Cross-Over Studies

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  Subject Areas on Research

  • A 13-week, randomized double-blind, placebo-controlled, cross-over trial of ziprasidone in bipolar spectrum disorder. 
  • A Bayesian approach on sample size calculation for comparing means. 
  • A Crossover Design for Comparative Efficacy: A 36-Week Randomized Trial of Bevacizumab and Ranibizumab for Diabetic Macular Edema. 
  • A Double-Blinded, Randomized, Placebo-Controlled Trial to Evaluate Efficacy, Safety, and Tolerability of Single Doses of Tirasemtiv in Patients with Acetylcholine Receptor-Binding Antibody-Positive Myasthenia Gravis. 
  • A Phase I, Open-Label, Single-Dose Safety, Pharmacokinetic, and Tolerability Study of the Sumatriptan Iontophoretic Transdermal System in Adolescent Migraine Patients. 
  • A Randomized Phase II Crossover Study of Imatinib or Rituximab for Cutaneous Sclerosis after Hematopoietic Cell Transplantation. 
  • A comparison of studies on the effects of controlled exposure to fine, coarse and ultrafine ambient particulate matter from a single location. 
  • A controlled trial of acute effects of human exposure to traffic particles on pulmonary oxidative stress and heart rate variability. 
  • A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults. 
  • A mobile application improves therapy-adherence rates in elderly patients undergoing rehabilitation: A crossover design study comparing documentation via iPad with paper-based control. 
  • A note on sample size calculation for mean comparisons based on noncentral t-statistics. 
  • A phase III extension trial with a 1-arm crossover from leuprolide to degarelix: comparison of gonadotropin-releasing hormone agonist and antagonist effect on prostate cancer. 
  • A pilot phase II randomized, cross-over, double-blinded, controlled efficacy study of octreotide versus hyoscine hydrobromide for control of noisy breathing at the end-of-life. 
  • A pilot study of cerebral and haemodynamic physiological changes during sedation with dexmedetomidine or propofol in patients with acute brain injury. 
  • A prospective, randomized, double-blind comparison of bilateral and right unilateral electroconvulsive therapy at different stimulus intensities. 
  • A randomized comparison of EUS-guided FNA versus CT or US-guided FNA for the evaluation of pancreatic mass lesions. 
  • A randomized crossover study comparing a novel needle guidance technology for simulated internal jugular vein cannulation. 
  • A randomized placebo-controlled double-blind study evaluating the time course of response to methylphenidate hydrochloride extended-release capsules in children with attention-deficit/hyperactivity disorder. 
  • A randomized, controlled study to assess the effect of silk-like textiles and high-absorbency adult incontinence briefs on pressure ulcer prevention. 
  • A randomized, crossover phase 1 study to assess the effects of formulation (capsule vs tablet) and meal consumption on the bioavailability of dovitinib (TKI258). 
  • A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee. 
  • A randomized, double-blind, placebo-controlled phase II study of eculizumab in patients with refractory generalized myasthenia gravis. 
  • A randomized, placebo-controlled trial of early eptifibatide for non-ST-segment elevation acute coronary syndromes. 
  • Accelerometer-Measured Daily Activity in Heart Failure With Preserved Ejection Fraction: Clinical Correlates and Association With Standard Heart Failure Severity Indices. 
  • Adrenergic dysregulation and pain with and without acute beta-blockade in women with fibromyalgia and temporomandibular disorder. 
  • Age moderates the short-term effects of transdermal 17beta-estradiol on endothelium-dependent vascular function in postmenopausal women. 
  • Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. 
  • An exploratory study of the combined effects of orally administered methylphenidate and delta-9-tetrahydrocannabinol (THC) on cardiovascular function, subjective effects, and performance in healthy adults. 
  • Antidepressant response to electroconvulsive therapy is sustained after catecholamine depletion. 
  • Applications of TMS to therapy in psychiatry. 
  • Assessing acute systemic effects of an inhaled drug with serial echocardiography: a placebo-controlled comparison of inhaled and intravenous dihydroergotamine. 
  • Assessing bioequivalence using genomic data. 
  • Baseline plasma GABA: its relationship to the adverse effects of acute lorazepam administration on cognition in the elderly. 
  • Blinded Patient Preference for Morphine Compared to Placebo in the Setting of Chronic Refractory Breathlessness--An Exploratory Study. 
  • Caffeine affects cardiovascular and neuroendocrine activation at work and home. 
  • Caffeine deprivation affects vigilance performance and mood. 
  • Caffeine impairs glucose metabolism in type 2 diabetes. 
  • Caffeine increases ambulatory glucose and postprandial responses in coffee drinkers with type 2 diabetes. 
  • Caffeine raises blood pressure at work. 
  • Can we predict which patients with refractory dyspnea will respond to opioids? 
  • Changes in plantar loading based on shoe type and sex during a jump-landing task. 
  • Chronic transdermal nicotine patch treatment effects on cognitive performance in age-associated memory impairment. 
  • Clinical characteristics and outcomes after unplanned intraaortic balloon counterpulsation in the Counterpulsation to Reduce Infarct Size Pre-PCI Acute Myocardial Infarction trial. 
  • Clinical outcomes of remission induction therapy for severe antineutrophil cytoplasmic antibody-associated vasculitis. 
  • Cocaine use and the occurrence of panic attacks in the community: a case-crossover approach. 
  • Combination insulin and sulfonylurea therapy in insulin-requiring type 2 diabetes mellitus. 
  • Combined catecholamine and indoleamine depletion following response to ECT. 
  • Comparative effectiveness of low- and high-fidelity bronchoscopy simulation for training in conventional transbronchial needle aspiration and user preferences. 
  • Comparative pharmacokinetics of voriconazole administered orally as either crushed or whole tablets. 
  • Comparison of self-expanding and balloon-expandable stents for the reduction of restenosis. 
  • Comparison of the efficacy and safety of arformoterol 15 microg twice daily and arformoterol 30 microg once daily in COPD: a single-dose, multicenter, randomized, modified-blind, two-way crossover study. 
  • Comparison of transbronchial lung biopsy yield between standard forceps and electrocautery hot forceps in swine. 
  • Controlled exposure to diesel exhaust causes increased nitrite in exhaled breath condensate among subjects with asthma. 
  • Culturally-sensitive weight loss program produces significant reduction in weight, blood pressure, and cholesterol in eight weeks. 
  • DHEA metabolism to the neurosteroid androsterone: a possible mechanism of DHEA's antidepressant action. 
  • Dexmedetomidine pharmacodynamics: Part II: Crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers. 
  • Dexmedetomidine pharmacodynamics: part I: crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers. 
  • Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans. 
  • Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. 
  • Differential effects of high-dose magnetic seizure therapy and electroconvulsive shock on cognitive function. 
  • Differential neurophysiological effects of magnetic seizure therapy (MST) and electroconvulsive shock (ECS) in non-human primates. 
  • EUR-1008 pancreatic enzyme replacement is safe and effective in patients with cystic fibrosis and pancreatic insufficiency. 
  • Effect of a high-fiber diet vs a fiber-supplemented diet on C-reactive protein level. 
  • Effect of a single dose of diazepam on balance measures in older people. 
  • Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study. 
  • Effect of citrus juice and SLCO2B1 genotype on the pharmacokinetics of montelukast. 
  • Effect of low versus high dialysate sodium concentration on blood pressure and endothelial-derived vasoregulators during hemodialysis: a randomized crossover study. 
  • Effect of simultaneous didanosine administration on itraconazole absorption in healthy volunteers. 
  • Effect of telcagepant on spontaneous ischemia in cardiovascular patients in a randomized study. 
  • Effect of virtual reality on time perception in patients receiving chemotherapy. 
  • Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment. 
  • Effectiveness of olanzapine, quetiapine, risperidone, and ziprasidone in patients with chronic schizophrenia following discontinuation of a previous atypical antipsychotic. 
  • Effects of concurrent use of an ankle support with a laterally wedged insole for medial knee osteoarthritis. 
  • Effects of lisdexamfetamine dimesylate treatment for ADHD on growth. 
  • Effects of low-dose morphine on perceived sleep quality in patients with refractory breathlessness: A hypothesis generating study. 
  • Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure. 
  • Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group. 
  • Efficacy and Tolerability of Evolocumab vs Ezetimibe in Patients With Muscle-Related Statin Intolerance: The GAUSS-3 Randomized Clinical Trial. 
  • Efficacy and safety of enoxaparin compared with unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention in the Superior Yield of the New Strategy of Enoxaparin, Revascularization and Glycoprotein IIb/IIIa Inhibitors (SYNERGY) trial. 
  • Efficacy of olanzapine and risperidone in schizophrenia: a randomized double-blind crossover design. 
  • Efficacy, safety and survival with ruxolitinib in patients with myelofibrosis: results of a median 2-year follow-up of COMFORT-I. 
  • Electrocardiographic safety of cangrelor, a new intravenous antiplatelet agent: a randomized, double-blind, placebo- and moxifloxacin-controlled thorough QT study. 
  • Emotional antecedents of hot flashes during daily life. 
  • Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) study. 
  • Examining outlying subjects and outlying records in bioequivalence trials. 
  • Exenatide Protects Against Glucose- and Lipid-Induced Endothelial Dysfunction: Evidence for Direct Vasodilation Effect of GLP-1 Receptor Agonists in Humans. 
  • Exposure to concentrated coarse air pollution particles causes mild cardiopulmonary effects in healthy young adults. 
  • Fibroblast growth factor 21 mediates specific glucagon actions. 
  • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. 
  • Footwear and running cardio-respiratory responses. 
  • Functional Incidental Training: applicability and feasibility in the Veterans Affairs nursing home patient population. 
  • Functional incidental training: a randomized, controlled, crossover trial in Veterans Affairs nursing homes. 
  • Glycoprotein IIb/IIIa Receptor Inhibitors in Combination With Vorapaxar, a Platelet Thrombin Receptor Antagonist, Among Patients With Non-ST-Segment Elevation Acute Coronary Syndromes (from the TRACER Trial). 
  • Group treatment improves trunk strength and psychological status in older women with vertebral fractures: results of a randomized, clinical trial. 
  • Gut hormone pharmacology of a novel GPR119 agonist (GSK1292263), metformin, and sitagliptin in type 2 diabetes mellitus: results from two randomized studies. 
  • Improvements in distal lung function correlate with asthma symptoms after treatment with oral montelukast. 
  • In-hospital costs of coronary stent implantation with and without eptifibatide (the ESPRIT Trial). Enhanced Suppression of the Platelet IIb/IIIa Receptor with Integrilin. 
  • Individual bioequivalence testing under 2x3 designs. 
  • Individual blood pressure responses to changes in salt intake: results from the DASH-Sodium trial. 
  • Inhaled fentanyl aerosol in healthy volunteers: pharmacokinetics and pharmacodynamics. 
  • Intravenous Allogeneic Mesenchymal Stem Cells for Nonischemic Cardiomyopathy: Safety and Efficacy Results of a Phase II-A Randomized Trial. 
  • Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction. 
  • Lack of effect of increased inspired oxygen concentrations on maximal exercise capacity or ventilation in stable heart failure. 
  • Lack of effect of ondansetron on the pharmacokinetics and analgesic effects of morphine and metabolites after single-dose morphine administration in healthy volunteers. 
  • Lack of relapse with tryptophan depletion following successful treatment with ECT. 
  • Long-term tolerability and efficacy of degarelix: 5-year results from a phase III extension trial with a 1-arm crossover from leuprolide to degarelix. 
  • Luteal support with both estradiol and progesterone after clomiphene citrate stimulation for in vitro fertilization. 
  • Macronutrient Regulation of Ghrelin and Peptide YY in Pediatric Obesity and Prader-Willi Syndrome. 
  • Multicenter crossover comparison of the safety and efficacy of Intraglobin-F with Gamimune-N, Sandoglobulin, and Gammagard in patients with primary immunodeficiency diseases. 
  • Neutral effect on markers of heart failure, inflammation, endothelial activation and function, and vagal tone after high-dose HMG-CoA reductase inhibition in non-diabetic patients with non-ischemic cardiomyopathy and average low-density lipoprotein level. 
  • Nonparametric tests for evaluation of biosimilarity in variability of follow-on biologics. 
  • On sample size calculation based on odds ratio in clinical trials. 
  • On sample size calculation in bioequivalence trials. 
  • On statistical analysis for placebo-challenging designs in clinical trials. 
  • On statistical power for average bioequivalence testing under replicated crossover designs. 
  • Outcomes following bail-out abciximab administration during primary intervention in acute myocardial infarction (The CADILLAC Trial). 
  • Outcomes in elderly patients with acute coronary syndromes randomized to enoxaparin vs. unfractionated heparin: results from the SYNERGY trial. 
  • Outcomes of bail-out stenting for suboptimal balloon angioplasty during primary intervention in acute myocardial infarction (The CADILLAC trial). 
  • Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: final results from the EGF104900 Study. 
  • Patient-ventilator synchrony during pressure-targeted versus flow-targeted small tidal volume assisted ventilation. 
  • Patients with asthma demonstrate airway inflammation after exposure to concentrated ambient particulate matter. 
  • Pharmacodynamic efficacy and safety of adjunctive cilostazol loading to clopidogrel and aspirin loading: the results of the ACCEL-LOADING (Accelerated Platelet Inhibition by Cilostazol Loading) study. 
  • Pharmacodynamic evaluation of clopidogrel plus PA32540: the Spaced PA32540 With Clopidogrel Interaction Gauging (SPACING) study. 
  • Pharmacokinetics and bioequivalence of a combined oral formulation of eniluracil, an inactivator of dihydropyrimidine dehydrogenase, and 5-fluorouracil in patients with advanced solid malignancies. 
  • Pharmacologic and sensorimotor components of satiation in cigarette smoking. 
  • Phosphodiesterase 5 inhibition improves beta-cell function in metabolic syndrome. 
  • Photobiomodulation delays the onset of skeletal muscle fatigue in a dose-dependent manner. 
  • Plantar loading during cutting while wearing a rigid carbon fiber insert. 
  • Platelet function measured by VerifyNow identifies generalized high platelet reactivity in aspirin treated patients. 
  • Platelet glycoprotein IIb/IIIa integrin blockade with eptifibatide in coronary stent intervention: the ESPRIT trial: a randomized controlled trial. 
  • Prasugrel 5 mg in the very elderly attenuates platelet inhibition but maintains noninferiority to prasugrel 10 mg in nonelderly patients: the GENERATIONS trial, a pharmacodynamic and pharmacokinetic study in stable coronary artery disease patients. 
  • Pulmonary delivery of nicotine pyruvate: sensory and pharmacokinetic characteristics. 
  • Pulmonary function, bronchial reactivity, and epithelial permeability are response phenotypes to ozone and develop differentially in healthy humans. 
  • QMG and MG-ADL correlations: Study of eculizumab treatment of myasthenia gravis. 
  • Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea. 
  • Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. 
  • Randomized crossover trial comparing the eZ.on plastic condom and a latex condom. 
  • Randomized placebo-controlled crossover trial of tadalafil in Raynaud's phenomenon secondary to systemic sclerosis. 
  • Randomized, controlled study of telcagepant in patients with migraine and coronary artery disease. 
  • Randomized, double-blind, placebo-controlled, crossover study of sertraline (Zoloft) for the treatment of hot flashes in women with early stage breast cancer taking tamoxifen. 
  • Randomized, multicenter trial of inhaled nitric oxide and high-frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn. 
  • Ranibizumab for treatment of neovascular age-related macular degeneration: a phase I/II multicenter, controlled, multidose study. 
  • Rationale and design of a randomized controlled trial of allogeneic mesenchymal stem cells in patients with nonischemic cardiomyopathy. 
  • Reach out to enhance wellness home-based diet-exercise intervention promotes reproducible and sustainable long-term improvements in health behaviors, body weight, and physical functioning in older, overweight/obese cancer survivors. 
  • Recombinant glucagon-like peptide-1 (7-36 amide) lowers fasting serum glucose in a broad spectrum of patients with type 2 diabetes. 
  • Remediation of sleep-deprivation-induced working memory impairment with fMRI-guided transcranial magnetic stimulation. 
  • Repetitive transcranial magnetic stimulation to SMA worsens complex movements in Parkinson's disease. 
  • Respiratory effects of exposure to diesel traffic in persons with asthma. 
  • Response to ticagrelor in clopidogrel nonresponders and responders and effect of switching therapies: the RESPOND study. 
  • Results from the IQ-CSRC prospective study support replacement of the thorough QT study by QT assessment in the early clinical phase. 
  • Safety and feasibility of magnetic seizure therapy (MST) in major depression: randomized within-subject comparison with electroconvulsive therapy. 
  • Safety of nifedipine in patients with hypertension: a meta-analysis. 
  • Sex-specific effects of cigarette mentholation on brain nicotine accumulation and smoking behavior. 
  • Short-term efficacy of methylphenidate: a randomized, double-blind, placebo-controlled trial among survivors of childhood cancer. 
  • Spaced administration of PA32540 and clopidogrel results in greater platelet inhibition than synchronous administration of enteric-coated aspirin and enteric-coated omeprazole and clopidogrel. 
  • Statistical methods for two-sequence three-period cross-over designs with incomplete data. 
  • Steady-state bioavailability of extended-release methylphenidate (MPH-MLR) capsule vs. immediate-release methylphenidate tablets in healthy adult volunteers. 
  • Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood. 
  • Testosterone rapidly increases neural reactivity to threat in healthy men: a novel two-step pharmacological challenge paradigm. 
  • Tests for inter-subject and total variabilities under crossover designs. 
  • The DASH diet enhances the blood pressure response to losartan in hypertensive patients. 
  • The Effect of Paging Reminders on Fellowship Conference Attendance: A Multi-Program Randomized Crossover Study. 
  • The Efficacy and Safety of Evekeo, Racemic Amphetamine Sulfate, for Treatment of Attention-Deficit/Hyperactivity Disorder Symptoms: A Multicenter, Dose-Optimized, Double-Blind, Randomized, Placebo-Controlled Crossover Laboratory Classroom Study. 
  • The PESSRI study: symptom relief outcomes of a randomized crossover trial of the ring and Gellhorn pessaries. 
  • The effect of aspirin dosing on platelet function in diabetic and nondiabetic patients: an analysis from the aspirin-induced platelet effect (ASPECT) study. 
  • The effect of body inclination during prone positioning on intraocular pressure in awake volunteers: a comparison of two operating tables. 
  • The effect of formulation and food consumption on the bioavailability of dovitinib (TKI258) in patients with advanced solid tumors. 
  • The effect of ticagrelor versus clopidogrel on high on-treatment platelet reactivity: combined analysis of the ONSET/OFFSET and RESPOND studies. 
  • The effects of smoking on levels of endothelial progenitor cells and microparticles in the blood of healthy volunteers. 
  • The impact of postrandomization crossover of therapy in acute coronary syndromes care. 
  • The independently fractal nature of respiration and heart rate during exercise under normobaric and hyperbaric conditions. 
  • The influence of smoking status on the pharmacokinetics and pharmacodynamics of clopidogrel and prasugrel: the PARADOX study. 
  • The use of the case-crossover design in studying illicit drug use. 
  • Topical versus oral carbonic anhydrase inhibitor therapy for pediatric glaucoma. 
  • Transdermal nicotine attenuates depression symptoms in nonsmokers: a double-blind, placebo-controlled trial. 
  • Treatment crossovers did not affect randomized treatment comparisons in the Mode Selection Trial (MOST). 
  • Treatment of hereditary angioedema with a vapor-heated C1 inhibitor concentrate. 
  • Use of vagal nerve stimulation as a treatment for refractory epilepsy in dogs. 
  • Usefulness of routine unfractionated heparin infusion following primary percutaneous coronary intervention for acute myocardial infarction in patients not receiving glycoprotein IIb/IIIa inhibitors. 
  • Usefulness of the VerifyNow P2Y12 assay to evaluate the antiplatelet effects of ticagrelor and clopidogrel therapies. 
  • Using observational data to estimate prognosis: an example using a coronary artery disease registry. 
  • Virtual reality as a distraction intervention for women receiving chemotherapy. 
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  Keywords of People

  • Allen, Nancy Bates, Professor of Medicine, Medicine, Rheumatology and Immunology
  • Gold, Deborah T., Professor in Psychiatry and Behavioral Sciences, Psychology and Neuroscience
  • Jowell, Paul Simon, Professor of Medicine, Medicine, Gastroenterology
  • Wu, Li-Tzy, Professor in Psychiatry and Behavioral Sciences, Medicine, General Internal Medicine