Cross-Over Studies

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  Subject Areas on Research

  • A Bayesian approach on sample size calculation for comparing means. 
  • A Crossover Design for Comparative Efficacy: A 36-Week Randomized Trial of Bevacizumab and Ranibizumab for Diabetic Macular Edema. 
  • A Double-Blinded, Randomized, Placebo-Controlled Trial to Evaluate Efficacy, Safety, and Tolerability of Single Doses of Tirasemtiv in Patients with Acetylcholine Receptor-Binding Antibody-Positive Myasthenia Gravis. 
  • A Phase I, Open-Label, Single-Dose Safety, Pharmacokinetic, and Tolerability Study of the Sumatriptan Iontophoretic Transdermal System in Adolescent Migraine Patients. 
  • A Randomized Controlled Trial Evaluating the Relative Effectiveness of the Multiple Traffic Light and Nutri-Score Front of Package Nutrition Labels. 
  • A Randomized Phase II Crossover Study of Imatinib or Rituximab for Cutaneous Sclerosis after Hematopoietic Cell Transplantation. 
  • A Single Bout of Premeal Resistance Exercise Improves Postprandial Glucose Metabolism in Obese Men with Prediabetes. 
  • A comparison of mirtazapine and nortriptyline following two consecutive failed medication treatments for depressed outpatients: a STAR*D report. 
  • A comparison of once-daily extended-release methylphenidate formulations in children with attention-deficit/hyperactivity disorder in the laboratory school (the Comacs Study). 
  • A comparison of studies on the effects of controlled exposure to fine, coarse and ultrafine ambient particulate matter from a single location. 
  • A comparison of the case-control and case-crossover designs for estimating medical costs of nonfatal fall-related injuries among older Americans. 
  • A comparison of ultrasound-guided and landmark-based approaches to saphenous nerve blockade: a prospective, controlled, blinded, crossover trial. 
  • A controlled trial of acute effects of human exposure to traffic particles on pulmonary oxidative stress and heart rate variability. 
  • A functional polymorphism in the ATP-Binding Cassette B1 transporter predicts pharmacologic response to combination of nortriptyline and morphine in neuropathic pain patients. 
  • A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults. 
  • A mobile application improves therapy-adherence rates in elderly patients undergoing rehabilitation: A crossover design study comparing documentation via iPad with paper-based control. 
  • A note on sample size calculation for mean comparisons based on noncentral t-statistics. 
  • A note on sample size determination for bioequivalence studies with high-order crossover designs. 
  • A phase III extension trial with a 1-arm crossover from leuprolide to degarelix: comparison of gonadotropin-releasing hormone agonist and antagonist effect on prostate cancer. 
  • A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans. 
  • A pilot study of cerebral and haemodynamic physiological changes during sedation with dexmedetomidine or propofol in patients with acute brain injury. 
  • A prospective, randomized, double-blind comparison of bilateral and right unilateral electroconvulsive therapy at different stimulus intensities. 
  • A randomized comparison of EUS-guided FNA versus CT or US-guided FNA for the evaluation of pancreatic mass lesions. 
  • A randomized controlled trial of ganaxolone in posttraumatic stress disorder. 
  • A randomized crossover study comparing a novel needle guidance technology for simulated internal jugular vein cannulation. 
  • A randomized placebo-controlled double-blind study evaluating the time course of response to methylphenidate hydrochloride extended-release capsules in children with attention-deficit/hyperactivity disorder. 
  • A randomized trial of a 6-week course of celecoxib on proteinuria in diabetic kidney disease. 
  • A randomized, controlled study to assess the effect of silk-like textiles and high-absorbency adult incontinence briefs on pressure ulcer prevention. 
  • A randomized, crossover phase 1 study to assess the effects of formulation (capsule vs tablet) and meal consumption on the bioavailability of dovitinib (TKI258). 
  • A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee. 
  • A randomized, double-blind, placebo-controlled phase II study of eculizumab in patients with refractory generalized myasthenia gravis. 
  • A randomized, placebo-controlled trial of early eptifibatide for non-ST-segment elevation acute coronary syndromes. 
  • Accelerometer-Measured Daily Activity in Heart Failure With Preserved Ejection Fraction: Clinical Correlates and Association With Standard Heart Failure Severity Indices. 
  • Acceptability of second-step treatments to depressed outpatients: a STAR*D report. 
  • Acceptability of sodium-reduced research diets, including the Dietary Approaches To Stop Hypertension diet, among adults with prehypertension and stage 1 hypertension. 
  • Acute 5-HT reuptake blockade potentiates human amygdala reactivity. 
  • Acute intravascular volume expansion with rapidly administered crystalloid or colloid in the setting of moderate hypovolemia. 
  • Acute neurocognitive response to methylphenidate among survivors of childhood cancer: a randomized, double-blind, cross-over trial. 
  • Age moderates the short-term effects of transdermal 17beta-estradiol on endothelium-dependent vascular function in postmenopausal women. 
  • Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. 
  • An Ex Vivo Study to Evaluate the Effect of Tegaserod on Platelet Activation and Aggregation. 
  • An evaluation of the efficacy and safety of eszopiclone over 12 months in patients with chronic primary insomnia. 
  • An exploratory study of the combined effects of orally administered methylphenidate and delta-9-tetrahydrocannabinol (THC) on cardiovascular function, subjective effects, and performance in healthy adults. 
  • Antidepressant response to electroconvulsive therapy is sustained after catecholamine depletion. 
  • Applications of TMS to therapy in psychiatry. 
  • Aspirin effects on platelet gene expression are associated with a paradoxical, increase in platelet function. 
  • Assessing acute systemic effects of an inhaled drug with serial echocardiography: a placebo-controlled comparison of inhaled and intravenous dihydroergotamine. 
  • Assessing bioequivalence and drug interchangeability. 
  • Assessing bioequivalence using genomic data. 
  • Assessing the effectiveness of 3 months day and night home closed-loop insulin delivery in adults with suboptimally controlled type 1 diabetes: a randomised crossover study protocol. 
  • Association Between Bedroom Particulate Matter Filtration and Changes in Airway Pathophysiology in Children With Asthma. 
  • Atrial fibrillation and quality of life after pacemaker implantation for sick sinus syndrome: data from the Mode Selection Trial (MOST). 
  • Baseline plasma GABA: its relationship to the adverse effects of acute lorazepam administration on cognition in the elderly. 
  • Bevacizumab in colorectal cancer. 
  • Bioequivalence and Therapeutic Equivalence of Generic and Brand Bupropion in Adults With Major Depression: A Randomized Clinical Trial. 
  • Bioequivalence review for drug interchangeability. 
  • Bipolar disorder and crossover design. 
  • Branched-chain amino acid supplementation and indicators of muscle damage after endurance exercise. 
  • Caffeine affects cardiovascular and neuroendocrine activation at work and home. 
  • Caffeine deprivation affects vigilance performance and mood. 
  • Caffeine impairs glucose metabolism in type 2 diabetes. 
  • Caffeine increases ambulatory glucose and postprandial responses in coffee drinkers with type 2 diabetes. 
  • Caffeine raises blood pressure at work. 
  • Cardiovascular effects of traffic-related air pollution: A multi-omics analysis from a randomized, crossover trial. 
  • Changes in plantar loading based on shoe type and sex during a jump-landing task. 
  • Characterization of bilateral frontal lobe cerebral oxygen saturation in patients with mild traumatic brain injury. 
  • Childhood asthma clusters and response to therapy in clinical trials. 
  • Chronic depression: medication (nefazodone) or psychotherapy (CBASP) is effective when the other is not. 
  • Chronic transdermal nicotine patch treatment effects on cognitive performance in age-associated memory impairment. 
  • Clinical Trial in a Dish: Personalized Stem Cell-Derived Cardiomyocyte Assay Compared With Clinical Trial Results for Two QT-Prolonging Drugs. 
  • Clinical characteristics and outcomes after unplanned intraaortic balloon counterpulsation in the Counterpulsation to Reduce Infarct Size Pre-PCI Acute Myocardial Infarction trial. 
  • Clinical outcomes of remission induction therapy for severe antineutrophil cytoplasmic antibody-associated vasculitis. 
  • Closing the Loop in Adults, Children and Adolescents With Suboptimally Controlled Type 1 Diabetes Under Free Living Conditions: A Psychosocial Substudy. 
  • Cocaine use and the occurrence of panic attacks in the community: a case-crossover approach. 
  • Cognitive therapy versus medication in augmentation and switch strategies as second-step treatments: a STAR*D report. 
  • Combination insulin and sulfonylurea therapy in insulin-requiring type 2 diabetes mellitus. 
  • Combined catecholamine and indoleamine depletion following response to ECT. 
  • Comparative effectiveness of low- and high-fidelity bronchoscopy simulation for training in conventional transbronchial needle aspiration and user preferences. 
  • Comparative pharmacokinetics of voriconazole administered orally as either crushed or whole tablets. 
  • Comparing diurnal and nocturnal effects of brinzolamide and timolol on intraocular pressure in patients receiving latanoprost monotherapy. 
  • Comparison in humans of the potency and pharmacokinetics of intravenously injected cocaethylene and cocaine. 
  • Comparison of Combined Endoscopic Ultrasonography and Endoscopic Secretin Testing With the Traditional Secretin Pancreatic Function Test in Patients With Suspected Chronic Pancreatitis: A Prospective Crossover Study. 
  • Comparison of Exogenous Ketone Administration Versus Dietary Carbohydrate Restriction on Myocardial Glucose Suppression: A Crossover Clinical Trial. 
  • Comparison of Glucosamine Absorption After Administration of Oral Liquid, Chewable, and Tablet Formulations to Dogs. 
  • Comparison of an Electronic Glycemic Management System Versus Provider-Managed Subcutaneous Basal Bolus Insulin Therapy in the Hospital Setting. 
  • Comparison of morning vs bedtime administration of the combination of valsartan/amlodipine on nocturnal brachial and central blood pressure in patients with hypertension. 
  • Comparison of self-expanding and balloon-expandable stents for the reduction of restenosis. 
  • Comparison of the efficacy and safety of arformoterol 15 microg twice daily and arformoterol 30 microg once daily in COPD: a single-dose, multicenter, randomized, modified-blind, two-way crossover study. 
  • Comparison of transbronchial lung biopsy yield between standard forceps and electrocautery hot forceps in swine. 
  • Complete longitudinal analyses of the randomized, placebo-controlled, phase III trial of sunitinib in patients with gastrointestinal stromal tumor following imatinib failure. 
  • Conclusions inconsistent with results with amphetamines and divalproex. 
  • Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil. 
  • Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation. 
  • Controlled exposure to diesel exhaust causes increased nitrite in exhaled breath condensate among subjects with asthma. 
  • Culturally-sensitive weight loss program produces significant reduction in weight, blood pressure, and cholesterol in eight weeks. 
  • Cyclosporine-inhibitable blood-brain barrier drug transport influences clinical morphine pharmacodynamics. 
  • Cyclosporine-inhibitable cerebral drug transport does not influence clinical methadone pharmacodynamics. 
  • DHEA metabolism to the neurosteroid androsterone: a possible mechanism of DHEA's antidepressant action. 
  • Day-and-Night Closed-Loop Insulin Delivery in a Broad Population of Pregnant Women With Type 1 Diabetes: A Randomized Controlled Crossover Trial. 
  • Design and Analysis of Biosimilar Switching Studies. 
  • Dexmedetomidine pharmacodynamics: Part II: Crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers. 
  • Dexmedetomidine pharmacodynamics: part I: crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers. 
  • Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans. 
  • Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. 
  • Differential effects of high-dose magnetic seizure therapy and electroconvulsive shock on cognitive function. 
  • Differential neurophysiological effects of magnetic seizure therapy (MST) and electroconvulsive shock (ECS) in non-human primates. 
  • Directional atherectomy versus balloon angioplasty for coronary ostial and nonostial left anterior descending coronary artery lesions: results from a randomized multicenter trial. The CAVEAT-I investigators. Coronary Angioplasty Versus Excisional Atherectomy Trial. 
  • Disposition of nasal, intravenous, and oral methadone in healthy volunteers. 
  • Double-Blind, Placebo-Controlled, Crossover Study of Armodafinil Treatment of Daytime Sleepiness Associated With Treated Nocturia. 
  • Dynamic molecular choreography induced by traffic exposure: A randomized, crossover trial using multi-omics profiling. 
  • Early Palliative Care Consultation in the Medical ICU: A Cluster Randomized Crossover Trial. 
  • Effect modification of greenness on temperature-mortality relationship among older adults: A case-crossover study in China. 
  • Effect of Bicarbonate on Net Acid Excretion, Blood Pressure, and Metabolism in Patients With and Without CKD: The Acid Base Compensation in CKD Study. 
  • Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial. 
  • Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study. 
  • Effect of citrus juice and SLCO2B1 genotype on the pharmacokinetics of montelukast. 
  • Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. 
  • Effect of glaucoma medications on 24-hour intraocular pressure-related patterns using a contact lens sensor. 
  • Effect of hawthorn standardized extract on flow mediated dilation in prehypertensive and mildly hypertensive adults: a randomized, controlled cross-over trial. 
  • Effect of isosorbide mononitrate on the human optic nerve and choroidal circulations. 
  • Effect of low versus high dialysate sodium concentration on blood pressure and endothelial-derived vasoregulators during hemodialysis: a randomized crossover study. 
  • Effect of low vs. high dietary sodium on blood pressure levels in a normotensive Indo-Asian population. 
  • Effect of predicted low suspend pump treatment on improving glycaemic control and quality of sleep in children with type 1 diabetes and their caregivers: the QUEST randomized crossover study. 
  • Effect of rifampicin on S-ketamine and S-norketamine plasma concentrations in healthy volunteers after intravenous S-ketamine administration. 
  • Effect of simultaneous didanosine administration on itraconazole absorption in healthy volunteers. 
  • Effect of telcagepant on spontaneous ischemia in cardiovascular patients in a randomized study. 
  • Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma. 
  • Effect of two prednisone exposures on mood and declarative memory. 
  • Effect of varying contrast material iodine concentration and injection technique on the conspicuity of hepatocellular carcinoma during 64-section MDCT of patients with cirrhosis. 
  • Effect of virtual reality on time perception in patients receiving chemotherapy. 
  • Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment. 
  • Effectiveness of olanzapine, quetiapine, risperidone, and ziprasidone in patients with chronic schizophrenia following discontinuation of a previous atypical antipsychotic. 
  • Effectiveness of targeted enhanced terminal room disinfection on hospital-wide acquisition and infection with multidrug-resistant organisms and Clostridium difficile: a secondary analysis of a multicentre cluster randomised controlled trial with crossover design (BETR Disinfection). 
  • Effects of a negative pressure venom extraction device (Extractor) on local tissue injury after artificial rattlesnake envenomation in a porcine model. 
  • Effects of blackcurrant anthocyanin intake on peripheral muscle circulation during typing work in humans. 
  • Effects of branched-chain amino acids on glucose metabolism in obese, prediabetic men and women: a randomized, crossover study. 
  • Effects of lisdexamfetamine dimesylate treatment for ADHD on growth. 
  • Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure. 
  • Effects of repleting organic phosphates in banked erythrocytes on plasma metabolites and vasoactive mediators after red cell exchange transfusion in sickle cell disease. 
  • Effects of spinal manipulation on trunk proprioception in subjects with chronic low back pain during symptom remission. 
  • Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group. 
  • Efficacy and Tolerability of Evolocumab vs Ezetimibe in Patients With Muscle-Related Statin Intolerance: The GAUSS-3 Randomized Clinical Trial. 
  • Efficacy and safety of enoxaparin compared with unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention in the Superior Yield of the New Strategy of Enoxaparin, Revascularization and Glycoprotein IIb/IIIa Inhibitors (SYNERGY) trial. 
  • Efficacy and safety of immediate-release methylphenidate treatment for preschoolers with ADHD. 
  • Efficacy of Flecainide in the Treatment of Catecholaminergic Polymorphic Ventricular Tachycardia: A Randomized Clinical Trial. 
  • Efficacy, safety and survival with ruxolitinib in patients with myelofibrosis: results of a median 2-year follow-up of COMFORT-I. 
  • Electrocardiographic safety of cangrelor, a new intravenous antiplatelet agent: a randomized, double-blind, placebo- and moxifloxacin-controlled thorough QT study. 
  • Emotional antecedents of hot flashes during daily life. 
  • Enhanced terminal room disinfection and acquisition and infection caused by multidrug-resistant organisms and Clostridium difficile (the Benefits of Enhanced Terminal Room Disinfection study): a cluster-randomised, multicentre, crossover study. 
  • Evaluating patient-reported outcome measurement comparability between paper and alternate versions, using the lung function questionnaire as an example. 
  • Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) study. 
  • Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using alfentanil and fexofenadine in combination. 
  • Evaluation of the pharmacokinetic drug interaction potential of tivantinib (ARQ 197) using cocktail probes in patients with advanced solid tumours. 
  • Everolimus with reduced tacrolimus improves renal function in de novo liver transplant recipients: a randomized controlled trial. 
  • Examining outlying subjects and outlying records in bioequivalence trials. 
  • Examining the Role of Lateral Parietal Cortex in Emotional Distancing Using TMS. 
  • Exenatide Protects Against Glucose- and Lipid-Induced Endothelial Dysfunction: Evidence for Direct Vasodilation Effect of GLP-1 Receptor Agonists in Humans. 
  • Experiences of closed-loop insulin delivery among pregnant women with Type 1 diabetes. 
  • Exposure to concentrated coarse air pollution particles causes mild cardiopulmonary effects in healthy young adults. 
  • Feasibility of Core Antimicrobial Stewardship Interventions in Community Hospitals. 
  • Fibroblast growth factor 21 mediates specific glucagon actions. 
  • Final analysis of a randomised trial comparing pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory advanced melanoma. 
  • Fine particulate matter air pollution and under-5 children mortality in China: A national time-stratified case-crossover study. 
  • Five-year Survival Prediction and Safety Outcomes with Enzalutamide in Men with Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer from the PREVAIL Trial. 
  • Fluvoxamine-theophylline interaction: gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2. 
  • Functional Incidental Training: applicability and feasibility in the Veterans Affairs nursing home patient population. 
  • Functional incidental training: a randomized, controlled, crossover trial in Veterans Affairs nursing homes. 
  • GLP-1 Receptor Blockade Reduces Stimulated Insulin Secretion in Fasted Subjects With Low Circulating GLP-1. 
  • Glucose and lipid effects of the ileal apical sodium-dependent bile acid transporter inhibitor GSK2330672: double-blind randomized trials with type 2 diabetes subjects taking metformin. 
  • Glycoprotein IIb/IIIa Receptor Inhibitors in Combination With Vorapaxar, a Platelet Thrombin Receptor Antagonist, Among Patients With Non-ST-Segment Elevation Acute Coronary Syndromes (from the TRACER Trial). 
  • Group treatment improves trunk strength and psychological status in older women with vertebral fractures: results of a randomized, clinical trial. 
  • Gut hormone pharmacology of a novel GPR119 agonist (GSK1292263), metformin, and sitagliptin in type 2 diabetes mellitus: results from two randomized studies. 
  • Health-related quality of life and pain with selinexor in patients with advanced dedifferentiated liposarcoma. 
  • High-Frequency Spinal Cord Stimulation at 10 kHz for the Treatment of Nonsurgical Refractory Back Pain: Design of a Pragmatic, Multicenter, Randomized Controlled Trial. 
  • Holding back the sea: the role for maintenance chemotherapy in metastatic breast cancer. 
  • Home Use of an Artificial Beta Cell in Type 1 Diabetes. 
  • Home use of closed-loop insulin delivery for overnight glucose control in adults with type 1 diabetes: a 4-week, multicentre, randomised crossover study. 
  • Hourly Air Pollutants and Acute Coronary Syndrome Onset in 1.29 Million Patients. 
  • Human retinal hemodynamics following administration of 5-isosorbide mononitrate. 
  • Identification of provider characteristics influencing prescription of analgesics: a systematic literature review. 
  • Impact of Antibiotic Stewardship Rounds in the Intensive Care Setting: A Prospective Cluster-Randomized Crossover Study. 
  • Impact of cinematic viewing on endothelial function. 
  • Impact of endovascular simulator training on vascular surgery as a career choice in medical students. 
  • Impact of ozone exposure on heart rate variability and stress hormones: A randomized-crossover study. 
  • Impact of tax and subsidy framed messages on high- and lower-sugar beverages sold in vending machines: a randomized crossover trial. 
  • Impairment and deportment responses to different methylphenidate doses in children with ADHD: the MTA titration trial. 
  • In-hospital costs of coronary stent implantation with and without eptifibatide (the ESPRIT Trial). Enhanced Suppression of the Platelet IIb/IIIa Receptor with Integrilin. 
  • Individual bioequivalence testing under 2x3 designs. 
  • Individual blood pressure responses to changes in salt intake: results from the DASH-Sodium trial. 
  • Influence of Amlodipine on Haemostatic Measurements during Clopidogrel Treatment in Patients with Coronary Artery Disease. 
  • Influence of crossover on mortality in a randomized study of revascularization in patients with systolic heart failure and coronary artery disease. 
  • Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate. 
  • Inhaled fentanyl aerosol in healthy volunteers: pharmacokinetics and pharmacodynamics. 
  • Intra-cluster correlations from the CLustered OUtcome Dataset bank to inform the design of longitudinal cluster trials. 
  • Intravenous Allogeneic Mesenchymal Stem Cells for Nonischemic Cardiomyopathy: Safety and Efficacy Results of a Phase II-A Randomized Trial. 
  • Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis. 
  • Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction. 
  • Lack of effect of increased inspired oxygen concentrations on maximal exercise capacity or ventilation in stable heart failure. 
  • Lack of food effect on single-dose pharmacokinetics of brivanib, and safety and efficacy following multiple doses in subjects with advanced or metastatic solid tumors. 
  • Lack of indinavir effects on methadone disposition despite inhibition of hepatic and intestinal cytochrome P4503A (CYP3A). 
  • Lack of relapse with tryptophan depletion following successful treatment with ECT. 
  • Lack of single-dose disulfiram effects on cytochrome P-450 2C9, 2C19, 2D6, and 3A4 activities: evidence for specificity toward P-450 2E1. 
  • Landing biomechanics are not immediately altered by a single-dose patellar tendon isometric exercise protocol in male athletes with patellar tendinopathy: A single-blinded randomized cross-over trial. 
  • Luteal support with both estradiol and progesterone after clomiphene citrate stimulation for in vitro fertilization. 
  • Macronutrient Regulation of Ghrelin and Peptide YY in Pediatric Obesity and Prader-Willi Syndrome. 
  • Mecamylamine modifies the pharmacokinetics and reinforcing effects of alcohol. 
  • Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics. 
  • Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance. 
  • Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities. 
  • Mechanistic link between right prefrontal cortical activity and anxious arousal revealed using transcranial magnetic stimulation in healthy subjects. 
  • Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity. 
  • Methadone pharmacokinetics are independent of cytochrome P4503A (CYP3A) activity and gastrointestinal drug transport: insights from methadone interactions with ritonavir/indinavir. 
  • Mexiletine for symptoms and signs of myotonia in nondystrophic myotonia: a randomized controlled trial. 
  • Microbiota responses to different prebiotics are conserved within individuals and associated with habitual fiber intake. 
  • Mode equivalence and acceptability of tablet computer-, interactive voice response system-, and paper-based administration of the U.S. National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE). 
  • Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level. 
  • More Evidence for Non-P2Y12-Mediated Effects of Ticagrelor. 
  • Multicenter crossover comparison of the safety and efficacy of Intraglobin-F with Gamimune-N, Sandoglobulin, and Gammagard in patients with primary immunodeficiency diseases. 
  • Near-infrared light therapy to attenuate strength loss after strenuous resistance exercise. 
  • Neuropsychological and psychiatric sequelae of pallidotomy for PD: clinical trial findings. 
  • Neutral effect on markers of heart failure, inflammation, endothelial activation and function, and vagal tone after high-dose HMG-CoA reductase inhibition in non-diabetic patients with non-ischemic cardiomyopathy and average low-density lipoprotein level. 
  • Nonparametric tests for evaluation of biosimilarity in variability of follow-on biologics. 
  • Novel dosing regimen of eptifibatide in planned coronary stent implantation (ESPRIT): a randomised, placebo-controlled trial. 
  • Olanzapine in refractory schizophrenia after failure of typical or atypical antipsychotic treatment: an open-label switch study. 
  • On hybrid parallel-crossover designs for assessing drug interchangeability of biosimilar products. 
  • On power and sample size calculation for QT studies with recording replicates at given time point. 
  • On sample size calculation based on odds ratio in clinical trials. 
  • On sample size calculation in bioequivalence trials. 
  • On statistical analysis for placebo-challenging designs in clinical trials. 
  • On statistical power for average bioequivalence testing under replicated crossover designs. 
  • On the assessment of dose proportionality: a comparison of two slope approaches. 
  • Online Learning and Residents' Acquisition of Mechanical Ventilation Knowledge: Sequencing Matters. 
  • Outcomes following bail-out abciximab administration during primary intervention in acute myocardial infarction (The CADILLAC Trial). 
  • Outcomes in elderly patients with acute coronary syndromes randomized to enoxaparin vs. unfractionated heparin: results from the SYNERGY trial. 
  • Outcomes of bail-out stenting for suboptimal balloon angioplasty during primary intervention in acute myocardial infarction (The CADILLAC trial). 
  • Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: final results from the EGF104900 Study. 
  • Overview of registered studies in orthodontics: Evaluation of the ClinicalTrials.gov registry. 
  • Paper versus web-based administration of the Pelvic Floor Distress Inventory 20 and Pelvic Floor Impact Questionnaire 7. 
  • Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies. 
  • Patient preference in a crossover clinical trial of patients with osteoarthritis of the knee or hip: face validity of self-report questionnaire ratings. 
  • Patient-ventilator synchrony during pressure-targeted versus flow-targeted small tidal volume assisted ventilation. 
  • Patients with asthma demonstrate airway inflammation after exposure to concentrated ambient particulate matter. 
  • Performance, acceptability, and validation of a phone application bowel diary. 
  • Pharmacodynamic efficacy and safety of adjunctive cilostazol loading to clopidogrel and aspirin loading: the results of the ACCEL-LOADING (Accelerated Platelet Inhibition by Cilostazol Loading) study. 
  • Pharmacodynamic evaluation of clopidogrel plus PA32540: the Spaced PA32540 With Clopidogrel Interaction Gauging (SPACING) study. 
  • Pharmacogenetics of methylphenidate response in preschoolers with ADHD. 
  • Pharmacokinetics and bioequivalence of a combined oral formulation of eniluracil, an inactivator of dihydropyrimidine dehydrogenase, and 5-fluorouracil in patients with advanced solid malignancies. 
  • Pharmacokinetics of low and maintenance dose valganciclovir in kidney transplant recipients. 
  • Pharmacokinetics of posaconazole administered orally or by nasogastric tube in healthy volunteers. 
  • Pharmacologic and sensorimotor components of satiation in cigarette smoking. 
  • Phase 2 and 3 clinical trial of oral bexarotene (Targretin capsules) for the treatment of refractory or persistent early-stage cutaneous T-cell lymphoma. 
  • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. 
  • Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation. 
  • Phosphodiesterase 5 inhibition improves beta-cell function in metabolic syndrome. 
  • Photobiomodulation delays the onset of skeletal muscle fatigue in a dose-dependent manner. 
  • Physical Activity, Quality of Life, and Biomarkers in Atrial Fibrillation and Heart Failure With Preserved Ejection Fraction (from the NEAT-HFpEF Trial). 
  • Plantar loading during cutting while wearing a rigid carbon fiber insert. 
  • Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men. 
  • Platelet function measured by VerifyNow identifies generalized high platelet reactivity in aspirin treated patients. 
  • Platelet glycoprotein IIb/IIIa integrin blockade with eptifibatide in coronary stent intervention: the ESPRIT trial: a randomized controlled trial. 
  • Power and sample size requirements for GEE analyses of cluster randomized crossover trials. 
  • Prasugrel 5 mg in the very elderly attenuates platelet inhibition but maintains noninferiority to prasugrel 10 mg in nonelderly patients: the GENERATIONS trial, a pharmacodynamic and pharmacokinetic study in stable coronary artery disease patients. 
  • Predicting methylphenidate response in long-term survivors of childhood cancer: a randomized, double-blind, placebo-controlled, crossover trial. 
  • Predictors and Outcomes of Crossover to Surgery from Physical Therapy for Meniscal Tear and Osteoarthritis: A Randomized Trial Comparing Physical Therapy and Surgery. 
  • Psychedelic effects of ketamine in healthy volunteers: relationship to steady-state plasma concentrations. 
  • Psychosocial aspects of closed- and open-loop insulin delivery: closing the loop in adults with Type 1 diabetes in the home setting. 
  • Pulmonary delivery of nicotine pyruvate: sensory and pharmacokinetic characteristics. 
  • Pulmonary function, bronchial reactivity, and epithelial permeability are response phenotypes to ozone and develop differentially in healthy humans. 
  • QMG and MG-ADL correlations: Study of eculizumab treatment of myasthenia gravis. 
  • Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl. 
  • Randomized Double-Blind Phase II Study of Regorafenib in Patients With Metastatic Osteosarcoma. 
  • Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. 
  • Randomized placebo-controlled crossover trial of tadalafil in Raynaud's phenomenon secondary to systemic sclerosis. 
  • Randomized trial evaluating the effectiveness of within versus across-category front-of-package lower-calorie labelling on food demand. 
  • Randomized trial of lacosamide versus fosphenytoin for nonconvulsive seizures. 
  • Randomized, controlled study of telcagepant in patients with migraine and coronary artery disease. 
  • Randomized, double-blind, placebo-controlled, crossover study of sertraline (Zoloft) for the treatment of hot flashes in women with early stage breast cancer taking tamoxifen. 
  • Randomized, multicenter trial of inhaled nitric oxide and high-frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn. 
  • Randomized, placebo-controlled trial of mixed amphetamine salts for symptoms of comorbid ADHD in pediatric bipolar disorder after mood stabilization with divalproex sodium. 
  • Randomized, placebo-controlled trial of nefazodone maintenance treatment in preventing recurrence in chronic depression. 
  • Ranibizumab for treatment of neovascular age-related macular degeneration: a phase I/II multicenter, controlled, multidose study. 
  • Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir. 
  • Rationale and design of a randomized controlled trial of allogeneic mesenchymal stem cells in patients with nonischemic cardiomyopathy. 
  • Reach out to enhance wellness home-based diet-exercise intervention promotes reproducible and sustainable long-term improvements in health behaviors, body weight, and physical functioning in older, overweight/obese cancer survivors. 
  • Recombinant glucagon-like peptide-1 (7-36 amide) lowers fasting serum glucose in a broad spectrum of patients with type 2 diabetes. 
  • Reduction in antimicrobial use among medical intensive care unit patients during a cluster randomized crossover trial of palliative care consultation. 
  • Remediation of sleep-deprivation-induced working memory impairment with fMRI-guided transcranial magnetic stimulation. 
  • Repetitive transcranial magnetic stimulation to SMA worsens complex movements in Parkinson's disease. 
  • Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study. 
  • Respiratory effects of exposure to diesel traffic in persons with asthma. 
  • Response to ticagrelor in clopidogrel nonresponders and responders and effect of switching therapies: the RESPOND study. 
  • Results from the IQ-CSRC prospective study support replacement of the thorough QT study by QT assessment in the early clinical phase. 
  • Role of CYP2B6 in stereoselective human methadone metabolism. 
  • Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine. 
  • Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone. 
  • Ropinirole 24-hour prolonged release and ropinirole immediate release in early Parkinson's disease: a randomized, double-blind, non-inferiority crossover study. 
  • Safety and efficacy of abciximab combined with dalteparin in treatment of acute coronary syndromes. 
  • Safety and feasibility of magnetic seizure therapy (MST) in major depression: randomized within-subject comparison with electroconvulsive therapy. 
  • Safety of nifedipine in patients with hypertension: a meta-analysis. 
  • Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction. 
  • Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity. 
  • Sertraline as a first-line treatment for cholestatic pruritus. 
  • Sertraline versus imipramine to prevent relapse in chronic depression. 
  • Sex-specific effects of cigarette mentholation on brain nicotine accumulation and smoking behavior. 
  • Sexual activity and cardiovascular disease: a scientific statement from the American Heart Association. 
  • Short-Term Risk of Serious Fall Injuries in Older Adults Initiating and Intensifying Treatment With Antihypertensive Medication. 
  • Short-term efficacy of methylphenidate: a randomized, double-blind, placebo-controlled trial among survivors of childhood cancer. 
  • Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil. 
  • Simultaneous measurement of in vivo P-glycoprotein and cytochrome P450 3A activities. 
  • Single-dose disulfiram does not inhibit CYP2A6 activity. 
  • Single-dose methoxsalen effects on human cytochrome P-450 2A6 activity. 
  • Single-point sampling for assessment of constitutive, induced, and inhibited cytochrome P450 3A activity with alfentanil or midazolam. 
  • Sleep and residual sedation after administration of zaleplon, zolpidem, and placebo during experimental middle-of-the-night awakening. 
  • Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys. 
  • Spaced administration of PA32540 and clopidogrel results in greater platelet inhibition than synchronous administration of enteric-coated aspirin and enteric-coated omeprazole and clopidogrel. 
  • Statistical assessment of QT/QTc prolongation based on maximum of correlated normal random variables. 
  • Statistical methods for assessing interchangeability of biosimilars. 
  • Statistical methods for two-sequence three-period cross-over designs with incomplete data. 
  • Steady-state bioavailability of extended-release methylphenidate (MPH-MLR) capsule vs. immediate-release methylphenidate tablets in healthy adult volunteers. 
  • Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma. 
  • Stereoselective Steady-State Disposition and Bioequivalence of Brand and Generic Bupropion in Adults. 
  • Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity. 
  • Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood. 
  • Temporo-parietal junction stimulation in the treatment of depersonalization disorder. 
  • Testosterone rapidly increases neural reactivity to threat in healthy men: a novel two-step pharmacological challenge paradigm. 
  • Tests for inter-subject and total variabilities under crossover designs. 
  • The Antimicrobial Scrub Contamination and Transmission (ASCOT) Trial: A Three-Arm, Blinded, Randomized Controlled Trial With Crossover Design to Determine the Efficacy of Antimicrobial-Impregnated Scrubs in Preventing Healthcare Provider Contamination. 
  • The DASH diet enhances the blood pressure response to losartan in hypertensive patients. 
  • The Effect of Paging Reminders on Fellowship Conference Attendance: A Multi-Program Randomized Crossover Study. 
  • The Efficacy and Safety of Evekeo, Racemic Amphetamine Sulfate, for Treatment of Attention-Deficit/Hyperactivity Disorder Symptoms: A Multicenter, Dose-Optimized, Double-Blind, Randomized, Placebo-Controlled Crossover Laboratory Classroom Study. 
  • The PESSRI study: symptom relief outcomes of a randomized crossover trial of the ring and Gellhorn pessaries. 
  • The authors reply. 
  • The control group dilemma in clinical research: applications for psychosocial and behavioral medicine trials. 
  • The costs of fatal and non-fatal falls among older adults. 
  • The effect of aprepitant and race on the pharmacokinetics of cyclophosphamide in breast cancer patients. 
  • The effect of aspirin dosing on platelet function in diabetic and nondiabetic patients: an analysis from the aspirin-induced platelet effect (ASPECT) study. 
  • The effect of formulation and food consumption on the bioavailability of dovitinib (TKI258) in patients with advanced solid tumors. 
  • The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone. 
  • The effect of ticagrelor versus clopidogrel on high on-treatment platelet reactivity: combined analysis of the ONSET/OFFSET and RESPOND studies. 
  • The effects of lapatinib on cardiac repolarization: results from a placebo controlled, single sequence, crossover study in patients with advanced solid tumors. 
  • The effects of smoking on levels of endothelial progenitor cells and microparticles in the blood of healthy volunteers. 
  • The electromechanical substrate for response to cardiac resynchronization therapy in patients with right bundle branch block. 
  • The impact of alcohol among injury patients in Moshi, Tanzania: a nested case-crossover study. 
  • The impact of heat exposure on reduced gestational age in pregnant women in North Carolina, 2011-2015. 
  • The impact of intraocular pressure reduction on retinal ganglion cell function measured using pattern electroretinogram in eyes receiving latanoprost 0.005% versus placebo. 
  • The impact of outlying subjects on decision of bioequivalence. 
  • The impact of postrandomization crossover of therapy in acute coronary syndromes care. 
  • The independently fractal nature of respiration and heart rate during exercise under normobaric and hyperbaric conditions. 
  • The influence of red wine or white wine intake on platelet function and viscoelastic property of blood in volunteers. 
  • The influence of smoking status on the pharmacokinetics and pharmacodynamics of clopidogrel and prasugrel: the PARADOX study. 
  • The sleep effects of lurasidone: a placebo-controlled cross-over study using a 4-h phase-advance model of transient insomnia. 
  • The steroid metabolome in women with premenstrual dysphoric disorder during GnRH agonist-induced ovarian suppression: effects of estradiol and progesterone addback. 
  • The treatment of chronic depression, part 1: study design and rationale for evaluating the comparative efficacy of sertraline and imipramine as acute, crossover, continuation, and maintenance phase therapies. 
  • The use of the case-crossover design in studying illicit drug use. 
  • Thoracic spine thrust manipulation for individuals with cervicogenic headache: a crossover randomized clinical trial. 
  • Topical versus oral carbonic anhydrase inhibitor therapy for pediatric glaucoma. 
  • Transcranial Direct Current Stimulation Applied to the Dorsolateral and Ventromedial Prefrontal Cortices in Smokers Modifies Cognitive Circuits Implicated in the Nicotine Withdrawal Syndrome. 
  • Transdermal nicotine attenuates depression symptoms in nonsmokers: a double-blind, placebo-controlled trial. 
  • Treatment crossovers did not affect randomized treatment comparisons in the Mode Selection Trial (MOST). 
  • Twenty-Four-Hour Cardiovascular Effects of Electronic Cigarettes Compared With Cigarette Smoking in Dual Users. 
  • Unsupervised home use of an overnight closed-loop system over 3-4 weeks: a pooled analysis of randomized controlled studies in adults and adolescents with type 1 diabetes. 
  • Use of vagal nerve stimulation as a treatment for refractory epilepsy in dogs. 
  • Usefulness of routine unfractionated heparin infusion following primary percutaneous coronary intervention for acute myocardial infarction in patients not receiving glycoprotein IIb/IIIa inhibitors. 
  • Usefulness of the VerifyNow P2Y12 assay to evaluate the antiplatelet effects of ticagrelor and clopidogrel therapies. 
  • Using observational data to estimate prognosis: an example using a coronary artery disease registry. 
  • Vaginal distribution of Replens and K-Y Jelly using three imaging techniques. 
  • Validation and reliability of a smartphone application for the International Prostate Symptom Score questionnaire: a randomized repeated measures crossover study. 
  • Validation of alternate modes of administration of the lung function questionnaire (LFQ) in subjects with smoking history. 
  • Virtual Reality Analgesia in Labor: The VRAIL Pilot Study-A Preliminary Randomized Controlled Trial Suggesting Benefit of Immersive Virtual Reality Analgesia in Unmedicated Laboring Women. 
  • Virtual reality as a distraction intervention for women receiving chemotherapy. 
• 

  Keywords of People

  • Allen, Nancy Bates, Professor Emeritus of Medicine, Medicine, Rheumatology and Immunology
  • Gold, Deborah T., Professor Emeritus in Psychiatry and Behavioral Sciences, Psychiatry, Child & Family Mental Health & Community Psychiatry
  • Jowell, Paul Simon, Professor of Medicine, Medicine, Gastroenterology
  • Wu, Li-Tzy, Professor in Psychiatry and Behavioral Sciences, Medicine, General Internal Medicine