Th2 Cells

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  Subject Areas on Research

  • AJRCCM: 100-Year Anniversary. Focus on Asthma in Children and Adults. 
  • Activation of the integrated stress response during T helper cell differentiation. 
  • Aerobic exercise attenuates airway inflammatory responses in a mouse model of atopic asthma. 
  • Aging is associated with a rapid decline in frequency, alterations in subset composition, and enhanced Th2 response in CD1d-restricted NKT cells from human peripheral blood. 
  • Allergen-induced airway disease is mouse strain dependent. 
  • An approach to modelling in immunology. 
  • B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis. 
  • BATF Modulates the Th2 Locus Control Region and Regulates CD4+ T Cell Fate during Antihelminth Immunity. 
  • Beta-arrestin-2 regulates the development of allergic asthma. 
  • Blocking CCR7 at the ocular surface impairs the pathogenic contribution of dendritic cells in allergic conjunctivitis. 
  • CD19 expression in B cells regulates atopic dermatitis in a mouse model. 
  • CD4+Thy1- thymocytes with a Th-type 2 cytokine response. 
  • Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. 
  • Chronic graft-versus-host disease. 
  • Cryptococcus neoformans hyperfilamentous strain is hypervirulent in a murine model of cryptococcal meningoencephalitis. 
  • Cytokine patterns during progression to AIDS in children with perinatal HIV infection. 
  • Cytokine transcriptional events during helper T cell subset differentiation. 
  • Delayed liver fibrosis in HTLV-2-infected patients co-infected with HIV-1 and hepatitis C virus with suppressive antiretroviral therapy. 
  • Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease. 
  • Differential modulation of Th1- and Th2-related cytokine mRNA expression by a synthetic peptide homologous to a conserved domain within retroviral envelope protein. 
  • Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. 
  • Donor specific bone marrow cells suppress lymphocyte reactivity to donor antigens and differentially modulate TH1 and TH2 cytokine gene expression in the responder cell population. 
  • Donor-specific bone marrow cells suppress lymphocyte reactivity to donor antigens and differentially modulate TH1 and TH2 cytokine gene expression in the responder cell population. 
  • Effect of desiccating environmental stress versus systemic muscarinic AChR blockade on dry eye immunopathogenesis. 
  • Elevated IgE and atopy in patients treated for early-onset ADA-SCID. 
  • Engineered recombinant peanut protein and heat-killed Listeria monocytogenes coadministration protects against peanut-induced anaphylaxis in a murine model. 
  • Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis. 
  • Exposure to particulate hexavalent chromium exacerbates allergic asthma pathology. 
  • G-CSF induces a potentially tolerant gene and immunophenotype profile in T cells in vivo. 
  • Generation of melanoma-specific, cytotoxic CD4(+) T helper 2 cells: requirement of both HLA-DR15 and Fas antigens on melanomas for their lysis by Th2 cells. 
  • H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection. 
  • Hepatic allograft-derived Kupffer cells regulate T cell response in rats. 
  • IL-13 in asthma and allergic disease: asthma phenotypes and targeted therapies. 
  • IL-2-controlled expression of multiple T cell trafficking genes and Th2 cytokines in the regulatory T cell-deficient scurfy mice: implication to multiorgan inflammation and control of skin and lung inflammation. 
  • IL-4 dependent resistance to the tapeworm Mesocestoides corti (Cestoda) in mice. 
  • IL-4 induces differentiation and expansion of Th2 cytokine-producing eosinophils. 
  • IL-9: Function, Sources, and Detection. 
  • Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections. 
  • Impaired germinal center formation and recall T-cell-dependent immune responses in mice lacking the costimulatory ligand B7-H2. 
  • Impairing oral tolerance promotes allergy and anaphylaxis: a new murine food allergy model. 
  • In vivo molecular analysis of cytokines in a murine model of ocular onchocerciasis. I. Up-regulation of IL-4 and IL-5 mRNAs and not IL-2 and IFN gamma mRNAs in the cornea due to experimental interstitial keratitis. 
  • Increased levels of IgE and autoreactive, polyreactive IgG in wild rodents: implications for the hygiene hypothesis. 
  • Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma. 
  • Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response. 
  • Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice. 
  • Lung effector memory and activated CD4+ T cells display enhanced proliferation in surfactant protein A-deficient mice during allergen-mediated inflammation. 
  • Mechanisms of food allergy. 
  • Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens. 
  • Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. 
  • Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter. 
  • Notch signaling represents an important checkpoint between follicular T-helper and canonical T-helper 2 cell fate. 
  • Ocular allergy modulation to hi-dose antigen sensitization is a Treg-dependent process. 
  • Pepsinized cashew proteins are hypoallergenic and immunogenic and provide effective immunotherapy in mice with cashew allergy. 
  • Peyer's patch CD8+ memory T cells secrete T helper type 1 and type 2 cytokines and provide help for immunoglobulin secretion. 
  • Positive selection on a human-specific transcription factor binding site regulating IL4 expression. 
  • Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma. 
  • Protein Phosphatase 1α and Cofilin Regulate Nuclear Translocation of NF-κB and Promote Expression of the Anti-Inflammatory Cytokine Interleukin-10 by T Cells. 
  • Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung. 
  • Reprograming immunity to food allergens. 
  • Role of tolerance in the development of eosinophilic gastrointestinal diseases. 
  • Selective and site-specific mobilization of dermal dendritic cells and Langerhans cells by Th1- and Th2-polarizing adjuvants. 
  • Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB. 
  • Serum periostin as a marker of T(H)2-dependent eosinophilic airway inflammation. 
  • Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice. 
  • Stability of Th1 and Th2 populations. 
  • Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response. 
  • Strain-dependent genomic factors affect allergen-induced airway hyperresponsiveness in mice. 
  • Studies on the mechanism and specificity of the effect of the synthetic random copolymer GLAT on graft-versus-host disease. 
  • T cell development and function in CrkL-deficient mice. 
  • T helper 2-dominant antilymphoma immune response is associated with fatal outcome. 
  • TH1/TH2 cytokine release pattern during in vivo cytomegalovirus disease in solid organ transplantation. 
  • Th1 to Th2 immune deviation facilitates, but does not cause, islet allograft tolerance in mice. 
  • Th2 cells: orchestrating barrier immunity. 
  • The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract. 
  • The differential expression of IL-4 and IL-13 and its impact on type-2 immunity. 
  • The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity. 
  • The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitro. 
  • Titrating T-cell epitopes within self-assembled vaccines optimizes CD4+ helper T cell and antibody outputs. 
  • Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells. 
  • Transcriptional profiling of whole blood and serum protein analysis of mice exposed to the neurotoxin Pacific Ciguatoxin-1. 
  • Transcriptional regulation of T lymphocyte development and function. 
  • [Antitumoral action of interferons and interleukins in combination with radiotherapy. Part I: immunologic basis]. 
  • [Study of immunoregulation of dendritic cells in allergic rhinitis]. 
  • gammadelta cells and the regulation of mucosal immune responses. 
  • β-Arrestin-2-Dependent Signaling Promotes CCR4-mediated Chemotaxis of Murine T-Helper Type 2 Cells. 
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  Keywords of People

  • Cianciolo, George James, Associate Professor in Pathology, Pathology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Immunology
  • Wray, Gregory Allan, Professor of Biology, Duke Innovation & Entrepreneurship
  • Zhong, Xiaoping, Professor of Pediatrics, Immunology