ras Proteins

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  Subject Areas on Research

  • A Fungal Arrestin Protein Contributes to Cell Cycle Progression and Pathogenesis. 
  • A Rac homolog functions downstream of Ras1 to control hyphal differentiation and high-temperature growth in the pathogenic fungus Cryptococcus neoformans. 
  • A Ras1-Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans. 
  • A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets. 
  • A genetically defined normal human somatic cell system to study ras oncogenesis in vivo and in vitro. 
  • A genomic strategy to elucidate modules of oncogenic pathway signaling networks. 
  • A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. 
  • A network of genetic events sufficient to convert normal human cells to a tumorigenic state. 
  • A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development. 
  • A phase II study of capecitabine, oxaliplatin, bevacizumab and cetuximab in the treatment of metastatic colorectal cancer. 
  • A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells. 
  • A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. 
  • A within-trial cost-effectiveness analysis of panitumumab compared with bevacizumab in the first-line treatment of patients with wild-type RAS metastatic colorectal cancer in the US. 
  • Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation. 
  • Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective. 
  • Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival. 
  • Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. 
  • Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells. 
  • Acute tissue injury activates satellite cells and promotes sarcoma formation via the HGF/c-MET signaling pathway. 
  • Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition. 
  • Adrenergic CaV1.2 Activation via Rad Phosphorylation Converges at α1C I-II Loop. 
  • Anti-EGFR-resistant clones decay exponentially after progression: implications for anti-EGFR re-challenge. 
  • Association between KRAS rs61764370 and triple-negative breast cancer--a false positive? 
  • Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. 
  • Blood-based markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: results from CALGB 80203 (Alliance). 
  • Cdc42p, GTP hydrolysis, and the cell's sense of direction. 
  • Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis. 
  • Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. 
  • Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response. 
  • Chemoradiotherapy and gefitinib in stage III non-small cell lung cancer with epidermal growth factor receptor and KRAS mutation analysis: cancer and leukemia group B (CALEB) 30106, a CALGB-stratified phase II trial. 
  • Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia. 
  • Colon cancer, version 3.2014. 
  • Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans. 
  • Concurrent molecular alterations in tumors with germ line epidermal growth factor receptor T790M mutations. 
  • Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. 
  • DOK2 inhibits EGFR-mutated lung adenocarcinoma. 
  • Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity. 
  • Development and validation of a scalable next-generation sequencing system for assessing relevant somatic variants in solid tumors. 
  • Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation. 
  • Diesel exhaust particles activate the matrix-metalloproteinase-1 gene in human bronchial epithelia in a beta-arrestin-dependent manner via activation of RAS. 
  • Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα. 
  • Discovery and characterization of small molecules that target the GTPase Ral. 
  • Disruption of lysosome function promotes tumor growth and metastasis in Drosophila. 
  • Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells. 
  • Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. 
  • Distinct gene expression profiles in adult mouse heart following targeted MAP kinase activation. 
  • Distinct requirements for Ras oncogenesis in human versus mouse cells. 
  • Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease. 
  • Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents. 
  • Endocervical-like (Müllerian) mucinous borderline tumours of the ovary are frequently associated with the KRAS mutation. 
  • Epidermal growth factor receptor signaling pathway is frequently altered in ampullary carcinoma at protein and genetic levels. 
  • Erbin suppresses the MAP kinase pathway. 
  • Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth. 
  • Evaluating The Role Of Nitric Oxide Synthase In Oncogenic Ras-Driven Tumorigenesis. 
  • Evaluation of KRAS mutations, angiogenic biomarkers, and DCE-MRI in patients with advanced non-small-cell lung cancer receiving sorafenib. 
  • Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha. 
  • Exploiting codon usage identifies intensity-specific modifiers of Ras/MAPK signaling in vivo. 
  • Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant. 
  • Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers. 
  • G beta gamma interactions with PH domains and Ras-MAPK signaling pathways. 
  • G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. 
  • G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors. 
  • GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer. 
  • GNAS and KRAS Mutations Define Separate Progression Pathways in Intraductal Papillary Mucinous Neoplasm-Associated Carcinoma. 
  • GNAS mutations identify a set of right-sided, RAS mutant, villous colon cancers. 
  • Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. 
  • Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation. 
  • Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance. 
  • Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function. 
  • Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males. 
  • High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors. 
  • Histological and molecular evaluation of patient-derived colorectal cancer explants. 
  • Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling. 
  • Impact of Protein Palmitoylation on the Virulence Potential of Cryptococcus neoformans. 
  • Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. 
  • Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer. 
  • Isolation of protein prenyltransferases from bovine brain and baculovirus expression system. 
  • Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms. 
  • KRAS mutation influences recurrence patterns in patients undergoing hepatic resection of colorectal metastases. 
  • KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin. 
  • LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. 
  • LigAmp for sensitive detection of single-nucleotide differences. 
  • Loss of EGFR signaling regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance. 
  • Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas. 
  • Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase. 
  • Mechanisms of protein prenylation and role in G protein function. 
  • Modeling RAS phenotype in colorectal cancer uncovers novel molecular traits of RAS dependency and improves prediction of response to targeted agents in patients. 
  • Mutational Analysis of Patients With Colorectal Cancer in CALGB/SWOG 80405 Identifies New Roles of Microsatellite Instability and Tumor Mutational Burden for Patient Outcome. 
  • Mutations of the BRAF gene in human cancer. 
  • NF1 inactivation in adult acute myelogenous leukemia. 
  • Negative regulation of mTOR activation by diacylglycerol kinases. 
  • Neurofibromatosis Type 1 and tumorigenesis: molecular mechanisms and therapeutic implications. 
  • Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway. 
  • Oncogenic mutations in ras create HLA-A2.1 binding peptides but affect their extracellular antigen processing. 
  • Pancreatic ductal adenocarcinoma with autoimmune pancreatitis-like histologic and immunohistochemical features. 
  • Phase III trial of cetuximab, bevacizumab, and 5-fluorouracil/leucovorin vs. FOLFOX-bevacizumab in colorectal cancer. 
  • Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1. 
  • Pleiotrophin mediates hematopoietic regeneration via activation of RAS. 
  • Pleiotropic roles of the Msi1-like protein Msl1 in Cryptococcus neoformans. 
  • Polycythemia vera erythroid precursors exhibit increased proliferation and apoptosis resistance associated with abnormal RAS and PI3K pathway activation. 
  • Post-prenylation-processing enzymes as new targets in oncogenesis. 
  • Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial. 
  • Primate-specific melanoma antigen-A11 regulates isoform-specific human progesterone receptor-B transactivation. 
  • Proceedings of the fifth international RASopathies symposium: When development and cancer intersect. 
  • Proliferative nodules arising within congenital melanocytic nevi: a histologic, immunohistochemical, and molecular analyses of 43 cases. 
  • Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. 
  • Protein farnesyltransferase. 
  • Protein prenylation: unique fats make their mark on biology. 
  • Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells. 
  • RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis. 
  • RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans. 
  • Rare codons regulate KRas oncogenesis. 
  • Ras controls melanocyte expansion during zebrafish fin stripe regeneration. 
  • Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye. 
  • Ras1 and Ras2 contribute shared and unique roles in physiology and virulence of Cryptococcus neoformans. 
  • Ras1 controls pheromone expression and response during mating in Cryptococcus neoformans. 
  • Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development. 
  • Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta. 
  • Regulation of endothelial cell adherens junctions by a Ras-dependent signal transduction pathway. 
  • Regulation of mitogen-activated protein kinase pathways by catecholamine receptors. 
  • Regulators of G protein signaling proteins as determinants of the rate of desensitization of presynaptic calcium channels. 
  • Relationship between statin use and colon cancer recurrence and survival: results from CALGB 89803. 
  • Relationship of DNA methylation to mutational changes and transcriptional organization in fusion-positive and fusion-negative rhabdomyosarcoma. 
  • Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR. 
  • Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases. 
  • Role of the YAP Oncoprotein in Priming Ras-Driven Rhabdomyosarcoma. 
  • Roles for Stress Response and Cell Wall Biosynthesis Pathways in Caspofungin Tolerance in Cryptococcus neoformans. 
  • Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart. 
  • Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis. 
  • Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection. 
  • Signaling specificity: the RTK/RAS/MAP kinase pathway in metazoans. 
  • Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo. 
  • Site-specific analysis of protein S-acylation by resin-assisted capture. 
  • Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function. 
  • Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder. 
  • Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. 
  • Studying signal transduction in single dendritic spines. 
  • Subcellular localization directs signaling specificity of the Cryptococcus neoformans Ras1 protein. 
  • Substitution of cadmium for zinc in farnesyl:protein transferase alters its substrate specificity. 
  • Substrate binding is required for release of product from mammalian protein farnesyltransferase. 
  • Supersensitive Ras activation in dendrites and spines revealed by two-photon fluorescence lifetime imaging. 
  • Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta. 
  • Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. 
  • Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate. 
  • Targeting eNOS in pancreatic cancer. 
  • The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway. 
  • The C-terminal polylysine region and methylation of K-Ras are critical for the interaction between K-Ras and microtubules. 
  • The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit. 
  • The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta. 
  • The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae. 
  • The Molecular Taxonomy of Primary Prostate Cancer. 
  • The Ras-related protein AGS1/RASD1 suppresses cell growth. 
  • The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia. 
  • The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2. 
  • The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing. 
  • The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation. 
  • The third international meeting on genetic disorders in the RAS/MAPK pathway: towards a therapeutic approach. 
  • The winged-helix/forkhead protein myocyte nuclear factor beta (MNF-beta) forms a co-repressor complex with mammalian sin3B. 
  • Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis. 
  • Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia. 
  • Tumour maintenance is mediated by eNOS. 
  • Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors. 
  • Ultrasensitive detection of KRAS2 mutations in bile and serum from patients with biliary tract carcinoma using LigAmp technology. 
  • Use of retrovirus expression of interfering RNA to determine the contribution of activated K-Ras and ras effector expression to human tumor cell growth. 
  • Using BioID to Characterize the RAS Interactome. 
  • Using a gene-switch transgenic approach to dissect distinct roles of MAP kinases in heart failure. 
  • VEGF stimulates MAPK through a pathway that is unique for receptor tyrosine kinases. 
  • Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. 
  • Whole Recombinant Saccharomyces cerevisiae Yeast Expressing Ras Mutations as Treatment for Patients With Solid Tumors Bearing Ras Mutations: Results From a Phase 1 Trial. 
  • Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog. 
  • beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. 
  • cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis. 
  • mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Cell Biology
  • McCall, Shannon Jones, Associate Professor of Pathology, Pathology
  • Pang, Herbert, Adjunct Assistant Professor in the Department of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology
  • Zhong, Xiaoping, Professor of Pediatrics, Integrative Immunobiology