. 
  • MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet. 
  • Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. 
  • Multifaceted Changes in Synaptic Composition and Astrocytic Involvement in a Mouse Model of Fragile X Syndrome. 
  • Multiple constraints at the level of TCRalpha rearrangement impact Valpha14i NKT cell development. 
  • Multiple gamma c-dependent cytokines regulate T-cell development. 
  • Multiple innate inflammatory responses induced after systemic adenovirus vector delivery depend on a functional complement system. 
  • Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis. 
  • Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release. 
  • Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro B cells. 
  • Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness. 
  • Multivariate MR biomarkers better predict cognitive dysfunction in mouse models of Alzheimer's disease. 
  • Munc13-1 is required for presynaptic long-term potentiation. 
  • Murine Glucocorticoid Receptors Orchestrate B Cell Migration Selectively between Bone Marrow and Blood. 
  • Murine cytomegalovirus retinitis during retrovirus-induced immunodeficiency (MAIDS) in mice: interleukin-2 immunotherapy correlates with increased intraocular levels of perforin mRNA. 
  • Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract. 
  • Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. 
  • Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging. 
  • Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment. 
  • Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice. 
  • Muscle Krüppel-like factor 15 regulates lipid flux and systemic metabolic homeostasis. 
  • Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet. 
  • Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility. 
  • Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization. 
  • Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch. 
  • Mutations in TFAM, encoding mitochondrial transcription factor A, cause neonatal liver failure associated with mtDNA depletion. 
  • Myc requires distinct E2F activities to induce S phase and apoptosis. 
  • Mycobacterium bovis bacille Calmette-Guérin infection in the CNS suppresses experimental autoimmune encephalomyelitis and Th17 responses in an IFN-gamma-independent manner. 
  • Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1. 
  • Myeloid-Specific Deletion of Mcl-1 Yields Severely Neutropenic Mice That Survive and Breed in Homozygous Form. 
  • Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis. 
  • Myeloperoxidase is increased in human cerebral aneurysms and increases formation and rupture of cerebral aneurysms in mice. 
  • Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations. 
  • Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF. 
  • N-cadherin functions as a growth suppressor in a model of K-ras-induced PanIN. 
  • N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity. 
  • N-formyl peptide receptors internalize but do not recycle in the absence of arrestins. 
  • N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias. 
  • NAD+ modulates p53 DNA binding specificity and function. 
  • NCKAP1 Disruptive Variants Lead to a Neurodevelopmental Disorder with Core Features of Autism. 
  • NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity. 
  • NF-κB activation persists into the remodeling phase of tendon healing and promotes myofibroblast survival. 
  • NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes. 
  • NK cell recruitment limits tissue damage during an enteric helminth infection. 
  • NLRC3 negatively regulates CD4+ T cells and impacts protective immunity during Mycobacterium tuberculosis infection. 
  • NLRP3 Promotes Diabetic Bladder Dysfunction and Changes in Symptom-Specific Bladder Innervation. 
  • NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis. 
  • NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses. 
  • NO and superoxide: opposite ends of the seesaw in cardiac contractility. 
  • NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease. 
  • NOS2 regulation of NF-kappaB by S-nitrosylation of p65. 
  • NOX2 protects against prolonged inflammation, lung injury, and mortality following systemic insults. 
  • NPAS3 is a trachealess homolog critical for lung development and homeostasis. 
  • Nasal vaccination with troponin reduces troponin specific T-cell responses and improves heart function in myocardial ischemia-reperfusion injury. 
  • Natural IgM Switches the Function of Lipopolysaccharide-Activated Murine Bone Marrow-Derived Dendritic Cells to a Regulatory Dendritic Cell That Suppresses Innate Inflammation. 
  • Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume. 
  • Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. 
  • Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunity. 
  • Near-infrared spectrometry of abdominal aortic aneurysm in the ApoE-/- mouse. 
  • Necroptosis-independent signaling by the RIP kinases in inflammation. 
  • Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1. 
  • Neonatal co-infection with helicobacter species markedly accelerates the development of inflammation-associated colonic neoplasia in IL-10(-/-) mice. 
  • Neonates support lymphopenia-induced proliferation. 
  • Nervous system defects of AnkyrinB (-/-) mice suggest functional overlap between the cell adhesion molecule L1 and 440-kD AnkyrinB in premyelinated axons. 
  • Neural circuit repair by low-intensity magnetic stimulation requires cellular magnetoreceptors and specific stimulation patterns. 
  • Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice. 
  • Neurodevelopmental mutation of giant ankyrin-G disrupts a core mechanism for axon initial segment assembly. 
  • Neuroendocrine effects of dehydration in mice lacking the angiotensin AT1a receptor. 
  • Neuroimmune perspectives in sepsis. 
  • Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis. 
  • Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice. 
  • Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect. 
  • Neuronal IL-4Rα modulates neuronal apoptosis and cell viability during the acute phases of cerebral ischemia. 
  • Neuronal ceroid lipofuscinosis: a common pathway? 
  • Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance. 
  • Neuropathology in respiratory-related motoneurons in young Pompe (Gaa(-/-)) mice. 
  • Neuroprotection mediated through estrogen receptor-alpha in astrocytes. 
  • Neurosteroid transport by the organic solute transporter OSTα-OSTβ. 
  • Neurotrophin-3 signaling maintains maturational homeostasis between neuronal populations in the olfactory epithelium. 
  • Neutrophil L-Plastin Controls Ocular Paucibacteriality and Susceptibility to Keratitis. 
  • Neutrophil accumulation and NET release contribute to thrombosis in HIT. 
  • New insights into adenosine-receptor-mediated immunosuppression and the role of adenosine in causing the immunodeficiency associated with adenosine deaminase deficiency. 
  • New mass spectrometric assay for angiotensin-converting enzyme 2 activity. 
  • Newborn, carrier, and early childhood screening recommendations for fragile X. 
  • Nicotine activates TRPM5-dependent and independent taste pathways. 
  • Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. 
  • Nicotinic alpha7- or beta2-containing receptor knockout: effects on radial-arm maze learning and long-term nicotine consumption in mice. 
  • Nitric oxide as an inflammatory mediator in autoimmune MRL-lpr/lpr mice. 
  • Nitric oxide mediates relative airway hyporesponsiveness to lipopolysaccharide in surfactant protein A-deficient mice. 
  • Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases. 
  • Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia. 
  • Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice. 
  • Nitric oxide-mediated intracellular growth restriction of pathogenic Rhodococcus equi can be prevented by iron. 
  • Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors. 
  • Nogo receptor 1 is expressed by nearly all retinal ganglion cells. 
  • Noradrenergic control of cortico-striato-thalamic and mesolimbic cross-structural synchrony. 
  • Norepinephrine induces hepatic fibrogenesis in leptin deficient ob/ob mice. 
  • Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis. 
  • Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. 
  • Novel role for surfactant protein A in gastrointestinal graft-versus-host disease. 
  • Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma. 
  • Novelty seeking and stereotypic activation of behavior in mice with disruption of the Dat1 gene. 
  • Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration. 
  • Nox2 NADPH oxidase is dispensable for platelet activation or arterial thrombosis in mice. 
  • Nox4 NADPH oxidase contributes to smooth muscle cell phenotypes associated with unstable atherosclerotic plaques. 
  • Nrf2-mediated protection against 6-hydroxydopamine. 
  • Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis. 
  • Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes. 
  • Nuclear receptors as potential therapeutic targets for age-related macular degeneration. 
  • Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice. 
  • OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection. 
  • Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications. 
  • Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. 
  • Odorant receptors govern the formation of a precise topographic map. 
  • Oestrogen receptors enhance dopamine neurone survival in rat midbrain. 
  • Of cardiovascular illness and diversity of biological response. 
  • Of mice, birds, and men: the mouse ultrasonic song system has some features similar to humans and song-learning birds. 
  • Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice. 
  • On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy. 
  • Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. 
  • One tissue, two fates: molecular genetic events that underlie testis versus ovary development. 
  • Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts. 
  • Opposing actions of renal tubular- and myeloid-derived porcupine in obstruction-induced kidney fibrosis. 
  • Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling. 
  • Optimal processing of photoreceptor signals is required to maximize behavioural sensitivity. 
  • Oral L-arginine stimulates GLP-1 secretion to improve glucose tolerance in male mice. 
  • Oral feeding with pig peripheral lymphocytes decreases the xenogeneic delayed type hypersensitivity reaction in galactosyltransferase knockout mice. 
  • Oral immunogenicity of the plant proteinase bromelain. 
  • Orphan nuclear receptors in T lymphocyte development. 
  • Osteoclast differentiation and function in aquaglyceroporin AQP9-null mice. 
  • Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages. 
  • Osteopontin deficiency ameliorates Alport pathology by preventing tubular metabolic deficits. 
  • Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. 
  • Osteopontin mediates Stat1 degradation to inhibit iNOS transcription in a cecal ligation and puncture model of sepsis. 
  • Overload-induced skeletal muscle extracellular matrix remodelling and myofibre growth in mice lacking IL-6. 
  • Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice. 
  • Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway. 
  • Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease. 
  • Oxygen seizure latency and peroxynitrite formation in mice lacking neuronal or endothelial nitric oxide synthases. 
  • Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2. 
  • Ozone inhalation promotes CX3CR1-dependent maturation of resident lung macrophages that limit oxidative stress and inflammation. 
  • P-glycoprotein is a major determinant of norbuprenorphine brain exposure and antinociception. 
  • PAD4 is not essential for disease in the K/BxN murine autoantibody-mediated model of arthritis. 
  • PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection. 
  • PAX9 regulates squamous cell differentiation and carcinogenesis in the oro-oesophageal epithelium. 
  • PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia. 
  • PD-1 blockade inhibits osteoclast formation and murine bone cancer pain. 
  • PD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue. 
  • PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis. 
  • PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1. 
  • PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo. 
  • PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. 
  • PECAM-1 dampens cytokine levels during LPS-induced endotoxemia by regulating leukocyte trafficking. 
  • PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis. 
  • PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons. 
  • PINK1 mediates the protective effects of thyroid hormone T3 in hyperoxia-induced lung injury. 
  • PKM1 Exerts Critical Roles in Cardiac Remodeling Under Pressure Overload in the Heart. 
  • PLEKHG5 deficiency leads to an intermediate form of autosomal-recessive Charcot-Marie-Tooth disease. 
  • PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance. 
  • PPAR alpha ligand protects during cisplatin-induced acute renal failure by preventing inhibition of renal FAO and PDC activity. 
  • PRCD is essential for high-fidelity photoreceptor disc formation. 
  • PTH receptor signaling in osteoblasts regulates endochondral vascularization in maintenance of postnatal growth plate. 
  • PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer. 
  • PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms. 
  • Packaging of an AAV vector encoding human acid alpha-glucosidase for gene therapy in glycogen storage disease type II with a modified hybrid adenovirus-AAV vector. 
  • Palmitoylation of the immunity related GTPase, Irgm1: impact on membrane localization and ability to promote mitochondrial fission. 
  • Pannexin 1 channels control the hemodynamic response to hypoxia by regulating O2-sensitive extracellular ATP in blood. 
  • Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma. 
  • Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin. 
  • Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1. 
  • Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP. 
  • Pathogenesis of growth failure and partial reversal with gene therapy in murine and canine Glycogen Storage Disease type Ia. 
  • Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity. 
  • Pathophysiology of SPINK mutations in pancreatic development and disease. 
  • Pattern recognition molecule mindin promotes intranasal clearance of influenza viruses. 
  • Perforin knockout mice, but not mice with MAIDS, show protection against experimental cytomegalovirus retinitis after adoptive transfer of immune cells with a functional perforin cytotoxic pathway. 
  • Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers. 
  • Peripheral nerve and neuromuscular junction pathology in Pompe disease. 
  • Peripheral sensory nerve defects in apolipoprotein E knockout mice. 
  • Peripheral serotonin causes dengue virus-induced thrombocytopenia through 5HT2 receptors. 
  • Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2. 
  • Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-γ+CD4+ T cell numbers during colitis development in mice. 
  • Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia. 
  • Peroxynitrite formation and decreased catalase activity in autoimmune MRL-lpr/lpr mice. 
  • Persistent expression of MNF identifies myogenic stem cells in postnatal muscles. 
  • Persistent hyperdopaminergia decreases the peak frequency of hippocampal theta oscillations during quiet waking and REM sleep. 
  • Persisting neurobehavioral effects of developmental copper exposure in wildtype and metallothionein 1 and 2 knockout mice. 
  • Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy. 
  • Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model. 
  • Pharmacometabolomic signature of ataxia SCA1 mouse model and lithium effects. 
  • Phenotype correction of hemophilia A mice by spliceosome-mediated RNA trans-splicing. 
  • Phenotypic characterization of murine models of cerebral cavernous malformations. 
  • Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouse. 
  • Phosducin regulates the expression of transducin betagamma subunits in rod photoreceptors and does not contribute to phototransduction adaptation. 
  • Phosducin regulates transmission at the photoreceptor-to-ON-bipolar cell synapse. 
  • Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging. 
  • Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins. 
  • Phosphodiesterase 4 Inhibitors Attenuate the Asthma Phenotype Produced by β2-Adrenoceptor Agonists in Phenylethanolamine N-Methyltransferase-Knockout Mice. 
  • Phosphorylation at tyrosine 262 promotes GADD34 protein turnover. 
  • Phosphorylation of G protein-coupled receptor kinase 1 (GRK1) is regulated by light but independent of phototransduction in rod photoreceptors. 
  • Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. 
  • Photon-counting cine-cardiac CT in the mouse. 
  • Photoreceptor discs form through peripherin-dependent suppression of ciliary ectosome release. 
  • Photoreceptors in a mouse model of Leigh syndrome are capable of normal light-evoked signaling. 
  • Physiologic Consequences of Caveolin-1 Ablation in Conventional Outflow Endothelia. 
  • Physiological roles of the GIP receptor in murine brown adipose tissue. 
  • Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis. 
  • Pik3c3 deletion in pyramidal neurons results in loss of synapses, extensive gliosis and progressive neurodegeneration. 
  • Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis. 
  • Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans. 
  • Plasminogen activator inhibitor-1 (PAI-1) modifies the formation of aggressive fibromatosis (desmoid tumor). 
  • Plasminogen alleles influence susceptibility to invasive aspergillosis. 
  • Plasticity and behavior: new genetic techniques to address multiple forms and functions. 
  • Plasticity of renal erythropoietin-producing cells governs fibrosis. 
  • Platelet-derived growth factor (PDGF) regulates Slingshot phosphatase activity via Nox1-dependent auto-dephosphorylation of serine 834 in vascular smooth muscle cells. 
  • Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell-bound CD154. 
  • Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches. 
  • Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche. 
  • Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation. 
  • Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease. 
  • Polysaccharides PS-G and protein LZ-8 from Reishi (Ganoderma lucidum) exhibit diverse functions in regulating murine macrophages and T lymphocytes. 
  • Postnatal TrkB ablation in corticolimbic interneurons induces social dominance in male mice. 
  • Postsynaptic Mechanisms Render Syn I/II/III Mice Highly Responsive to Psychostimulants. 
  • Posttranslational regulation of TCR Valpha allelic exclusion during T cell differentiation. 
  • Potential role of Hedgehog signaling and microRNA-29 in liver fibrosis of IKKβ-deficient mouse. 
  • Precise regulation of porcupine activity is required for physiological Wnt signaling. 
  • Pregnenolone rescues schizophrenia-like behavior in dopamine transporter knockout mice. 
  • Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver. 
  • Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases. 
  • Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection. 
  • Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice. 
  • Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors. 
  • Presynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca2+ entry pathway. 
  • Prevention of the polycystic ovarian phenotype and characterization of ovulatory capacity in the estrogen receptor-alpha knockout mouse. 
  • Pro- and antiatherogenic effects of a dominant-negative P465L mutation of peroxisome proliferator-activated receptor-γ in apolipoprotein E-Null mice. 
  • ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine. 
  • Progenitor cell dose determines the pace and completeness of engraftment in a xenograft model for cord blood transplantation. 
  • Progressive improvement in wound healing with increased therapy in haemophilia B mice. 
  • Progressive optic atrophy in a retinal ganglion cell-specific mouse model of complex I deficiency. 
  • Proinflammatory actions of thromboxane receptors to enhance cellular immune responses. 
  • Prolactin receptor signal transduction pathways and actions determined in prolactin receptor knockout mice. 
  • Prolactin receptor signaling is essential for perinatal brown adipocyte function: a role for insulin-like growth factor-2. 
  • Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance. 
  • Prolonged survival of class II transactivator-deficient cardiac allografts. 
  • Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination. 
  • Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism in animal models. 
  • Prostacyclin protects against elevated blood pressure and cardiac fibrosis. 
  • Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. 
  • Protease-activated receptor-2 signaling triggers dendritic cell development. 
  • Proteasome overload is a common stress factor in multiple forms of inherited retinal degeneration. 
  • Protection from experimental asthma by an endogenous bronchodilator. 
  • Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. 
  • Protective immunity in recurrent Staphylococcus aureus infection reflects localized immune signatures and macrophage-conferred memory. 
  • Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. 
  • Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions. 
  • Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation. 
  • Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity. 
  • Proteomic identification of specific oxidized proteins in ApoE-knockout mice: relevance to Alzheimer's disease. 
  • Prothymosin-alpha inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction. 
  • Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways. 
  • Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism. 
  • Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes. 
  • R-spondin1 tips the balance in sex determination. 
  • R9AP targeting to rod outer segments is independent of rhodopsin and is guided by the SNARE homology domain. 
  • RGS2-deficient mice exhibit decreased intraocular pressure and increased retinal ganglion cell survival. 
  • RGS2: a "turn-off" in hypertension. 
  • RGS9 knockout causes a short delay in light responses of ON-bipolar cells. 
  • RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression. 
  • ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm. 
  • RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2. 
  • Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. 
  • Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo. 
  • Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). 
  • Rapamycin does not control hemophagocytic lymphohistiocytosis in LCMV-infected perforin-deficient mice. 
  • Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing. 
  • Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction. 
  • RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer. 
  • Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium. 
  • Reactive oxygen species induce antibiotic tolerance during systemic Staphylococcus aureus infection. 
  • Receptor tyrosine kinase MerTK suppresses an allogenic type I IFN response to promote transplant tolerance. 
  • Receptors and signaling mechanisms required for prostaglandin E2-mediated regulation of mast cell degranulation and IL-6 production. 
  • Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse. 
  • Recipient Myd88 Deficiency Promotes Spontaneous Resolution of Kidney Allograft Rejection. 
  • Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2. 
  • Recruited exudative macrophages selectively produce CXCL10 after noninfectious lung injury. 
  • Recurrent GNAQ mutation encoding T96S in natural killer/T cell lymphoma. 
  • Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles. 
  • Reduced arsenic clearance and increased toxicity in aquaglyceroporin-9-null mice. 
  • Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice. 
  • Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. 
  • Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis. 
  • Reduced prostate branching morphogenesis in stromal fibroblast, but not in epithelial, estrogen receptor α knockout mice. 
  • Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice. 
  • Reduction of Autophagic Accumulation in Pompe Disease Mouse Model Following Gene Therapy. 
  • Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice. 
  • Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo. 
  • Regional absence of mitochondria causing energy depletion in the myocardium of muscle LIM protein knockout mice. 
  • Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase. 
  • Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage. 
  • Regulation of Intrinsic and Bystander T Follicular Helper Cell Differentiation and Autoimmunity by Tsc1. 
  • Regulation of T cell receptor beta allelic exclusion at a level beyond accessibility. 
  • Regulation of T-cell survival and mitochondrial homeostasis by TSC1. 
  • Regulation of TCR delta and alpha repertoires by local and long-distance control of variable gene segment chromatin structure. 
  • Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility. 
  • Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation. 
  • Regulation of blood pressure by the type 1A angiotensin II receptor gene. 
  • Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction. 
  • Regulation of humoral immune responses by CD21/CD35. 
  • Regulation of inflammation by β-arrestins: Not just receptor tales. 
  • Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis. 
  • Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation. 
  • Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL. 
  • Regulation of sodium balance and blood pressure by the AT(1A) receptor for angiotensin II. 
  • Regulation of steady-state neutrophil homeostasis by macrophages. 
  • Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein. 
  • Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2. 
  • Regulation of transcription factor NFAT by ADP-ribosylation. 
  • Regulator of G protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor. 
  • Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice. 
  • Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis. 
  • Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity. 
  • Regulatory T cell ablation causes acute T cell lymphopenia. 
  • Relation of addiction genes to hypothalamic gene changes subserving genesis and gratification of a classic instinct, sodium appetite. 
  • Relative contributions of rod and cone bipolar cell inputs to AII amacrine cell light responses in the mouse retina. 
  • Relative contributions of selectins and intercellular adhesion molecule-1 to tissue injury induced by immune complex deposition. 
  • Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery. 
  • Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition. 
  • Renal actions of RGS2 control blood pressure. 
  • Renal function in the AT1A receptor knockout mouse during normal and volume-expanded conditions. 
  • Renal growth and development in mice lacking AT1A receptors for angiotensin II. 
  • Renal segmental microvascular responses to ANG II in AT1A receptor null mice. 
  • Renal vascular reactivity in mice: AngII-induced vasoconstriction in AT1A receptor null mice. 
  • Reperfusion injury in skeletal muscle is reduced in inducible nitric oxide synthase knockout mice. 
  • Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor. 
  • Requirement for Ca2+/calmodulin-dependent kinase type IV/Gr in setting the thymocyte selection threshold. 
  • Requirements for T lymphocyte migration in explanted lymph nodes. 
  • Rescue of Pompe disease in mice by AAV-mediated liver delivery of secretable acid α-glucosidase. 
  • Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family. 
  • Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels. 
  • Resistance to hypertension mediated by intercalated cells of the collecting duct. 
  • Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. 
  • Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. 
  • Restoring hemostatic thrombin generation at the time of cutaneous wounding does not normalize healing in hemophilia B. 
  • Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia. 
  • Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice. 
  • Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways. 
  • Retinal pigment epithelial cells induce foxp3(+) regulatory T cells via membrane-bound TGF-β. 
  • Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis. 
  • Retrovirus-elicited interleukin-12 and tumour necrosis factor-alpha as inducers of interferon-gamma-mediated pathology in mouse AIDS. 
  • Review: Collectins link innate and adaptive immunity in allergic airway disease. 
  • Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease. 
  • Role for the target enzyme in deactivation of photoreceptor G protein in vivo. 
  • Role for thromboxane receptors in angiotensin-II-induced hypertension. 
  • Role of CCR5 in the pathogenesis of IL-13-induced inflammation and remodeling. 
  • Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease. 
  • Role of EP(2) and EP(3) PGE(2) receptors in control of murine renal hemodynamics. 
  • Role of Fn14 in acute alcoholic steatohepatitis in mice. 
  • Role of LAT in the granule-mediated cytotoxicity of CD8 T cells. 
  • Role of TRPV ion channels in sensory transduction of osmotic stimuli in mammals. 
  • Role of Transient Receptor Potential Vanilloid 4 in Neutrophil Activation and Acute Lung Injury. 
  • Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal. 
  • Role of complement receptors 1 and 2 (CD35 and CD21), C3, C4, and C5 in survival by mice of Staphylococcus aureus bacteremia. 
  • Role of interleukin-1beta in postoperative cognitive dysfunction. 
  • Role of metabolic activation and the TRPA1 receptor in the sensory irritation response to styrene and naphthalene. 
  • Role of microsomal prostaglandin E synthase 1 in the kidney. 
  • Role of prostacyclin in the cardiovascular response to thromboxane A2. 
  • Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. 
  • Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. 
  • Role of transcription factor NFAT in glucose and insulin homeostasis. 
  • Role of tumor suppressor TSC1 in regulating antigen-specific primary and memory CD8 T cell responses to bacterial infection. 
  • Roles of estrogen in the formation of intracranial aneurysms in ovariectomized female mice. 
  • Roles of organizer factors and BMP antagonism in mammalian forebrain establishment. 
  • Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency. 
  • Rpl13a small nucleolar RNAs regulate systemic glucose metabolism. 
  • Ryk controls remapping of motor cortex during functional recovery after spinal cord injury. 
  • S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection. 
  • SEMA3A signaling controls layer-specific interneuron branching in the cerebellum. 
  • SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons. 
  • SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. 
  • SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. 
  • SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion. 
  • SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. 
  • SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. 
  • SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. 
  • SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model. 
  • SMPDL3b modulates insulin receptor signaling in diabetic kidney disease. 
  • SP-A preserves airway homeostasis during Mycoplasma pneumoniae infection in mice. 
  • SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart. 
  • STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection. 
  • STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration. 
  • STAT3-enhancing germline mutations contribute to tumor-extrinsic immune evasion. 
  • STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib. 
  • STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice. 
  • STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node. 
  • SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease. 
  • SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development. 
  • SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. 
  • SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. 
  • Salmeterol enhances the cardiac response to gene therapy in Pompe disease. 
  • Salmeterol with Liver Depot Gene Therapy Enhances the Skeletal Muscle Response in Murine Pompe Disease. 
  • Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines. 
  • Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity. 
  • Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity. 
  • Secondary allergic T cell responses are regulated by dendritic cell-derived thrombospondin-1 in the setting of allergic eye disease. 
  • Secreted osteopontin from CD4+ T cells limits acute graft-versus-host disease. 
  • Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. 
  • Selective role for TRPV4 ion channels in visceral sensory pathways. 
  • Self-assembled peptide nanofibers raising durable antibody responses against a malaria epitope. 
  • Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic. 
  • Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism. 
  • Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels. 
  • Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity. 
  • Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. 
  • Serum cholesterol levels and tumor growth in a PTEN-null transgenic mouse model of prostate cancer. 
  • Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins. 
  • Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background. 
  • Sex-Specific Mechanisms of Resistance Vessel Endothelial Dysfunction Induced by Cardiometabolic Risk Factors. 
  • Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9. 
  • Signals from dying hepatocytes trigger growth of liver progenitors. 
  • Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation. 
  • Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site. 
  • Sirtuin 5 is required for mouse survival in response to cardiac pressure overload. 
  • Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. 
  • Skeletal muscle mass recovery from atrophy in IL-6 knockout mice. 
  • Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin. 
  • Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair. 
  • Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice. 
  • Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. 
  • Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. 
  • Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain. 
  • Smoothelin-like 1 deletion enhances myogenic reactivity of mesenteric arteries with alterations in PKC and myosin phosphatase signaling. 
  • Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase. 
  • Sodium channels and mammalian sensory mechanotransduction. 
  • Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney. 
  • Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport. 
  • Somatic Liver Knockout (SLiK): A Quick and Efficient Way to Generate Liver-Specific Knockout Mice Using Multiplex CRISPR/Cas9 Gene Editing. 
  • Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate. 
  • Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination. 
  • Sonic hedgehog is required for cardiac outflow tract and neural crest cell development. 
  • Sour taste responses in mice lacking PKD channels. 
  • Sox2 regulates cholinergic amacrine cell positioning and dendritic stratification in the retina. 
  • Sox6 as a new modulator of renin expression in the kidney. 
  • Spatial organization of bacterial flora in normal and inflamed intestine: a fluorescence in situ hybridization study in mice. 
  • Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function. 
  • Spermatogenesis and the regulation of Ca(2+)-calmodulin-dependent protein kinase IV localization are not dependent on calspermin. 
  • Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4. 
  • Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. 
  • Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1. 
  • Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine. 
  • Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. 
  • Splenectomy and partial splenectomy improve hematopoietic stem cell engraftment in hypersplenic mice. 
  • Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis. 
  • Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure-Lowering Effects of Latanoprost. 
  • Starch Binding Domain-containing Protein 1 Plays a Dominant Role in Glycogen Transport to Lysosomes in Liver. 
  • Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems. 
  • Stbd1 is highly elevated in skeletal muscle of Pompe disease mice but suppression of its expression does not affect lysosomal glycogen accumulation. 
  • Steroid hormones drive cancer development. 
  • Steroidogenic factor 1 (SF-1) is essential for endocrine development and function. 
  • Steroidogenic factor 1 (SF-1) is essential for ovarian development and function. 
  • Steroidogenic factor 1 is the essential transcript of the mouse Ftz-F1 gene. 
  • Steroidogenic factor 1 plays multiple roles in endocrine development and function. 
  • Steroidogenic factor 1: an essential mediator of endocrine development. 
  • Stimulating Type 1 Angiotensin Receptors on T Lymphocytes Attenuates Renal Fibrosis. 
  • Stimulation of Respiratory Motor Output and Ventilation in a Murine Model of Pompe Disease by Ampakines. 
  • Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension. 
  • Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53. 
  • Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival. 
  • Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts. 
  • Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones. 
  • Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis. 
  • Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors. 
  • Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D₂ receptor agonists. 
  • Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3). 
  • Substance P receptor mediated maintenance of chronic inflammation in EAE. 
  • Subtype specific estrogen receptor action protects against changes in MMP-2 activation in mouse retinal pigmented epithelial cells. 
  • Sulfation of glycosaminoglycans depends on the catalytic activity of lithium-inhibited phosphatase BPNT2 in vitro. 
  • Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. 
  • Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis. 
  • Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization. 
  • Suppression of aberrant choroidal neovascularization through activation of the aryl hydrocarbon receptor. 
  • Surfactant protein A integrates activation signal strength to differentially modulate T cell proliferation. 
  • Surfactant protein A modulates induction of regulatory T cells via TGF-β. 
  • Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair. 
  • Surfactant protein D facilitates Cryptococcus neoformans infection. 
  • Surfactant protein D increases phagocytosis of hypocapsular Cryptococcus neoformans by murine macrophages and enhances fungal survival. 
  • Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis. 
  • Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis. 
  • Susceptibility to vascular neoplasms but no increased susceptibility to renal carcinogenesis in Vhl knockout mice. 
  • Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis. 
  • Synapsins differentially control dopamine and serotonin release. 
  • Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance. 
  • Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways. 
  • Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment. 
  • Syncoilin isoform organization and differential expression in murine striated muscle. 
  • Syncoilin modulates peripherin filament networks and is necessary for large-calibre motor neurons. 
  • Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation. 
  • Synergistic Efficacy from Gene Therapy with Coreceptor Blockade and a β2-Agonist in Murine Pompe Disease. 
  • Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta. 
  • Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass. 
  • Systemic correction of the muscle disorder glycogen storage disease type II after hepatic targeting of a modified adenovirus vector encoding human acid-alpha-glucosidase. 
  • Systems biology of vaccination for seasonal influenza in humans. 
  • T cell engagement of cross-presenting microglia protects the brain from a nasal virus infection. 
  • T-bet-dependent expression of osteopontin contributes to T cell polarization. 
  • T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells. 
  • TASK-1 and TASK-3 channels modulate pressure overload-induced cardiac remodeling and dysfunction. 
  • TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Nonfunctioning Pituitary Adenomas in Mice. 
  • TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation. 
  • TERC is not a major gene in human neural tube defects. 
  • TGFβ/Smad3 signal pathway is not required for epidermal Langerhans cell development. 
  • TLR adaptor MyD88 is essential for pathogen control during oral toxoplasma gondii infection but not adaptive immunity induced by a vaccine strain of the parasite. 
  • TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk. 
  • TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and neuroinflammation. 
  • TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. 
  • TLR4 signaling attenuates ongoing allergic inflammation. 
  • TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury. 
  • TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. 
  • TNF is required for the induction but not the maintenance of compression-induced BME signals in murine tail vertebrae: limitations of anti-TNF therapy for degenerative disc disease. 
  • TNF-α contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2. 
  • TNF-α in T lymphocytes attenuates renal injury and fibrosis during nephrotoxic nephritis. 
  • TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis. 
  • TRPA1 is a major oxidant sensor in murine airway sensory neurons. 
  • TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. 
  • TRPA1 mediates the noxious effects of natural sesquiterpene deterrents. 
  • TRPC1 channels are critical for hypertrophic signaling in the heart. 
  • TRPC6 enhances angiotensin II-induced albuminuria. 
  • TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain. 
  • TRPV1 receptors mediate particulate matter-induced apoptosis. 
  • TRPV4 Is Required for Hypoxic Pulmonary Vasoconstriction. 
  • TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension. 
  • TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation. 
  • TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells. 
  • TRPV4 channels augment macrophage activation and ventilator-induced lung injury. 
  • TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses. 
  • TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs. 
  • TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure. 
  • TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation. 
  • TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice. 
  • Targeted HAS2 Expression Lessens Airway Responsiveness in Chronic Murine Allergic Airway Disease. 
  • Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance. 
  • Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation. 
  • Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice. 
  • Targeted disruption of the estrogen receptor-alpha gene in female mice: characterization of ovarian responses and phenotype in the adult. 
  • Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis. 
  • Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. 
  • Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. 
  • Targeted gene disruption in endocrine research--the case of glucagon-like peptide-1 and neuroendocrine function. 
  • Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function. 
  • Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. 
  • Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells. 
  • Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle. 
  • Targeted proteomic profiling of renal Na(+) transporter and channel abundances in angiotensin II type 1a receptor knockout mice. 
  • Targeting CXCR4-dependent immunosuppressive Ly6Clow monocytes improves antiangiogenic therapy in colorectal cancer. 
  • Targeting Endoglin-Expressing Regulatory T Cells in the Tumor Microenvironment Enhances the Effect of PD1 Checkpoint Inhibitor Immunotherapy. 
  • Targeting High Mobility Group Box-1 (HMGB1) Promotes Cell Death in Myelodysplastic Syndrome. 
  • Targeting PIM Kinase with PD1 Inhibition Improves Immunotherapeutic Antitumor T-cell Response. 
  • Targeting VE-PTP phosphatase protects the kidney from diabetic injury. 
  • Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation. 
  • Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease. 
  • Targeting proximal tubule mitochondrial dysfunction attenuates the renal disease of methylmalonic acidemia. 
  • Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms. 
  • Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma. 
  • Taste perception: how to make a gourmet mouse. 
  • Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression. 
  • Tau is essential to beta -amyloid-induced neurotoxicity. 
  • Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation. 
  • Tau--an inhibitor of deacetylase HDAC6 function. 
  • Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits. 
  • Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub. 
  • Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire. 
  • Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney. 
  • Temporal modulation of collective cell behavior controls vascular network topology. 
  • Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy. 
  • Tenascin knockout mice: barrels, boundary molecules, and glial scars. 
  • Tenascin-C knockout mouse has no detectable tenascin-C protein. 
  • Tetraspanin CD37 protects against the development of B cell lymphoma. 
  • Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout mice. 
  • Th1-Dependent Cryptococcus-Associated Immune Reconstitution Inflammatory Syndrome Model With Brain Damage. 
  • Th17 Immunity in the Colon Is Controlled by Two Novel Subsets of Colon-Specific Mononuclear Phagocytes. 
  • Thalamic relay of spontaneous retinal activity prior to vision. 
  • The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia. 
  • The Arp2/3 Complex Is Essential for Distinct Stages of Spine Synapse Maturation, Including Synapse Unsilencing. 
  • The BMP antagonists Chordin and Noggin have essential but redundant roles in mouse mandibular outgrowth. 
  • The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system. 
  • The Cell-Intrinsic Circadian Clock Is Dispensable for Lymphocyte Differentiation and Function. 
  • The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy. 
  • The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency. 
  • The Enigma of CRB1 and CRB1 Retinopathies. 
  • The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies. 
  • The GARP Domain of the Rod CNG Channel's β1-Subunit Contains Distinct Sites for Outer Segment Targeting and Connecting to the Photoreceptor Disk Rim. 
  • The GS Protein-coupled A2a Adenosine Receptor Controls T Cell Help in the Germinal Center. 
  • The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia. 
  • The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment. 
  • The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages. 
  • The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection. 
  • The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. 
  • The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. 
  • The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. 
  • The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons. 
  • The PD-1 Regulatory Axis Inhibits T Cell-Independent B Cell Memory Generation and Reactivation. 
  • The Phagocyte Oxidase Controls Tolerance to Mycobacterium tuberculosis Infection. 
  • The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis. 
  • The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation. 
  • The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections. 
  • The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. 
  • The Toll-Like Receptor 2/6 Agonist, FSL-1 Lipopeptide, Therapeutically Mitigates Acute Radiation Syndrome. 
  • The Ubiquitin-Modifying Enzyme A20 Terminates C-Type Lectin Receptor Signals and Is a Suppressor of Host Defense against Systemic Fungal Infection. 
  • The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation. 
  • The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor. 
  • The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety. 
  • The anorectic effect of GLP-1 in rats is nutrient dependent. 
  • The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel. 
  • The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes. 
  • The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages. 
  • The autophagy gene ATG5 plays an essential role in B lymphocyte development. 
  • The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development. 
  • The bi-modal effects of estradiol on gonadotropin synthesis and secretion in female mice are dependent on estrogen receptor-alpha. 
  • The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. 
  • The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice. 
  • The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19. 
  • The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival. 
  • The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition. 
  • The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. 
  • The capsaicin receptor participates in artificial sweetener aversion. 
  • The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits. 
  • The central effectors of cell death in the immune system. 
  • The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression. 
  • The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. 
  • The contribution of type I interferon signaling to immunity induced by alphavirus replicon vaccines. 
  • The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression. 
  • The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis. 
  • The death-inducing activity of RIPK1 is regulated by the pH environment. 
  • The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling. 
  • The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. 
  • The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity. 
  • The dopamine metabolite 3-methoxytyramine is a neuromodulator. 
  • The double-stranded RNA-activated protein kinase mediates viral-induced encephalitis. 
  • The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer. 
  • The effect of inflammatory cell-derived MCP-1 loss on neuronal survival during chronic neuroinflammation. 
  • The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. 
  • The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. 
  • The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense. 
  • The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. 
  • The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. 
  • The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation. 
  • The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. 
  • The helix-loop-helix gene E2A is required for B cell formation. 
  • The host defense peptide cathelicidin is required for NK cell-mediated suppression of tumor growth. 
  • The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background. 
  • The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy. 
  • The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. 
  • The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy. 
  • The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. 
  • The long isoform of cellular FLIP is essential for T lymphocyte proliferation through an NF-kappaB-independent pathway. 
  • The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis. 
  • The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice. 
  • The lung is protected from spontaneous inflammation by autophagy in myeloid cells. 
  • The m6A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis. 
  • The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation. 
  • The mammalian twisted gastrulation gene functions in foregut and craniofacial development. 
  • The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via μ- and κ-opioid receptors. 
  • The naturally occurring luteinizing hormone surge is diminished in mice lacking estrogen receptor Beta in the ovary. 
  • The necroptosis adaptor RIPK3 promotes injury-induced cytokine expression and tissue repair. 
  • The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. 
  • The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration. 
  • The oral iron chelator deferiprone protects against systemic iron overload-induced retinal degeneration in hepcidin knockout mice. 
  • The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. 
  • The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice. 
  • The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18. 
  • The posterior cricoarytenoid muscle is spared from MuRF1-mediated muscle atrophy in mice with acute lung injury. 
  • The prolyl isomerase Pin1 modulates development of CD8+ cDC in mice. 
  • The relationship between slow photoresponse recovery rate and temporal resolution of vision. 
  • The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development. 
  • The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes. 
  • The role of Smad3 in mediating mouse hepatic stellate cell activation. 
  • The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice. 
  • The role of complement dysregulation in AMD mouse models. 
  • The role of diacylglycerol kinase ζ and phosphatidic acid in the mechanical activation of mammalian target of rapamycin (mTOR) signaling and skeletal muscle hypertrophy. 
  • The role of hyaluronan degradation products as innate alloimmune agonists. 
  • The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury. 
  • The role of the forkhead transcription factor, Foxc1, in the development of the mouse lacrimal gland. 
  • The role of the macrophage scavenger receptor in immune stimulation by bacterial DNA and synthetic oligonucleotides. 
  • The role of the transcription factor ETV5 in insulin exocytosis. 
  • The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets. 
  • The role of β cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs. 
  • The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome. 
  • The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches. 
  • The roles of steroidogenic factor-1 in reproductive function. 
  • The scaffold-dependent function of RIPK1 in dendritic cells promotes injury-induced colitis. 
  • The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment. 
  • The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells. 
  • The transcription factor interferon regulatory factor-1 mediates liver damage during ischemia-reperfusion injury. 
  • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. 
  • The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction. 
  • The tyrosine receptor kinase B ligand, neurotrophin-4, is not required for either epileptogenesis or tyrosine receptor kinase B activation in the kindling model. 
  • The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin. 
  • The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination. 
  • The upstream enhancer elements of the G6PC promoter are critical for optimal G6PC expression in murine glycogen storage disease type Ia. 
  • The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression. 
  • The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility. 
  • Therapeutic Benefit of Autophagy Modulation in Pompe Disease. 
  • Three-dimensional tissue-engineered human skeletal muscle model of Pompe disease. 
  • Thrittene, homologous with somatostatin-28((1-13)), is a novel peptide in mammalian gut and circulation. 
  • Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes. 
  • Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. 
  • Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke. 
  • Thromboxane A2 induces airway constriction through an M3 muscarinic acetylcholine receptor-dependent mechanism. 
  • Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection. 
  • Thromboxane receptor signalling in renal ischemia reperfusion injury. 
  • Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death. 
  • Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development. 
  • Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy. 
  • Thyroid hormone action at the cellular, genomic and target gene levels. 
  • Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. 
  • Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function. 
  • Tight regulation of diacylglycerol-mediated signaling is critical for proper invariant NKT cell development. 
  • Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist. 
  • Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice. 
  • Tissue-specific inactivation of murine M6P/IGF2R. 
  • Toll-like receptor 2-dependent and -independent activation of macrophages by group B streptococci. 
  • Toll-like receptor 4 contributes to chronic itch, alloknesis, and spinal astrocyte activation in male mice. 
  • Toll-like receptor 4 deficiency causes pulmonary emphysema. 
  • Toll-like receptor 7 mediates pruritus. 
  • Topographic specificity within membranes of a single muscle detected in vitro. 
  • Toward a mouse model of diabetic nephropathy: is endothelial nitric oxide synthase the missing link? 
  • Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney Development. 
  • Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression. 
  • Transcription factor short stature homeobox 2 is required for proper development of tropomyosin-related kinase B-expressing mechanosensory neurons. 
  • Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation. 
  • Transcriptional regulation of the mouse presenilin-1 gene. 
  • Transducin gamma-subunit sets expression levels of alpha- and beta-subunits and is crucial for rod viability. 
  • Transducin translocation in rods is triggered by saturation of the GTPase-activating complex. 
  • Transducin β-Subunit Can Interact with Multiple G-Protein γ-Subunits to Enable Light Detection by Rod Photoreceptors. 
  • Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element. 
  • Transgelin-2 as a therapeutic target for asthmatic pulmonary resistance. 
  • Transgenic animals in integrative biology: approaches and interpretations of outcome. 
  • Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype. 
  • Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol. 
  • Transient Receptor Potential Vanilloid 4 Channel Deficiency Aggravates Tubular Damage after Acute Renal Ischaemia Reperfusion. 
  • Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch. 
  • Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism. 
  • Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice. 
  • Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission. 
  • Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia. 
  • Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury. 
  • Transient receptor potential vanilloid channels functioning in transduction of osmotic stimuli. 
  • Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms. 
  • Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire. 
  • Treatment with a laminin-derived peptide suppresses lupus nephritis. 
  • Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease. 
  • Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli. 
  • Troponin T3 expression in skeletal and smooth muscle is required for growth and postnatal survival: characterization of Tnnt3(tm2a(KOMP)Wtsi) mice. 
  • Tuberous sclerosis 1 promotes invariant NKT cell anergy and inhibits invariant NKT cell-mediated antitumor immunity. 
  • Tumor Subtype Determines Therapeutic Response to Chimeric Polypeptide Nanoparticle-based Chemotherapy in Pten-deleted Mouse Models of Sarcoma. 
  • Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. 
  • Tumor necrosis factor-α produced in the kidney contributes to angiotensin II-dependent hypertension. 
  • Tumor suppressor TSC1 is critical for T-cell anergy. 
  • Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. 
  • Twist1 in T Lymphocytes Augments Kidney Fibrosis after Ureteral Obstruction. 
  • Type 1 Angiotensin Receptors on CD11c-Expressing Cells Protect Against Hypertension by Regulating Dendritic Cell-Mediated T Cell Activation. 
  • Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis. 
  • Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage. 
  • U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia. 
  • UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis. 
  • USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis. 
  • UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent manner. 
  • Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion. 
  • Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins. 
  • Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation. 
  • Ubiquitination of Innate Immune Regulator TRAF3 Orchestrates Expulsion of Intracellular Bacteria by Exocyst Complex. 
  • Ubiquitination regulates the neuroprotective function of the deubiquitinase ataxin-3 in vivo. 
  • Ultrastructural abnormalities in CA1 hippocampus caused by deletion of the actin regulator WAVE-1. 
  • Ultraviolet light exposure suppresses contact hypersensitivity by abrogating endothelial intercellular adhesion molecule-1 up-regulation at the elicitation site. 
  • Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2). 
  • Understanding the mechanism of bias signaling of the insulin-like growth factor 1 receptor: Effects of LL37 and HASF. 
  • Unexpected anti-alpha GalNAc antibodies in alpha-galactosyl transferase-deficient mice: complex relationship between genotype and the natural antibody repertoire. 
  • Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation. 
  • Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells. 
  • Unmasking Proteolytic Activity for Adult Visual Cortex Plasticity by the Removal of Lynx1. 
  • Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy. 
  • Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension. 
  • Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons. 
  • Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion. 
  • Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice. 
  • Use of genetically modified mouse models for evaluation of carcinogenic risk: considerations for the laboratory animal scientist. 
  • VEGF inhibition and renal thrombotic microangiopathy. 
  • VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. 
  • Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. 
  • Variable Extent of Lineage-Specificity and Developmental Stage-Specificity of Cohesin and CCCTC-Binding Factor Binding Within the Immunoglobulin and T Cell Receptor Loci. 
  • Variation in interferon sensitivity and induction among strains of eastern equine encephalitis virus. 
  • Vascular Endothelial Growth Factor Receptor 3 Regulates Endothelial Function Through β-Arrestin 1. 
  • Vascular control of kidney epithelial transporters. 
  • Vascular endothelial growth factor signaling is necessary for expansion of medullary microvessels during postnatal kidney development. 
  • Vascular morphogenesis: tales of two syndromes. 
  • Vasoconstrictor responses in thromboxane receptor knockout mice: tubuloglomerular feedback and ureteral obstruction. 
  • Vesicular zinc promotes presynaptic and inhibits postsynaptic long-term potentiation of mossy fiber-CA3 synapse. 
  • Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling. 
  • Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo. 
  • WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory. 
  • What can knockout mice contribute to an understanding of hypertension? 
  • Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations. 
  • Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells. 
  • Wound healing in haemophilia--breaking the vicious cycle. 
  • Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53. 
  • Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. 
  • ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation. 
  • Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse. 
  • [Degeneration of growth cones in a culture of embryonic neurons of mouse with presenilin 1 gene knockout]. 
  • [Potential role of presenilin 1 in regulation of synaptic function]. 
  • beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation. 
  • beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. 
  • beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. 
  • beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. 
  • beta-Catenin protects the epidermis from mechanical stresses. 
  • beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. 
  • beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics. 
  • c-FLIP protects T lymphocytes from apoptosis in the intrinsic pathway. 
  • cFLIP regulates skin homeostasis and protects against TNF-induced keratinocyte apoptosis. 
  • gammadelta T cells are a component of early immunity against preerythrocytic malaria parasites. 
  • iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions. 
  • mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis. 
  • mTOR is critical for intestinal T-cell homeostasis and resistance to Citrobacter rodentium. 
  • mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice. 
  • mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development. 
  • meaRtools: An R package for the analysis of neuronal networks recorded on microelectrode arrays. 
  • miR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammation. 
  • miR-21 depletion in macrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy. 
  • miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis. 
  • miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus. 
  • microRNA-142 guards against autoimmunity by controlling Treg cell homeostasis and function. 
  • p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. 
  • p53-dependent control of transactivation of the Pen2 promoter by presenilins. 
  • p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. 
  • ΔN-TRPV1: A Molecular Co-detector of Body Temperature and Osmotic Stress. 
  • α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin. 
  • α7-Nicotinic receptors and cognition. 
  • α7-cholinergic receptor mediates vagal induction of splenic norepinephrine. 
  • αB-crystallin: a novel regulator of breast cancer metastasis to the brain. 
  • β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility. 
  • β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel. 
  • β-Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway. 
  • β-Arrestin-2-Dependent Signaling Promotes CCR4-mediated Chemotaxis of Murine T-Helper Type 2 Cells. 
  • β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury. 
  • β-Arrestin2 mediates progression of murine primary myelofibrosis. 
  • β-Arrestin2 mediates the initiation and progression of myeloid leukemia. 
  • β-Catenin modulation in neurofibromatosis type 1 bone repair: therapeutic implications. 
  • β-Catenin-regulated myeloid cell adhesion and migration determine wound healing. 
  • β-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation. 
  • β-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice. 
  • β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment. 
  • β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix. 
  • β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain. 
  • β-arrestin1-biased β1-adrenergic receptor signaling regulates microRNA processing. 
  • β1-integrin-matrix interactions modulate cerebral microvessel endothelial cell tight junction expression and permeability. 
  • β2-Adrenoceptor agonists are required for development of the asthma phenotype in a murine model. 
  • β2-Adrenoreceptors of regulatory lymphocytes are essential for vagal neuromodulation of the innate immune system. 
  • βII-spectrin promotes mouse brain connectivity through stabilizing axonal plasma membranes and enabling axonal organelle transport. 
  • κ-Opioid receptors in the central amygdala regulate ethanol actions at presynaptic GABAergic sites. 
• 

  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Bowes Rickman, Catherine, George and Geneva Boguslavsky Distinguished Professor of Eye Research, Cell Biology
  • Calakos, Nicole, Lincoln Financial Group Distinguished Professor of Neurobiology, Duke Science & Society
  • Chen, Jun, Professor of Medicine, Duke Cancer Institute
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • Ciofani, Maria, Associate Professor of Immunology, Immunology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Cell Biology
  • Farsiu, Sina, Professor in the Department of Biomedical Engineering, Electrical and Computer Engineering
  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Hirschey, Matthew, Associate Professor of Medicine, Pharmacology & Cancer Biology
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology
  • Johnson, G. Allan, Charles E. Putman University Distinguished Professor of Radiology, Biomedical Engineering
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Immunology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Immunology
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Science & Society
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Pharmacology & Cancer Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Nicolelis, Miguel Angelo L., Duke School of Medicine Distinguished Professor in Neuroscience, Neurobiology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Schmehl, Meredith, Student, Neurobiology
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology
  • Sparks, Matthew A., Associate Professor of Medicine, Medicine, Nephrology
  • Sunday, Mary Elizabeth Anne, Professor of Pathology, Cell Biology
  • Taylor, Gregory Alan, Professor in Medicine, Immunology
  • Zhong, Xiaoping, Professor of Pediatrics, Immunology