Homeodomain Proteins

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  Subject Areas on Research

  • A Common Glaucoma-risk Variant of SIX6 Alters Retinal Nerve Fiber Layer and Optic Disc Measures in a European Population: The EPIC-Norfolk Eye Study. 
  • A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement. 
  • A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation. 
  • A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function. 
  • A binding site for Pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord. 
  • A candidate gene for congenital bilateral isolated ptosis identified by molecular analysis of a de novo balanced translocation. 
  • A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. 
  • A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development. 
  • A cell-specific nuclear receptor regulates the steroid hydroxylases. 
  • A cortico-hippocampal learning rule shapes inhibitory microcircuit activity to enhance hippocampal information flow. 
  • A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition. 
  • A disinhibitory circuit mediates motor integration in the somatosensory cortex. 
  • A functional variant in HOXA11-AS, a novel long non-coding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancer. 
  • A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. 
  • A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5. 
  • A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans. 
  • A role for histone acetylation in the developmental regulation of VDJ recombination. 
  • A role of the CTCF binding site at enhancer Eα in the dynamic chromatin organization of the Tcra-Tcrd locus. 
  • A seminal finding for prostate cancer? 
  • A systematic analysis of recombination activity and genotype-phenotype correlation in human recombination-activating gene 1 deficiency. 
  • ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory. 
  • Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. 
  • Acidic stress promotes a glioma stem cell phenotype. 
  • Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1. 
  • Activation of pmar1 controls specification of micromeres in the sea urchin embryo. 
  • An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development. 
  • An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. 
  • An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. 
  • Antibody is critical for the clearance of murine norovirus infection. 
  • Application of Bayesian modeling of autologous antibody responses against ovarian tumor-associated antigens to cancer detection. 
  • Association of common SIX6 polymorphisms with peripapillary retinal nerve fiber layer thickness: the Singapore Chinese Eye Study. 
  • Associations between variants near a monoaminergic pathways gene (PHOX2B) and amygdala reactivity: a genome-wide functional imaging study. 
  • Astrocytes follow ganglion cell axons to establish an angiogenic template during retinal development. 
  • Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway. 
  • BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning. 
  • BMP4 is essential for lens induction in the mouse embryo. 
  • BMPs induce dermal markers and ectopic feather tracts. 
  • BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene. 
  • BP1, a new homeobox gene, is frequently expressed in acute leukemias. 
  • Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway. 
  • Biochemical analysis of ++Prospero protein during asymmetric cell division: cortical Prospero is highly phosphorylated relative to nuclear Prospero. 
  • Biphasic functions for the GDNF-Ret signaling pathway in chemosensory neuron development and diversification. 
  • Bmp and Fgf signaling are essential for liver specification in zebrafish. 
  • Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. 
  • Brassinosteroid gene regulatory networks at cellular resolution in the Arabidopsis root. 
  • CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. 
  • Cadherin-6 expression transiently delineates specific rhombomeres, other neural tube subdivisions, and neural crest subpopulations in mouse embryos. 
  • Caenorhabditis elegans cog-1 locus encodes GTX/Nkx6.1 homeodomain proteins and regulates multiple aspects of reproductive system development. 
  • Carcinoma of unknown primary with a colon-cancer profile-changing paradigm and emerging definitions. 
  • Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation. 
  • Cell cycle progression in G1 and S phases is CCR4 dependent following ionizing radiation or replication stress in Saccharomyces cerevisiae. 
  • Cell identity and sexual development in Cryptococcus neoformans are controlled by the mating-type-specific homeodomain protein Sxi1alpha. 
  • Cell patterning in the Drosophila segment: engrailed and wingless antigen distributions in segment polarity mutant embryos. 
  • Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen. 
  • Characterization of cis-regulatory elements controlling repo transcription in Drosophila melanogaster. 
  • Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. 
  • Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer. 
  • Chromatin architecture, CCCTC-binding factor, and V(D)J recombination: managing long-distance relationships at antigen receptor loci. 
  • Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt/beta-catenin signaling. 
  • Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer. 
  • Cloning of zebrafish vsx1: expression of a paired-like homeobox gene during CNS development. 
  • Comment on 'A PAX6 gene polymorphism is associated with genetic predisposition to extreme myopia'. 
  • Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. 
  • Compromised HOXA5 function can limit p53 expression in human breast tumours. 
  • Conjugates of antisense oligonucleotides with the Tat and antennapedia cell-penetrating peptides: effects on cellular uptake, binding to target sequences, and biologic actions. 
  • Contributions of beta2-microglobulin-dependent molecules and lymphocytes to iron regulation: insights from HfeRag1(-/-) and beta2mRag1(-/-) double knock-out mice. 
  • Convergent evolution of linked mating-type loci in basidiomycete fungi. 
  • Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. 
  • Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing. 
  • Cytokine storm-based mechanisms for extrapulmonary manifestations of SARS-CoV-2 infection. 
  • DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties. 
  • Dependence of corneal stem/progenitor cells on ocular surface innervation. 
  • Development and clinical validation of a real-time PCR assay for PITX2 DNA methylation to predict prostate-specific antigen recurrence in prostate cancer patients following radical prostatectomy. 
  • Development of the human female reproductive tract. 
  • Developmental and spatial patterns of expression of the mouse homeobox gene, Hox 2.1. 
  • Differential DNA methylation patterns in human Schlemm's canal endothelial cells with glaucoma. 
  • Differential cellular localization of CELSR2 and ING4 and correlations with hormone receptor status in breast cancer. 
  • Differentiation of human embryonic stem cells along a hepatic lineage. 
  • Diploid strains of the pathogenic basidiomycete Cryptococcus neoformans are thermally dimorphic. 
  • Direct regulation of beta3-integrin subunit gene expression by HOXA10 in endometrial cells. 
  • Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells. 
  • Discovering sequences with potential regulatory characteristics. 
  • Discovery and functional annotation of SIX6 variants in primary open-angle glaucoma. 
  • Disruption of Gen1 Causes Congenital Anomalies of the Kidney and Urinary Tract in Mice. 
  • Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon. 
  • Dissecting the genetics of human high myopia: a molecular biologic approach. 
  • Distal-Less Homeobox 5 Is a Therapeutic Target for Attenuating Hypertrophy and Apoptosis of Mesenchymal Progenitor Cells. 
  • Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene. 
  • Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines. 
  • Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13. 
  • Diversity, topographic differentiation, and positional memory in human fibroblasts. 
  • Do convergent developmental mechanisms underlie convergent phenotypes? 
  • Do germinal centers have a role in the generation of lymphomas? 
  • Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene. 
  • Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. 
  • Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. 
  • Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer. 
  • Essential and unexpected role of Yin Yang 1 to promote mesodermal cardiac differentiation. 
  • Evaluation of an epithelial plasticity biomarker panel in men with localized prostate cancer. 
  • Evolution of regeneration and fission in annelids: insights from engrailed- and orthodenticle-class gene expression. 
  • Expression and modification of Hox 2.1 protein in mouse embryos. 
  • Expression of SOX9 and CDX2 in nongoblet columnar-lined esophagus predicts the detection of Barrett's esophagus during follow-up. 
  • Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours. 
  • Expression profile of an androgen regulated prostate specific homeobox gene NKX3.1 in primary prostate cancer. 
  • Fezf2 regulates telencephalic precursor differentiation from mouse embryonic stem cells. 
  • Fgf8 is required for anterior heart field development. 
  • Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis 
  • Focus on butterfly eyespot development. 
  • Formation of Rathke's pouch requires dual induction from the diencephalon. 
  • FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. 
  • G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. 
  • GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst. 
  • Gene expression and larval evolution: changing roles of distal-less and orthodenticle in echinoderm larvae. 
  • Gene expression during echinoderm metamorphosis. 
  • Gene expression during normal and FSHD myogenesis. 
  • Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus. 
  • Gene expression signatures of individual ductal carcinoma in situ lesions identify processes and biomarkers associated with progression towards invasive ductal carcinoma. 
  • Genes on the wing. 
  • Genetic deletion of A2A adenosine receptors in the striatum selectively impairs habit formation 
  • Genetic factors influencing prostate cancer risk in Norwegian men. 
  • Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb. 
  • Genetic screen of African Americans with Fuchs endothelial corneal dystrophy. 
  • Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer. 
  • Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis. 
  • Genome-wide association studies of the PR interval in African Americans. 
  • Genome-wide association study identifies ZFHX1B as a susceptibility locus for severe myopia. 
  • Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4. 
  • Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos. 
  • Genome-wide linkage scan for prostate cancer susceptibility from the University of Michigan Prostate Cancer Genetics Project: suggestive evidence for linkage at 16q23. 
  • Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. 
  • Genome-wide significant risk associations for mucinous ovarian carcinoma. 
  • Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. 
  • Germline HOXB13 G84E mutation carriers and risk to twenty common types of cancer: results from the UK Biobank. 
  • Germline Variants in DNA Damage Repair Genes and HOXB13 Among Black Patients With Early-Onset Prostate Cancer. 
  • Germline genetic variants in men with prostate cancer and one or more additional cancers. 
  • Germline mutations in HOXB13 and prostate-cancer risk. 
  • HEC of a job regulating stem cells. 
  • HOXB13 G84E-related familial prostate cancers: a clinical, histologic, and molecular survey. 
  • HOXB13 and other high penetrant genes for prostate cancer. 
  • HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer. 
  • HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG). 
  • HOXB13 mutations and prostate cancer risk. 
  • HPV status-independent association of alcohol and tobacco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinomas. 
  • Have gene knockouts caused evolutionary reversals in the mammalian first arch? 
  • Heterogeneous association between engrailed-2 and autism in the CPEA network. 
  • Hierarchical assembly and disassembly of a transcriptionally active RAG locus in CD4+CD8+ thymocytes. 
  • Histological and molecular evaluation of patient-derived colorectal cancer explants. 
  • Homeobox genes Hoxd3 and Hoxd8 are differentially expressed in fetal mouse excisional wounds. 
  • HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis. 
  • Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish. 
  • Human syndromes of immunodeficiency and dysregulation are characterized by distinct defects in T-cell receptor repertoire development. 
  • Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid. 
  • Identification of a candidate gene for astigmatism. 
  • Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells. 
  • Identification of differentially methylated genes in normal prostate tissues from African American and Caucasian men. 
  • Identification of molecular signature of head and neck cancer stem-like cells. 
  • Identification of novel mutations and sequence variants in the SOX2 and CHX10 genes in patients with anophthalmia/microphthalmia. 
  • Immobilized molecular beacons: a new strategy using UV-activated poly(methyl methacrylate) surfaces to provide large fluorescence sensitivities for reporting on molecular association events. 
  • Immunoglobulin gene hypermutation in germinal centers is independent of the RAG-1 V(D)J recombinase. 
  • Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine. 
  • In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. 
  • Increase in PDX-1 levels suppresses insulin gene expression in RIN 1046-38 cells. 
  • Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss. 
  • Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development. 
  • Inherited Predisposition to Prostate Cancer: From Gene Discovery to Clinical Impact. 
  • Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle. 
  • Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells. 
  • Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. 
  • Intrinsic disorder within and flanking the DNA-binding domains of human transcription factors. 
  • Investigation of known genetic risk factors for primary open angle glaucoma in two populations of African ancestry. 
  • LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system. 
  • Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system. 
  • Loss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determination. 
  • Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes. 
  • Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. 
  • Misexpression of ptf1a in cortical pyramidal cells in vivo promotes an inhibitory peptidergic identity. 
  • Missense mutations in TCF8 cause late-onset Fuchs corneal dystrophy and interact with FCD4 on chromosome 9p. 
  • Modeling Glaucoma: Retinal Ganglion Cells Generated from Induced Pluripotent Stem Cells of Patients with SIX6 Risk Allele Show Developmental Abnormalities. 
  • Molecular mechanisms of development of the human fetal female reproductive tract. 
  • More on Data Sharing. 
  • Msx Homeobox Genes Act Downstream of BMP2 to Regulate Endometrial Decidualization in Mice and in Humans. 
  • Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction. 
  • Multicenter clinical validation of PITX2 methylation as a prostate specific antigen recurrence predictor in patients with post-radical prostatectomy prostate cancer. 
  • Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro B cells. 
  • Mutational spectrum of the ZEB1 gene in corneal dystrophies supports a genotype-phenotype correlation. 
  • Mutations in SPATA5 Are Associated with Microcephaly, Intellectual Disability, Seizures, and Hearing Loss. 
  • Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow. 
  • Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunity. 
  • Negative regulation of Armadillo, a Wingless effector in Drosophila. 
  • Negative regulation of CD4 gene expression by a HES-1-c-Myb complex. 
  • Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. 
  • Neural induction and patterning in the mouse in the absence of the node and its derivatives. 
  • Neuronal vulnerability and multilineage diversity in multiple sclerosis. 
  • Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors. 
  • No evidence for linkage of liability to autism to HOXA1 in a sample from the CPEA network. 
  • Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies. 
  • Notch signaling maintains Leydig progenitor cells in the mouse testis. 
  • Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting. 
  • Nuclear Snail1 and nuclear ZEB1 protein expression in invasive and intraductal human breast carcinomas. 
  • Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway. 
  • Opposing LSD1 complexes function in developmental gene activation and repression programmes. 
  • Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development. 
  • Outcomes and Treatment Strategies for Autoimmunity and Hyperinflammation in Patients with RAG Deficiency. 
  • PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. 
  • Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet+ B cells. 
  • Partial co-option of the appendage patterning pathway in the development of abdominal appendages in the sepsid fly Themira biloba. 
  • Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2. 
  • Phase I trial of weekly MK-0752 in children with refractory central nervous system malignancies: a pediatric brain tumor consortium study. 
  • Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. 
  • Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality. 
  • Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction. 
  • Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A. 
  • Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line. 
  • Prevalence of the HOXB13 G84E prostate cancer risk allele in men treated with radical prostatectomy. 
  • Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination. 
  • Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Patients with Localized Disease Undergoing Radical Prostatectomy across Multiple Rare Cell Detection Platforms. 
  • Protective immunity in recurrent Staphylococcus aureus infection reflects localized immune signatures and macrophage-conferred memory. 
  • Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux. 
  • Quantitative Trait Locus Analysis of SIX1-SIX6 With Retinal Nerve Fiber Layer Thickness in Individuals of European Descent. 
  • RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. 
  • RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila. 
  • RNA-Mediated Reprogramming of Primary Adult Human Dermal Fibroblasts into c-kit(+) Cardiac Progenitor Cells. 
  • Radical alterations in the roles of homeobox genes during echinoderm evolution. 
  • Re: Diverse AR-V7 Cistromes in Castration-Resistant Prostate Cancer are Governed by HoxB13. 
  • Reciprocal signaling between the transcriptional co-factor Eya2 and specific members of the Galphai family. 
  • Recombinant human pentraxin-2 therapy in patients with idiopathic pulmonary fibrosis: safety, pharmacokinetics and exploratory efficacy. 
  • Reduced prostate branching morphogenesis in stromal fibroblast, but not in epithelial, estrogen receptor α knockout mice. 
  • Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility. 
  • Regulation of chromatin accessibility for V(D)J recombination. 
  • Regulation of complex I by Engrailed is complex too. 
  • Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background. 
  • Regulation of myeloid leukaemia by the cell-fate determinant Musashi. 
  • Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps. 
  • Role for ETS domain transcription factors Pea3/Erm in mouse lung development. 
  • Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling. 
  • STING suppresses bone cancer pain via immune and neuronal modulation. 
  • Screening for familial and hereditary prostate cancer. 
  • Sequence variants in the transforming growth beta-induced factor (TGIF) gene are not associated with high myopia. 
  • Sex determining region Y-Box 2 (SOX2) is a potential cell-lineage gene highly expressed in the pathogenesis of squamous cell carcinomas of the lung. 
  • Sex-specific homeodomain proteins Sxi1alpha and Sxi2a coordinately regulate sexual development in Cryptococcus neoformans. 
  • Shaping Chromatin States in Prostate Cancer by Pioneer Transcription Factors. 
  • Signaling the tips: regulation of stem cell function in plants. 
  • Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection. 
  • Six1 and Six1 cofactor expression is altered during early skeletal muscle overload in mice. 
  • Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiation. 
  • Spdeadringer, a sea urchin embryo gene required separately in skeletogenic and oral ectoderm gene regulatory networks. 
  • Sry induces cell proliferation in the mouse gonad. 
  • Steroidogenic factor 1 (SF-1) is essential for endocrine development and function. 
  • Steroidogenic factor 1 (SF-1) is essential for ovarian development and function. 
  • Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development. 
  • Steroidogenic factor 1 is the essential transcript of the mouse Ftz-F1 gene. 
  • Steroidogenic factor 1 plays multiple roles in endocrine development and function. 
  • Steroidogenic factor 1: an essential mediator of endocrine development. 
  • Steroidogenic factor-1 is a sphingolipid binding protein. 
  • Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1. 
  • Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones. 
  • Symmetry breaking in plants: molecular mechanisms regulating asymmetric cell divisions in Arabidopsis. 
  • T-lymphocytes enable osteoblast maturation via IL-17F during the early phase of fracture repair. 
  • TFBSshape: a motif database for DNA shape features of transcription factor binding sites. 
  • TP53, CDKN2A/P16, and NFE2L2/NRF2 regulate the incidence of pure- and combined-small cell lung cancer in mice. 
  • Testing for the recurrent HOXB13 G84E germline mutation in men with clinical indications for prostate biopsy. 
  • The AP2/ERF Transcription Factor TINY Modulates Brassinosteroid-Regulated Plant Growth and Drought Responses in Arabidopsis. 
  • The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia. 
  • The Development of TALE Nucleases for Biotechnology. 
  • The HOXB13 G84E Mutation Is Associated with an Increased Risk for Prostate Cancer and Other Malignancies. 
  • The HOXB13 variant X285K is associated with clinical significance and early age at diagnosis in African American prostate cancer patients. 
  • The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. 
  • The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality. 
  • The cell-specific nuclear receptor steroidogenic factor 1 plays multiple roles in reproductive function. 
  • The chromosomal region containing pab-1, mip, and the A mating type locus of the secondarily homothallic homobasidiomycete Coprinus bilanatus. 
  • The diagnosis of severe combined immunodeficiency: Implementation of the PIDTC 2022 Definitions. 
  • The exon junction complex component Magoh controls brain size by regulating neural stem cell division. 
  • The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate. 
  • The genetic landscape of mutations in Burkitt lymphoma. 
  • The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. 
  • The homeodomain protein HOXB13 regulates the cellular response to androgens. 
  • The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo. 
  • The human fetal lymphocyte lineage: identification by CD27 and LIN28B expression in B cell progenitors. 
  • The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype. 
  • The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis. 
  • The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. 
  • The origin and evolution of animal appendages. 
  • The role of HOM-C genes in segmental transformations: reexamination of the Drosophila Sex combs reduced embryonic phenotype. 
  • The role of epigenetics in the endothelial cell shear stress response and atherosclerosis 
  • The roles of steroidogenic factor-1 in reproductive function. 
  • Thyroid hormone negatively regulates CDX2 and SOAT2 mRNA expression via induction of miRNA-181d in hepatic cells. 
  • Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression. 
  • Tissue remodeling in the female reproductive tract--a complex process becomes more complex: the role of Hox genes. 
  • Transcription factor short stature homeobox 2 is required for proper development of tropomyosin-related kinase B-expressing mechanosensory neurons. 
  • Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae. 
  • Transient requirement for ganglion cells during assembly of retinal synaptic layers. 
  • Treatment of erythrocytes with the 2-cys peroxiredoxin inhibitor, Conoidin A, prevents the growth of Plasmodium falciparum and enhances parasite sensitivity to chloroquine. 
  • Ultrabithorax function in butterfly wings and the evolution of insect wing patterns. 
  • Updated insights into genetic contribution to prostate cancer predisposition: focus on HOXB13. 
  • Validation of DNA methylation biomarkers for diagnosis of acute lymphoblastic leukemia. 
  • Vasculitis as a Major Morbidity Factor in Patients With Partial RAG Deficiency. 
  • Wingless signaling generates pattern through two distinct mechanisms. 
  • dishevelled and armadillo act in the wingless signalling pathway in Drosophila. 
  • miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β. 
  • mirror controls planar polarity and equator formation through repression of fringe expression and through control of cell affinities. 
  • mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye. 
  • optix Drives the Repeated Convergent Evolution of Butterfly Wing Pattern Mimicry 
  • p38α MAPK Regulates Lineage Commitment and OPG Synthesis of Bone Marrow Stromal Cells to Prevent Bone Loss under Physiological and Pathological Conditions. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • Lee, Walter T, Professor of Head and Neck Surgery & Communication Sciences, Radiation Oncology
  • Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics
  • McCall, Shannon Jones, Associate Professor of Pathology, Pathology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Tsalik, Ephraim, Adjunct Associate Professor in the Department of Medicine, Medicine, Infectious Diseases
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology