Microscopy, Confocal

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  Subject Areas on Research

  • A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation. 
  • A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation. 
  • A broad competence to respond to SHORT ROOT revealed by tissue-specific ectopic expression. 
  • A compact CMOS biochip immunosensor towards the detection of a single bacteria. 
  • A cut above the other caspases. 
  • A microfluidic device and computational platform for high-throughput live imaging of gene expression. 
  • A model of giant vacuole dynamics in human Schlemm's canal endothelial cells. 
  • A novel imaging method for quantitative Golgi localization reveals differential intra-Golgi trafficking of secretory cargoes. 
  • A novel role for XIAP in copper homeostasis through regulation of MURR1. 
  • A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models. 
  • A prominent role of the flagellin receptor FLAGELLIN-SENSING2 in mediating stomatal response to Pseudomonas syringae pv tomato DC3000 in Arabidopsis. 
  • A role for myocilin in receptor-mediated endocytosis. 
  • A system for the direct co-culture of endothelium on smooth muscle cells. 
  • A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics. 
  • AAV Gene Therapy for MPS1-associated Corneal Blindness. 
  • AJAP1 is dysregulated at an early stage of gliomagenesis and suppresses invasion through cytoskeleton reorganization. 
  • ARF1 regulates Nef-induced CD4 degradation. 
  • Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits. 
  • Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation. 
  • Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. 
  • Activation of NAD(P)H oxidase by lipid hydroperoxides: mechanism of oxidant-mediated smooth muscle cytotoxicity. 
  • Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells. 
  • Adult c-Kit(+) progenitor cells are necessary for maintenance and regeneration of olfactory neurons. 
  • Advances in the management of conjunctival melanoma. 
  • Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration. 
  • Altered regulation of brain-derived neurotrophic factor protein in hippocampus following slice preparation. 
  • An enteroendocrine cell-enteric glia connection revealed by 3D electron microscopy. 
  • An in vivo look at vertebrate liver architecture: three-dimensional reconstructions from medaka (Oryzias latipes). 
  • An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses. 
  • Anatomy and spatial organization of Müller glia in mouse retina. 
  • Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons. 
  • Antibody-targeted photodynamic therapy. 
  • Apical and basolateral endocytic pathways of MDCK cells meet in acidic common endosomes distinct from a nearly-neutral apical recycling endosome. 
  • Apoptotic force and tissue dynamics during Drosophila embryogenesis. 
  • Apparent elastic modulus and hysteresis of skeletal muscle cells throughout differentiation. 
  • Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver. 
  • Aquaporin-1 channels in human retinal pigment epithelium: role in transepithelial water movement. 
  • Aquaporin-1 expression and conventional aqueous outflow in human eyes. 
  • Arabidopsis calcium-dependent protein kinase 3 regulates actin cytoskeleton organization and immunity. 
  • Astrocytes refine cortical connectivity at dendritic spines. 
  • Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS. 
  • Attenuation of acid induced oesophagitis in VR-1 deficient mice. 
  • Automated Recognition of Retinal Pigment Epithelium Cells on Limited Training Samples Using Neural Networks. 
  • Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. 
  • Bacterial-induced cell fusion is a danger signal triggering cGAS-STING pathway via micronuclei formation. 
  • Barnacle biology before, during and after settlement and metamorphosis: a study of the interface. 
  • Beta-arrestin-mediated localization of smoothened to the primary cilium. 
  • Beta2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains. 
  • Biocatalytic microcontact printing. 
  • Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. 
  • Brain-derived neurotrophic factor but not vesicular zinc promotes TrkB activation within mossy fibers of mouse hippocampus in vivo. 
  • C-reactive protein activates the nuclear factor-kappaB signal transduction pathway in saphenous vein endothelial cells: implications for atherosclerosis and restenosis. 
  • CD90(+) stromal cells are the major source of IL-6, which supports cancer stem-like cells and inflammation in colorectal cancer. 
  • COMMD proteins, a novel family of structural and functional homologs of MURR1. 
  • CX3CR1 deficiency impairs dendritic cell accumulation in arterial intima and reduces atherosclerotic burden. 
  • Cadmium- and chromium-induced oxidative stress, DNA damage, and apoptotic cell death in cultured human chronic myelogenous leukemic K562 cells, promyelocytic leukemic HL-60 cells, and normal human peripheral blood mononuclear cells. 
  • Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis. 
  • Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. 
  • Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII. 
  • Central and peripheral expression of galanin in response to inflammation. 
  • Centrosome and spindle function of the Drosophila Ncd microtubule motor visualized in live embryos using Ncd-GFP fusion proteins. 
  • Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis. 
  • Chaperone-mediated 26S proteasome remodeling facilitates free K63 ubiquitin chain production and aggresome clearance. 
  • Characterization of Artifacts Associated With Multicolor Confocal Scanning Laser Ophthalmoscopy. 
  • Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia. 
  • Chromosome segregation. Programmed to stay together. 
  • Circumferential tensile stiffness of glaucomatous trabecular meshwork. 
  • Clustering of voltage-sensitive sodium channels on axons is independent of direct Schwann cell contact in the dystrophic mouse. 
  • Coiled-coil targeting of myocilin to intracellular membranes. 
  • Comparative analysis of peritoneum and tumor eicosanoids and pathways in advanced ovarian cancer. 
  • Concerted use of immunologic and ultrastructural analyses in diagnostic medicine: immunoelectron microscopy and correlative microscopy. 
  • Conditional root expansion mutants of Arabidopsis. 
  • Confocal imaging of intracellular chloride in living brain slices: measurement of GABAA receptor activity. 
  • Confocal microscopy-based goniometry of barnacle cyprid permanent adhesive. 
  • Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling. 
  • Correlative Confocal and 3D Electron Microscopy of a Specific Sensory Cell. 
  • Cortical granule exocytosis is triggered by different thresholds of calcium during fertilisation in sea urchin eggs. 
  • Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa. 
  • Cse1l is a negative regulator of CFTR-dependent fluid secretion. 
  • Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics. 
  • Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans. 
  • Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice. 
  • Cytokine deposition alters leukocyte morphology and initial recruitment of monocytes and γδT cells after corneal injury. 
  • Cytoskeletal dependence of adenosine triphosphate release by human trabecular meshwork cells. 
  • Cytosolic delivery of macromolecules. II. Mechanistic studies with pH-sensitive morpholine lipids. 
  • Deconstructing Pompe disease by analyzing single muscle fibers: to see a world in a grain of sand.. 
  • Deep hypothermia markedly activates the small ubiquitin-like modifier conjugation pathway; implications for the fate of cells exposed to transient deep hypothermic cardiopulmonary bypass. 
  • Definition of distinct compartments in polarized Madin-Darby canine kidney (MDCK) cells for membrane-volume sorting, polarized sorting and apical recycling. 
  • Depletion of passenger leukocytes from corneal grafts: an effective means of promoting transplant survival? 
  • Development of polyploidy of scale-building cells in the wings of Manduca sexta. 
  • Differences in Outflow Facility Between Angiographically Identified High- Versus Low-Flow Regions of the Conventional Outflow Pathways in Porcine Eyes. 
  • Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells. 
  • Differential Roles of Phospholipase D Proteins in FcεRI-Mediated Signaling and Mast Cell Function. 
  • Differential dynamics and activity-dependent regulation of alpha- and beta-neurexins at developing GABAergic synapses. 
  • Differential maturation and subcellular localization of severe acute respiratory syndrome coronavirus surface proteins S, M and E. 
  • Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics. 
  • Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. 
  • Distribution, spherical structure and predicted Mie scattering of multilamellar bodies in human age-related nuclear cataracts. 
  • Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone. 
  • Dual-wavelength pump-probe microscopy analysis of melanin composition. 
  • Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch. 
  • EUS and confocal endomicroscopic diagnosis of pancreatic acinar cell cystadenoma. 
  • Effect of cytofectins on the immune response of murine macrophages to mammalian DNA. 
  • Effect of pulmonary surfactant on the dissolution, stability and uptake of zinc oxide nanowires by human respiratory epithelial cells. 
  • Effects of Cell-Based Therapy for Treating Tympanic Membrane Perforations in Mice. 
  • Effects of cardiotonic steroids on trabecular meshwork cells: search for mediator of ouabain-enhanced outflow facility. 
  • Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology. 
  • Electric field-mediated transport of plasmid DNA in tumor interstitium in vivo. 
  • Electric fields and MAP kinase signaling can regulate early wound healing in lens epithelium. 
  • Electron microscopic diagnosis of human flavivirus encephalitis: use of confocal microscopy as an aid. 
  • Emergent properties during dorsal closure in Drosophila morphogenesis. 
  • Enhanced green fluorescent protein as a marker for localizing murine cytomegalovirus in acute and latent infection. 
  • Enhanced uptake of a thermally responsive polypeptide by tumor cells in response to its hyperthermia-mediated phase transition. 
  • Error-prone polyploid mitosis during normal Drosophila development. 
  • Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERα signaling on astrocytes but not through ERβ signaling on astrocytes or neurons. 
  • Evaluation of an elastin-like polypeptide-doxorubicin conjugate for cancer therapy. 
  • Expanded polyglutamine domain proteins bind neurofilament and alter the neurofilament network. 
  • Fabrication of multifaceted, micropatterned surfaces and image-guided patterning using laser scanning lithography. 
  • Fate Mapping In Vivo to Distinguish Bona Fide Microglia Versus Recruited Monocyte-Derived Macrophages in Retinal Disease. 
  • Fibronectin isoforms in megakaryocytes. 
  • Flow Cytometric Analysis of Myeloid Cells in Human Blood, Bronchoalveolar Lavage, and Lung Tissues. 
  • Fluorescence imaging of blood-brain barrier disruption. 
  • Fluorescence imaging of changes in intracellular chloride in living brain slices. 
  • Forces for morphogenesis investigated with laser microsurgery and quantitative modeling. 
  • Full-field swept-source phase microscopy. 
  • G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation. 
  • GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling. 
  • Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide. 
  • Genome-wide direct target analysis reveals a role for SHORT-ROOT in root vascular patterning through cytokinin homeostasis. 
  • Glycosylphosphatidylinositol (GPI) Modification Serves as a Primary Plasmodesmal Sorting Signal. 
  • Growth factor induced activation of Rho and Rac GTPases and actin cytoskeletal reorganization in human lens epithelial cells. 
  • High-affinity augmentation of endothelial cell attachment: long-term effects on focal contact and actin filament formation. 
  • High-content imaging-based screening of microenvironment-induced changes to stem cells. 
  • High-resolution, noninvasive longitudinal live imaging of immune responses. 
  • Identification of BfmR, a response regulator involved in biofilm development, as a target for a 2-Aminoimidazole-based antibiofilm agent. 
  • Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions. 
  • Identification of focal viral infections by confocal microscopy for subsequent ultrastructural analysis. 
  • Identification of genes expressed in the Xenopus inner ear. 
  • Identification of nonvisual photomotor response cells in the vertebrate hindbrain. 
  • Identification of viral infection by confocal microscopy. 
  • Imaging Escherichia coli using functionalized core/shell CdSe/CdS quantum dots. 
  • Imaging microscopic pigment chemistry in conjunctival melanocytic lesions using pump-probe laser microscopy. 
  • Imaging primary mouse sarcomas after radiation therapy using cathepsin-activatable fluorescent imaging agents. 
  • Imaging synaptic inhibition in transgenic mice expressing the chloride indicator, Clomeleon. 
  • Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon. 
  • Imaging the behavior of molecules in biological systems: breaking the 3D speed barrier with 3D multi-resolution microscopy. 
  • Immuno-characterization of the switch of peptide elongation factors eEF1A-1/EF-1alpha and eEF1A-2/S1 in the central nervous system during mouse development. 
  • Impairment of Tissue-Resident Mesenchymal Stem Cells in Chronic Ulcerative Colitis and Crohn's Disease. 
  • In Vivo Confocal Microscopy Evaluation of Microbial Keratitis. 
  • In vivo gene delivery and visualization of corneal stromal cells using an adenoviral vector and keratocyte-specific promoter. 
  • In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment. 
  • In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma. 
  • In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptide. 
  • Incomplete MyoD-induced transdifferentiation is associated with chromatin remodeling deficiencies. 
  • Incorporation of active DNA/cationic polymer polyplexes into hydrogel scaffolds 
  • Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans. 
  • Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation. 
  • Increasing atmospheric CO2 reduces metabolic and physiological differences between isoprene- and non-isoprene-emitting poplars. 
  • Indispensable pre-mitotic endocycles promote aneuploidy in the Drosophila rectum. 
  • Inhibition of integrative repair of the meniscus following acute exposure to interleukin-1 in vitro. 
  • Initiation of allelic exclusion by stochastic interaction of Tcrb alleles with repressive nuclear compartments. 
  • Innovations in Intraoperative Tumor Visualization. 
  • Insulin-triggered repositioning of munc18c on syntaxin-4 in GLUT4 signalling. 
  • Interleukin-1 and tumor necrosis factor alpha inhibit repair of the porcine meniscus in vitro. 
  • Interleukin-1, tumor necrosis factor-alpha, and transforming growth factor-beta 1 and integrative meniscal repair: influences on meniscal cell proliferation and migration. 
  • Interplay between SCARECROW, GA and LIKE HETEROCHROMATIN PROTEIN 1 in ground tissue patterning in the Arabidopsis root. 
  • Involvement of cellular caveolae in bacterial entry into mast cells. 
  • Involvement of corneal lymphangiogenesis in a mouse model of allergic eye disease. 
  • Ionic liquid-assisted PDMS microchannel modification for efficiently resolving fluorescent dye and protein adsorption. 
  • Isolated chondrons: a viable alternative for studies of chondrocyte metabolism in vitro. 
  • Isolation of oligodendrocyte-like cells from human umbilical cord blood. 
  • Kinetic-dependent Killing of Oral Pathogens with Nitric Oxide. 
  • Label-free in vivo optical imaging of microvasculature and oxygenation level. 
  • Large Cellular Inclusions Accumulate in Arabidopsis Roots Exposed to Low-Sulfur Conditions. 
  • Large-scale quantitative LC-MS/MS analysis of detergent-resistant membrane proteins from rat renal collecting duct. 
  • Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline. 
  • Laser-scanning lithography (LSL) for the soft lithographic patterning of cell-adhesive self-assembled monolayers. 
  • Laser-scanning velocimetry: a confocal microscopy method for quantitative measurement of cardiovascular performance in zebrafish embryos and larvae. 
  • Left ventricular hypertrophy in ascending aortic stenosis mice: anoikis and the progression to early failure. 
  • Life-cycle effects of single-walled carbon nanotubes (SWNTs) on an estuarine meiobenthic copepod. 
  • Lithographic patterning of photoreactive cell-adhesive proteins. 
  • Live-cell confocal microscopy and quantitative 4D image analysis of anchor-cell invasion through the basement membrane in Caenorhabditis elegans. 
  • Localization of brain-derived neurotrophic factor to distinct terminals of mossy fiber axons implies regulation of both excitation and feedforward inhibition of CA3 pyramidal cells. 
  • Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations. 
  • Low-cost, scalable laser scanning module for real-time reflectance and fluorescence confocal microscopy. 
  • Mast cell activation by Mycobacterium tuberculosis: mediator release and role of CD48. 
  • Measurement of chloride movement in neuronal preparations. 
  • Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics 
  • Mechanical homeostasis is altered in uterine leiomyoma. 
  • Mechanism of Dual Targeting of the Phytochrome Signaling Component HEMERA/pTAC12 to Plastids and the Nucleus. 
  • Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow. 
  • Mechanisms regulating SHORT-ROOT intercellular movement. 
  • Mechanoactivation of the angiotensin II type 1 receptor induces β-arrestin-biased signaling through Gαi coupling. 
  • Methods of Melanoma Detection. 
  • Micro-anatomical quantitative optical imaging: toward automated assessment of breast tissues. 
  • Microscale diffusion properties of the cartilage pericellular matrix measured using 3D scanning microphotolysis. 
  • Microtubule treadmilling in vitro investigated by fluorescence speckle and confocal microscopy. 
  • Mie light scattering calculations for an Indian age-related nuclear cataract with a high density of multilamellar bodies. 
  • Mimicking brain tumor-vasculature microanatomical architecture via co-culture of brain tumor and endothelial cells in 3D hydrogels. 
  • Mitochondrial FtsZ in a chromophyte alga 
  • Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions. 
  • Modular nanotransporters: a multipurpose in vivo working platform for targeted drug delivery. 
  • Modulation of phagosome biogenesis by Legionella pneumophila creates an organelle permissive for intracellular growth. 
  • Modulation of the GABA(A)-gated chloride channel by reactive oxygen species. 
  • Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*. 
  • Multilamellar bodies as potential scattering particles in human age-related nuclear cataracts. 
  • Multimodal optical and Gd-based nanoparticles for imaging in inflammatory arthritis. 
  • Multiple forces contribute to cell sheet morphogenesis for dorsal closure in Drosophila. 
  • Muscarinic acetylcholine receptors in macaque V1 are most frequently expressed by parvalbumin-immunoreactive neurons. 
  • Myocardial NF-κB activation is essential for zebrafish heart regeneration. 
  • Myocardial volume and organization are changed by failure of addition of secondary heart field myocardium to the cardiac outflow tract. 
  • Myosin VIIA defects, which underlie the Usher 1B syndrome in humans, lead to deafness in Drosophila. 
  • Near-infrared optical imaging of B16 melanoma cells via low-density lipoprotein-mediated uptake and delivery of high emission dipole strength tris[(porphinato)zinc(II)] fluorophores. 
  • Near-infrared-emissive polymersomes: self-assembled soft matter for in vivo optical imaging. 
  • Nelfinavir inhibits maturation and export of herpes simplex virus 1. 
  • Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. 
  • Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice. 
  • Nitric oxide-releasing silica nanoparticle inhibition of ovarian cancer cell growth. 
  • Non invasive high resolution in vivo imaging of alpha-naphthylisothiocyanate (ANIT) induced hepatobiliary toxicity in STII medaka. 
  • Nonmuscle myosin II generates forces that transmit tension and drive contraction in multiple tissues during dorsal closure. 
  • Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis. 
  • Novel delivery of oligonucleotides using a topical hydrogel tissue sealant in a murine partial nephrectomy model. 
  • Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo. 
  • Nuclear transport kinetics in microarrays of nuclear envelope patches. 
  • Observations on the growth of loose bodies in joints. 
  • Ontology-guided segmentation and object identification for developmental mouse lung immunofluorescent images. 
  • Optical aberrations and objective choice in multicolor confocal microscopy. 
  • Optical imaging of hippocampal neurons with a chloride-sensitive dye: early effects of in vitro ischemia. 
  • Optical imaging of intracellular chloride in living brain slices. 
  • Optical imaging of living brain slices. 
  • Optical imaging reveals elevated intracellular chloride in hippocampal pyramidal neurons after oxidative stress. 
  • Optimization of confocal scanning laser ophthalmoscope design. 
  • Osmotic loading to determine the intrinsic material properties of guinea pig knee cartilage. 
  • Osteoblasts express the inflammatory cytokine interleukin-6 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissue. 
  • Osteoblasts produce monocyte chemoattractant protein-1 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissue. 
  • Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors. 
  • Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity. 
  • Overexpression of cell surface cytokeratin 8 in multidrug-resistant MCF-7/MX cells enhances cell adhesion to the extracellular matrix. 
  • PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complex. 
  • Patterning cells in highly deformable microstructures: effect of plastic deformation of substrate on cellular phenotype and gene expression. 
  • Peptide-derivatized shell-cross-linked nanoparticles. 1. Synthesis and characterization. 
  • Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling. 
  • Performance comparison between the high-speed Yokogawa spinning disc confocal system and single-point scanning confocal systems. 
  • Pericyte-like location of GFP-tagged melanoma cells: ex vivo and in vivo studies of extravascular migratory metastasis. 
  • Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons. 
  • Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2. 
  • Persistence of zinc-binding bacterial superantigens at the surface of antigen-presenting cells contributes to the extreme potency of these superantigens as T-cell activators. 
  • Phase separation behavior of fusidic acid and rifampicin in PLGA microspheres. 
  • Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. 
  • Physiology of neuronal subtypes in the respiratory-vocal integration nucleus retroamigualis of the male zebra finch. 
  • Piezo-assisted nuclear transfer affects cloning efficiency and may cause apoptosis. 
  • Poly(ethylene glycol) hydrogels conjugated with a collagenase-sensitive fluorogenic substrate to visualize collagenase activity during three-dimensional cell migration. 
  • Porphyromonas gingivalis-mediated Epithelial Cell Entry of HIV-1. 
  • Postsynaptic positioning of endocytic zones and AMPA receptor cycling by physical coupling of dynamin-3 to Homer. 
  • Primary mesenchyme cell patterning during the early stages following ingression. 
  • Prostaglandin F2 alpha receptors in the human trabecular meshwork. 
  • Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network. 
  • Protein kinase C isoforms in human aortic smooth muscle cells. 
  • Proteolytically degradable hydrogels with a fluorogenic substrate for studies of cellular proteolytic activity and migration. 
  • Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity. 
  • Protonophore- and pH-insensitive glucose and sucrose accumulation detected by FRET nanosensors in Arabidopsis root tips. 
  • Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin-2. 
  • Quantification of transcription factor expression from Arabidopsis images. 
  • Quantifying cellular traction forces in three dimensions. 
  • Quantitative analysis of Pc 4 localization in mouse lymphoma (LY-R) cells via double-label confocal fluorescence microscopy. 
  • Quantitative laser scanning confocal autofluorescence microscopy of normal, premalignant, and malignant colonic tissues. 
  • Quantum dot penetration into viable human skin. 
  • RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB231 breast cancer cells. 
  • Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells. 
  • Rapid identification of kidney cyst mutations by whole exome sequencing in zebrafish. 
  • Recapitulation and Modulation of the Cellular Architecture of a User-Chosen Cell of Interest Using Cell-Derived, Biomimetic Patterning. 
  • Receptor mediated and fluid phase pathways for internalization of the ER Hsp90 chaperone GRP94 in murine macrophages. 
  • Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. 
  • Reflectance confocal microscopy features of angioma serpiginosum. 
  • Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination. 
  • Reversibly switchable fluorescence microscopy with enhanced resolution and image contrast. 
  • Robust approaches to quantitative ratiometric FRET imaging of CFP/YFP fluorophores under confocal microscopy. 
  • Role of NHERF and scaffolding proteins in proximal tubule transport. 
  • Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction. 
  • Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB. 
  • Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion. 
  • Sequence- or position-specific mutations in the carboxyl-terminal FL motif of the kidney sodium bicarbonate cotransporter (NBC1) disrupt its basolateral targeting and alpha-helical structure. 
  • Size and ionic currents of unexcitable cells coupled to cardiomyocytes distinctly modulate cardiac action potential shape and pacemaking activity in micropatterned cell pairs. 
  • Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy. 
  • Sorting of lens aquaporins and connexins into raft and nonraft bilayers: role of protein homo-oligomerization. 
  • Spatial and temporal regulation of biosynthesis of the plant immune signal salicylic acid. 
  • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. 
  • Sphingosine-1-phosphate effects on the inner wall of Schlemm's canal and outflow facility in perfused human eyes. 
  • Structural basement membrane components and corresponding integrins in Schlemm's canal endothelia. 
  • Sub-retinal drusenoid deposits in human retina: organization and composition. 
  • Subcellular Localization of Pseudomonas syringae pv. tomato Effector Proteins in Plants. 
  • Substance P dependence of endosomal fusion during bladder inflammation. 
  • Supersensitive Ras activation in dendrites and spines revealed by two-photon fluorescence lifetime imaging. 
  • Surface modified poly(β amino ester)-containing nanoparticles for plasmid DNA delivery. 
  • Surrogate markers in antiangiogenesis clinical trials. 
  • Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma. 
  • Swept source optical coherence tomography using an all-fiber 1300-nm ring laser source. 
  • The Arabidopsis PLEIOTROPIC DRUG RESISTANCE8/ABCG36 ATP binding cassette transporter modulates sensitivity to the auxin precursor indole-3-butyric acid. 
  • The COPI complex functions in nuclear envelope breakdown and is recruited by the nucleoporin Nup153. 
  • The HDAC complex and cytoskeleton. 
  • The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells. 
  • The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. 
  • The candidate sour taste receptor, PKD2L1, is expressed by type III taste cells in the mouse. 
  • The changing landscape of dermatology practice: melanoma and pump-probe laser microscopy. 
  • The effect of Rho-associated kinase inhibition on the ocular penetration of timolol maleate. 
  • The effects of the apoE4 genotype on the developing mouse retina. 
  • The granulin-epithelin precursor is a steroid-regulated growth factor in endometrial cancer. 
  • The importance of a multifaceted approach to characterizing the microbial flora of chronic wounds. 
  • The intestinal glucose-apelin cycle controls carbohydrate absorption in mice. 
  • The more the merrier? 
  • The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila. 
  • The role of Alzheimer's disease-related presenilin 1 in intercellular adhesion. 
  • The stabilization and targeting of surfactant-synthesized gold nanorods. 
  • The tetraspanin superfamily member NET-6 is a new tumor suppressor gene. 
  • Theoretical simulation of oxygen transport to tumors by three-dimensional networks of microvessels. 
  • Three-dimensional culture systems in cancer research: Focus on tumor spheroid model. 
  • Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration. 
  • Three-dimensional photolithographic micropatterning: a novel tool to probe the complexities of cell migration. 
  • Three-dimensional structure of the developing mouse genital ridge. 
  • Thrombin-cleaved COOH(-) terminal osteopontin peptide binds with cyclophilin C to CD147 in murine breast cancer cells. 
  • Tissue clearing techniques for three-dimensional optical imaging of intact human prostate and correlations with multi-parametric MRI. 
  • Tissue engineering of functional cardiac muscle: molecular, structural, and electrophysiological studies. 
  • Tissue transglutaminase regulates focal adhesion kinase/AKT activation by modulating PTEN expression in pancreatic cancer cells. 
  • Trabodenoson, an Adenosine Mimetic With A1 Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice. 
  • Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination. 
  • Transbilayer peptide sorting between raft and nonraft bilayers: comparisons of detergent extraction and confocal microscopy. 
  • Treatment of Fuchs Endothelial Dystrophy by Descemet Stripping Without Endothelial Keratoplasty. 
  • Treatment of Inherited Eye Defects by Systemic Hematopoietic Stem Cell Transplantation. 
  • Tryptase activates the mitogen-activated protein kinase/activator protein-1 pathway in human peripheral blood eosinophils, causing cytokine production and release. 
  • Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. 
  • Two-color, two-photon, and excited-state absorption microscopy. 
  • Two-dimensional fluorescence intensity distribution analysis: theory and applications. 
  • Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage. 
  • Understanding indocyanine green angiography in polypoidal choroidal vasculopathy: the group experience with digital fundus photography and confocal scanning laser ophthalmoscopy. 
  • Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice. 
  • Using confocal microscopy and the fluorescent indicator, 6-methoxy-N-ethylquinolinium iodide, to measure changes in intracellular chloride. 
  • VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation. 
  • Visualization and characterization of inflammatory cell recruitment and migration through the corneal stroma in endotoxin-induced keratitis. 
  • Visualization of Immune Responses in the Cornea. 
  • Visualization of replication initiation and elongation in Drosophila. 
  • Visualizing receptor endocytosis and trafficking. 
  • Whole-brain activity mapping onto a zebrafish brain atlas. 
  • Wide-field fast-scanning photoacoustic microscopy based on a water-immersible MEMS scanning mirror. 
  • Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. 
  • beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. 
  • beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. 
  • bullwinkle is required for epithelial morphogenesis during Drosophila oogenesis. 
  • zipper Nonmuscle myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation. 
  • β-Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Bohorquez, Diego V., Associate Professor in Medicine, Cell Biology
  • Farsiu, Sina, Professor in the Department of Biomedical Engineering, Electrical and Computer Engineering
  • Fox, Donald T, Associate Professor of Pharmacology & Cancer Biology, Duke Science & Society
  • Hirschey, Matthew, Associate Professor of Medicine, Cell Biology
  • Johnson, G. Allan, Charles E. Putman University Distinguished Professor of Radiology, Biomedical Engineering
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Mruthyunjaya, Prithvi, Adjunct Associate Professor in the Department of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery
  • Munjal, Akankshi, Assistant Professor of Cell Biology, Cell Biology
  • Roy Choudhury, Kingshuk, Adjunct Associate Professor in the Department of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Sunday, Mary Elizabeth Anne, Professor of Pathology, Cell Biology