Oxidative Stress

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  Subject Areas on Research

  • 6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions. 
  • A Western diet induced NAFLD in LDLR(-/)(-) mice is associated with reduced hepatic glutathione synthesis. 
  • A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 
  • A comprehensive evaluation of the enzymatic and nonenzymatic antioxidant systems in childhood asthma. 
  • A controlled trial of acute effects of human exposure to traffic particles on pulmonary oxidative stress and heart rate variability. 
  • A dietary pattern that lowers oxidative stress increases antibodies to oxidized LDL: results from a randomized controlled feeding study. 
  • A flucytosine-responsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans. 
  • A genetic analysis of nitrosative stress. 
  • A homeostatic model of oxidative damage explains paradoxes observed in earlier aging experiments: a fusion and extension of older theories of aging. 
  • A manganese porphyrin suppresses oxidative stress and extends the life span of streptozotocin-diabetic rats. 
  • A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism. 
  • A mathematical model of glutathione metabolism. 
  • A multifunctional, light-activated prochelator inhibits UVA-induced oxidative stress. 
  • A neuronal model of Alzheimer's disease: an insight into the mechanisms of oxidative stress-mediated mitochondrial injury. 
  • A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity. 
  • A new role for ATM: regulating mitochondrial function and mitophagy. 
  • A population model of folate-mediated one-carbon metabolism. 
  • A regulatory hierarchy controls the dynamic transcriptional response to extreme oxidative stress in archaea. 
  • ACE2-mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function. 
  • ALS Multicenter Cohort Study of Oxidative Stress (ALS COSMOS): study methodology, recruitment, and baseline demographic and disease characteristics. 
  • ALSUntangled No. 29: MitoQ. 
  • ALSUntangled No. 35: Hyperbaric Oxygen Therapy. 
  • APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress. 
  • ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. 
  • ATM: genome stability, neuronal development, and cancer cross paths. 
  • Aberrant S-nitrosylation mediates calcium-triggered ventricular arrhythmia in the intact heart. 
  • Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits. 
  • Activation of Sirtuin 3 Protects the Heart From Ischemia-Reperfusion Injury by Increased Cellular Antioxidant Defenses 
  • Activation of transcription factors activator protein-1 and nuclear factor-kappaB by 2,3,7,8-tetrachlorodibenzo-p-dioxin. 
  • Acute kidney injury to chronic kidney disease transition: insufficient cellular stress response. 
  • Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs SOD1-Mediated Inhibition of Mitochondrial Respiration. 
  • African Ancestry Gradient Is Associated with Lower Systemic F2-Isoprostane Levels. 
  • Aldosterone-Induced Vascular Remodeling and Endothelial Dysfunction Require Functional Angiotensin Type 1a Receptors. 
  • Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer. 
  • Allosteric effects on oxidative and nitrosative reactions of cell-free hemoglobins. 
  • Alteration of peripheral blood monocyte gene expression in humans following diesel exhaust inhalation. 
  • Alterations in microRNA expression in stress-induced cellular senescence. 
  • Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study. 
  • Alterations of excitatory amino acid receptors in the brain of manganese-treated mice. 
  • Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia. 
  • Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells. 
  • An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivation. 
  • An oxidized extracellular oxidation-reduction state increases Nox1 expression and proliferation in vascular smooth muscle cells via epidermal growth factor receptor activation. 
  • Androgen-induced expression of endoplasmic reticulum (ER) stress response genes in prostate cancer cells. 
  • Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension. 
  • Angiotensin converting enzyme 2 and the kidney. 
  • Animal models of steatohepatitis. 
  • Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor. 
  • Anticancer therapeutic potential of Mn porphyrin/ascorbate system. 
  • Anticipation of oxidative damage decelerates aging in virgin female medflies: hypothesis tested by statistical modeling. 
  • Antioxidant defenses in killifish (Fundulus heteroclitus) exposed to contaminated sediments and model prooxidants: short-term and heritable responses. 
  • Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish. 
  • Antioxidant responses and oxidative stress in sheepshead minnow larvae exposed to Corexit 9500® or its component surfactant, DOSS. 
  • Antiproliferative action of dopamine and norepinephrine in neuroblastoma cells expressing the human dopamine transporter. 
  • Apolipoprotein E Exerts a Whole-Brain Protective Property by Promoting M1? Microglia Quiescence After Experimental Subarachnoid Hemorrhage in Mice. 
  • Apolipoprotein E genotype and oxidative stress response to traumatic brain injury. 
  • Apolipoprotein E protects against oxidative stress in mixed neuronal-glial cell cultures by reducing glutamate toxicity. 
  • Arctigenin Attenuates Ischemia/Reperfusion Induced Ventricular Arrhythmias by Decreasing Oxidative Stress in Rats. 
  • Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells. 
  • Assessment and application of the biotin switch technique for examining protein S-nitrosylation under conditions of pharmacologically induced oxidative stress. 
  • Association of Ozone Exposure With Cardiorespiratory Pathophysiologic Mechanisms in Healthy Adults. 
  • Association of air pollution sources and aldehydes with biomarkers of blood coagulation, pulmonary inflammation, and systemic oxidative stress. 
  • Atherosclerosis and cancer: common molecular pathways of disease development and progression. 
  • Atherosclerosis: a cancer of the blood vessels? 
  • Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase. 
  • Autophagic dysregulation in glaucomatous trabecular meshwork cells. 
  • Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis. 
  • Avicinylation (thioesterification): a protein modification that can regulate the response to oxidative and nitrosative stress. 
  • Biochemical and genetic analyses of yeast and human high affinity copper transporters suggest a conserved mechanism for copper uptake. 
  • Biological chemistry of carbon monoxide. 
  • Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells. 
  • Blocking neutrophil influx reduces DNA damage in hyperoxia-exposed newborn rat lung. 
  • Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration. 
  • Bone morphogenetic protein 4 mediates myocardial ischemic injury through JNK-dependent signaling pathway. 
  • Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells. 
  • Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. 
  • CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-α-Gabpa and stress-induced adaptive responses via NF-κB-cMYC. 
  • CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis. 
  • CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5. 
  • COPD: balancing oxidants and antioxidants. 
  • CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis. 
  • Calcium oxalate and iron accumulation in sarcoidosis. 
  • Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. 
  • Calpain inhibition decreases myocardial apoptosis in a swine model of chronic myocardial ischemia. 
  • Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species. 
  • Carbon monoxide reversibly alters iron homeostasis and respiratory epithelial cell function. 
  • Carbon monoxide, oxidative stress, and mitochondrial permeability pore transition. 
  • Carbon monoxide, reactive oxygen signaling, and oxidative stress. 
  • Carbon monoxide, skeletal muscle oxidative stress, and mitochondrial biogenesis in humans. 
  • Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart. 
  • Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury. 
  • Cardiopulmonary Bypass Decreases Activation of the Signal Transducer and Activator of Transcription 3 (STAT3) Pathway in Diabetic Human Myocardium. 
  • Cardiorespiratory biomarker responses in healthy young adults to drastic air quality changes surrounding the 2008 Beijing Olympics. 
  • Cardiovascular disease and chronic kidney disease: insights and an update. 
  • Catabolism of (2E)-4-hydroxy-2-nonenal via ω- and ω-1-oxidation stimulated by ketogenic diet. 
  • Cell senescence reduced the mechanotransduction sensitivity of porcine angular aqueous plexus cells to elevation of pressure. 
  • Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. 
  • Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues. 
  • Changes in primary lymphoid organs with aging. 
  • Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products. 
  • Characterization of transformed Arabidopsis with altered alternative oxidase levels and analysis of effects on reactive oxygen species in tissue. 
  • Charting the travels of copper in eukaryotes from yeast to mammals. 
  • Chemical characterization of a protein-4-hydroxy-2-nonenal cross-link: immunochemical detection in mitochondria exposed to oxidative stress. 
  • Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor. 
  • Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation. 
  • Chronic oxidative DNA damage due to DNA repair defects causes chromosomal instability in Saccharomyces cerevisiae. 
  • Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration. 
  • Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis. 
  • Clara cell secretory protein-deficient mice differ from wild-type mice in inflammatory chemokine expression to oxygen and ozone, but not to endotoxin. 
  • Clinical review: oxygen as a signaling molecule. 
  • Combined exposure to sarin and pyridostigmine bromide increased levels of rat urinary 3-nitrotyrosine and 8-hydroxy-2'-deoxyguanosine, biomarkers of oxidative stress. 
  • Comparative toxicity of silver nanoparticles on oxidative stress and DNA damage in the nematode, Caenorhabditis elegans. 
  • Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans. 
  • Comparison of gene expression profiles induced by coarse, fine, and ultrafine particulate matter. 
  • Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. 
  • Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury. 
  • Comparisons of ultrafine and fine particles in their associations with biomarkers reflecting physiological pathways. 
  • Competitive apnea and its effect on the human brain: focus on the redox regulation of blood-brain barrier permeability and neuronal-parenchymal integrity. 
  • Comprehensive molecular characterization of urothelial bladder carcinoma. 
  • Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+. 
  • Concentrations of urinary 8-hydroxy-2'-deoxyguanosine and 8-isoprostane in women exposed to woodsmoke in a cookstove intervention study in San Marcos, Peru. 
  • Concerted regulation of skeletal muscle contractility by oxygen tension and endogenous nitric oxide. 
  • Concurrent production of reactive oxygen and nitrogen species by airway epithelial cells in vitro. 
  • Controlled exposure to diesel exhaust causes increased nitrite in exhaled breath condensate among subjects with asthma. 
  • Correction: Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease. 
  • Correlation between two markers of inflammation, serum C-reactive protein and interleukin 6, and indices of oxidative stress in patients with high risk of cardiovascular disease. 
  • Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone. 
  • Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination. 
  • Cryptococcal cell morphology affects host cell interactions and pathogenicity. 
  • Cryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growth. 
  • Cultured porcine trabecular meshwork cells display altered lysosomal function when subjected to chronic oxidative stress. 
  • Cytochrome c peroxidase contributes to the antioxidant defense of Cryptococcus neoformans. 
  • Cytoprotective effects of proteasome beta5 subunit overexpression in lens epithelial cells. 
  • Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase. 
  • Cytosolic hydroxymethyldihydropterin pyrophosphokinase/dihydropteroate synthase from Arabidopsis thaliana: a specific role in early development and stress response. 
  • Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate. 
  • Decreased Uptake and Enhanced Mitochondrial Protection Underlie Reduced Toxicity of Nanoceria in Human Monocyte-Derived Macrophages. 
  • Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction. 
  • Defusing redox bombs? 
  • Dementia and Alzheimer's disease in community-dwelling elders taking vitamin C and/or vitamin E. 
  • Dependence of the cyanobacterium Prochlorococcus on hydrogen peroxide scavenging microbes for growth at the ocean's surface. 
  • Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities. 
  • Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators. 
  • Determination of residual manganese in Mn porphyrin-based superoxide dismutase (SOD) and peroxynitrite reductase mimics. 
  • Developmental neurotoxicity of perfluorinated chemicals modeled in vitro. 
  • Dietary CdSe/ZnS quantum dot exposure in estuarine fish: bioavailability, oxidative stress responses, reproduction, and maternal transfer. 
  • Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress. 
  • Dietary regulation of catabolic disposal of 4-hydroxynonenal analogs in rat liver. 
  • Differences in Reperfusion-Induced Mitochondrial Oxidative Stress and Cell Death Between Hippocampal CA1 and CA3 Subfields Are Due to the Mitochondrial Thioredoxin System. 
  • Differential susceptibility of fish and rat liver cells to oxidative stress and cytotoxicity upon exposure to prooxidants. 
  • Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy. 
  • Disruption of iron homeostasis in mesothelial cells after talc pleurodesis. 
  • Disruption of iron homeostasis in the lungs of transplant patients. 
  • Disruption of the Ang II type 1 receptor promotes longevity in mice. 
  • Distinctive RNA expression profiles in blood associated with white matter hyperintensities in brain. 
  • Distinctive adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest. 
  • Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer. 
  • Divalent metal transporter-1 decreases metal-related injury in the lung. 
  • Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics. 
  • Dopamine and α-synuclein dysfunction in Smad3 null mice. 
  • Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction. 
  • Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging. 
  • Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. 
  • EGF and PDGF receptor tyrosine kinases as therapeutic targets for chronic lung diseases. 
  • EGF-Like Ligands Contribute to Neointimal Formation via Nox1-Mediated SMC Growth 
  • Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity. 
  • Editor's Highlight: Base Excision Repair Variants and Pesticide Exposure Increase Parkinson's Disease Risk. 
  • Effect of edaravone, a novel free radical scavenger, supplemented to cardioplegia on myocardial function after cardioplegic arrest: in vitro study of isolated rat heart. 
  • Effect of oxidative stress on homer scaffolding proteins. 
  • Effect of size fractionation on the toxicity of amosite and Libby amphibole asbestos. 
  • Effect of vitamin E on tamoxifen-treated breast cancer cells. 
  • Effective blue light photodynamic therapy does not affect cutaneous langerhans cell number or oxidatively damage DNA. 
  • Effects of Acetaminophen on Oxidant and Irritant Respiratory Tract Responses to Environmental Tobacco Smoke in Female Mice. 
  • Effects of Xanthine Oxidase Inhibition in Hyperuricemic Heart Failure Patients: The Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients (EXACT-HF) Study. 
  • Effects of a single bout of ultraendurance exercise on lipid levels and susceptibility of lipids to peroxidation in triathletes. 
  • Effects of aerobic training on oxidative status in postsurgical non-small cell lung cancer patients: a pilot study. 
  • Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys. 
  • Electrostatic contribution in the catalysis of O2*- dismutation by superoxide dismutase mimics. MnIIITE-2-PyP5+ versus MnIIIBr8T-2-PyP+. 
  • Emerging biomarkers in heart failure. 
  • Enhanced Angiotensin II-Induced Cardiac and Aortic Remodeling in ACE2 Knockout Mice 
  • Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice. 
  • ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cells. 
  • Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4. 
  • Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. 
  • Ethanol induces redox-sensitive cell-cycle inhibitors and inhibits liver regeneration after partial hepatectomy. 
  • Evaluation of Biomarkers of Oxidative Stress and Apoptosis in Patients With Severe Methotrexate Neurotoxicity: A Case Series. 
  • Evolving role of biomarkers in acute cerebrovascular disease. 
  • Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats. 
  • Exploring the potential role of the oxidant-activated transcription factor aryl hydrocarbon receptor in the pathogenesis of AMD. 
  • Extracellular superoxide dismutase (EC-SOD) binds to type i collagen and protects against oxidative fragmentation. 
  • Extracellular superoxide dismutase overexpression improves behavioral outcome from closed head injury in the mouse. 
  • Extracellular superoxide dismutase overexpression protects against aging-induced cognitive impairment in mice. 
  • Extracellular superoxide dismutase regulates cardiac function and fibrosis. 
  • F2-isoprostanes: a measure of oxidative stress in children receiving treatment for leukemia. 
  • Facilitation of robust growth of Prochlorococcus colonies and dilute liquid cultures by "helper" heterotrophic bacteria. 
  • Fatigue and Oxidative Stress in Children Undergoing Leukemia Treatment. 
  • Ferruginous bodies: implications in the mechanism of fiber and particle toxicity. 
  • Fiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuli. 
  • Fine ambient particles induce oxidative stress and metal binding genes in human alveolar macrophages. 
  • Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism. 
  • Functional crosstalk among oxidative stress and O-GlcNAc signaling pathways. 
  • Gene expression profile in circulating mononuclear cells after exposure to ultrafine carbon particles. 
  • Gene signatures of postoperative atrial fibrillation in atrial tissue after coronary artery bypass grafting surgery in patients receiving β-blockers. 
  • Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene. 
  • Genes of innate immunity and the biological response to inhaled ozone. 
  • Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension. 
  • Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice. 
  • Genetic variants and cellular stressors associated with exfoliation syndrome modulate promoter activity of a lncRNA within the LOXL1 locus. 
  • Genetics and women's health issues--the commitment of EMS to women scientists and gender-associated disease topics. 
  • Glutamine prevents apoptosis in intestinal epithelial cells and induces differential protective pathways in heat and oxidant injury models. 
  • Glutathione and zebrafish: Old assays to address a current issue. 
  • Glutathione peroxidase-deficient smooth muscle cells cause paracrine activation of normal smooth muscle cells via cyclophilin A. 
  • Glutathione regulates susceptibility to oxidant-induced mitochondrial DNA damage in human lymphocytes. 
  • Glutathione-S-transferase polymorphisms and complications of microvascular head and neck reconstruction. 
  • Growth differentiation factor 15, a marker of oxidative stress and inflammation, for risk assessment in patients with atrial fibrillation: insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial. 
  • Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems. 
  • Heme oxygenase 1 is required for mammalian iron reutilization. 
  • Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity. 
  • Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype-specific manner. 
  • Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription. 
  • High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease. 
  • Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury. 
  • Homeostatic imbalance of purine catabolism in first-episode neuroleptic-naïve patients with schizophrenia. 
  • How an individual fecundity pattern looks in Drosophila and medflies. 
  • How copper traverses cellular membranes through the mammalian copper transporter 1, Ctr1. 
  • Hydrogen peroxide promotes aging-related platelet hyperactivation and thrombosis. 
  • Hypercapnia is essential to reduce the cerebral oxidative metabolism during extreme apnea in humans. 
  • Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and γδ T Cells from Hematopoietic Stem Cells. 
  • Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells. 
  • Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. 
  • Hypothesis: hyperhomocysteinemia is an indicator of oxidant stress. 
  • Hypoxia inducible factor 1alpha signaling in fractionated radiation-induced lung injury: role of oxidative stress and tissue hypoxia. 
  • Identification and characterization of an SKN7 homologue in Cryptococcus neoformans. 
  • Identification of JWA as a novel functional gene responsive to environmental oxidative stress induced by benzo[a]pyrene and hydrogen peroxide. 
  • Identification of a negative feedback loop in biological oxidant formation fegulated by 4-hydroxy-2-(E)-nonenal. 
  • Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes. 
  • Immune activation by histones: plusses and minuses in inflammation. 
  • Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier. 
  • Impact of nitric-oxide-mediated vasodilation and oxidative stress on renal medullary oxygenation: a modeling study. 
  • Impacts of nitric oxide and superoxide on renal medullary oxygen transport and urine concentration. 
  • Increase in oxidative stress as measured by cerebrospinal fluid lipid peroxidation during treatment for childhood acute lymphoblastic leukemia. 
  • Increased expression of extracellular glutathione peroxidase in mice with dextran sodium sulfate-induced experimental colitis. 
  • Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits. 
  • Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation. 
  • Individual responses to chemotherapy-induced oxidative stress. 
  • Induction of ferritin and heme oxygenase-1 by endotoxin in the lung. 
  • Induction of oxidative cell damage by photo-treatment with zinc meta N-methylpyridylporphyrin. 
  • Induction of the protective antioxidant response element pathway by 6-hydroxydopamine in vivo and in vitro. 
  • Induction of urinary excretion of 3-nitrotyrosine, a marker of oxidative stress, following administration of pyridostigmine bromide, DEET (N,N-diethyl-m-toluamide) and permethrin, alone and in combination in rats. 
  • Inflammatory and oxidative stress responses of healthy young adults to changes in air quality during the Beijing Olympics. 
  • Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65. 
  • Influence of Nitrosative Stress on Fatigue During Childhood Leukemia Treatment. 
  • Inhaled carbon monoxide and hyperoxic lung injury in rats. 
  • Inhaled ethyl nitrite prevents hyperoxia-impaired postnatal alveolar development in newborn rats. 
  • Inherited variants in mitochondrial biogenesis genes may influence epithelial ovarian cancer risk. 
  • Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. 
  • Inhibition of apoptotic signaling and neointimal hyperplasia by tempol and nitric oxide synthase following vascular injury. 
  • Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. 
  • Inhibition of the cardiomyocyte-specific troponin I-interacting kinase limits oxidative stress, injury, and adverse remodeling due to ischemic heart disease. 
  • Inhibitory effect of hydrogen sulfide on ozone-induced airway inflammation, oxidative stress, and bronchial hyperresponsiveness. 
  • Inorganic nitrite attenuates NADPH oxidase-derived superoxide generation in activated macrophages via a nitric oxide-dependent mechanism. 
  • Interleukin 1-induced production of nitric oxide inhibits benzenetriol-mediated oxidative injury in rat hepatocytes. 
  • Intracellular uptake and associated toxicity of silver nanoparticles in Caenorhabditis elegans. 
  • Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress. 
  • Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study. 
  • Iron homeostasis in the lung. 
  • Iron uptake and Nramp2/DMT1/DCT1 in human bronchial epithelial cells. 
  • Is antioxidant use protective of cognitive function in the community-dwelling elderly? 
  • Is fipronil safer than chlorpyrifos? Comparative developmental neurotoxicity modeled in PC12 cells. 
  • Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos? 
  • Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells. 
  • Is the flavohemoglobin a nitric oxide dioxygenase? 
  • Isofurans, but not F2-isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body disease. 
  • Joint effects of alcohol consumption and polymorphisms in alcohol and oxidative stress metabolism genes on risk of head and neck cancer. 
  • Ketamine potentiates oxidative stress and influences behavior and inflammation in response to lipolysaccharide (LPS) exposure in early life. 
  • Klotho, an antiaging molecule, attenuates oxidant-induced alveolar epithelial cell mtDNA damage and apoptosis. 
  • Knockdown of mouse VCAM-1 by vector-based siRNA. 
  • L-arginine or tempol supplementation improves renal and cardiovascular function in rats with reduced renal mass and chronic high salt intake. 
  • Lack of the P2X7 receptor protects against AMD-like defects and microparticle accumulation in a chronic oxidative stress-induced mouse model of AMD. 
  • Late administration of Mn porphyrin-based SOD mimic enhances diabetic complications. 
  • Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis. 
  • Lipid-induced mitochondrial stress and insulin action in muscle. 
  • Lipids and diabetic retinopathy. 
  • Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways. 
  • Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins. 
  • Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis. 
  • Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1. 
  • Liver disease in menopause. 
  • Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat. 
  • Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration. 
  • Luminal alkalinization attenuates proteinuria-induced oxidative damage in proximal tubular cells. 
  • Lung injury after ozone exposure is iron dependent. 
  • Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis. 
  • M1 polarization bias and subsequent nonalcoholic steatohepatitis progression is attenuated by nitric oxide donor DETA NONOate via inhibition of CYP2E1-induced oxidative stress in obese mice. 
  • MFN1 deacetylation activates adaptive mitochondrial fusion and protects metabolically challenged mitochondria. 
  • Maintenance of nitric oxide and redox homeostasis by the salmonella flavohemoglobin hmp. 
  • Malondialdehyde in exhaled breath condensate and urine as a biomarker of air pollution induced oxidative stress. 
  • Manganese porphyrin reduces retinal injury induced by ocular hypertension in rats. 
  • Manganese porphyrins and related compounds as mimics of superoxide dismutase. 
  • Manganese superoxide dismutase is a mitochondrial fidelity protein that protects Polγ against UV-induced inactivation. 
  • Markers of oxidative status in a clinical model of oxidative assault: a pilot study in human blood following doxorubicin administration. 
  • Maternal dietary exposure to selenium nanoparticle led to malformation in offspring. 
  • Measurement of inflammation and oxidative stress following drastic changes in air pollution during the Beijing Olympics: a panel study approach. 
  • Mechanism of silver nanoparticle toxicity is dependent on dissolved silver and surface coating in Caenorhabditis elegans. 
  • Mechanisms of cell death governed by the balance between nitrosative and oxidative stress. 
  • Memory decline of aging reduced by extracellular superoxide dismutase overexpression. 
  • Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction. 
  • Metabolic capacity regulates iron homeostasis in endothelial cells. 
  • Metabolomic changes in autopsy-confirmed Alzheimer's disease. 
  • Metalloporphyrins as therapeutic catalytic oxidoreductants in central nervous system disorders. 
  • Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of Ca2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme. 
  • Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells. 
  • Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis. 
  • Microarray analysis of murine retinal light damage reveals changes in iron regulatory, complement, and antioxidant genes in the neurosensory retina and isolated RPE. 
  • Microglial contribution to oxidative stress in Alzheimer's disease. 
  • Mitochondria and nitric oxide. 
  • Mitochondria in lung biology and pathology: more than just a powerhouse. 
  • Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma. 
  • Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice. 
  • Mitochondrial adaptations to obesity-related oxidant stress. 
  • Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis. 
  • Mitochondrial biogenesis: regulation by endogenous gases during inflammation and organ stress. 
  • Mitochondrial reactive oxygen species. Contribution to oxidative stress and interorganellar signaling. 
  • Mn porphyrin-based SOD mimic, MnTnHex-2-PyP(5+), and non-SOD mimic, MnTBAP(3-), suppressed rat spinal cord ischemia/reperfusion injury via NF-κB pathways. 
  • Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression. 
  • Modifications of boronic ester pro-chelators triggered by hydrogen peroxide tune reactivity to inhibit metal-promoted oxidative stress. 
  • Modulation of the GABA(A)-gated chloride channel by reactive oxygen species. 
  • Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson's Disease Patients. 
  • Molecular medicine: Defence against oxidative damage. 
  • Molecular therapies for vascular diseases. 
  • Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation. 
  • Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease. 
  • Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress. 
  • Muscle oxidative capacity during IL-6-dependent cancer cachexia. 
  • Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons. 
  • NAD(P)H quinone oxidoreductase 1 is essential for ozone-induced oxidative stress in mice and humans. 
  • NAD(P)H quinone oxidoreductase 1 regulates neutrophil elastase-induced mucous cell metaplasia. 
  • NK-1 antagonist reduces colonic inflammation and oxidative stress in dextran sulfate-induced colitis in rats. 
  • Neurobehavioral radiation mitigation to standard brain cancer therapy regimens by Mn(III) n-butoxyethylpyridylporphyrin-based redox modifier. 
  • Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant. 
  • Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress. 
  • Neuroprotective effect of curcumin in an experimental rat model of subarachnoid hemorrhage. 
  • Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. 
  • Neurospora clock-controlled gene 9 (ccg-9) encodes trehalose synthase: circadian regulation of stress responses and development. 
  • Neutrophils exert protection in the early tuberculous granuloma by oxidative killing of mycobacteria phagocytosed from infected macrophages. 
  • New insights provided by a comparison of impaired deformability with erythrocyte oxidative stress for sickle cell disease. 
  • Nitration of tyrosine by hydrogen peroxide and nitrite. 
  • Nitric oxide and acetaminophen-mediated oxidative injury: modulation of interleukin-1-induced nitric oxide synthesis in cultured rat hepatocytes. 
  • Nitric oxide and redox regulation in the liver: Part I. General considerations and redox biology in hepatitis. 
  • Nitric oxide and redox regulation in the liver: part II. Redox biology in pathologic hepatocytes and implications for intervention. 
  • Nitric oxide in the central nervous system. 
  • Nitric oxide-associated regulation of hepatocyte glutathione synthesis is a guanylyl cyclase-independent event. 
  • Nitrosation and oxidation in the regulation of gene expression. 
  • Nitrosative stress. 
  • Nitrosative stress: activation of the transcription factor OxyR. 
  • Nonadditive effects of PAHs on Early Vertebrate Development: mechanisms and implications for risk assessment. 
  • Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling. 
  • Nox4 NADPH oxidase contributes to smooth muscle cell phenotypes associated with unstable atherosclerotic plaques. 
  • Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes. 
  • Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis. 
  • Obstructive sleep apnea and delirium: exploring possible mechanisms. 
  • Occupational exposure to woodsmoke and oxidative stress in wildland firefighters. 
  • Opioid use affects antioxidant activity and purine metabolism: preliminary results. 
  • Opportunity nox: the future of NADPH oxidases as therapeutic targets in cardiovascular disease. 
  • Optical and pharmacological tools to investigate the role of mitochondria during oxidative stress and neurodegeneration. 
  • Optical imaging reveals elevated intracellular chloride in hippocampal pyramidal neurons after oxidative stress. 
  • Optimizing the dose of glutamine dipeptides and antioxidants in critically ill patients: a phase I dose-finding study. 
  • Organic matter modifies biochemical but not most behavioral responses of the clam Ruditapes philippinarum to nanosilver exposure. 
  • Organophosphorus ester-induced chronic neurotoxicity. 
  • Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease. 
  • Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity. 
  • Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan. 
  • Overexpression of extracellular superoxide dismutase decreases lung injury after exposure to oil fly ash. 
  • Overexpression of extracellular superoxide dismutase protects mice from radiation-induced lung injury. 
  • Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity. 
  • Overexpression of hMTH in peripheral lymphocytes and risk of prostate cancer: a case-control analysis. 
  • Oxidant generation promotes iron sequestration in BEAS-2B cells exposed to asbestos. 
  • Oxidants, antioxidants and the ischemic brain. 
  • Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease. 
  • Oxidative DNA damage during night shift work. 
  • Oxidative DNA damage during sleep periods among nightshift workers. 
  • Oxidative Stress and Total Antioxidant Status During Internal Carotid Artery Clamping with or without Shunting: An Experimental Pilot Study. 
  • Oxidative Stress, Motor Abilities, and Behavioral Adjustment in Children Treated for Acute Lymphoblastic Leukemia. 
  • Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa. 
  • Oxidative damage to macromolecules in human Parkinson disease and the rotenone model. 
  • Oxidative damage-induced inflammation initiates age-related macular degeneration. 
  • Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos. 
  • Oxidative metabolism in rat hepatocytes and mitochondria during sepsis. 
  • Oxidative metabolism in sepsis and sepsis syndrome. 
  • Oxidative modifications in nitrosative stress. 
  • Oxidative stress activates anion exchange protein 2 and AP-1 in airway epithelial cells. 
  • Oxidative stress and adenine nucleotide control of mitochondrial permeability transition. 
  • Oxidative stress and executive function in children receiving chemotherapy for acute lymphoblastic leukemia. 
  • Oxidative stress and inflammation contribute to lung toxicity after a common breast cancer chemotherapy regimen. 
  • Oxidative stress and nerve function after cardiopulmonary bypass in patients with diabetes. 
  • Oxidative stress and neurobehavioral problems in pediatric acute lymphoblastic leukemia patients undergoing chemotherapy. 
  • Oxidative stress from diverse developmental neurotoxicants: antioxidants protect against lipid peroxidation without preventing cell loss. 
  • Oxidative stress impact on barrier function of porcine angular aqueous plexus cell monolayers. 
  • Oxidative stress in cardiovascular disease. 
  • Oxidative stress in diseases of the human cornea. 
  • Oxidative stress in human abdominal aortic aneurysms: a potential mediator of aneurysmal remodeling. 
  • Oxidative stress in toxicology: established mammalian and emerging piscine model systems. 
  • Oxidative stress in two populations of killifish (Fundulus heteroclitus) with differing contaminant exposure histories. 
  • Oxidative stress increases hepatocyte iNOS gene transcription and promoter activity. 
  • Oxidative stress induced heat shock factor phosphorylation and HSF-dependent activation of yeast metallothionein gene transcription. 
  • Oxidative stress mediates monocrotaline-induced alterations in tenascin expression in pulmonary artery endothelial cells. 
  • Oxidative stress survival in a clinical Saccharomyces cerevisiae isolate is influenced by a major quantitative trait nucleotide. 
  • Oxidative stress, oxidative balance score, and hypertension among a racially diverse population. 
  • Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina. 
  • Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy. 
  • Oxidative/nitrosative stress and antidepressants: targets for novel antidepressants. 
  • Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway. 
  • Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2. 
  • Oxygen-induced mitochondrial biogenesis in the rat hippocampus. 
  • Ozone inhalation promotes CX3CR1-dependent maturation of resident lung macrophages that limit oxidative stress and inflammation. 
  • PM2.5 constituents and oxidative DNA damage in humans. 
  • PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cells. 
  • Pathogenic triad in COPD: oxidative stress, protease-antiprotease imbalance, and inflammation. 
  • Pentraxin 3 recruits complement factor H to protect against oxidative stress-induced complement and inflammasome overactivation. 
  • Perfluorooctyl bromide (perflubron) attenuates oxidative injury to biological and nonbiological systems. 
  • Peroxisome proliferator-activated receptor γ co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis. 
  • Peroxynitrite formation and decreased catalase activity in autoimmune MRL-lpr/lpr mice. 
  • Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function. 
  • Persistent systemic inflammation in chronic critical illness. 
  • Personal exposure to particulate PAHs and anthraquinone and oxidative DNA damages in humans. 
  • Phagocyte-generated superoxide reduces Fe3+ to displace it from the surface of asbestos. 
  • Phase 1 Study of a Sulforaphane-Containing Broccoli Sprout Homogenate for Sickle Cell Disease. 
  • Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity. 
  • Pollutant particles enhanced H2O2 production from NAD(P)H oxidase and mitochondria in human pulmonary artery endothelial cells. 
  • Polyglutamine expansion inhibits respiration by increasing reactive oxygen species in isolated mitochondria. 
  • Postlipopolysaccharide oxidative damage of mitochondrial DNA. 
  • Potential role of lysosomal dysfunction in the pathogenesis of primary open angle glaucoma. 
  • Potential role of lysosomal dysfunction in the pathogenesis of primary open angle glaucoma. 
  • Prenatal nicotine exposure in rhesus monkeys compromises development of brainstem and cardiac monoamine pathways involved in perinatal adaptation and sudden infant death syndrome: amelioration by vitamin C. 
  • Pro-thrombotic and pro-oxidant effects of diet-induced hyperhomocysteinemia. 
  • Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation. 
  • Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress. 
  • Production of hydroxyl radical in the hippocampus after CO hypoxia or hypoxic hypoxia in the rat. 
  • Progesterone, Inflammatory Cytokine (TNF-α), and Oxidative Stress (H2O2) Regulate Progesterone Receptor Membrane Component 1 Expression in Fetal Membrane Cells. 
  • Proteasome inhibition by chronic oxidative stress in human trabecular meshwork cells. 
  • Protecting the permeability pore and mitochondrial biogenesis. 
  • Protection from nitrosative stress by yeast flavohemoglobin. 
  • Protection from nitrosative stress: a central role for microbial flavohemoglobin. 
  • Protection from oxidation enhances the survival of cultured mesencephalic neurons. 
  • Protective role of fructose in the metabolism of astroglial C6 cells exposed to hydrogen peroxide. 
  • Protective role of ortho-substituted Mn(III) N-alkylpyridylporphyrins against the oxidative injury induced by tert-butylhydroperoxide. 
  • Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease. 
  • Pulmonary fibrosis and ferruginous bodies associated with exposure to synthetic fibers. 
  • Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy. 
  • Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis. 
  • Quantification of the oxidative damage biomarker 2,3-dinor-8-isoprostaglandin-F(2alpha) in human urine using liquid chromatography-tandem mass spectrometry. 
  • Quitting smoking raises whole blood glutathione. 
  • RAS and ROS in rhabdomyosarcoma. 
  • RETRACTED: NAD(P)H:quinone oxidoreductase 1 protects lungs from oxidant-induced emphysema in mice. 
  • ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function. 
  • Racial differences in urinary F2-isoprostane levels and the cross-sectional association with BMI. 
  • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. 
  • Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+. 
  • Radioprotective effects of amifostine on acute and chronic esophageal injury in rodents. 
  • Raising the bar: how HIF-1 helps determine tumor radiosensitivity. 
  • Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). 
  • Rapid up-regulation of peptide elongation factor EF-1alpha protein levels is an immediate early event during oxidative stress-induced apoptosis. 
  • Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination. 
  • Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress. 
  • Reactive oxygen species produced by liver mitochondria of rats in sepsis. 
  • Reassessing serum urate targets in the management of refractory gout: can you go too low? 
  • Recent progress in metabolic signaling pathways regulating aging and life span. 
  • Recognition and assessment of shift work disorder. 
  • Redox modulation of oxidative stress by Mn porphyrin-based therapeutics: the effect of charge distribution. 
  • Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress. 
  • Redox regulation of mitochondrial biogenesis. 
  • Redox regulation of neuronal migration in a Down Syndrome model. 
  • Redox regulation of the rat hepatocyte iNOS promoter. 
  • Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme. 
  • Reduced stress defense in heme oxygenase 1-deficient cells. 
  • Regulation of mitochondrial biogenesis and its intersection with inflammatory responses. 
  • Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress. 
  • Relevance of the ability of fructose 1,6-bis(phosphate) to sequester ferrous but not ferric ions. 
  • Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels. 
  • Resveratrol prevention of oxidative stress damage to lens epithelial cell cultures is mediated by forkhead box O activity. 
  • Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells. 
  • Retinal pigment epithelial cell death by the alternative complement cascade: role of membrane regulatory proteins, calcium, PKC, and oxidative stress. 
  • Rhabdomyolysis and hemolysis associated with sickle cell trait and glucose-6-phosphate dehydrogenase deficiency. 
  • Ribonomic analysis of human Pum1 reveals cis-trans conservation across species despite evolution of diverse mRNA target sets. 
  • Role of alternative oxidase gene in pathogenesis of Cryptococcus neoformans. 
  • Role of fructose in the adaptation of plants to cold-induced oxidative stress. 
  • Role of guanylate cyclase modulators in decompensated heart failure. 
  • Role of miR-204 in the regulation of apoptosis, endoplasmic reticulum stress response, and inflammation in human trabecular meshwork cells. 
  • Role of miR-29b on the regulation of the extracellular matrix in human trabecular meshwork cells under chronic oxidative stress. 
  • Role of oxidative stress in a rat model of radiation-induced erectile dysfunction. 
  • Rpl13a small nucleolar RNAs regulate systemic glucose metabolism. 
  • S-Nitrosylation of Sarcomeric Proteins Depresses Myofilament Ca2+)Sensitivity in Intact Cardiomyocytes. 
  • S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents. 
  • S-nitrosylation of the Mitochondrial Chaperone TRAP1 Sensitizes Hepatocellular Carcinoma Cells to Inhibitors of Succinate Dehydrogenase. 
  • Saccharomyces cerevisiae: population divergence and resistance to oxidative stress in clinical, domesticated and wild isolates. 
  • Seasonal variations in air pollution particle-induced inflammatory mediator release and oxidative stress. 
  • Sequestration of mitochondrial iron by silica particle initiates a biological effect. 
  • Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. 
  • Sex-specific computational models of the spontaneously hypertensive rat kidneys: factors affecting nitric oxide bioavailability. 
  • Silver impairs neurodevelopment: studies in PC12 cells. 
  • Silver nanoparticle toxicity is related to coating materials and disruption of sodium concentration regulation. 
  • Silver nanoparticles compromise neurodevelopment in PC12 cells: critical contributions of silver ion, particle size, coating, and composition. 
  • Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis. 
  • Simultaneous proteomic profiling of four different growth states of human fibroblasts, using amine-reactive isobaric tagging reagents and tandem mass spectrometry. 
  • Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation. 
  • Skeletal muscle sarcoplasmic reticulum contains a NADH-dependent oxidase that generates superoxide. 
  • Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress. 
  • Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation. 
  • Stress response of the trabecular meshwork. 
  • Stressed-out podocytes in diabetes? 
  • Subcellular organelle lipidomics in TLR-4-activated macrophages. 
  • Subtype specific estrogen receptor action protects against changes in MMP-2 activation in mouse retinal pigmented epithelial cells. 
  • Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. 
  • Superoxide enhances interleukin 1beta-mediated transcription of the hepatocyte-inducible nitric oxide synthase gene. 
  • Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. 
  • Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma. 
  • Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. 
  • Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance. 
  • Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. 
  • Sustained stress response after oxidative stress in trabecular meshwork cells. 
  • Synergistic activity of the SRC family kinase inhibitor dasatinib and oxaliplatin in colon carcinoma cells is mediated by oxidative stress. 
  • Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production. 
  • Synthetic surfactant scavenges oxidants and protects against hyperoxic lung injury. 
  • Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retina. 
  • Systemic markers of oxidative status and colorectal adenomatous polyps. 
  • Systemic oxidative stress, as measured by urinary allantoin and F(2)-isoprostanes, is not increased in Down syndrome. 
  • T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration. 
  • TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity. 
  • Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer. 
  • Temporal dynamics of host molecular responses differentiate symptomatic and asymptomatic influenza a infection. 
  • Temporal onset of hypoxia and oxidative stress after pulmonary irradiation. 
  • Teratogenic, bioenergetic, and behavioral effects of exposure to total particulate matter on early development of zebrafish (Danio rerio) are not mimicked by nicotine. 
  • Tetrahydroindenoindole inhibits the progression of diabetes in mice. 
  • Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout mice. 
  • The Abl family kinases: mechanisms of regulation and signaling. 
  • The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration. 
  • The autophagic lysosomal system in outflow pathway physiology and pathophysiology. 
  • The cardiopulmonary effects of ambient air pollution and mechanistic pathways: a comparative hierarchical pathway analysis. 
  • The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part I: Pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease). 
  • The cooperative roles of inflammation and oxidative stress in the pathogenesis of hypertension. 
  • The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies. 
  • The effects of tempol on cyclophosphamide-induced oxidative stress in rat micturition reflexes. 
  • The future of biology in driving the field of hyperthermia. 
  • The hydrolytic susceptibility of prochelator BSIH in aqueous solutions. 
  • The impact of human and mouse differences in NOS2 gene expression on the brain's redox and immune environment. 
  • The importance of Bcl-xL in the survival of human RPE cells. 
  • The influence of air cleaners on indoor particulate matter components and oxidative potential in residential households in Beijing. 
  • The influence of oxidative stress on symptom occurrence, severity, and distress during childhood leukemia treatment. 
  • The inhibition of the kynurenine pathway prevents behavioral disturbances and oxidative stress in the brain of adult rats subjected to an animal model of schizophrenia. 
  • The involvement of superoxide and iNOS-derived NO in cardiac dysfunction induced by pro-inflammatory cytokines. 
  • The iron cycle and oxidative stress in the lung. 
  • The multifaceted roles of nitric oxide in cancer. 
  • The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration. 
  • The oral iron chelator deferiprone protects against systemic iron overload-induced retinal degeneration in hepcidin knockout mice. 
  • The oxidative stress product carboxyethylpyrrole potentiates TLR2/TLR1 inflammatory signaling in macrophages. 
  • The relationship between intracellular and plasma levels of folate and metabolites in the methionine cycle: a model. 
  • The role of oxidative damage in mitochondria during aging: a review. 
  • The role of oxidative stress in cerebral aneurysm formation and rupture. 
  • The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism. 
  • The role of proteolytic cellular systems in trabecular meshwork homeostasis. 
  • The sirtuins, oxidative stress and aging: an emerging link. 
  • The transcriptional response to oxidative stress during vertebrate development: effects of tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin. 
  • The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense. 
  • Thermal stability of the prototypical Mn porphyrin-based superoxide dismutase mimic and potent oxidative-stress redox modulator Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin chloride, MnTE-2-PyP(5+). 
  • Thioredoxin and hematologic malignancies. 
  • Thioredoxin-interacting protein (Txnip) is a feedback regulator of S-nitrosylation. 
  • Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling. 
  • Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli. 
  • Toward the development of prochelators as fluorescent probes of copper-mediated oxidative stress. 
  • Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression. 
  • Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans. 
  • Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation. 
  • Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes. 
  • Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo. 
  • Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation. 
  • Two faces of nitric oxide: implications for cellular mechanisms of oxygen toxicity. 
  • Ultrastructural characterization and Fourier analysis of fiber cell cytoplasm in the hyperbaric oxygen treated guinea pig lens opacification model. 
  • Up-regulated expression of extracellular matrix remodeling genes in phagocytically challenged trabecular meshwork cells. 
  • Urinary F2-isoprostanes and the risk of hypertension. 
  • Urinary F2-isoprostanes are not associated with increased risk of type 2 diabetes. 
  • Urinary F2-isoprostanes, obesity, and weight gain in the IRAS cohort. 
  • Urinary Isoprostane Levels and Age-Related Macular Degeneration. 
  • Urinary biomarkers of oxidative status in a clinical model of oxidative assault. 
  • Urinary biomarkers of oxidative status. 
  • Utility of Growth Differentiation Factor-15, A Marker of Oxidative Stress and Inflammation, in Chronic Heart Failure: Insights From the HF-ACTION Study. 
  • Vascular biology: the past 50 years. 
  • Vitamin E therapy of acute CCl4-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding. 
  • What if cell culture media do not mimic in vivo redox settings? 
  • Xanthine oxidase inhibition for hyperuricemic heart failure patients: design and rationale of the EXACT-HF study. 
  • ZAP-70-dependent and -independent activation of Erk in Jurkat T cells. Differences in signaling induced by H2o2 and Cd3 cross-linking. 
  • c-myc-Dependent hepatoma cell apoptosis results from oxidative stress and not a deficiency of growth factors. 
  • miR-21-mediated decreased neutrophil apoptosis is a determinant of impaired coronary collateral growth in metabolic syndrome. 
  • microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease. 
• 

  Keywords of People

  • Abbruzzese, James, D. C. I. Professor of Medical Oncology, Medicine, Medical Oncology
  • Bowes Rickman, Catherine, Professor of Ophthalmology, Cell Biology
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Farsiu, Sina, Associate Professor in the Department of Biomedical Engineering, Electrical and Computer Engineering
  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Grambow, Steven C., Assistant Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Hirschey, Matthew, Associate Professor, Pharmacology & Cancer Biology
  • Hoffman, Maureane Richardson, Professor of Pathology, Immunology
  • Hsu-Kim, Heileen, Mary Milus Yoh and Harold L. Yoh, Jr. Associate Professor of Civil and Environmental Engineering, Civil and Environmental Engineering
  • Jordt, Sven Eric, Associate Professor in Anesthesiology, Pharmacology & Cancer Biology
  • Koontz, Bridget Fey, Associate Professor of Radiation Oncology, Radiation Oncology
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Innovation & Entrepreneurship
  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Pharmacology & Cancer Biology
  • Liton, Paloma Borrajo, Associate Professor in Ophthalmology, Pathology
  • Moorman, Patricia Gripka, Professor in Community and Family Medicine, Duke Cancer Institute
  • Schmid, Amy K., Associate Professor of Biology, Duke Science & Society
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology
  • Sparks, Matthew A., Assistant Professor of Medicine, Medicine, Nephrology
  • Svetkey, Laura Pat, Professor of Medicine, Medicine
  • Toth, Cynthia Ann, Joseph A.C. Wadsworth Professor of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery
  • Turi, Jennifer Lilly, Associate Professor of Pediatrics, Pediatrics, Critical Care Medicine
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology