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Subject Areas on Research
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A PCR-based strategy to generate integrative targeting alleles with large regions of homology.
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A conversation with Oliver Smithies.
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A family of hierarchically self-assembling linear-dendritic hybrid polymers for highly efficient targeted gene delivery.
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A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice.
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A genetic memory initiates the epigenetic loop necessary to preserve centromere position.
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A mouse model of familial porphyria cutanea tarda.
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A new Cre driver mouse line, Tcf21/Pod1-Cre, targets metanephric mesenchyme.
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A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening.
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A suppression strategy for antibiotic discovery.
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AAV does the shuffle.
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ATM Paradoxically Promotes Oncogenic Transformation via Transcriptional Reprogramming.
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Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation.
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Adeno-associated virus-mediated ILK gene silencing in the rat NAc core.
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Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death.
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Advanced magnetic resonance imaging of cerebral cavernous malformations: part II. Imaging of lesions in murine models.
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Advances in targeted genome editing.
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An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus.
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An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production.
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An evolved AAV variant enables efficient genetic engineering of murine T cells.
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Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages.
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Anti-gene padlocks eliminate Escherichia coli based on their genotype.
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Assessing a role for enhancer-blocking activity in gene regulation within the murine T-cell receptor alpha/delta locus.
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Aurora-A kinase is essential for bipolar spindle formation and early development.
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B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.
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Behavioral characterization of P311 knockout mice.
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Bmp4 is required for the generation of primordial germ cells in the mouse embryo.
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Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis.
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Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.
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CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor.
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CRISPR-Cas9-Guided Genome Engineering in Caenorhabditis elegans.
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Cas9 loosens its grip on off-target sites.
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Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras.
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Cell wall integrity is dependent on the PKC1 signal transduction pathway in Cryptococcus neoformans.
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Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus.
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Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles.
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Defective T cell development and function in the absence of Abelson kinases.
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Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate.
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Delivery of viral vectors to tumor cells: extracellular transport, systemic distribution, and strategies for improvement.
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Design, Assembly, and Characterization of TALE-Based Transcriptional Activators and Repressors.
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Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction.
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Disruption of the mouse oestrogen receptor gene: resulting phenotypes and experimental findings.
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Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production.
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Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice.
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Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor.
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Efficient Genome Editing in Caenorhabditis elegans with a Toolkit of Dual-Marker Selection Cassettes.
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Energy metabolism in uncoupling protein 3 gene knockout mice.
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Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine.
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Enhanced pancreatic cancer gene therapy by combination of adenoviral vector expressing c-erb-B2 (Her-2/neu)-targeted immunotoxin with a replication-competent adenovirus or etoposide.
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Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes.
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Examination of Endogenous Rotund Expression and Function in Developing Drosophila Olfactory System Using CRISPR-Cas9-Mediated Protein Tagging.
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Exploring type I angiotensin (AT1) receptor functions through gene targeting.
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Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice.
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Expression of the 71 kDa dystrophin isoform (Dp71) evaluated by gene targeting.
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Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis.
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Gene Function Analysis in the Ubiquitous Human Commensal and Pathogen Malassezia Genus.
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Gene delivery through cell culture substrate adsorbed DNA complexes
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Gene targeting in physiological investigations: studies of the renin-angiotensin system.
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Gene targeting to the ROSA26 locus directed by engineered zinc finger nucleases
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Gene targeting: applications in transplantation research.
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Gene therapy for prostate cancer: where are we now?
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Gene-targeting studies of the renin-angiotensin system: mechanisms of hypertension and cardiovascular disease.
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Generation and characterization of mice lacking gastrin-releasing peptide receptor.
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Generation of a Magoh conditional allele in mice.
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Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice.
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Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells.
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Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor).
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Genetic labeling of neurons in mouse brain.
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Genetic targeting for cardiovascular therapeutics: are we near the summit or just beginning the climb?
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Genetic therapies for cardiovascular diseases.
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Genetic variation in SP-A2 leads to differential binding to Mycoplasma pneumoniae membranes and regulation of host responses.
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Genome-editing Technologies for Gene and Cell Therapy.
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Group II introns designed to insert into therapeutically relevant DNA target sites in human cells.
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Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway.
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Heme oxygenase 1 is required for mammalian iron reutilization.
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Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis.
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High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice.
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Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice.
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Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior.
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Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology.
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Human apolipoprotein E4 targeted replacement mice show increased prevalence of intracerebral hemorrhage associated with vascular amyloid deposition.
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Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2.
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Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice.
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Identification of specific EP receptors responsible for the hemodynamic effects of PGE2.
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Improved techniques for endogenous epitope tagging and gene deletion in Toxoplasma gondii.
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In vivo reprogramming of hTERT by trans-splicing ribozyme to target tumor cells.
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Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice.
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Insights into the functions of type 1 (AT1) angiotensin II receptors provided by gene targeting.
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Interacting targets of the farnesyl of transducin gamma-subunit.
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Jumping at the chance for precise DNA integration.
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Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions.
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Leukocyte migration is regulated by L-selectin endoproteolytic release.
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Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition.
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Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease.
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Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells.
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Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice.
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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
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Meeting report: targeting protein phosphatases-medicines for the new millenium.
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MicroRNAs preferentially target the genes with high transcriptional regulation complexity.
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Minimal phenotype of mice homozygous for a null mutation in the forkhead/winged helix gene, Mf2.
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Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination.
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Negative regulation of lymphocyte activation by the adaptor protein LAX.
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Noncoding RNAs: biology and applications-a Keystone Symposia report.
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Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors.
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Physiological impact of increased expression of the AT1 angiotensin receptor.
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Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible.
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Prostate cancer gene therapy.
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Reading frame correction by targeted genome editing restores dystrophin expression in cells from Duchenne muscular dystrophy patients.
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Regional-specific effects of ovarian hormone loss on synaptic plasticity in adult human APOE targeted replacement mice.
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Regulation of E2A gene expression in B-lymphocyte development.
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Regulation of blood pressure by the type 1A angiotensin II receptor gene.
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Requirement of MIP-1 alpha for an inflammatory response to viral infection.
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Retrograde gene delivery to hypoglossal motoneurons using adeno-associated virus serotype 9.
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Reverse engineering gene regulatory networks.
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Role of 14-3-3-mediated p38 mitogen-activated protein kinase inhibition in cardiac myocyte survival.
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Role of alternative oxidase gene in pathogenesis of Cryptococcus neoformans.
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Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses.
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SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development.
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SR1, a mouse odorant receptor with an unusually broad response profile.
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Separating the wheat from the chaff: focus on "in silico data filtering to identify new angiogenesis targets from a large in vitro gene profile data set".
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SpHnf6, a transcription factor that executes multiple functions in sea urchin embryogenesis.
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Specific targeting of gene expression to a subset of human trabecular meshwork cells using the chitinase 3-like 1 promoter.
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Specification of Vδ and Vα usage by Tcra/Tcrd locus V gene segment promoters.
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Structure-guided reprogramming of serine recombinase DNA sequence specificity.
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Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease.
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Synergistic enhancement of both initiation and elongation by acidic transcription activation domains.
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Synthesis of programmable integrases.
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Targeted disruption of Mapk14 (p38MAPKalpha) in granulosa cells and cumulus cells causes cell-specific changes in gene expression profiles that rescue COC expansion and maintain fertility.
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Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis.
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Targeted downregulation of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase significantly mitigates chondroitin sulfate proteoglycan-mediated inhibition.
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Targeted entry via somatostatin receptors using a novel modified retrovirus glycoprotein that delivers genes at levels comparable to those of wild-type viral glycoproteins.
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Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide.
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Targeted gene transfer to Schlemm's canal by retroperfusion.
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Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function.
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Targeted metabolomics and mathematical modeling demonstrate that vitamin B-6 restriction alters one-carbon metabolism in cultured HepG2 cells.
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Targeted overexpression of noncleavable and secreted forms of tumor necrosis factor provokes disparate cardiac phenotypes.
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Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase.
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Targeted suppression of beta-catenin blocks intestinal adenoma formation in APC Min mice.
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Targeting cells with single vectors using multiple-feature Boolean logic.
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Targeting genes in the renin-angiotensin system.
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Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy.
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Tea with Dr Oliver Smithies, 2007 Nobel laureate in physiology and medicine. Interview by Dr. Anthony Viera.
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The Development of TALE Nucleases for Biotechnology.
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The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice.
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The colorectal microRNAome.
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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.
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The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse.
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The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy.
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The menthol receptor TRPM8 is the principal detector of environmental cold.
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The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection.
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Tissue-specific inactivation of murine M6P/IGF2R.
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Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans.
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Transgenic targeting of a dominant negative corepressor to liver and analyses by cDNA microarray.
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Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2.
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VEGF inhibition and renal thrombotic microangiopathy.
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Windows into development: historic, current, and future perspectives on transgenic zebrafish.
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c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes.
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Keywords of People
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Hartemink, Alexander J.,
Professor in the Department of Computer Science,
Biology
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Hirschey, Matthew,
Associate Professor of Medicine,
Cell Biology
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Hogan, Brigid L. M.,
Research Professor of Cell Biology,
Cell Biology
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Krangel, Michael S.,
George Barth Geller Distinguished Professor of Immunology,
Immunology
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Silver, Debra Lynn,
Associate Professor of Molecular Genetics and Microbiology,
Duke Science & Society
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Sunday, Mary Elizabeth Anne,
Professor of Pathology,
Cell Biology
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Taylor, Gregory Alan,
Professor in Medicine,
Immunology
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Zhong, Xiaoping,
Professor of Pediatrics,
Immunology