Th2 Cells
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Subject Areas on Research
- AJRCCM: 100-Year Anniversary. Focus on Asthma in Children and Adults.
- Aerobic exercise attenuates airway inflammatory responses in a mouse model of atopic asthma.
- Aging is associated with a rapid decline in frequency, alterations in subset composition, and enhanced Th2 response in CD1d-restricted NKT cells from human peripheral blood.
- Allergen-induced airway disease is mouse strain dependent.
- An approach to modelling in immunology.
- B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis.
- BATF Modulates the Th2 Locus Control Region and Regulates CD4+ T Cell Fate during Antihelminth Immunity.
- Beta-arrestin-2 regulates the development of allergic asthma.
- Blocking CCR7 at the ocular surface impairs the pathogenic contribution of dendritic cells in allergic conjunctivitis.
- CD19 expression in B cells regulates atopic dermatitis in a mouse model.
- CD4+Thy1- thymocytes with a Th-type 2 cytokine response.
- Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.
- Chronic graft-versus-host disease.
- Cryptococcus neoformans hyperfilamentous strain is hypervirulent in a murine model of cryptococcal meningoencephalitis.
- Cytokine patterns during progression to AIDS in children with perinatal HIV infection.
- Cytokine transcriptional events during helper T cell subset differentiation.
- Delayed liver fibrosis in HTLV-2-infected patients co-infected with HIV-1 and hepatitis C virus with suppressive antiretroviral therapy.
- Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease.
- Differential modulation of Th1- and Th2-related cytokine mRNA expression by a synthetic peptide homologous to a conserved domain within retroviral envelope protein.
- Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity.
- Donor specific bone marrow cells suppress lymphocyte reactivity to donor antigens and differentially modulate TH1 and TH2 cytokine gene expression in the responder cell population.
- Donor-specific bone marrow cells suppress lymphocyte reactivity to donor antigens and differentially modulate TH1 and TH2 cytokine gene expression in the responder cell population.
- Effect of desiccating environmental stress versus systemic muscarinic AChR blockade on dry eye immunopathogenesis.
- Elevated IgE and atopy in patients treated for early-onset ADA-SCID.
- Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis.
- Exposure to particulate hexavalent chromium exacerbates allergic asthma pathology.
- Generation of melanoma-specific, cytotoxic CD4(+) T helper 2 cells: requirement of both HLA-DR15 and Fas antigens on melanomas for their lysis by Th2 cells.
- H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection.
- Hepatic allograft-derived Kupffer cells regulate T cell response in rats.
- IL-13 in asthma and allergic disease: asthma phenotypes and targeted therapies.
- IL-2-controlled expression of multiple T cell trafficking genes and Th2 cytokines in the regulatory T cell-deficient scurfy mice: implication to multiorgan inflammation and control of skin and lung inflammation.
- IL-4 induces differentiation and expansion of Th2 cytokine-producing eosinophils.
- IL-9: Function, Sources, and Detection.
- Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections.
- Impaired germinal center formation and recall T-cell-dependent immune responses in mice lacking the costimulatory ligand B7-H2.
- Impairing oral tolerance promotes allergy and anaphylaxis: a new murine food allergy model.
- In vivo molecular analysis of cytokines in a murine model of ocular onchocerciasis. I. Up-regulation of IL-4 and IL-5 mRNAs and not IL-2 and IFN gamma mRNAs in the cornea due to experimental interstitial keratitis.
- Increased levels of IgE and autoreactive, polyreactive IgG in wild rodents: implications for the hygiene hypothesis.
- Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma.
- Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response.
- Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice.
- Lung effector memory and activated CD4+ T cells display enhanced proliferation in surfactant protein A-deficient mice during allergen-mediated inflammation.
- Mechanisms of food allergy.
- Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens.
- Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4.
- Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter.
- Notch signaling represents an important checkpoint between follicular T-helper and canonical T-helper 2 cell fate.
- Ocular allergy modulation to hi-dose antigen sensitization is a Treg-dependent process.
- Pepsinized cashew proteins are hypoallergenic and immunogenic and provide effective immunotherapy in mice with cashew allergy.
- Peyer's patch CD8+ memory T cells secrete T helper type 1 and type 2 cytokines and provide help for immunoglobulin secretion.
- Positive selection on a human-specific transcription factor binding site regulating IL4 expression.
- Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma.
- Protein Phosphatase 1α and Cofilin Regulate Nuclear Translocation of NF-κB and Promote Expression of the Anti-Inflammatory Cytokine Interleukin-10 by T Cells.
- Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung.
- Reprograming immunity to food allergens.
- Selective and site-specific mobilization of dermal dendritic cells and Langerhans cells by Th1- and Th2-polarizing adjuvants.
- Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB.
- Serum periostin as a marker of T(H)2-dependent eosinophilic airway inflammation.
- Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice.
- Stability of Th1 and Th2 populations.
- Strain-dependent genomic factors affect allergen-induced airway hyperresponsiveness in mice.
- Studies on the mechanism and specificity of the effect of the synthetic random copolymer GLAT on graft-versus-host disease.
- T helper 2-dominant antilymphoma immune response is associated with fatal outcome.
- TH1/TH2 cytokine release pattern during in vivo cytomegalovirus disease in solid organ transplantation.
- Th2 cells: orchestrating barrier immunity.
- The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract.
- The differential expression of IL-4 and IL-13 and its impact on type-2 immunity.
- The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity.
- The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitro.
- Titrating T-cell epitopes within self-assembled vaccines optimizes CD4+ helper T cell and antibody outputs.
- Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.
- Transcriptional profiling of whole blood and serum protein analysis of mice exposed to the neurotoxin Pacific Ciguatoxin-1.
- Transcriptional regulation of T lymphocyte development and function.
- [Antitumoral action of interferons and interleukins in combination with radiotherapy. Part I: immunologic basis].
- [Study of immunoregulation of dendritic cells in allergic rhinitis].
- gammadelta cells and the regulation of mucosal immune responses.
- β-Arrestin-2-Dependent Signaling Promotes CCR4-mediated Chemotaxis of Murine T-Helper Type 2 Cells.
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Keywords of People
- Cianciolo, George James, Associate Professor in Pathology, Pathology
- Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Immunology
- Wray, Gregory Allan, Professor of Biology, Duke Innovation & Entrepreneurship
- Zhong, Xiaoping, Professor of Pediatrics, Immunology