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Subject Areas on Research
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"Ultra-Long Single- Wall Carbon Nanotubes"
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A biomechanical role for perlecan in the pericellular matrix of articular cartilage.
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A gas nanosensor unaffected by humidity.
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A general and efficient cantilever functionalization technique for AFM molecular recognition studies.
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A highly distributed Bragg stack with unique geometry provides effective camouflage for Loliginid squid eyes.
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A hybrid polymer gel with controlled rates of cross-link rupture and self-repair.
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A nanoscale force probe for gauging intermolecular interactions.
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A relocated technique of atomic force microscopy (AFM) samples and its application in molecular biology.
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A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice.
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A tactile response in Staphylococcus aureus.
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A thin-layer model for viscoelastic, stress-relaxation testing of cells using atomic force microscopy: do cell properties reflect metastatic potential?
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AFM-Based Single-Molecule Force Spectroscopy of Proteins.
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Altered mechanobiology of Schlemm's canal endothelial cells in glaucoma.
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Altered trabecular bone structure and delayed cartilage degeneration in the knees of collagen VI null mice.
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An approach for fabricating self-assembled monolayer of Ag nanoparticles on gold as the SERS-active substrate.
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Apparent elastic modulus and hysteresis of skeletal muscle cells throughout differentiation.
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Atomic force and total internal reflection fluorescence microscopy for the study of force transmission in endothelial cells.
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Atomic force microscope investigation of large-circle DNA molecules.
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Atomic force microscopy captures MutS tetramers initiating DNA mismatch repair.
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Atomic force microscopy captures folded ribosome bound nascent chains.
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Atomic force microscopy captures length phenotypes in single proteins.
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Atomic force microscopy captures the initiation of methyl-directed DNA mismatch repair.
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Atomic levers control pyranose ring conformations.
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Barnacle Cement as Surface Anchor for "Clicking" of Antifouling and Antimicrobial Polymer Brushes on Stainless Steel.
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Barnacle cement: a polymerization model based on evolutionary concepts.
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Biocompatibility studies of functionalized regioregular poly(3-hexylthiophene) layers for sensing applications.
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Biomechanical effects of flow and coculture on human aortic and cord blood-derived endothelial cells.
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Biophysical and ultrastructural characterization of adeno-associated virus capsid uncoating and genome release.
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Bovine serum albumin conformation on methyl and amine functionalized surfaces compared by scanning force microscopy.
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Can Dissipative Properties of Single Molecules Be Extracted from a Force Spectroscopy Experiment?
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Capture and release of proteins on the nanoscale by stimuli-responsive elastin-like polypeptide "switches".
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Capturing the mechanical unfolding pathway of a large protein with coiled-coil probes.
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Chair-boat transitions in single polysaccharide molecules observed with force-ramp AFM.
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Chaperones rescue luciferase folding by separating its domains.
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Characterization and property of DNA incorporated bilayer lipid membranes.
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Characterization of local elastic modulus in confined polymer films via AFM indentation.
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Characterization of the adhesive plaque of the barnacle Balanus amphitrite: amyloid-like nanofibrils are a major component.
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Combined Atomic Force Microscope and Volumetric Light Sheet System for Correlative Force and Fluorescence Mechanobiology Studies.
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Conformation change of horseradish peroxidase in lipid membrane.
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Construction and control of plasmid DNA network.
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Controlled rearrangement of adsorbed undecanol films on mica surfaces induced by an atomic force microscopy tip.
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Correlation between fundamental binding forces and clinical prognosis of Staphylococcus aureus infections of medical implants.
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DNA bioassay-on-chip using SERS detection for dengue diagnosis.
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DNA nanotubes self-assembled from triple-crossover tiles as templates for conductive nanowires.
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DNA network structures on various solid substrates investigated by atomic force microscopy.
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DNA sequencing: detecting methylation with force.
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DNA-Templated Self-Assembly of Protein Arrays and Highly Conductive Nanowires
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DNA-templated self-assembly of protein and nanoparticle linear arrays.
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Deformation and collapse of microtubules on the nanometer scale.
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Design and construction of double-decker tile as a route to three-dimensional periodic assembly of DNA.
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Designing an extracellular matrix protein with enhanced mechanical stability.
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Detecting solvent-driven transitions of poly(A) to double-stranded conformations by atomic force microscopy.
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Detecting ultraviolet damage in single DNA molecules by atomic force microscopy.
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Development of a YIGSR-peptide-modified polyurethaneurea to enhance endothelialization.
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Direct atomic force microscope imaging of EcoRI endonuclease site specifically bound to plasmid DNA molecules.
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Direct detection of inter-residue hydrogen bonds in polysaccharides by single-molecule force spectroscopy.
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Direct force measurements of the streptavidin-biotin interaction.
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Direct measurements of base stacking interactions in DNA by single-molecule atomic-force spectroscopy.
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Direct observation of multimer stabilization in the mechanical unfolding pathway of a protein undergoing oligomerization.
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Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha.
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Directed nucleation assembly of DNA tile complexes for barcode-patterned lattices.
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Discrete fracture patterns of virus shells reveal mechanical building blocks.
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Dissociation rate constants of human fibronectin binding to fibronectin-binding proteins on living Staphylococcus aureus isolated from clinical patients.
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Dynamic microcontact printing for patterning polymer-brush microstructures.
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Effect of compressive force on unbinding specific protein-ligand complexes with force spectroscopy.
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Elastic properties of single amylose chains in water: a quantum mechanical and AFM study.
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Elastic response, buckling, and instability of microtubules under radial indentation.
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Electrical and gas sensing properties of polyaniline functionalized single-walled carbon nanotubes.
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Encoded multichromophore response for simultaneous label-free detection.
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Endothelial, cardiac muscle and skeletal muscle exhibit different viscous and elastic properties as determined by atomic force microscopy.
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Envelope control of outer membrane vesicle production in Gram-negative bacteria.
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Enzymatic nanolithography of a self-assembled oligonucleotide monolayer on gold.
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Enzymatic polymerization of high molecular weight DNA amphiphiles that self-assemble into star-like micelles.
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Failure of viral shells.
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Fast and forceful refolding of stretched alpha-helical solenoid proteins.
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Fingerprinting polysaccharides with single-molecule atomic force microscopy.
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Flow and high affinity binding affect the elastic modulus of the nucleus, cell body and the stress fibers of endothelial cells.
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Force Spectroscopy of Single Protein Molecules Using an Atomic Force Microscope.
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Force measurements of the alpha5beta1 integrin-fibronectin interaction.
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Free-electron laser etching of dental enamel
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Functional nanostructures from surface chemistry patterning.
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Growth of cationic lipid toward bilayer lipid membrane by solution spreading: scanning probe microscopy study.
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High resolution AFM topographs of the Escherichia coli water channel aquaporin Z.
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High-content profiling of cell responsiveness to graded substrates based on combinyatorially variant polymers.
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Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration.
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Hydration and conformational mechanics of single, end-tethered elastin-like polypeptides.
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Identifying sequence similarities between DNA molecules.
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Imaging microtubules and kinesin decorated microtubules using tapping mode atomic force microscopy in fluids.
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Immunofluorescence-guided atomic force microscopy to measure the micromechanical properties of the pericellular matrix of porcine articular cartilage.
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Improving single molecule force spectroscopy through automated real-time data collection and quantification of experimental conditions.
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In situ friction measurement on murine cartilage by atomic force microscopy.
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Influence of pulling handles and device stiffness in single-molecule force spectroscopy.
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Inkless microcontact printing on SAMs of Boc- and TBS-protected thiols.
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Interaction of K7Fe3+P2W17O62H2 with supported bilayer lipid membranes on platinum electrode.
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Interaction of lubricin with type II collagen surfaces: adsorption, friction, and normal forces.
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Kinesin walks the line: single motors observed by atomic force microscopy.
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Label-free biosensing by surface plasmon resonance of nanoparticles on glass: optimization of nanoparticle size.
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Label-free plasmonic detection of biomolecular binding by a single gold nanorod.
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Localized DNA Hybridization Chain Reactions on DNA Origami.
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Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4.
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Mapping individual cosmid DNAs by direct AFM imaging.
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Mechanical Stability of a Small, Highly-Luminescent Engineered Protein NanoLuc.
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Mechanical Unfolding and Refolding of NanoLuc via Single-Molecule Force Spectroscopy and Computer Simulations.
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Mechanical analysis of rat trabecular meshwork.
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Mechanical and chemical unfolding of a single protein: a comparison.
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Mechanical anisotropy of ankyrin repeats.
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Mechanical design of proteins studied by single-molecule force spectroscopy and protein engineering.
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Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines.
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Mechanical unfolding intermediates in titin modules.
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Mechanical unfolding of an ankyrin repeat protein.
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Micro- and nanostructured poly[oligo(ethylene glycol)methacrylate] brushes grown from photopatterned halogen initiators by atom transfer radical polymerization.
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Micromechanical mapping of early osteoarthritic changes in the pericellular matrix of human articular cartilage.
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Minimizing pulling geometry errors in atomic force microscope single molecule force spectroscopy.
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Modular, Nondegenerate Polyprotein Scaffolds for Atomic Force Spectroscopy.
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Molecular basis for a protein-mediated DNA-bridging mechanism that functions in condensation of the E. coli chromosome.
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Molecular dynamics simulations of forced conformational transitions in 1,6-linked polysaccharides.
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Molecular stress relief through a force-induced irreversible extension in polymer contour length.
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Moving into the cell: single-molecule studies of molecular motors in complex environments.
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Nanoindentation studies of full and empty viral capsids and the effects of capsid protein mutations on elasticity and strength.
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Nanomechanical fingerprints of gamma radiation damage to DNA.
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Nanomechanics of streptavidin hubs for molecular materials.
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Nanopatterned polymer brushes by combining AFM anodization lithography with ring-opening metathesis polymerization in the liquid and vapor phase.
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Nanopatterned polymer brushes: conformation, fabrication and applications.
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Nanoscale detection of ionizing radiation damage to DNA by atomic force microscopy.
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Nanoscale structures and mechanics of barnacle cement.
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Nanospring behaviour of ankyrin repeats.
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Noncovalent functionalization of carbon nanotubes by fluorescein-polyethylene glycol: supramolecular conjugates with pH-dependent absorbance and fluorescence.
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Obesity alters the collagen organization and mechanical properties of murine cartilage.
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Optical characterizations and electronic devices of nearly pure (10,5) single-walled carbon nanotubes.
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Optical near-field mapping of plasmonic nanoprisms.
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Origin of overstretching transitions in single-stranded nucleic acids.
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Peptide-PEG amphiphiles as cytophobic coatings for mammalian and bacterial cells.
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Physical constraints on charge transport through bacterial nanowires.
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Piecewise All-Atom SMD Simulations Reveal Key Secondary Structures in Luciferase Unfolding Pathway.
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Plasmid DNA network on a mica substrate investigated by atomic force microscopy.
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Plasmonic Luneburg and Eaton lenses.
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Point mutations alter the mechanical stability of immunoglobulin modules.
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Polymorphisms in fibronectin binding protein A of Staphylococcus aureus are associated with infection of cardiovascular devices.
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Polysaccharide elasticity governed by chair-boat transitions of the glucopyranose ring.
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Pretreatment of amphiphilic comb polymer surfaces dramatically affects protein adsorption
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Programmable DNA self-assemblies for nanoscale organization of ligands and proteins.
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Programming DNA tube circumferences.
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Protein tracking and detection of protein motion using atomic force microscopy.
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Pulling geometry-induced errors in single molecule force spectroscopy measurements.
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Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication.
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Rapid nanoimprinting of silk fibroin films for biophotonic applications.
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Reconstruction of mechanical unfolding and refolding pathways of proteins with atomic force spectroscopy and computer simulations.
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Regenerating titanium ventricular assist device surfaces after gold/palladium coating for scanning electron microscopy.
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Relationship between Atomic Force Microscopy and Centrifugation Measurements for Dust Fractions Implicated in Solar Panel Soiling.
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Relevance of the Speed and Direction of Pulling in Simple Modular Proteins.
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Resolving the molecular structure of microtubules under physiological conditions with scanning force microscopy.
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Reverse engineering of the giant muscle protein titin.
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Role of fibronectin in topographical guidance of neurite extension on electrospun fibers.
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Round versus flat: bone cell morphology, elasticity, and mechanosensing.
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Self-cleaning of superhydrophobic surfaces by self-propelled jumping condensate.
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Separating DNA with different topologies by atomic force microscopy in comparison with gel electrophoresis.
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Shear Modulus Measurement by Quantitative Phase Imaging and Correlation with Atomic Force Microscopy.
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Simulating force-induced conformational transitions in polysaccharides with the SMD replica exchange method.
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Single Molecule Force Spectroscopy to Compare Natural versus Artificial Antibody-Antigen Interaction.
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Single molecular force spectroscopy of modular proteins in the nervous system.
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Single molecule mechanical manipulation for studying biological properties of proteins, DNA, and sugars.
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Single protein misfolding events captured by atomic force microscopy.
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Single-handed helical wrapping of single-walled carbon nanotubes by chiral, ionic, semiconducting polymers.
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Single-molecule Force Spectroscopy Reveals the Calcium Dependence of the Alternative Conformations in the Native State of a βγ-Crystallin Protein.
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Spatial mapping of the biomechanical properties of the pericellular matrix of articular cartilage measured in situ via atomic force microscopy.
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Specific binding at the cellulose binding module-cellulose interface observed by force spectroscopy.
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Spermidine-Induced Attraction of Like-Charged Surfaces Is Correlated with the pH-Dependent Spermidine Charge: Force Spectroscopy Characterization.
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Stepwise self-assembly of DNA tile lattices using dsDNA bridges.
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Stretching single molecules into novel conformations using the atomic force microscope.
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Stretching single polysaccharides and proteins using atomic force microscopy.
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Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage.
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Structure of supported bilayers composed of lipopolysaccharides and bacterial phospholipids: raft formation and implications for bacterial resistance.
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Subatomic deformation driven by vertical piezoelectricity from CdS ultrathin films.
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Surface-initiated enzymatic polymerization of DNA.
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Surface-to-surface bridges formed by reversibly assembled polymers.
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Synergistic effect of high-affinity binding and flow preconditioning on endothelial cell adhesion.
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Tau protein binding forms a 1 nm thick layer along protofilaments without affecting the radial elasticity of microtubules.
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The aquaporin sidedness revisited.
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The force-driven conformations of heparin studied with single molecule force microscopy.
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The mechanical stability of ubiquitin is linkage dependent.
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The micro-mechanics of single molecules studied with atomic force microscopy.
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The molecular elasticity of the extracellular matrix protein tenascin.
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The relationship between ligand-binding thermodynamics and protein-ligand interaction forces measured by atomic force microscopy.
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The study of protein mechanics with the atomic force microscope.
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The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface.
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Three-Helix Bundle DNA Tiles Self-Assemble into 2D Lattice or 1D Templates for Silver Nanowires.
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Time and distance dependence of reversible polymer bridging followed by single-molecule force spectroscopy.
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Tissue-culture surfaces with mixtures of aminated and fluorinated functional groups. Part 1. Synthesis and characterization.
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Total internal reflection microscopy and atomic force microscopy (TIRFM-AFM) to study stress transduction mechanisms in endothelial cells.
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Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury.
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UVA generates pyrimidine dimers in DNA directly.
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Using microcantilever deflection to detect HIV-1 envelope glycoprotein gp120.
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Viscoelastic properties of zonal articular chondrocytes measured by atomic force microscopy.
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Warhammers for Peaceful Times.
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Keywords of People
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Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Erickson, Harold Paul,
Professor Emeritus of Cell Biology,
Cell Biology
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Leddy, Holly,
Research & Dev Engineer III,
Pratt School of Engineering