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Subject Areas on Research
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(Aryloxy)aryl semicarbazones and related compounds: a novel class of anticonvulsant agents possessing high activity in the maximal electroshock screen.
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131I-labeled Anti-HER2 Camelid sdAb as a Theranostic Tool in Cancer Treatment.
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2.2 Å resolution cryo-EM structure of β-galactosidase in complex with a cell-permeant inhibitor.
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3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.
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De Novo
Design, Solution Characterization, and Crystallographic Structure of an Abiological Mn-Porphyrin-Binding Protein Capable of Stabilizing a Mn(V) Species.
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A Convenient Synthesis of Cis and Trans 4-tert-Butoxycarbonyl-Substituted Cyclohexylglycine
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A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation.
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A Structural Basis for Restricted Codon Recognition Mediated by 2-thiocytidine in tRNA Containing a Wobble Position Inosine.
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A Therapeutic Antibody for Cancer, Derived from Single Human B Cells.
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A bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteins.
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A core-weighted fitting method for docking atomic structures into low-resolution maps: application to cryo-electron microscopy.
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A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface.
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A designed glycoprotein analogue of Gc-MAF exhibits native-like phagocytic activity.
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A kinesin motor in a force-producing conformation.
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A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada.
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A multidisciplinary approach to probing enthalpy-entropy compensation and the interfacial mobility model.
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A new generation of crystallographic validation tools for the protein data bank.
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A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases.
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A photolabile ligand for light-activated release of caged copper.
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A pro-chelator triggered by hydrogen peroxide inhibits iron-promoted hydroxyl radical formation.
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A prochelator activated by hydrogen peroxide prevents metal-induced amyloid Beta aggregation.
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A series of new organic-inorganic molybdenum arsenate complexes based on [(ZnO6)(As3O3)2Mo6O18]4- and [HxAs2Mo6O26](6-x)- clusters as SBUs.
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A structural basis for lithium and substrate binding of an inositide phosphatase.
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A structural pathway for activation of the kinesin motor ATPase.
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A structural pathway for signaling in the E46Q mutant of photoactive yellow protein.
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A test of enhancing model accuracy in high-throughput crystallography.
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Accurate Quantum Mechanical/Molecular Mechanical Calculations of Reduction Potentials in Azurin Variants.
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Activation-dependent conformational changes in {beta}-arrestin 2.
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Advances, interactions, and future developments in the CNS, Phenix, and Rosetta structural biology software systems.
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Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains.
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Affinity of (alpha-P-borano)-NTP analogs to rabbit muscle pyruvate kinase.
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All-atom contacts: a new approach to structure validation.
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Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.
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Allosteric transition intermediates modelled by crosslinked haemoglobins.
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Alternate states of proteins revealed by detailed energy landscape mapping.
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An unusual dienone-phenol rearrangement product formed during the synthesis of mometasone furoate (Sch 32088).
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An unusual rearrangement product formed during production of mometasone furoate (Sch 32088).
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Analysis of experimental time-resolved crystallographic data by singular value decomposition.
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Anti-AIDS agents. 42. Synthesis and anti-HIV activity of disubstituted (3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone analogues.
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Anti-sm autoantibodies in systemic lupus target highly basic surface structures of complexed spliceosomal autoantigens.
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Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
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Antitumor Agents. 152. In Vitro Inhibitory Activity of Etoposide Derivative NPF Against Human Tumor Cell Lines and a Study of its Conformation by X-Ray Crystallography, Molecular Modeling, and NMR Spectroscopy
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Antitumor Agents. 154. Cytotoxic and Antimitotic Flavonols from Polanisia dodecandra
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Antitumor agents. 172. Synthesis and biological evaluation of novel deacetamidothiocolchicin-7-ols and ester analogs as antitubulin agents.
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Antitumor agents. 190. Absolute stereochemistry of the cytotoxic germacranolides, tomenphantins A and B, from Elephantopus tomentosus.
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Application of ruthenium-induced macrocyclization for the construction of macrocyclic depsipeptides.
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Asparagine and glutamine: using hydrogen atom contacts in the choice of side-chain amide orientation.
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Asteropsin A: an unusual cystine-crosslinked peptide from porifera enhances neuronal Ca2+ influx.
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Atomic Resolution Cryo-EM Structure of β-Galactosidase.
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Atomic structures of tubulin and FtsZ.
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Atomistic basis of force generation, translocation, and coordination in a viral genome packaging motor.
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Autofix for backward-fit sidechains: using MolProbity and real-space refinement to put misfits in their place.
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Automated identification of elemental ions in macromolecular crystal structures.
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Away from the edge II: in-house Se-SAS phasing with chromium radiation.
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Bacterially expressed HIV-1 gp120 outer-domain fragment immunogens with improved stability and affinity for CD4-binding site neutralizing antibodies.
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Base-pairing potential identified by in vitro selection predicts the kinked RNA backbone observed in the crystal structure of the alfalfa mosaic virus RNA-coat protein complex.
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Biophysical highlights from 54 years of macromolecular crystallography.
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Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.
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Boranophosphate nucleic acids--a versatile DNA backbone.
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Both heptad repeats of human respiratory syncytial virus fusion protein are potent inhibitors of viral fusion.
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Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery.
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BtubA-BtubB heterodimer is an essential intermediate in protofilament assembly.
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C2-symmetrical tetrahydroxyazepanes as inhibitors of glycosidases and HIV/FIV proteases.
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Caged protein prenyltransferase substrates: tools for understanding protein prenylation.
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Cell biology: How to combat stress.
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Characterization and crystal structure of Escherichia coli KDPGal aldolase.
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Characterization and structure of the manganese-responsive transcriptional regulator ScaR.
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Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U.
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Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I.
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Characterization of the Adeno-Associated Virus 1 and 6 Sialic Acid Binding Site.
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Characterizing Watson-Crick versus Hoogsteen Base Pairing in a DNA-Protein Complex Using Nuclear Magnetic Resonance and Site-Specifically 13C- and 15N-Labeled DNA.
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Characterizing the protonation state of cytosine in transient G·C Hoogsteen base pairs in duplex DNA.
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Chasing acyl carrier protein through a catalytic cycle of lipid A production.
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Chemical logic of MraY inhibition by antibacterial nucleoside natural products.
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Chemical synthesis of highly congested gp120 V1V2 N-glycopeptide antigens for potential HIV-1-directed vaccines.
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Chromophore conformation and the evolution of tertiary structural changes in photoactive yellow protein.
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Classification of crystallization outcomes using deep convolutional neural networks.
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Cloning and sequencing of V genes from anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: location of lysine residues and implications for radiolabeling.
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Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV.
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Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.
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Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1.
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Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate.
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Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass.
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Competition between monomeric and dimeric crystals in schematic models for globular proteins.
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Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold.
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Computational Methods for RNA Structure Validation and Improvement.
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Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope.
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Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor.
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Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase.
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Conformational changes in the photocycle of Anabaena sensory rhodopsin: absence of the Schiff base counterion protonation signal.
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Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine.
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Conformational plasticity in the selectivity filter of the TRPV2 ion channel.
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Conformational plasticity of the coiled-coil domain of BmrR is required for bmr operator binding: the structure of unliganded BmrR.
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Conversion of protein farnesyltransferase to a geranylgeranyltransferase.
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Counterions influence reactivity of metal ions with cysteinyldopa model compounds.
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Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle.
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Cryo-EM model validation recommendations based on outcomes of the 2019 EMDataResource challenge.
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Cryo-electron microscopy of biological samples.
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Crystal and molecular structures of ionophore-siderophore host-guest supramolecular assemblies relevant to molecular recognition.
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Crystal structure of DMSO reductase: redox-linked changes in molybdopterin coordination.
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Crystal structure of HPr kinase/phosphatase from Mycoplasma pneumoniae.
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Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices.
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Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis.
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Crystal structure of MtaN, a global multidrug transporter gene activator.
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Crystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism.
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Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization.
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Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4 Å.
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Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region.
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Crystal structure of a photoactive yellow protein from a sensor histidine kinase: conformational variability and signal transduction.
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Crystal structure of a pol alpha family DNA polymerase from the hyperthermophilic archaeon Thermococcus sp. 9 degrees N-7.
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Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 A resolution.
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Crystal structure of activated CheY. Comparison with other activated receiver domains.
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Crystal structure of alkaline phosphatase from the Antarctic bacterium TAB5.
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Crystal structure of an Escherichia coli Hfq Core (residues 2-69)-DNA complex reveals multifunctional nucleic acid binding sites.
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Crystal structure of an RNA aptamer bound to thrombin.
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Crystal structure of an activated response regulator bound to its target.
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Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue.
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Crystal structure of human type III collagen Gly991-Gly1032 cystine knot-containing peptide shows both 7/2 and 10/3 triple helical symmetries.
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Crystal structure of inositol polyphosphate 1-phosphatase at 2.3-A resolution.
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Crystal structure of molybdopterin synthase and its evolutionary relationship to ubiquitin activation.
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Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution.
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Crystal structure of the MOP flippase MurJ in an inward-facing conformation.
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Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity.
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Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.
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Crystal structure of the phage T4 recombinase UvsX and its functional interaction with the T4 SF2 helicase UvsW.
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Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin.
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Crystal structure of the transcription activator BmrR bound to DNA and a drug.
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Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env.
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Crystal structures of SarA, a pleiotropic regulator of virulence genes in S. aureus.
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Crystal structures of T. brucei MRP1/MRP2 guide-RNA binding complex reveal RNA matchmaking mechanism.
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Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding.
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Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding.
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Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding.
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Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani.
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Crystal structures of apocalmodulin and an apocalmodulin/SK potassium channel gating domain complex.
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Crystal structures of the Klenow fragment of DNA polymerase I complexed with deoxynucleoside triphosphate and pyrophosphate.
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Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus.
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Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity.
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Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.
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Crystal structures of the membrane-binding C2 domain of human coagulation factor V.
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Crystallization and initial X-ray crystallographic characterization of recombinant bovine inositol polyphosphate 1-phosphatase produced in Spodoptera frugiperda cells.
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Crystallization and preliminary X-ray analysis of an Escherichia coli purine repressor-hypoxanthine-DNA complex.
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Crystallization and preliminary X-ray crystallographic investigations on several thermostable forms of a Bacillus subtilis lipase.
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Crystallization and preliminary X-ray diffraction studies on the DNA-binding domain of the multidrug transporter activation protein (MtaN) from Bacillus subtilis.
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Crystallization and preliminary diffraction analysis of a hyperthermostable DNA polymerase from a Thermococcus archaeon.
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Crystallization and preliminary x-ray studies of NADPH-cytochrome P450 reductase.
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Crystallization of a fragment of human fibronectin: introduction of methionine by site-directed mutagenesis to allow phasing via selenomethionine.
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Crystallization of succinylated concanavalin A bound to a synthetic bivalent ligand and preliminary structural analysis.
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Crystallization, preliminary X-ray analysis and biophysical characterization of HPr kinase/phosphatase of Mycoplasma pneumoniae.
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Crystallizing thinking about the beta2-adrenergic receptor.
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Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.
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Crystallographic analysis of oxygenated and deoxygenated states of arthropod hemocyanin shows unusual differences.
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Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes.
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Crystallographic model validation: from diagnosis to healing.
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DNA mismatches reveal conformational penalties in protein-DNA recognition.
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De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures.
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DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe.
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Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure.
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Design of a ruthenium-labeled cytochrome c derivative to study electron transfer with the cytochrome bc1 complex.
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Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands.
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Detection and characterization of xenon-binding sites in proteins by 129Xe NMR spectroscopy.
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Determining absolute configuration in flexible molecules: a case study.
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Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8.
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Direct evidence for methyl group coordination by carbon-oxygen hydrogen bonds in the lysine methyltransferase SET7/9.
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Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli.
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Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R).
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Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor.
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Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers.
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Disulfide bond requirements for active Wnt ligands.
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Dithiol Aryl Arsenic Compounds as Potential Diagnostic and Therapeutic Radiopharmaceuticals.
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Doing molecular biophysics: finding, naming, and picturing signal within complexity.
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Drug design from the cryptic inhibitor envelope.
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Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.
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Dynamics of backbone conformational heterogeneity in Bacillus subtilis ribonuclease P protein.
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Effect of famoxadone on photoinduced electron transfer between the iron-sulfur center and cytochrome c1 in the cytochrome bc1 complex.
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Electronic structure of a paramagnetic {MNO}6 complex: MnNO 5,5-tropocoronand.
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Enhanced protein flexibility caused by a destabilizing amino acid replacement in BPTI.
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Equilibration of tyrosyl radicals (Y356•, Y731•, Y730•) in the radical propagation pathway of the Escherichia coli class Ia ribonucleotide reductase.
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Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase.
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Essential role of an active-site guanine in glmS ribozyme catalysis.
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Evaluating the quality of NMR structures by local density of protons.
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Evolution of a σ-(c-di-GMP)-anti-σ switch.
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Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.
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Expression, purification and primary crystallographic study of human androgen receptor in complex with DNA and coactivator motifs.
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Expression, purification, crystallization and preliminary X-ray analysis of human argininosuccinic acid lyase.
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Flipping of the ribosomal A-site adenines provides a basis for tRNA selection.
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Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing.
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From chain to network: design and analysis of novel organic-inorganic assemblies from organically functionalized zinc-substituted polyoxovanadates and zinc organoamine subunits.
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From crystal structure to clinic: highlights of the Tenth International Parvovirus Workshop.
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FtsZ filament capping by MciZ, a developmental regulator of bacterial division.
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Functional consequences of truncating amino acid side chains located at a calmodulin-peptide interface.
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Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody.
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Generation, characterization and crystallization of a highly active and stable cytochrome bc1 complex mutant from Rhodobacter sphaeroides.
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Getting a grip on the CTD of Pol II.
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Gibberellin-induced DELLA recognition by the gibberellin receptor GID1.
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Global folds of proteins with low densities of NOEs using residual dipolar couplings: application to the 370-residue maltodextrin-binding protein.
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Glutamate receptor desensitization is mediated by changes in quaternary structure of the ligand binding domain.
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HGT in the human and skin commensal Malassezia: A bacterially derived flavohemoglobin is required for NO resistance and host interaction.
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Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.
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Heavy chain-only IgG2b llama antibody effects near-pan HIV-1 neutralization by recognizing a CD4-induced epitope that includes elements of coreceptor- and CD4-binding sites.
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Hepatitis C virus NS5B polymerase: QM/MM calculations show the important role of the internal energy in ligand binding.
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High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.
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High-resolution crystal structures of Escherichia coli FtsZ bound to GDP and GTP.
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High-resolution solution structure of the beryllofluoride-activated NtrC receiver domain.
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HipBA-promoter structures reveal the basis of heritable multidrug tolerance.
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How an enzyme binds the C1 carrier tetrahydromethanopterin. Structure of the tetrahydromethanopterin-dependent formaldehyde-activating enzyme (Fae) from Methylobacterium extorquens AM1.
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How can a single second sphere amino acid substitution cause reduction midpoint potential changes of hundreds of millivolts?
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IMDA/aldol strategy for transforming carbohydrates into functionalized trans-decalins.
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Identification of a cyclic nucleotide as a cryptic intermediate in molybdenum cofactor biosynthesis.
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Identification of a potent and selective non-basic cathepsin K inhibitor.
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Identification of a residue critical for maintaining the functional conformation of BPTI.
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Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.
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Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape.
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Improved chemistry restraints for crystallographic refinement by integrating the Amber force field into Phenix.
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In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia.
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Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope.
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Infrared Spectroscopic Observation of a G-C+ Hoogsteen Base Pair in the DNA:TATA-Box Binding Protein Complex Under Solution Conditions.
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Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype.
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Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
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Ion channels: an open and shut case.
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Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields.
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Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor.
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K channel gating by an affinity-switching selectivity filter.
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Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma.
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Large assembly formation via a two-step process in a chromonic liquid crystal.
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Large conformational changes in a kinesin motor catalyzed by interaction with microtubules.
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Ligand-induced conformational changes in a thermophilic ribose-binding protein.
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Light uncages a copper complex to induce nonapoptotic cell death.
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Lipid molecules induce p38α activation via a novel molecular switch.
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Localization and structure of the ankyrin-binding site on beta2-spectrin.
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Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix.
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Mechanism of OMP decarboxylation in orotidine 5'-monophosphate decarboxylase.
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Mechanism of corepressor-mediated specific DNA binding by the purine repressor.
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Mechanism of intracellular allosteric β2
AR antagonist revealed by X-ray crystal structure.
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Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex.
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Mechanism of β2AR regulation by an intracellular positive allosteric modulator.
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Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight.
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Mechanistic characterization of the tetraacyldisaccharide-1-phosphate 4'-kinase LpxK involved in lipid A biosynthesis.
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Mechanistic studies of the cycloisomerization of dimethyl diallylmalonate catalyzed by a cationic palladium phenanthroline complex.
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Methodologies for the characterization, identification and quantification of S-nitrosylated proteins.
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Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer.
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Model validation: local diagnosis, correction and when to quit.
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Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.
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Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP.
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MolProbity: all-atom structure validation for macromolecular crystallography.
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Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check.
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Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB.
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Molecular structure and function of the novel BrnT/BrnA toxin-antitoxin system of Brucella abortus.
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Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies.
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Multiscale conformational heterogeneity in staphylococcal protein a: possible determinant of functional plasticity.
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Mutagenesis studies of substrate recognition and catalysis in the sortase A transpeptidase from Staphylococcus aureus.
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N-methylated 5-alkenyloxazolium salt transformations.
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Neck-motor interactions trigger rotation of the kinesin stalk.
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New insights into Hoogsteen base pairs in DNA duplexes from a structure-based survey.
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New insights into the fundamental role of topological constraints as a determinant of two-way junction conformation.
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New tools and data for improving structures, using all-atom contacts.
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New tools in MolProbity validation: CaBLAM for CryoEM backbone, UnDowser to rethink "waters," and NGL Viewer to recapture online 3D graphics.
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Nitric-oxide synthase forms N-NO-pterin and S-NO-cys: implications for activity, allostery, and regulation.
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Novel adamantyl cannabinoids as CB1 receptor probes.
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Novel disulfide engineering in human carbonic anhydrase II using the PAIRWISE side-chain geometry database.
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Odorant Receptor 7D4 Activation Dynamics.
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On the intractability of estrogen-related receptor alpha as a target for activation by small molecules.
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Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design.
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Oxalate decarboxylase uses electron hole hopping for catalysis.
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Oxalate deposition on asbestos bodies.
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PHENIX: a comprehensive Python-based system for macromolecular structure solution.
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Phenylalanine 30 plays an important role in receptor binding of verotoxin-1.
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Plasmid protein TubR uses a distinct mode of HTH-DNA binding and recruits the prokaryotic tubulin homolog TubZ to effect DNA partition.
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Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.
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Preliminary structural studies on the multi-ligand-binding domain of the transcription activator, BmrR, from Bacillus subtilis.
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Probing the catalytic mechanism of sulfite reductase by X-ray crystallography: structures of the Escherichia coli hemoprotein in complex with substrates, inhibitors, intermediates, and products.
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Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress.
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Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 9.
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Protein imperfections: separating intrinsic from extrinsic variation of torsion angles.
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Protein kinetics: structures of intermediates and reaction mechanism from time-resolved x-ray data.
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Protein serine/threonine phosphatases: life, death, and sleeping.
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Protein-Protein Docking Benchmark 2.0: an update.
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Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβ.
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QacR-cation recognition is mediated by a redundancy of residues capable of charge neutralization.
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Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation.
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RNA backbone is rotameric.
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RNA backbone rotamers--finding your way in seven dimensions.
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RNABC: forward kinematics to reduce all-atom steric clashes in RNA backbone.
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Radical Breakthroughs in Natural Product and Cofactor Biosynthesis.
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Rapid stereoselective access to key pumiliotoxin precursors from a common intermediate.
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Reaction mechanisms of mononuclear non-heme iron oxygenases.
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Reaction path of protein farnesyltransferase at atomic resolution.
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Recent developments in enantioselective gold(I) catalysis.
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Recent developments in phasing and structure refinement for macromolecular crystallography.
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Recognition Patterns of the C1/C2 Epitopes Involved in Fc-Mediated Response in HIV-1 Natural Infection and the RV114 Vaccine Trial.
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Recognition of U-rich RNA by Hfq from the Gram-positive pathogen Listeria monocytogenes.
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Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design.
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Requirement of helix P2.2 and nucleotide G1 for positioning the cleavage site and cofactor of the glmS ribozyme.
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Revealing A-T and G-C Hoogsteen base pairs in stressed protein-bound duplex DNA.
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Reverse actin sliding triggers strong myosin binding that moves tropomyosin.
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Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor.
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Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd.
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Rotational Symmetry of Two Pyrethroid Receptor Sites in the Mosquito Sodium Channel.
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Rotational isomers of N-alkylpyridylporphyrins and their metal complexes. HPLC separation, (1)H NMR and X-ray structural characterization, electrochemistry, and catalysis of O(2)(.-) disproportionation.
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S-nitrosylation-induced conformational change in blackfin tuna myoglobin.
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Segrosome structure revealed by a complex of ParR with centromere DNA.
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Sequence-specific B-DNA flexibility modulates Z-DNA formation.
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Signatures of protein-DNA recognition in free DNA binding sites.
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Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs.
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Sites of interaction between kinase-related protein and smooth muscle myosin.
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Sliding clamp of the bacteriophage T4 polymerase has open and closed subunit interfaces in solution.
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Sliding clamp-DNA interactions are required for viability and contribute to DNA polymerase management in Escherichia coli.
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SlmA forms a higher-order structure on DNA that inhibits cytokinetic Z-ring formation over the nucleoid.
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Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177).
-
Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence.
-
Solution structure of a sweet protein single-chain monellin determined by nuclear magnetic resonance and dynamical simulated annealing calculations.
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Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase.
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Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
-
Statistical analysis of crystallization database links protein physico-chemical features with crystallization mechanisms.
-
Stereoselective synthesis and osteogenic activity of subglutinols A and B
-
Structural adaptations that modulate monosaccharide, disaccharide, and trisaccharide specificities in periplasmic maltose-binding proteins.
-
Structural analyses of Ca²⁺/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation.
-
Structural analysis of a periplasmic binding protein in the tripartite ATP-independent transporter family reveals a tetrameric assembly that may have a role in ligand transport.
-
Structural analysis of semi-specific oligosaccharide recognition by a cellulose-binding protein of thermotoga maritima reveals adaptations for functional diversification of the oligopeptide periplasmic binding protein fold.
-
Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee.
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Structural and Dynamic Basis for Low-Affinity, High-Selectivity Binding of L-Glutamine by the Glutamine Riboswitch.
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Structural and Functional Analyses Reveal Insights into the Molecular Properties of the Escherichia coli Z Ring Stabilizing Protein, ZapC.
-
Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.
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Structural and Functional Characterization of Sulfonium Carbon-Oxygen Hydrogen Bonding in the Deoxyamino Sugar Methyltransferase TylM1.
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Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA.
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Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex.
-
Structural and transcriptional analyses of a purine nucleotide-binding protein from Pyrococcus furiosus: a component of a novel, membrane-bound multiprotein complex unique to this hyperthermophilic archaeon.
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Structural basis for ADP-mediated transcriptional regulation by P1 and P7 ParA.
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Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody.
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Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase.
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Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR.
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Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16.
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Structural basis for highly effective HIV-1 neutralization by CD4-mimetic miniproteins revealed by 1.5 Å cocrystal structure of gp120 and M48U1.
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Structural basis for the differential regulation of DNA by the methionine repressor MetJ.
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Structural basis for the metal-selective activation of the manganese transport regulator of Bacillus subtilis.
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Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase.
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Structural basis for the remarkable stability of Bacillus subtilis lipase (Lip A) at low pH.
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Structural basis for the root effect in haemoglobin.
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Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling.
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Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ζ, and Pol κ.
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Structural basis of core promoter recognition in a primitive eukaryote.
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Structural basis of diverse membrane target recognitions by ankyrins.
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Structural basis of lipid binding for the membrane-embedded tetraacyldisaccharide-1-phosphate 4'-kinase LpxK.
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Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter.
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Structural basis of multifunctional bovine mitochondrial cytochrome bc1 complex.
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Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.
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Structural basis of pilus subunit recognition by the PapD chaperone.
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Structural basis of salicylic acid perception by Arabidopsis NPR proteins.
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Structural basis of selection and thermostability of laboratory evolved Bacillus subtilis lipase.
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Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein.
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Structural basis of the promiscuous inhibitor susceptibility of Escherichia coli LpxC.
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Structural definition of an antibody-dependent cellular cytotoxicity response implicated in reduced risk for HIV-1 infection.
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Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.
-
Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides.
-
Structural genomics of Pyrococcus furiosus: X-ray crystallography reveals 3D domain swapping in rubrerythrin.
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Structural insights into alternative splicing-mediated desensitization of jasmonate signaling.
-
Structural insights into inhibition of lipid I production in bacterial cell wall synthesis.
-
Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase.
-
Structural mechanism of ATP-induced polymerization of the partition factor ParF: implications for DNA segregation.
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Structural mechanism of organic hydroperoxide induction of the transcription regulator OhrR.
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Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein.
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Structural mechanisms of QacR induction and multidrug recognition.
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Structural plasticity and Mg2+ binding properties of RNase P P4 from combined analysis of NMR residual dipolar couplings and motionally decoupled spin relaxation.
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Structural reorganization and preorganization in enzyme active sites: comparisons of experimental and theoretically ideal active site geometries in the multistep serine esterase reaction cycle.
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Structural studies and protein engineering of inositol phosphate multikinase.
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Structural studies of binding site tryptophan mutants in the high-affinity streptavidin-biotin complex.
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Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2.
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Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae.
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Structure and Stereochemistry of Pseudolarolide J, a Novel Nortriterpene Lactone from Pseudolarix kaempferi
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Structure and filament dynamics of the pSK41 actin-like ParM protein: implications for plasmid DNA segregation.
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Structure and functional properties of the Bacillus subtilis transcriptional repressor Rex.
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Structure and hydride transfer mechanism of a moderate thermophilic dihydrofolate reductase from Bacillus stearothermophilus and comparison to its mesophilic and hyperthermophilic homologues.
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Structure and immune recognition of trimeric pre-fusion HIV-1 Env.
-
Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors.
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Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity.
-
Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength.
-
Structure of Escherichia coli Hfq bound to polyriboadenylate RNA.
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Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs.
-
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
-
Structure of a trimeric bacterial microcompartment shell protein, EtuB, associated with ethanol utilization in Clostridium kluyveri.
-
Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.
-
Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR family.
-
Structure of protein geranylgeranyltransferase-I from the human pathogen Candida albicans complexed with a lipid substrate.
-
Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule.
-
Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation.
-
Structure of the Z Ring-associated Protein, ZapD, Bound to the C-terminal Domain of the Tubulin-like Protein, FtsZ, Suggests Mechanism of Z Ring Stabilization through FtsZ Cross-linking.
-
Structure of the endonuclease domain of MutL: unlicensed to cut.
-
Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis.
-
Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin.
-
Structure of the hypothetical protein PF0899 from Pyrococcus furiosus at 1.85 A resolution.
-
Structure of the manganese-bound manganese transport regulator of Bacillus subtilis.
-
Structure of the outer membrane translocator domain of the Haemophilus influenzae Hia trimeric autotransporter.
-
Structure of β-galactosidase at 3.2-Å resolution obtained by cryo-electron microscopy.
-
Structure-based Design of Cyclically Permuted HIV-1 gp120 Trimers That Elicit Neutralizing Antibodies.
-
Structure-based classification of 45 FK506-binding proteins.
-
Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.
-
Structure-based design of robust glucose biosensors using a Thermotoga maritima periplasmic glucose-binding protein.
-
Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190.
-
Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma.
-
Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein.
-
Structures of BmrR-drug complexes reveal a rigid multidrug binding pocket and transcription activation through tyrosine expulsion.
-
Structures of Cryptococcus neoformans protein farnesyltransferase reveal strategies for developing inhibitors that target fungal pathogens.
-
Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design.
-
Structures of ParB bound to DNA reveal mechanism of partition complex formation.
-
Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators.
-
Structures of human ENT1 in complex with adenosine reuptake inhibitors.
-
Structures of maintenance of carboxysome distribution Walker-box McdA and McdB adaptor homologs.
-
Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4.
-
Structures of the activator of K. pneumonia biofilm formation, MrkH, indicates PilZ domains involved in c-di-GMP and DNA binding.
-
Structures of the bacterial ribosome in classical and hybrid states of tRNA binding.
-
Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein.
-
Structures of the siroheme- and Fe4S4-containing active center of sulfite reductase in different states of oxidation: heme activation via reduction-gated exogenous ligand exchange.
-
Structures of three polycystic kidney disease-like domains from Clostridium histolyticum collagenases ColG and ColH.
-
Studying and polishing the PDB's macromolecules.
-
Sulfite reductase structure at 1.6 A: evolution and catalysis for reduction of inorganic anions.
-
Suppression of conformational heterogeneity at a protein-protein interface.
-
Syntheses, X-ray crystal structures, and solution behavior of monomeric, cationic, two-coordinate gold(I) pi-alkene complexes.
-
Synthesis and NK(1)/NK(2) binding activities of a series of diacyl-substituted 2-arylpiperazines.
-
Synthesis of new 2'-deoxy-2'-fluoro-4'-azido nucleoside analogues as potent anti-HIV agents.
-
Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease.
-
Targeting Pim Kinases and DAPK3 to Control Hypertension.
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Temperature-sensitive mutants of the EcoRI endonuclease.
-
Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding.
-
Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development.
-
The 1.2 A structure of the human sulfite oxidase cytochrome b(5) domain.
-
The 2.0 A crystal structure of a heterotrimeric G protein.
-
The 2.1 A structure of Aerococcus viridans L-lactate oxidase (LOX).
-
The Closing Mechanism of DNA Polymerase I at Atomic Resolution.
-
The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.
-
The Phenix software for automated determination of macromolecular structures.
-
The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.
-
The Structure of the Biofilm-controlling Response Regulator BfmR from Acinetobacter baumannii Reveals Details of Its DNA-binding Mechanism.
-
The T4 phage SF1B helicase Dda is structurally optimized to perform DNA strand separation.
-
The X-ray structure of the PurR-guanine-purF operator complex reveals the contributions of complementary electrostatic surfaces and a water-mediated hydrogen bond to corepressor specificity and binding affinity.
-
The activation domain of the MotA transcription factor from bacteriophage T4.
-
The backbone structure of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein is essentially identical to its mesophilic E. coli homolog.
-
The backrub motion: how protein backbone shrugs when a sidechain dances.
-
The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.
-
The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes.
-
The conformations of the manganese transport regulator of Bacillus subtilis in its metal-free state.
-
The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor.
-
The crystal structure of Escherichia coli MoeA and its relationship to the multifunctional protein gephyrin.
-
The crystal structure of a collagen-like polypeptide with 3(S)-hydroxyproline residues in the Xaa position forms a standard 7/2 collagen triple helix.
-
The crystal structure of a thermophilic glucose binding protein reveals adaptations that interconvert mono and di-saccharide binding sites.
-
The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.
-
The crystal structure of the Escherichia coli MobA protein provides insight into molybdopterin guanine dinucleotide biosynthesis.
-
The crystal structure of the RsbN-σBldN complex from Streptomyces venezuelae defines a new structural class of anti-σ factor.
-
The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding.
-
The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase.
-
The high-throughput protein-to-structure pipeline at SECSG.
-
The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist.
-
The importance of residue-level filtering and the Top2018 best-parts dataset of high-quality protein residues.
-
The mechanism of discrimination between oxidized and reduced coenzyme in the aldehyde dehydrogenase domain of Aldh1l1.
-
The mechanism of the translocation step in DNA replication by DNA polymerase I: a computer simulation analysis.
-
The performance of ZDOCK and ZRANK in rounds 6-11 of CAPRI.
-
The protein surface is a moving target.
-
The role of tyrosine 343 in substrate binding and catalysis by human sulfite oxidase.
-
The significance of degenerate processes to enantioselective olefin metathesis reactions promoted by stereogenic-at-Mo complexes.
-
The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present.
-
The structural basis for the mutagenicity of O(6)-methyl-guanine lesions.
-
The structural basis for the selectivity of benzotriazole inhibitors of PTP1B.
-
The structural basis of repertoire shift in an immune response to phosphocholine.
-
The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus.
-
The structure of PurR mutant L54M shows an alternative route to DNA kinking.
-
The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding.
-
The structure of a calmodulin mutant with a deletion in the central helix: implications for molecular recognition and protein binding.
-
The structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with its coenzymes.
-
The structure of irisin reveals a novel intersubunit β-sheet fibronectin type III (FNIII) dimer: implications for receptor activation.
-
Thiopyranol[2,3,4-c,d]indoles as inhibitors of 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase.
-
Three-dimensional structures of soluble CD4-bound states of trimeric simian immunodeficiency virus envelope glycoproteins determined by using cryo-electron tomography.
-
Topology of an amiloride-binding protein.
-
Toward the development of prochelators as fluorescent probes of copper-mediated oxidative stress.
-
Towards structural genomics of RNA: rapid NMR resonance assignment and simultaneous RNA tertiary structure determination using residual dipolar couplings.
-
Turnip yellow mosaic virus as a chemoaddressable bionanoparticle.
-
Two crystal polymorphs of a flavonoid from Melicope ellyrana.
-
Two extended structures constructed from sandwich-type polyoxometalates functionalized by organic amines.
-
Two-dimensional crystallization and projection structure of KcsA potassium channel.
-
Ultrastructure and function of dimeric, soluble intercellular adhesion molecule-1 (ICAM-1).
-
Uncoupling of nucleotide hydrolysis and polymerization in the ParA protein superfamily disrupts DNA segregation dynamics.
-
Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc.
-
Unusual Synergism of Transferrin and Citrate in the Regulation of Ti(IV) Speciation, Transport, and Toxicity.
-
Use of knowledge-based restraints in phenix.refine to improve macromolecular refinement at low resolution.
-
Using Cryo-EM to Map Small Ligands on Dynamic Metabolic Enzymes: Studies with Glutamate Dehydrogenase.
-
Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal.
-
Visualizing and quantifying molecular goodness-of-fit: small-probe contact dots with explicit hydrogen atoms.
-
Visualizing conformation transitions of the Lipid II flippase MurJ.
-
Visualizing multistep elevator-like transitions of a nucleoside transporter.
-
Water-Mediated Carbon-Oxygen Hydrogen Bonding Facilitates S-Adenosylmethionine Recognition in the Reactivation Domain of Cobalamin-Dependent Methionine Synthase.
-
X-ray analysis reveals conformational adaptation of the linker in functional calmodulin mutants.
-
X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg.ADP to 2.3 A resolution.
-
X-ray crystallographic analysis of adipocyte fatty acid binding protein (aP2) modified with 4-hydroxy-2-nonenal.
-
X-ray crystallographic studies of streptavidin mutants binding to biotin.
-
YbiV from Escherichia coli K12 is a HAD phosphatase.
-
cis-Proline-mediated Ser(P)5 dephosphorylation by the RNA polymerase II C-terminal domain phosphatase Ssu72.
-
cis-parthenolid-9-one from Anvillea garcinii.
-
“A robust platform for the synthesis of new tetracycline antibiotics
-
Keywords of People
-
Erickson, Harold Paul,
Professor Emeritus of Cell Biology,
Cell Biology
-
Kelsoe, Garnett H.,
James B. Duke Distinguished Professor of Immunology,
Immunology
-
Luftig, Micah Alan,
Associate Professor of Molecular Genetics and Microbiology,
Cell Biology
-
Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology
-
Richardson, David C.,
Professor of Biochemistry,
Biochemistry