Muscle Fibers, Skeletal

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  Subject Areas on Research

  • A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. 
  • A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. 
  • AAEM minimonograph #25: single-fiber electromyography. 
  • Abnormal extracellular material in the levator palpebrae superioris complex in congenital ptosis. 
  • Aging of skeletal muscle: a 12-yr longitudinal study. 
  • Altered stored calcium release in skeletal myotubes deficient of triadin and junctin. 
  • Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain. 
  • Association between muscle fiber composition and blood pressure levels during exercise in men. 
  • Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway. 
  • Ca2+/calmodulin-based signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression. 
  • Calcium-dependent gene regulation in myocyte hypertrophy and remodeling. 
  • Cellular and functional defects in a mouse model of heart failure. 
  • Chemoradiation impairs myofiber hypertrophic growth in a pediatric tumor model. 
  • Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function. 
  • Continuous contractile activity induces fiber type specific expression of HSP70 in skeletal muscle. 
  • Control of muscle formation by the fusogenic micropeptide myomixer. 
  • Deconstructing Pompe disease by analyzing single muscle fibers: to see a world in a grain of sand... 
  • Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. 
  • Dietary consistency and plasticity of masseter fiber architecture in postweaning rabbits. 
  • Directed in vitro myogenesis of human embryonic stem cells and their in vivo engraftment. 
  • Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis. 
  • Distinct patterns of fat metabolism in skeletal muscle of normal-weight, overweight, and obese humans. 
  • Early de novo DNA methylation and prolonged demethylation in the muscle lineage. 
  • Economy and Endurance in Human Evolution. 
  • Effect of cyclic stretch on beta1D-integrin expression and activation of FAK and RhoA. 
  • Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies. 
  • Effects of long-term denervation on skeletal muscle in old rats. 
  • Effects of spaceflight on murine skeletal muscle gene expression. 
  • Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle. 
  • Electron microscopy and x-ray diffraction evidence for two Z-band structural states. 
  • Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. 
  • Engineering human pluripotent stem cells into a functional skeletal muscle tissue. 
  • Enhanced MyoD-induced transdifferentiation to a myogenic lineage by fusion to a potent transactivation domain. 
  • Epaxial muscle fiber architecture favors enhanced excursion and power in the leaper Galago senegalensis. 
  • Excitation of a cardiac muscle fiber by extracellularly applied sinusoidal current. 
  • Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. 
  • Expression and glycogenic effect of glycogen-targeting protein phosphatase 1 regulatory subunit GL in cultured human muscle. 
  • Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling. 
  • Fiber type composition of epaxial muscles is geared toward facilitating rapid spinal extension in the leaper Galago senegalensis. 
  • Fiber-type phenotype of the jaw-closing muscles in Gorilla gorilla, Pan troglodytes, and Pan paniscus: A test of the Frequent Recruitment Hypothesis. 
  • Fluorescence changes on contractile activation in TnC(DANZ) labeled skinned rabbit psoas fibers. 
  • Frequency of celiac disease in individuals with Down syndrome in the United States. 
  • Functional and molecular adaptations in skeletal muscle of myoglobin-mutant mice. 
  • Functional correlates of fiber architecture of the lateral caudal musculature in prehensile and nonprehensile tails of the platyrrhini (primates) and procyonidae (carnivora). 
  • G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. 
  • Gene expression during normal and FSHD myogenesis. 
  • Glucocorticoid treatment alleviates dystrophic myofiber pathology by activation of the calcineurin/NF-AT pathway. 
  • Glucose uptake in muscle cell cultures from endurance-trained men. 
  • HDAC4 regulates muscle fiber type-specific gene expression programs. 
  • Homer modulates NFAT-dependent signaling during muscle differentiation. 
  • Human skeletal muscle fibre contractile properties and proteomic profile: adaptations to 3 weeks of unilateral lower limb suspension and active recovery. 
  • Human, Tissue-Engineered, Skeletal Muscle Myobundles to Measure Oxygen Uptake and Assess Mitochondrial Toxicity. 
  • Hypoxia reprograms calcium signaling and regulates myoglobin expression. 
  • Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations. 
  • Impaired growth and force production in skeletal muscles of young partially pancreatectomized rats: a model of adolescent type 1 diabetic myopathy? 
  • Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders. 
  • Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. 
  • Investigations into pulsed high-intensity focused ultrasound-enhanced delivery: preliminary evidence for a novel mechanism. 
  • Jaw muscles of New World squirrels. 
  • Jaw-muscle fiber architecture in tufted capuchins favors generating relatively large muscle forces without compromising jaw gape. 
  • Jitter recordings with concentric needle electrodes. 
  • Knocking down type 2 but not type 1 calsequestrin reduces calcium sequestration and release in C2C12 skeletal muscle myotubes. 
  • Lipid partitioning, incomplete fatty acid oxidation, and insulin signal transduction in primary human muscle cells: effects of severe obesity, fatty acid incubation, and fatty acid translocase/CD36 overexpression. 
  • Localizing synaptic mRNAs at the neuromuscular junction: it takes more than transcription. 
  • Longevity-related molecular pathways are subject to midlife "switch" in humans. 
  • Lower capillarization, VEGF protein, and VEGF mRNA response to acute exercise in the vastus lateralis muscle of aged vs. young women. 
  • MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type. 
  • Magnetic resonance imaging of intramuscular myxoma with histological comparison and a review of the literature. 
  • Magnetic resonance myocardial fiber-orientation mapping with direct histological correlation. 
  • Mesoscopic hydrogel molding to control the 3D geometry of bioartificial muscle tissues. 
  • Metabolic remodeling of human skeletal myocytes by cocultured adipocytes depends on the lipolytic state of the system. 
  • Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. 
  • Modeling statin myopathy in a human skeletal muscle microphysiological system. 
  • Mouse transgenic lines that selectively label Type I, Type IIA, and Types IIX+B skeletal muscle fibers. 
  • Multiple regulatory events controlling the expression and localization of utrophin in skeletal muscle fibers: insights into a therapeutic strategy for Duchenne muscular dystrophy. 
  • Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK. 
  • Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility. 
  • Myocardial fiber orientation mapping using reduced encoding diffusion tensor imaging. 
  • Nonsteroidal anti-inflammatory drugs and acetaminophen in the treatment of an acute muscle injury. 
  • Notch signaling genes: myogenic DNA hypomethylation and 5-hydroxymethylcytosine. 
  • Nox2 Inhibition Regulates Stress Response and Mitigates Skeletal Muscle Fiber Atrophy during Simulated Microgravity. 
  • Obesity and lipid stress inhibit carnitine acetyltransferase activity. 
  • Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly. 
  • Orientation and length of mammalian skeletal myocytes in response to a unidirectional stretch. 
  • Overload-induced skeletal muscle extracellular matrix remodelling and myofibre growth in mice lacking IL-6. 
  • PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. 
  • PGC1-α over-expression prevents metabolic alterations and soleus muscle atrophy in hindlimb unloaded mice. 
  • Paced activation mapping reveals organization of myocardial fibers: a simulation study. 
  • Pharmacological activation of PPARbeta/delta stimulates utrophin A expression in skeletal muscle fibers and restores sarcolemmal integrity in mature mdx mice. 
  • Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi. 
  • Postnatal development and plasticity of specialized muscle fiber characteristics in the hindlimb. 
  • Prepubertal skeletal muscle growth requires Pax7-expressing satellite cell-derived myonuclear contribution. 
  • Rapid up-regulation of peptide elongation factor EF-1alpha protein levels is an immediate early event during oxidative stress-induced apoptosis. 
  • Reference values in concentric needle electrode studies. 
  • Region specific modeling of cardiac muscle: comparison of simulated and experimental potentials. 
  • Regulation and function of the muscle glycogen-targeting subunit of protein phosphatase 1 (GM) in human muscle cells depends on the COOH-terminal region and glycogen content. 
  • Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. 
  • Roles of adherent myogenic cells and dynamic culture in engineered muscle function and maintenance of satellite cells. 
  • SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control. 
  • Simulation and prediction of functional block in the presence of structural and ionic heterogeneity. 
  • Single fiber electromyography and measuring jitter with concentric needle electrodes. 
  • Single fiber electromyography. 
  • Single-institutional reference values for concentric needle jitter analysis using the extrapolated reference values procedure: Comparison to published reference values. 
  • Skeletal muscle protein synthesis and the abundance of the mRNA translation initiation repressor PDCD4 are inversely regulated by fasting and refeeding in rats. 
  • Skeletal muscle-specific genetic determinants contribute to the differential strain-dependent effects of hindlimb ischemia in mice. 
  • Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx mice. 
  • Stretch-induced nitric oxide modulates mechanical properties of skeletal muscle cells. 
  • Suppression of revertant fibers in mdx mice by expression of a functional dystrophin. 
  • TNF Receptor-Associated Factor 6 Mediates TNFα-Induced Skeletal Muscle Atrophy in Mice During Aging. 
  • Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle. 
  • The functional correlates of jaw-muscle fiber architecture in tree-gouging and nongouging callitrichid monkeys. 
  • The morphology of the masticatory apparatus facilitates muscle force production at wide jaw gapes in tree-gouging common marmosets (Callithrix jacchus). 
  • The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle. 
  • The superfast extraocular myosin (MYH13) is localized to the innervation zone in both the global and orbital layers of rabbit extraocular muscle. 
  • The utrophin A 5'-untranslated region confers internal ribosome entry site-mediated translational control during regeneration of skeletal muscle fibers. 
  • Tissue engineered skeletal muscle model of rheumatoid arthritis using human primary skeletal muscle cells. 
  • Tissue-Engineered Human Myobundle System as a Platform for Evaluation of Skeletal Muscle Injury Biomarkers. 
  • Topographic specificity within membranes of a single muscle detected in vitro. 
  • Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice. 
  • Troponin C modulates the activation of thin filaments by rigor cross-bridges. 
  • Variable presentation of nemaline myopathy: novel mutation of alpha actin gene. 
  • WNT3A promotes myogenesis of human embryonic stem cells and enhances in vivo engraftment. 
  • l-Citrulline supplementation improves glucose and exercise tolerance in obese male mice. 
  • β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility. 
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  Keywords of People

  • Henriquez, Craig S., Professor of Biomedical Engineering, Biomedical Engineering
  • Roth, V. Louise, Professor of Biology, Evolutionary Anthropology