Centrosome

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  Subject Areas on Research

  • A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size. 
  • A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization. 
  • AURKA amplification, chromosome instability, and centrosome abnormality in human pancreatic carcinoma cells. 
  • Arl2- and Msps-dependent microtubule growth governs asymmetric division. 
  • Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. 
  • Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. 
  • Cell contacts orient some cell division axes in the Caenorhabditis elegans embryo. 
  • Cell cycle-dependent localization of macroH2A in chromatin of the inactive X chromosome. 
  • Centrosome and spindle function of the Drosophila Ncd microtubule motor visualized in live embryos using Ncd-GFP fusion proteins. 
  • Ciliopathies. 
  • Cohesin: it's not just for chromosomes anymore. 
  • Desmoplakin: an unexpected regulator of microtubule organization in the epidermis. 
  • Divergent regulation of functionally distinct γ-tubulin complexes during differentiation. 
  • EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules. 
  • Fluorescence recovery kinetic analysis of gamma-tubulin binding to the mitotic spindle. 
  • Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. 
  • Genetically induced microtubule disruption in the mouse intestine impairs intracellular organization and transport. 
  • Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. 
  • Intracellular and extracellular forces drive primary cilia movement. 
  • Intrinsic and cyclin-dependent kinase-dependent control of spindle pole body duplication in budding yeast. 
  • MKKS/BBS6, a divergent chaperonin-like protein linked to the obesity disorder Bardet-Biedl syndrome, is a novel centrosomal component required for cytokinesis. 
  • Microtubule organization, dynamics and functions in differentiated cells. 
  • Multi-step control of spindle pole body duplication by cyclin-dependent kinase. 
  • Mutations in CSPP1, encoding a core centrosomal protein, cause a range of ciliopathy phenotypes in humans. 
  • Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis. 
  • Pitchfork regulates primary cilia disassembly and left-right asymmetry. 
  • Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses. 
  • Reduced ATR or Chk1 expression leads to chromosome instability and chemosensitization of mismatch repair-deficient colorectal cancer cells. 
  • SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. 
  • Symmetry breaking in C. elegans: another gift from the sperm. 
  • The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. 
  • The centrosome in human genetic disease. 
  • The forces that position a mitotic spindle asymmetrically are tethered until after the time of spindle assembly. 
  • Ubiquitylated Tax targets and binds the IKK signalosome at the centrosome. 
  • beta-Catenin is a Nek2 substrate involved in centrosome separation.