Lymphocyte Count

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  Subject Areas on Research

  • A 9-yr evaluation of carrier erythrocyte encapsulated adenosine deaminase (ADA) therapy in a patient with adult-type ADA deficiency. 
  • A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution. 
  • A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis. 
  • A quantitative evaluation of inflammatory cells in human temporomandibular joint tissues from patients with and without implants. 
  • A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. 
  • Absolute lymphocyte count is a prognostic marker in Covid-19: A retrospective cohort review. 
  • Absolute lymphocyte counts as prognostic indicators for immune thrombocytopenia outcomes in children. 
  • Acute and chronic B cell depletion disrupts CD4+ and CD8+ T cell homeostasis and expansion during acute viral infection in mice. 
  • Adult dual umbilical cord blood transplantation using myeloablative total body irradiation (1350 cGy) and fludarabine conditioning. 
  • Advances in the understanding and treatment of human severe combined immunodeficiency. 
  • Alpha-glycosylceramides enhance the antitumor cytotoxicity of hepatic lymphocytes obtained from cancer patients by activating CD3-CD56+ NK cells in vitro. 
  • An integrative model using flow cytometry identifies nosocomial infection after trauma. 
  • Antiretroviral therapy corrects HIV-1-induced expansion of CD8+ CD45RA+ CD2-) CD11a(bright) activated T cells. 
  • Attrition of memory CD8 T cells during sepsis requires LFA-1. 
  • Autologous Ex Vivo Lentiviral Gene Therapy for Adenosine Deaminase Deficiency. 
  • B cell loss leading to remission in severe systemic lupus erythematosus. 
  • Bone marrow B cell precursor number after allogeneic stem cell transplantation and GVHD development. 
  • CAMPATH-1H in rheumatoid arthritis--an intravenous dose-ranging study. 
  • CD3+CD8+ cell levels as predictors of transmission in human immunodeficiency virus-infected couples: a report from the heterosexual HIV transmission study. 
  • CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis. 
  • Campath-1H in intestinal and multivisceral transplantation: preliminary data. 
  • Characterization of banked umbilical cord blood hematopoietic progenitor cells and lymphocyte subsets and correlation with ethnicity, birth weight, sex, and type of delivery: a Cord Blood Transplantation (COBLT) Study report. 
  • Chronic Alcohol Ingestion Delays T Cell Activation and Effector Function in Sepsis. 
  • Clinical application of whole-genome sequencing in patients with primary immunodeficiency. 
  • Clonal expansion and decreased occurrence of peripheral blood gamma delta T cells of the V delta 2J delta 3 lineage in multiple sclerosis patients. 
  • Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia. 
  • Coexistent naïve phenotype and higher cycling rate of cord blood T cells as compared to adult peripheral blood. 
  • Combined deletion of Id2 and Id3 genes reveals multiple roles for E proteins in invariant NKT cell development and expansion. 
  • Comparison of interlaboratory variation in absolute T-cell counts by single-platform and optimized dual-platform methods. 
  • Complete DiGeorge syndrome: persistence of profound immunodeficiency. 
  • Control of viremia and maintenance of intestinal CD4(+) memory T cells in SHIV(162P3) infected macaques after pathogenic SIV(MAC251) challenge. 
  • Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. 
  • Cryopreserving whole blood for functional assays using viable lymphocytes in molecular epidemiology studies. 
  • Decreased normal NK-cells is a characteristic of T-cell large granular lymphocytic leukemia and is strongly associated with cytopenia. 
  • Delayed onset adenosine deaminase deficiency associated with acute disseminated encephalomyelitis. 
  • Delayed-type hypersensitivity testing in Tanzanian adults with HIV infection. 
  • Differential CMV-specific CD8+ effector T cell responses in the lung allograft predominate over the blood during human primary infection. 
  • Differential Immune Microenvironments and Response to Immune Checkpoint Blockade among Molecular Subtypes of Murine Medulloblastoma. 
  • Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion. 
  • Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. 
  • Dyspoietic changes associated with hepatosplenic T-cell lymphoma are not a manifestation of a myelodysplastic syndrome: analysis of 25 patients. 
  • E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression. 
  • Effect of Alemtuzumab (CAMPATH 1-H) in patients with inclusion-body myositis. 
  • Effect of an intravitreal cyclosporine implant on experimental uveitis in horses. 
  • Effect of complement consumption by cobra venom factor on the course of primary infection with simian immunodeficiency virus in rhesus monkeys. 
  • Effect of influenza virus vaccine on the expression of human immunodeficiency virus co-receptor CCR5. 
  • Effect of thymectomy on human peripheral blood T cell pools in myasthenia gravis. 
  • Effects of enzyme replacement therapy on immune function in ADA deficiency patient. 
  • Elevated level of peripheral CD8(+)CD28(-) T lymphocytes are an independent predictor of progression-free survival in patients with metastatic breast cancer during the course of chemotherapy. 
  • Enhanced differentiation of splenic plasma cells but diminished long-lived high-affinity bone marrow plasma cells in aged mice. 
  • Evaluation of T-lymphocyte subsets present in semen and peripheral blood of healthy donors: a report from the heterosexual transmission study. 
  • Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection. 
  • FOXN1 mutation abrogates prenatal T-cell development in humans. 
  • Failure of T-cell homeostasis preceding AIDS in HIV-1 infection. The Multicenter AIDS Cohort Study. 
  • Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. 
  • Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children. 
  • Galectin-1 is essential for the induction of MOG35-55 -based intravenous tolerance in experimental autoimmune encephalomyelitis. 
  • Gene therapy for immunodeficiency due to adenosine deaminase deficiency. 
  • Graft-versus-host disease prevention by rapamycin: cellular mechanisms. 
  • HIV infection and the dynamic interplay between the thymus and the peripheral T cell pool. 
  • Hematopoietic stem cell transplantation for severe combined immunodeficiency in the neonatal period leads to superior thymic output and improved survival. 
  • Hematopoietic stem cell transplantation rescues the immunologic phenotype and prevents vasculopathy in patients with adenosine deaminase 2 deficiency. 
  • Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence. 
  • Hyperexpansion of Functional Viral-Specific CD8+ T Cells in Lymphopenia-Associated MCMV Pneumonitis. 
  • IL-15 regulates homeostasis and terminal maturation of NKT cells. 
  • Id3 and Id2 act as a dual safety mechanism in regulating the development and population size of innate-like γδ T cells. 
  • Immune recovery in adult patients after myeloablative dual umbilical cord blood, matched sibling, and matched unrelated donor hematopoietic cell transplantation. 
  • Immune responses in asymptomatic HIV-1-infected patients after HIV-DNA immunization followed by highly active antiretroviral treatment. 
  • Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation. 
  • Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL. 
  • Immunological findings in thymoma and thymoma-related syndromes. 
  • Improved strategy for mononuclear cell collection for donor lymphocyte infusions. 
  • In the shadow of antibodies: how T cells defend against COVID-19. 
  • Infections during peginterferon/ribavirin therapy are associated with the magnitude of decline in absolute lymphocyte count: results of the IDEAL study. 
  • Infectious morbidity in long-term survivors of allogeneic marrow transplantation is associated with low CD4 T cell counts. 
  • Inter- and intrainstitutional evaluation of automated volumetric capillary cytometry for the quantitation of CD4- and CD8-positive T lymphocytes in the peripheral blood of persons infected with human immunodeficiency virus. Site Investigators and the NIAID New CD4 Technologies Focus Group. 
  • Interleukin-15 receptor blockade in non-human primate kidney transplantation. 
  • Kinetics of TCR use in response to repeated epitope-specific immunization. 
  • LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function. 
  • Laboratory Accuracy Improvement in the UK NEQAS Leucocyte Immunophenotyping Immune Monitoring Program: An Eleven-Year Review via Longitudinal Mixed Effects Modeling. 
  • Leukocyte counts in cerebrospinal fluid and blood following firategrast treatment in subjects with relapsing forms of multiple sclerosis. 
  • Long-term efficacy of enzyme replacement therapy for adenosine deaminase (ADA)-deficient severe combined immunodeficiency (SCID). 
  • Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans. 
  • Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection. 
  • Low lymphocyte ratio as a novel prognostic factor in acute heart failure: results from the Pre-RELAX-AHF study. 
  • Lymphocyte and monocyte subset changes during cardiopulmonary bypass: effects of aging and gender. 
  • Lymphocyte reconstitution following non-myeloablative hematopoietic stem cell transplantation follows two patterns depending on age and donor/recipient chimerism. 
  • Lymphocyte shedding from genital tract of human immunodeficiency virus-infected women: immunophenotypic and clinical correlates. 
  • M-HIFU inhibits tumor growth, suppresses STAT3 activity and enhances tumor specific immunity in a transplant tumor model of prostate cancer. 
  • Metastatic clear cell renal cell carcinoma: Circulating biomarkers to guide antiangiogenic and immune therapies. 
  • Monoclonal B cell lymphocytosis: clinical and population perspectives. 
  • Morbidity, Mortality, and Therapeutics in Combined Immunodeficiency: Data From the USIDNET Registry. 
  • Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys. 
  • Mutations in the mu heavy-chain gene in patients with agammaglobulinemia. 
  • Nasal peptide vaccination elicits CD8 responses and reduces viral burden after challenge with virulent murine cytomegalovirus. 
  • Natural killer cells and lymphocytes increase in women with breast cancer following massage therapy. 
  • Neutrophil-to-Lymphocyte Ratio as a Prognostic Factor of Disease-free Survival in Postnephrectomy High-risk Locoregional Renal Cell Carcinoma: Analysis of the S-TRAC Trial. 
  • Normal IgH Repertoire Diversity in an Infant with ADA Deficiency After Gene Therapy. 
  • Novel role for surfactant protein A in gastrointestinal graft-versus-host disease. 
  • OX40+ Regulatory T Cells in Cutaneous Squamous Cell Carcinoma Suppress Effector T-Cell Responses and Associate with Metastatic Potential. 
  • Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet+ B cells. 
  • Passive infusion of immune serum into simian immunodeficiency virus-infected rhesus macaques undergoing a rapid disease course has minimal effect on plasma viremia. 
  • Pathogenic Correlates of Simian Immunodeficiency Virus-Associated B Cell Dysfunction. 
  • Positive Family History, Infection, Low Absolute Lymphocyte Count (ALC), and Absent Thymic Shadow: Diagnostic Clues for All Molecular Forms of Severe Combined Immunodeficiency (SCID). 
  • Post-transplantation B cell activating factor and B cell recovery before onset of chronic graft-versus-host disease. 
  • Preclinical Modeling of Surgery and Steroid Therapy for Glioblastoma Reveals Changes in Immunophenotype that are Associated with Tumor Growth and Outcome. 
  • Predicting CD4 lymphocyte count <200 cells/mm(3) in an HIV type 1-infected African population. 
  • Predictive value of low relative lymphocyte count in patients hospitalized for heart failure with reduced ejection fraction: insights from the EVEREST trial. 
  • Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection. 
  • Primary cytomegalovirus phosphoprotein 65-specific CD8+ T-cell responses and T-bet levels predict immune control during early chronic infection in lung transplant recipients. 
  • Prognostic impact of the neutrophil-to-lymphocyte ratio in men with metastatic castration-resistant prostate cancer. 
  • Progressive lentivirus infection induces natural killer cell receptor-expressing B cells in the gastrointestinal tract. 
  • Protective and pathogenic roles for B cells during systemic autoimmunity in NZB/W F1 mice. 
  • Questionable relevance of gamma delta T lymphocytes in renal cell carcinoma. 
  • Rabbit antithymocyte globulin induction and sirolimus monotherapy supports prolonged islet allograft function in a nonhuman primate islet transplantation model. 
  • Recombinant human granulocyte colony-stimulating factor therapy for patients with neutropenia and/or neutrophil dysfunction secondary to glycogen storage disease type 1b. 
  • Recombinant poxvirus boosting of DNA-primed rhesus monkeys augments peak but not memory T lymphocyte responses. 
  • Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation. 
  • Regulatory B10 Cells Increase after Rituximab Therapy but Not after Conventional Immunosuppression in Patients with Pemphigus. 
  • Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice. 
  • Results from a human renal allograft tolerance trial evaluating T-cell depletion with alemtuzumab combined with deoxyspergualin. 
  • Results of a phase 1 study utilizing monocyte-derived dendritic cells pulsed with tumor RNA in children and young adults with brain cancer. 
  • Results of a prospective multicentre myeloablative double-unit cord blood transplantation trial in adult patients with acute leukaemia and myelodysplasia. 
  • Reversibility of peripheral blood leukocyte phenotypic and functional changes after exposure to and withdrawal from tofacitinib, a Janus kinase inhibitor, in healthy volunteers. 
  • Rituximab therapy for primary Sjögren's syndrome: an open-label clinical trial and mechanistic analysis. 
  • SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery. 
  • Screening of 181 Patients With Antibody Deficiency for Deficiency of Adenosine Deaminase 2 Sheds New Light on the Disease in Adulthood. 
  • Serum elevation of B lymphocyte stimulator does not increase regulatory B cells in glioblastoma patients undergoing immunotherapy. 
  • T cell repertoire development in humans with SCID after nonablative allogeneic marrow transplantation. 
  • T cell traffic and the inflammatory response in experimental autoimmune uveoretinitis. 
  • T cell-mediated elimination of B7.2 transgenic B cells. 
  • T cells in ovarian cancer. 
  • T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates. 
  • T-Cell recovery in adults and children following umbilical cord blood transplantation. 
  • T-lymphocyte alloresponses of Campath-1H-treated kidney transplant patients. 
  • The Systemic Immune-Inflammation Index Predicts Clinical Outcomes in Kidney Transplant Recipients. 
  • The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation. 
  • The dynamics of T-cell receptor repertoire diversity following thymus transplantation for DiGeorge anomaly. 
  • The effect of total lymphoid irradiation and low-dose steroids on T lymphocyte populations in multiple sclerosis: correlation with clinical and MRI status. 
  • The immunological axis in heart failure: importance of the leukocyte differential. 
  • The intragraft CD8+ T cell response in renal allograft rejection in the mouse. 
  • The metabolic life and times of a T-cell. 
  • The use of enzyme therapy to regulate the metabolic and phenotypic consequences of adenosine deaminase deficiency in mice. Differential impact on pulmonary and immunologic abnormalities. 
  • Thymic function after hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency. 
  • Thymic function, aging, and AIDS. 
  • Thymoma-associated immunodeficiency: a syndrome characterized by severe alterations in NK, T and B-cells and progressive increase in naïve CD8+ T Cells. 
  • Total lymphocyte count and World Health Organization pediatric clinical stage as markers to assess need to initiate antiretroviral therapy among human immunodeficiency virus-infected children in Moshi, Northern Tanzania. 
  • Transplantation outcomes for severe combined immunodeficiency, 2000-2009. 
  • Treatment of rheumatoid arthritis with a DR4/1 peptide. 
  • Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways. 
  • Why newborn screening for severe combined immunodeficiency is essential: a case report. 
  • [Lymphocyte subpopulations in spleen and blood after early wound debridement and acute/chronic treatment with hyperbaric oxygen]. 
  • eComment: Neutrophil-to-lymphocyte ratio: Ambitious but Ambiguous marker. 
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  Keywords of People

  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine, Pediatrics, Allergy and Immunology
  • Chen, Jun, Professor of Medicine, Duke Cancer Institute
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology