Dopamine Agonists

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  Subject Areas on Research

  • "Speed" warps time: methamphetamine's interactive roles in drug abuse, habit formation, and the biological clocks of circadian and interval timing. 
  • A case of transient hallucination with ropinirole augmentation antidepressant in a patient with treatment-resistant depression: Is there differential effect of ropinirole dose on developing psychotic symptom? 
  • A pre-clinical study showing how dopaminergic drugs administered during pre-exposure can impair or facilitate latent inhibition. 
  • A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation. 
  • Acquiring local field potential information from amperometric neurochemical recordings. 
  • Activity patterns in mesolimbic regions in rats during operant tasks for reward. 
  • Acute and chronic continuous methamphetamine have different long-term behavioral and neurochemical consequences. 
  • Alterations in baseline activity and quinpirole sensitivity in putative dopamine neurons in the substantia nigra and ventral tegmental area after withdrawal from cocaine pretreatment. 
  • Altered activity of midbrain dopamine neurons following 7-day withdrawal from chronic cocaine abuse is normalized by D2 receptor stimulation during the early withdrawal phase. 
  • Anatomically dissociable effects of dopamine D1 receptor agonists on reward and relief of withdrawal in morphine-dependent rats. 
  • Apomorphine: North American clinical experience. 
  • Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal. 
  • Chronic loss of noradrenergic tone produces β-arrestin2-mediated cocaine hypersensitivity and alters cellular D2 responses in the nucleus accumbens. 
  • Chronic nicotine working and reference memory effects in the 16-arm radial maze: interactions with D1 agonist and antagonist drugs. 
  • Clinical spectrum of impulse control disorders in Parkinson's disease. 
  • D2 Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine. 
  • Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. 
  • Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins. 
  • Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. 
  • Dopamine modulates the response of the human amygdala: a study in Parkinson's disease. 
  • Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. 
  • Early treatment benefits of ropinirole prolonged release in Parkinson's disease patients with motor fluctuations. 
  • Effect of daily dosing duration of direct and indirect dopamine receptor agonists: cocaine cross-tolerance following chronic regimens. 
  • Effect of fenoldopam mesylate in critically ill patients at risk for acute renal failure is dose dependent. 
  • Effects of Adjunctive Brexpiprazole on Sleep Disturbances in Patients With Major Depressive Disorder: An Open-Label, Flexible-Dose, Exploratory Study. 
  • Effects of intermittent and continuous cocaine administration on dopamine release and uptake regulation in the striatum: in vitro voltammetric assessment. 
  • Effects of intrastriatal infusion of D2 and D3 dopamine receptor preferring antagonists on dopamine release in rat dorsal striatum (in vivo microdialysis study). 
  • Estimation of the interstitial free concentration of the putative dopamine D3 receptor selective agonist 7-OH-DPAT in the dorsal striatum of freely moving rats. 
  • Fenoldopam mesylate for the prevention of contrast-induced nephropathy: a randomized controlled trial. 
  • Fenoldopam mesylate in early acute tubular necrosis: a randomized, double-blind, placebo-controlled clinical trial. 
  • Fenoldopam: a new parenteral antihypertensive: consensus roundtable on the management of perioperative hypertension and hypertensive crises. 
  • Food for thought: the physiological relevance of ghrelin and dopamine D2 receptor heterodimerization in the regulation of appetite. 
  • Frontal cortex lesions eliminate the clock speed effect of dopaminergic drugs on interval timing. 
  • Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase. 
  • Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs. 
  • Glucose Activates Vagal Control of Hyperglycemia and Inflammation in Fasted Mice. 
  • Her vision was tied down. 
  • Hyperactivity and impaired response habituation in hyperdopaminergic mice. 
  • Impact of adolescent nicotine exposure on adenylyl cyclase-mediated cell signaling: enzyme induction, neurotransmitter-specific effects, regional selectivities, and the role of withdrawal. 
  • Impulse control disorders arising in 3 patients treated with rotigotine. 
  • Impulse control disorders in Parkinson disease: a multicenter case--control study. 
  • Impulsive and compulsive behaviors in Parkinson's disease. 
  • Loss of autoreceptor functions in mice lacking the dopamine transporter. 
  • Medical treatment of Parkinson disease. 
  • Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. 
  • New Concepts in Dopamine D2 Receptor Biased Signaling and Implications for Schizophrenia Therapy. 
  • Novel roles for β-arrestins in the regulation of pharmacological sequestration to predict agonist-induced desensitization of dopamine D3 receptors. 
  • Nucleus accumbens, entorhinal cortex and latent inhibition: a neural network model. 
  • Ontogeny of the behavioral response to dopamine agonists after chronic cocaine. 
  • Optimizing long-term therapy for Parkinson disease: levodopa, dopamine agonists, and treatment-associated dyskinesia. 
  • Other formulations and future considerations for apomorphine for subcutaneous injection therapy. 
  • PI3 kinase is involved in cocaine behavioral sensitization and its reversal with brain area specificity. 
  • Pathological gambling associated with dopamine agonist therapy in Parkinson's disease. 
  • Pharmacological and nonpharmacological interventions in the treatment of Parkinson's disease. 
  • Pharmacotherapy for advanced Parkinson's disease. 
  • Postsynaptic Mechanisms Render Syn I/II/III Mice Highly Responsive to Psychostimulants. 
  • Pramipexole vs levodopa as initial treatment for Parkinson disease: A randomized controlled trial. Parkinson Study Group. 
  • Presynaptic dopaminergic function is largely unaltered in mesolimbic and mesostriatal terminals of adult rats that were prenatally exposed to cocaine. 
  • Psychopharmacology of latent inhibition: a neural network approach. 
  • Psychosis related to ropinirole. 
  • Quinpirole-induced sensitization to noisy/sparse periodic input: temporal synchronization as a component of obsessive-compulsive disorder. 
  • Randomized clinical trial of quick-release bromocriptine among patients with type 2 diabetes on overall safety and cardiovascular outcomes. 
  • Rapid corneal adrenochrome deposition from topical ibopamine in the setting of infectious keratitis. 
  • Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter. 
  • Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors. 
  • Role of nicotinic receptors in the lateral habenula in the attenuation of amphetamine-induced prepulse inhibition deficits of the acoustic startle response in rats. 
  • Selective inhibition of adenylyl cyclase type V by the dopamine D3 receptor. 
  • Spontaneous Eye Blink Rate (EBR) Is Uncorrelated with Dopamine D2 Receptor Availability and Unmodulated by Dopamine Agonism in Healthy Adults. 
  • Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane. 
  • Synthesis, dopaminergic profile, and molecular dynamics calculations of N-aralkyl substituted 2-aminoindans. 
  • The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation. 
  • The effects of continuous cocaine dose on the induction of behavioral tolerance and dopamine autoreceptor function. 
  • Transnasal Transsphenoidal Elevation of Optic Chiasm in Secondary Empty Sella Syndrome Following Prolactinoma Treatment. 
  • Treatment options for early Parkinson's disease. 
  • Ventral hippocampal dopamine D1 and D2 systems and spatial working memory in rats. 
  • [Novel central dopaminergic agents derived from atypical di-substituted 2-aminoindane-4, 7. Synthesis and central pharmacological profile]. 
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  Keywords of People

  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. Distinguished Professor, Medicine, Clinical Pharmacology