Th1 Cells

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  Subject Areas on Research

  • A2E Suppresses Regulatory Function of RPE Cells in Th1 Cell Differentiation Via Production of IL-1β and Inhibition of PGE2. 
  • AML-loaded DC generate Th1-type cellular immune responses in vitro. 
  • Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation. 
  • Alpha-melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon. 
  • An approach to modelling in immunology. 
  • B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis. 
  • CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response. 
  • CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines. 
  • Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. 
  • Characterization of CD4 and CD8 T cell responses in MuSK myasthenia gravis. 
  • Characterization of effector T cells in dry eye disease. 
  • Coadministration of IL-12 or IL-10 expression cassettes drives immune responses toward a Th1 phenotype. 
  • Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. 
  • Cytokine expression by first-trimester human chorionic villi. 
  • Cytokine patterns during progression to AIDS in children with perinatal HIV infection. 
  • Cytokine transcriptional events during helper T cell subset differentiation. 
  • Cytokines in murine lyme carditis: Th1 cytokine expression follows expression of proinflammatory cytokines in a susceptible mouse strain. 
  • Cytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis. 
  • Decreased interferon-alpha production in HIV-infected patients correlates with numerical and functional deficiencies in circulating type 2 dendritic cell precursors. 
  • Delayed liver fibrosis in HTLV-2-infected patients co-infected with HIV-1 and hepatitis C virus with suppressive antiretroviral therapy. 
  • Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii. 
  • Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease. 
  • Differential modulation of Th1- and Th2-related cytokine mRNA expression by a synthetic peptide homologous to a conserved domain within retroviral envelope protein. 
  • Differential reconstitution of T cell subsets following immunodepleting treatment with alemtuzumab (anti-CD52 monoclonal antibody) in patients with relapsing-remitting multiple sclerosis. 
  • Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism. 
  • Donor specific bone marrow cells suppress lymphocyte reactivity to donor antigens and differentially modulate TH1 and TH2 cytokine gene expression in the responder cell population. 
  • Donor-specific bone marrow cells suppress lymphocyte reactivity to donor antigens and differentially modulate TH1 and TH2 cytokine gene expression in the responder cell population. 
  • Effect of desiccating environmental stress versus systemic muscarinic AChR blockade on dry eye immunopathogenesis. 
  • Engagement of monocytes, NK cells, and CD4+ Th1 cells by ALVAC-SIV vaccination results in a decreased risk of SIVmac251 vaginal acquisition. 
  • Engineered recombinant peanut protein and heat-killed Listeria monocytogenes coadministration protects against peanut-induced anaphylaxis in a murine model. 
  • Enhanced Immune Responses to HIV-1 Envelope Elicited by a Vaccine Regimen Consisting of Priming with Newcastle Disease Virus Expressing HIV gp160 and Boosting with gp120 and SOSIP gp140 Proteins. 
  • Enhanced activation of human dendritic cells by inducible CD40 and Toll-like receptor-4 ligation. 
  • Enhanced type 1 immunity after secondary viral challenge in mice primed as neonates. 
  • Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand. 
  • Enriched environment regulates thymocyte development and alleviates experimental autoimmune encephalomyelitis in mice. 
  • Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans. 
  • G-CSF induces a potentially tolerant gene and immunophenotype profile in T cells in vivo. 
  • Glucose-regulated protein 94/glycoprotein 96 elicits bystander activation of CD4+ T cell Th1 cytokine production in vivo. 
  • H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection. 
  • Helicobacter pylori-induced Th17 responses modulate Th1 cell responses, benefit bacterial growth, and contribute to pathology in mice. 
  • Human S100A15 splice variants are differentially expressed in inflammatory skin diseases and regulated through Th1 cytokines and calcium. 
  • Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections. 
  • Impaired germinal center formation and recall T-cell-dependent immune responses in mice lacking the costimulatory ligand B7-H2. 
  • In vitro priming and expansion of cytomegalovirus-specific Th1 and Tc1 T cells from naive cord blood lymphocytes. 
  • In vivo molecular analysis of cytokines in a murine model of ocular onchocerciasis. I. Up-regulation of IL-4 and IL-5 mRNAs and not IL-2 and IFN gamma mRNAs in the cornea due to experimental interstitial keratitis. 
  • In vivo protein expression and immune responses generated by DNA vaccines expressing mycobacterial antigens fused with a reporter protein. 
  • Increased levels of IgE and autoreactive, polyreactive IgG in wild rodents: implications for the hygiene hypothesis. 
  • Infection with Mycobacterium bovis BCG diverts traffic of myelin oligodendroglial glycoprotein autoantigen-specific T cells away from the central nervous system and ameliorates experimental autoimmune encephalomyelitis. 
  • Inflammatory Th1 and Th17 in the Intestine Are Each Driven by Functionally Specialized Dendritic Cells with Distinct Requirements for MyD88. 
  • Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response. 
  • Interleukin-7 permits Th1/Tc1 maturation and promotes ex vivo expansion of cord blood T cells: a critical step toward adoptive immunotherapy after cord blood transplantation. 
  • Mechanisms of food allergy. 
  • Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli. 
  • Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens. 
  • Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation. 
  • Monocyte-derived CD40 expression is regulated by interferon-γ/interferon-γ receptor-1 pathway when acting as a bridge during their interaction with T cells and allogeneic endothelial cells. 
  • NLRC3 expression in dendritic cells attenuates CD4+ T cell response and autoimmunity. 
  • Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter. 
  • Peyer's patch CD8+ memory T cells secrete T helper type 1 and type 2 cytokines and provide help for immunoglobulin secretion. 
  • Pulmonary immune responses to Propionibacterium acnes in C57BL/6 and BALB/c mice. 
  • Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung. 
  • Reduced T regulatory cell response during acute Plasmodium falciparum infection in Malian children co-infected with Schistosoma haematobium. 
  • Regulation of T-helper-cell lineage development by osteopontin: the inside story. 
  • Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella. 
  • Reprograming immunity to food allergens. 
  • Rim Pathway-Mediated Alterations in the Fungal Cell Wall Influence Immune Recognition and Inflammation. 
  • Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. 
  • Role of interleukin 12 and costimulators in T cell anergy in vivo. 
  • Selective and site-specific mobilization of dermal dendritic cells and Langerhans cells by Th1- and Th2-polarizing adjuvants. 
  • Simvastatin inhibits secretion of Th17-polarizing cytokines and antigen presentation by DCs in patients with relapsing remitting multiple sclerosis. 
  • Stability of Th1 and Th2 populations. 
  • Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response. 
  • Studies on the mechanism and specificity of the effect of the synthetic random copolymer GLAT on graft-versus-host disease. 
  • T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha. 
  • T cell development and function in CrkL-deficient mice. 
  • T helper 2-dominant antilymphoma immune response is associated with fatal outcome. 
  • T-bet-dependent expression of osteopontin contributes to T cell polarization. 
  • TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection. 
  • TH1/TH2 cytokine release pattern during in vivo cytomegalovirus disease in solid organ transplantation. 
  • Tacrolimus inhibits Th1 and Th17 responses in MuSK-antibody positive myasthenia gravis patients. 
  • Tgf-beta inhibits activation and uveitogenicity of primary but not of fully polarized retinal antigen-specific memory-effector T cells. 
  • Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout mice. 
  • Th1 to Th2 immune deviation facilitates, but does not cause, islet allograft tolerance in mice. 
  • Th17 cells are long lived and retain a stem cell-like molecular signature. 
  • The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity. 
  • The role of IL12 in helper T-cell differentiation. 
  • Titrating T-cell epitopes within self-assembled vaccines optimizes CD4+ helper T cell and antibody outputs. 
  • Transcriptional regulation of T lymphocyte development and function. 
  • Type B CpG oligodeoxynucleotides induce Th1 responses to peanut antigens: modulation of sensitization and utility in a truncated immunotherapy regimen in mice. 
  • Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation. 
  • Vitamin D, D-dimer, Interferon γ, and sCD14 Levels are Independently Associated with Immune Reconstitution Inflammatory Syndrome: A Prospective, International Study. 
  • [LMP-420, a new therapeutic approach for cerebral malaria?]. 
  • [Study of immunoregulation of dendritic cells in allergic rhinitis]. 
  • gammadelta cells and the regulation of mucosal immune responses. 
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  Keywords of People

  • Cianciolo, George James, Associate Professor in Pathology, Pathology
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology
  • Zhong, Xiaoping, Professor of Pediatrics, Immunology