Models, Immunological

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  Subject Areas on Research

  • A model for migratory B cell oscillations from receptor down-regulation induced by external chemokine fields. 
  • A novel role for activation-induced cytidine deaminase: central B-cell tolerance. 
  • Acute endotoxin-induced thymic atrophy is characterized by intrathymic inflammatory and wound healing responses. 
  • Adaptor proteins in lymphocyte activation. 
  • Age related changes in population of peripheral T cells: towards a model of immunosenescence. 
  • An approach to modelling in immunology. 
  • Analysis of cytokine dynamics in corneal allograft rejection. 
  • Application of Bayesian modeling of autologous antibody responses against ovarian tumor-associated antigens to cancer detection. 
  • Association of HIV-1 Envelope-Specific Breast Milk IgA Responses with Reduced Risk of Postnatal Mother-to-Child Transmission of HIV-1. 
  • B lymphocytes contribute to autoimmune disease pathogenesis: current trends and clinical implications. 
  • B lymphocytes: how they develop and function. 
  • B-cell homeostasis: digital survival or analog growth? 
  • Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury. 
  • Bottom up: a modular view of immunology. 
  • CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction. 
  • CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. 
  • CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines. 
  • Cancer immunoediting in malignant glioma. 
  • Copy number variation of KIR genes influences HIV-1 control. 
  • Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model. 
  • Development of tolerogenic strategies in the clinic. 
  • Exposure to topical bovine thrombin during surgery elicits a response against the xenogeneic carbohydrate galactose alpha1-3galactose. 
  • Extent of stimulation controls the formation of memory CD8 T cells. 
  • Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes. 
  • Feedback control of T-cell receptor activation. 
  • Functions of skin-resident γδ T cells. 
  • Germinal center B cell depletion diminishes CD4+ follicular T helper cells in autoimmune mice. 
  • Haplotype exclusion and receptor editing: irreconcilable differences? 
  • Homeostatic control of lymphocyte survival: potential origins and implications. 
  • How do plants achieve immunity? Defence without specialized immune cells. 
  • Human gammadelta-T cells in adoptive immunotherapy of malignant and infectious diseases. 
  • Human monocytes as intermediaries between allogeneic endothelial cells and allospecific T cells: a role for direct scavenger receptor-mediated endothelial membrane uptake in the initiation of alloimmunity. 
  • IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells. 
  • Identification of MAVS splicing variants that interfere with RIGI/MAVS pathway signaling. 
  • IgG and complement-mediated tissue damage in the absence of C2: evidence of a functionally active C2-bypass pathway in a guinea pig model. 
  • IkappaB kinase inhibitors for treating autoimmune and inflammatory disorders: potential and challenges. 
  • Immune Tolerance for Autoimmune Disease and Cell Transplantation. 
  • Immunotherapy of cancer using dendritic cells. 
  • Induction of tolerance to parental parathyroid grafts using allogeneic thymus tissue in patients with DiGeorge anomaly. 
  • Induction of transplantation tolerance in non-human primate preclinical models. 
  • Location, location, location: regional immune mechanisms critically influence rejection. 
  • Mechanisms of peripheral T cell tolerance. 
  • Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. 
  • Modeling nuclear molecule release during in vitro cell death. 
  • Modified T-cell receptor ligands: moving beyond a strict occupancy model for T-cell activation by antigen. 
  • Molecular basis of T cell inactivation by CTLA-4. 
  • Multiple constraints at the level of TCRalpha rearrangement impact Valpha14i NKT cell development. 
  • Multiple gamma c-dependent cytokines regulate T-cell development. 
  • New insights into adenosine-receptor-mediated immunosuppression and the role of adenosine in causing the immunodeficiency associated with adenosine deaminase deficiency. 
  • On sexual dimorphism in immune function. 
  • Ordinary Differential Equation Models for Adoptive Immunotherapy. 
  • Oscillations in the immune system. 
  • Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling. 
  • Porcine CD80: cloning, characterization, and evidence for its role in direct human T-cell activation. 
  • Profiles of serum cytokines in acute drug-induced liver injury and their prognostic significance. 
  • Rasmussen's encephalitis: an autoimmune disorder? 
  • Re-evaluating the role of heat-shock protein-peptide interactions in tumour immunity. 
  • Regulation of corneal inflammation by neutrophil-dependent cleavage of keratan sulfate proteoglycans as a model for breakdown of the chemokine gradient. 
  • Role of Toll-like receptors in HMGB1 release from macrophages. 
  • Self and non-self discrimination of intracellular membranes by the innate immune system. 
  • Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis. 
  • Spatiotemporal programming of a simple inflammatory process. 
  • Statistical analysis of antigen receptor spectratype data. 
  • Staying alive: cell death in antiviral immunity. 
  • Studies investigating pretransplant donor-specific blood transfusion, rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin allotransplantation. 
  • Systemic acquired resistance. 
  • T-cell-receptor affinity and thymocyte positive selection. 
  • Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub. 
  • The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease. 
  • The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system. 
  • The bridge between dendritic cells and asthma. 
  • The dynamics of T-cell receptor repertoire diversity following thymus transplantation for DiGeorge anomaly. 
  • The effect of covalently immobilized rhIL-1ra-ELP fusion protein on the inflammatory profile of LPS-stimulated human monocytes. 
  • The human thymus. A chimeric organ comprised of central and peripheral lymphoid components. 
  • The impact of host immune status on the within-host and population dynamics of antigenic immune escape. 
  • The metabolic life and times of a T-cell. 
  • The nature of immune responses to urinary tract infections. 
  • The road to tolerance: renal transplant tolerance induction in nonhuman primate studies and clinical trials. 
  • The role of mast cells in host defense and their subversion by bacterial pathogens. 
  • Treatment with immunotoxin. 
  • Understanding specificity and sensitivity of T-cell recognition. 
  • c-FLIP protects mature T lymphocytes from TCR-mediated killing. 
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  Keywords of People

  • Shinohara, Mari L., Associate Professor of Immunology, Immunology