Patch-Clamp Techniques

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  Subject Areas on Research

  • "Silent" NMDA Synapses Enhance Motion Sensitivity in a Mature Retinal Circuit. 
  • A CNS catecholaminergic cell line expresses voltage-gated currents. 
  • A Common Neuroendocrine Substrate for Diverse General Anesthetics and Sleep. 
  • A TRPA1-dependent mechanism for the pungent sensation of weak acids. 
  • A circuit model for saccadic suppression in the superior colliculus. 
  • A cortico-hippocampal learning rule shapes inhibitory microcircuit activity to enhance hippocampal information flow. 
  • A disinhibitory circuit mediates motor integration in the somatosensory cortex. 
  • A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia. 
  • A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5. 
  • A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. 
  • A non-pungent resiniferatoxin analogue, phorbol 12-phenylacetate 13 acetate 20-homovanillate, reveals vanilloid receptor subtypes on rat trigeminal ganglion neurons. 
  • A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias. 
  • A novel chloride channel in Vicia faba guard cell vacuoles activated by the serine/threonine kinase, CDPK. 
  • A voltage-gated calcium-selective channel encoded by a sodium channel-like gene. 
  • ATP receptor activation potentiates a voltage-dependent Ca channel in hippocampal neurons. 
  • Abnormal cardiac Na(+) channel properties and QT heart rate adaptation in neonatal ankyrin(B) knockout mice. 
  • Action potential and QT prolongation not sufficient to cause Torsade de Pointes: role of action potential triangulation. 
  • Activation of G551D CFTR channel with MPB-91: regulation by ATPase activity and phosphorylation. 
  • Activation of Glutamatergic Fibers in the Anterior NAc Shell Modulates Reward Activity in the aNAcSh, the Lateral Hypothalamus, and Medial Prefrontal Cortex and Transiently Stops Feeding. 
  • Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains. 
  • Activation of calcium channels by cAMP in STC-1 cells is dependent upon Ca2+ calmodulin-dependent protein kinase II. 
  • Activation-dependent subconductance levels in the drk1 K channel suggest a subunit basis for ion permeation and gating. 
  • Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism. 
  • Amyloid-beta1-42 reduces neuronal excitability in mouse dentate gyrus. 
  • An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing. 
  • An important role of a pyrethroid-sensing residue F1519 in the action of the N-alkylamide insecticide BTG 502 on the cockroach sodium channel. 
  • An in vitro study of horizontal connections in the intermediate layer of the superior colliculus. 
  • An interaction between the III-IV linker and CTD in NaV1.5 confers regulation of inactivation by CaM and FHF. 
  • Analysis of the action of lidocaine on insect sodium channels. 
  • Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. 
  • Ankyrin-G regulates inactivation gating of the neuronal sodium channel, Nav1.6. 
  • Aquaporins and ion conductance. 
  • Arterial response to shear stress critically depends on endothelial TRPV4 expression. 
  • BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. 
  • Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels. 
  • CFTR as a cAMP-dependent regulator of sodium channels. 
  • Ca(v)3.1 splice variant expression during neuronal differentiation of Y-79 retinoblastoma cells. 
  • CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation. 
  • Calcium channels activated by hydrogen peroxide mediate abscisic acid signalling in guard cells. 
  • Calmodulin regulation of excitation-contraction coupling in cardiac myocytes. 
  • Capsaicin activated currents in rat dorsal root ganglion cells. 
  • Capsaicin, acid and heat-evoked currents in rat trigeminal ganglion neurons: relationship to functional VR1 receptors. 
  • Capsaicin-induced currents with distinct desensitization and Ca2+ dependence in rat trigeminal ganglion cells. 
  • Cardiac muscarinic potassium channel activity is attenuated by inhibitors of G beta gamma. 
  • Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus. 
  • Changes in osmolality sensitize the response to capsaicin in trigeminal sensory neurons. 
  • Characterization of the hyperpolarization-activated chloride current in dissociated rat sympathetic neurons. 
  • Cholecystokinin action on layer 6b neurons in somatosensory cortex. 
  • Cholecystokinin enhances GABAergic inhibitory transmission in basolateral amygdala. 
  • Cholecystokinin excites interneurons in rat basolateral amygdala. 
  • Cholinergic neurons constitutively engage the ISR for dopamine modulation and skill learning in mice. 
  • Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder. 
  • Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch. 
  • Conformational plasticity in the selectivity filter of the TRPV2 ion channel. 
  • Correlation between axonal morphologies and synaptic input kinetics of interneurons from mouse visual cortex. 
  • Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain. 
  • Crucial role of copper in detection of metal-coordinating odorants. 
  • Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. 
  • Cytoskeletal actin gates a Cl- channel in neocortical astrocytes. 
  • Defibrillation and the geometry of the heart: a novel measurement with implications for defibrillation mechanisms. 
  • Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. 
  • Developing High-Throughput Assays to Analyze and Screen Electrophysiological Phenotypes. 
  • Development of intrinsic and synaptic properties in a forebrain nucleus essential to avian song learning. 
  • Developmental sensitivity of hippocampal interneurons to ethanol: involvement of the hyperpolarization-activated current, Ih. 
  • Dietary prenatal choline supplementation alters postnatal hippocampal structure and function. 
  • Different responses to repeated applications of zingerone in behavioral studies, recordings from intact and cultured TG neurons, and from VR1 receptors. 
  • Differential P1-purinergic modulation of human Schlemm's canal inner-wall cells. 
  • Differential abscisic acid regulation of guard cell slow anion channels in Arabidopsis wild-type and abi1 and abi2 mutants. 
  • Differential actions of diazepam and zolpidem in basolateral and central amygdala nuclei. 
  • Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig. 
  • Differential effect of ethanol on NMDA EPSCs in pyramidal cells in the posterior cingulate cortex of juvenile and adult rats. 
  • Differential expression of GABA and glutamate-receptor subunits and enzymes involved in GABA metabolism between electrophysiologically identified hippocampal CA1 pyramidal cells and interneurons. 
  • Differential sensitivity of hippocampal interneurons to ethanol in adolescent and adult rats. 
  • Disinhibition in rat superior colliculus mediated by GABAc receptors. 
  • Distinct timing in the activity of cannabinoid-sensitive and cannabinoid-insensitive basket cells. 
  • Diurnal changes in exocytosis and the number of synaptic ribbons at active zones of an ON-type bipolar cell terminal. 
  • Dopamine attenuates evoked inhibitory synaptic currents in central amygdala neurons. 
  • Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation. 
  • Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane. 
  • Dysregulation of the Synaptic Cytoskeleton in the PFC Drives Neural Circuit Pathology, Leading to Social Dysfunction. 
  • ENaC- and CFTR-dependent ion and fluid transport in mammary epithelia. 
  • Electrical alternans and hemodynamics in the anesthetized guinea pig can discriminate the cardiac safety of antidepressants. 
  • Electrical coupling mediates tunable low-frequency oscillations and resonance in the cerebellar Golgi cell network. 
  • Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function. 
  • Endogenous opioids regulate long-term potentiation of synaptic inhibition in the dentate gyrus of rat hippocampus. 
  • Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. 
  • Engineering biosynthetic excitable tissues from unexcitable cells for electrophysiological and cell therapy studies. 
  • Enhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine-induced status epilepticus. 
  • Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors. 
  • Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons. 
  • Ethanol reverses the direction of long-term synaptic plasticity in the dorsomedial striatum. 
  • Excitation of a cardiac muscle fiber by extracellularly applied sinusoidal current. 
  • Excitatory and inhibitory circuitry in the superficial gray layer of the superior colliculus. 
  • Excitatory synaptic site heterogeneity during paired pulse plasticity in CA1 pyramidal cells in rat hippocampus in vitro. 
  • Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7, Species Differences, and Regulation by Paclitaxel. 
  • Expression of a Cs(+)-resistant guard cell K+ channel confers Cs(+)-resistant, light-induced stomatal opening in transgenic arabidopsis. 
  • Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion. 
  • Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1. 
  • Fast endocytosis is inhibited by GABA-mediated chloride influx at a presynaptic terminal. 
  • Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts. 
  • Fibroblast growth factor homologous factors modulate cardiac calcium channels. 
  • Forskolin stimulation of water and cation permeability in aquaporin 1 water channels. 
  • Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling. 
  • Functional analysis of a mammalian odorant receptor subfamily. 
  • Functional asymmetry of transmembrane segments in nicotinic acetylcholine receptors. 
  • Functional reentry in cultured monolayers of neonatal rat cardiac cells. 
  • Functional repair of a mutant chloride channel using a trans-splicing ribozyme. 
  • G protein-coupled receptor kinase mediates desensitization of norepinephrine-induced Ca2+ channel inhibition. 
  • GABA transport modulates the ethanol sensitivity of tonic inhibition in the rat dentate gyrus. 
  • Generation and customization of biosynthetic excitable tissues for electrophysiological studies and cell-based therapies. 
  • Highly selective water channel activity measured by voltage clamp: analysis of planar lipid bilayers reconstituted with purified AqpZ. 
  • Human trabecular meshwork cell volume regulation. 
  • Hyperpolarization induces a long-term increase in the spontaneous firing rate of cerebellar Golgi cells. 
  • Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4. 
  • Hyposmotic activation of ICl,swell in rabbit nonpigmented ciliary epithelial cells involves increased ClC-3 trafficking to the plasma membrane. 
  • Hyposmotically activated chloride channels in cultured rabbit non-pigmented ciliary epithelial cells. 
  • Hysteresis in human HCN4 channels: a crucial feature potentially affecting sinoatrial node pacemaking. 
  • Idealization and simulation of single ion channel data. 
  • Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction. 
  • Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity. 
  • Identity of a pathway for saccadic suppression. 
  • Imaging auditory representations of song and syllables in populations of sensorimotor neurons essential to vocal communication. 
  • Imaging synaptic inhibition in transgenic mice expressing the chloride indicator, Clomeleon. 
  • Impaired firing and sodium channel function in CA1 hippocampal interneurons after transient cerebral ischemia. 
  • In the rat, chronic intermittent ethanol exposure during adolescence alters the ethanol sensitivity of tonic inhibition in adulthood. 
  • In vitro properties of neurons in the rat pretectal nucleus of the optic tract. 
  • In vivo and in vitro analyses of amygdalar function reveal a role for copper. 
  • Increased vascular smooth muscle contractility in TRPC6-/- mice. 
  • Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton. 
  • Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. 
  • Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons. 
  • Interaction between TRPV1-expressing neurons in the hypothalamus. 
  • Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition. 
  • Interneurons of the dentate-hilus border of the rat dentate gyrus: morphological and electrophysiological heterogeneity. 
  • Ion channels in analgesia research. 
  • Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect? 
  • Isoflurane, but not halothane, induces protection of human myocardium via adenosine A1 receptors and adenosine triphosphate-sensitive potassium channels. 
  • JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. 
  • K channel subconductance levels result from heteromeric pore conformations. 
  • KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin. 
  • Lack of effect of mossy fiber-released zinc on granule cell GABA(A) receptors in the pilocarpine model of epilepsy. 
  • Local excitatory circuits in the intermediate gray layer of the superior colliculus. 
  • Localization of the activation gate for small conductance Ca2+-activated K+ channels. 
  • Long-range inhibition within the zebra finch song nucleus RA can coordinate the firing of multiple projection neurons. 
  • Long-term enhancement of central synaptic transmission by chronic brain-derived neurotrophic factor treatment. 
  • Long-term plasticity mediated by mGluR1 at a retinal reciprocal synapse. 
  • Loss of NR1 subunit of NMDARs in primary sensory neurons leads to hyperexcitability and pain hypersensitivity: involvement of Ca(2+)-activated small conductance potassium channels. 
  • Lysophosphatidic acid receptor signaling in mammalian retinal pigment epithelial cells. 
  • Lysophosphatidic acid stimulates neurotransmitter-like conductance changes that precede GABA and L-glutamate in early, presumptive cortical neuroblasts. 
  • Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. 
  • Manipulations of Central Amygdala Neurotensin Neurons Alter the Consumption of Ethanol and Sweet Fluids in Mice. 
  • Mapping the interaction surface of scorpion β-toxins with an insect sodium channel. 
  • Measuring Feedforward Inhibition and Its Impact on Local Circuit Function. 
  • Mechanisms of increased hippocampal excitability in the Mashl+/- mouse model of Na+ /K+ -ATPase dysfunction. 
  • Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons. 
  • Molecular basis of differential sensitivity of insect sodium channels to DCJW, a bioactive metabolite of the oxadiazine insecticide indoxacarb. 
  • Molecular characterization and functional expression of the DSC1 channel. 
  • Molecular dissection of gating in the ClC-2 chloride channel. 
  • Molecular taxonomy of major neuronal classes in the adult mouse forebrain. 
  • Morphologic integration of hilar ectopic granule cells into dentate gyrus circuitry in the pilocarpine model of temporal lobe epilepsy. 
  • Mossy fiber-granule cell synapses in the normal and epileptic rat dentate gyrus studied with minimal laser photostimulation. 
  • Mu-opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: lack of ethanol interactions. 
  • Multiple arrhythmic syndromes in a newborn, owing to a novel mutation in SCN5A. 
  • Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release. 
  • Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment. 
  • Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization. 
  • Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait. 
  • N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. 
  • NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons in vitro. 
  • NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: a potential mechanism of neurotoxicity. 
  • NMDA-Receptor-dependent synaptic activation of voltage-dependent calcium channels in basolateral amygdala. 
  • Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4. 
  • Neocortical disynaptic inhibition requires somatodendritic integration in interneurons. 
  • Neuregulin-1 enhances depolarization-induced GABA release. 
  • Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesia. 
  • Neuropeptide Y regulates recurrent mossy fiber synaptic transmission less effectively in mice than in rats: Correlation with Y2 receptor plasticity. 
  • Neuropeptides modulate compound postsynaptic potentials in basolateral amygdala. 
  • Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors. 
  • Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling. 
  • Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain. 
  • Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors. 
  • Nitroxyl anion regulation of the NMDA receptor. 
  • Nociceptors are interleukin-1beta sensors. 
  • Noradrenergic Signaling Disengages Feedforward Transmission in the Nucleus Accumbens Shell. 
  • Novel hybrid action of GABA mediates inhibitory feedback in the mammalian retina. 
  • Okadaic acid disrupts synaptic vesicle trafficking in a ribbon-type synapse. 
  • Operant self-stimulation of dopamine neurons in the substantia nigra. 
  • Opposing effects of traumatic brain injury on excitatory synaptic function in the lateral amygdala in the absence and presence of preinjury stress. 
  • Organization of the intermediate gray layer of the superior colliculus. I. Intrinsic vertical connections. 
  • Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons. 
  • Patch-clamp recording methods for examining adrenergic regulation of potassium currents in ocular epithelial cells. 
  • Patterns of excitation and inhibition evoked by horizontal connections in visual cortex share a common relationship to orientation columns. 
  • Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord. 
  • Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. 
  • Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10). 
  • Piezo1 ion channels inherently function as independent mechanotransducers. 
  • Plant "helper" immune receptors are Ca²⁺ -permeable nonselective cation channels. 
  • Polarized expression of cAMP-activated chloride channels in isolated epithelial cells. 
  • Pore region of TRPV3 ion channel is specifically required for heat activation. 
  • Postsynaptic mechanisms govern the differential excitation of cortical neurons by thalamic inputs. 
  • Postsynaptic positioning of endocytic zones and AMPA receptor cycling by physical coupling of dynamin-3 to Homer. 
  • Postsynaptic response to stimulation of the Schaffer collaterals with properties similar to those of synaptosomal aspartate release. 
  • Probing Computation in the Primate Visual System at Single-Cone Resolution. 
  • Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2. 
  • Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption. 
  • Protein tyrosine kinase and protein phosphatase signaling pathways regulate volume-sensitive chloride currents in a nonpigmented ciliary epithelial cell line. 
  • Quantifying electrical interactions between cardiomyocytes and other cells in micropatterned cell pairs. 
  • Recurrent mossy fiber pathway in rat dentate gyrus: synaptic currents evoked in presence and absence of seizure-induced growth. 
  • Reduction of voltage-dependent currents by ethanol contributes to inhibition of NMDA receptor-mediated excitatory synaptic transmission. 
  • Regulatory Roles of Anoctamin-6 in Human Trabecular Meshwork Cells. 
  • Relationship between structure and sodium channel blockade by lidocaine and its amino-alkyl derivatives. 
  • Relative contributions of rod and cone bipolar cell inputs to AII amacrine cell light responses in the mouse retina. 
  • Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. 
  • Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. 
  • Response features of parvalbumin-expressing interneurons suggest precise roles for subtypes of inhibition in visual cortex. 
  • Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss. 
  • Role of intrinsic synaptic circuitry in collicular sensorimotor integration. 
  • Role of sodium channel deglycosylation in the genesis of cardiac arrhythmias in heart failure. 
  • Role of the GLT-1 subtype of glutamate transporter in glutamate homeostasis: the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus. 
  • Role of the sixth transmembrane segment of domain IV of the cockroach sodium channel in the action of sodium channel blocker insecticides. 
  • SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia. 
  • SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons. 
  • STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle. 
  • STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice. 
  • Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses. 
  • Schizophrenia-like GABAergic gene expression deficits in cerebellar Golgi cells from rats chronically exposed to low-dose phencyclidine. 
  • Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels. 
  • Serotonin regulates dynamics of cerebellar granule cell activity by modulating tonic inhibition. 
  • Short-term frequency-dependent plasticity at recurrent mossy fiber synapses of the epileptic brain. 
  • Signature morpho-electric, transcriptomic, and dendritic properties of human layer 5 neocortical pyramidal neurons. 
  • Similarities and differences in the currents activated by capsaicin, piperine, and zingerone in rat trigeminal ganglion cells. 
  • Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates. 
  • Size and ionic currents of unexcitable cells coupled to cardiomyocytes distinctly modulate cardiac action potential shape and pacemaking activity in micropatterned cell pairs. 
  • Slow sodium channel inactivation and use-dependent block modulated by the same domain IV S6 residue. 
  • Sonic hedgehog induces GLT-1 degradation via PKC delta to suppress its transporter activities. 
  • Specific functions of synaptically localized potassium channels in synaptic transmission at the neocortical GABAergic fast-spiking cell synapse. 
  • Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine. 
  • Spontaneous release of neuropeptide Y tonically inhibits recurrent mossy fiber synaptic transmission in epileptic brain. 
  • Stretch and poke stimulation for characterizing mechanically activated ion channels. 
  • Strong single-fiber sensory inputs to olfactory cortex: implications for olfactory coding. 
  • Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. 
  • Supersensitive Ras activation in dendrites and spines revealed by two-photon fluorescence lifetime imaging. 
  • Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex. 
  • Synapse-specific downregulation of NMDA receptors by early experience: a critical period for plasticity of sensory input to olfactory cortex. 
  • Synaptic activation of presynaptic glutamate transporter currents in nerve terminals. 
  • Synaptic cleft acidification and modulation of short-term depression by exocytosed protons in retinal bipolar cells. 
  • Synaptic connections from multiple subfields contribute to granule cell hyperexcitability in hippocampal slice cultures. 
  • Synaptic plasticity in morphologically identified CA1 stratum radiatum interneurons and giant projection cells. 
  • Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance. 
  • Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses. 
  • THG113.31, a specific PGF2alpha receptor antagonist, induces human myometrial relaxation and BKCa channel activation. 
  • TRPA1 is a major oxidant sensor in murine airway sensory neurons. 
  • TRPC6 enhances angiotensin II-induced albuminuria. 
  • Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain. 
  • Tetraethylammonium block of water flux in Aquaporin-1 channels expressed in kidney thin limbs of Henle's loop and a kidney-derived cell line. 
  • The Kv2.1 channels mediate neuronal apoptosis induced by excitotoxicity. 
  • The NMDA receptor M3 segment is a conserved transduction element coupling ligand binding to channel opening. 
  • The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells. 
  • The influence of removing extracellular Ca2+ in the desensitization responses to capsaicin, zingerone and olvanil in rat trigeminal ganglion neurons. 
  • The responses of rat trigeminal ganglion neurons to capsaicin and two nonpungent vanilloid receptor agonists, olvanil and glyceryl nonamide. 
  • The role of protein synthesis in striatal long-term depression. 
  • The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets. 
  • Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel. 
  • Threshold variability in fibers with field stimulation of excitable membranes. 
  • Transducin gamma-subunit sets expression levels of alpha- and beta-subunits and is crucial for rod viability. 
  • Transfection via whole-cell recording in vivo: bridging single-cell physiology, genetics and connectomics. 
  • Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. 
  • Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. 
  • Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels. 
  • Use of bulleyaconitine A as an adjuvant for prolonged cutaneous analgesia in the rat. 
  • VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. 
  • Visual representations by cortical somatostatin inhibitory neurons--selective but with weak and delayed responses. 
  • Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel. 
  • Voltage-dependent potassium currents of urethral afferent neurons in diabetes mellitus. 
  • Voltage-gated ion channels in nociceptors: modulation by cGMP. 
  • Whole-cell chloride currents in rat astrocytes accompany changes in cell morphology. 
  • beta-Adrenergic action on wild-type and KPQ mutant human cardiac Na+ channels: shift in gating but no change in Ca2+:Na+ selectivity. 
  • p38 Mitogen-activated protein kinase mediates a negative inotropic effect in cardiac myocytes. 
  • ΔN-TRPV1: A Molecular Co-detector of Body Temperature and Osmotic Stress. 
  • β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel. 
  • κ-Opioid receptors in the central amygdala regulate ethanol actions at presynaptic GABAergic sites. 
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  Keywords of People

  • Calakos, Nicole, Lincoln Financial Group Distinguished Professor of Neurobiology, Duke Science & Society
  • Jordt, Sven Eric, Associate Professor in Anesthesiology, Pharmacology & Cancer Biology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Starmer, Charles Franklin, Professor Emeritus of Computer Science, Computer Science