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Subject Areas on Research
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A multicenter study of recombinant human interleukin 12 for the treatment of chronic hepatitis C virus infection in patients nonresponsive to previous therapy.
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A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization.
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A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas.
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A phase II open-label study of recombinant human interleukin-12 in patients with stage IA, IB, or IIA mycosis fungoides.
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A possible coagulation-independent mechanism for pregnancy loss involving β(2) glycoprotein 1-dependent antiphospholipid antibodies and CD1d.
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A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production.
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A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment.
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Activation of decidual invariant natural killer T cells promotes lipopolysaccharide-induced preterm birth.
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Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: potential mechanism for sensitization to liver damage.
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An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cells.
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Anti-angiogenic effects of interleukin-12 delivered by a novel hyperthermia induced gene construct.
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Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha.
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CD40 ligand is essential for generation of specific cytotoxic T cell responses in RNA-pulsed dendritic cell immunotherapy.
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CD58/LFA-3 and IL-12 provided by activated monocytes are critical in the in vitro expansion of CD56+ T cells.
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Characterization of a recombinant adenovirus vector encoding heat-inducible feline interleukin-12 for use in hyperthermia-induced gene-therapy.
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Co-delivery of antigen and IL-12 by Venezuelan equine encephalitis virus replicon particles enhances antigen-specific immune responses and antitumor effects.
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Coadministration of IL-12 or IL-10 expression cassettes drives immune responses toward a Th1 phenotype.
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Combination treatment of murine tumors by adenovirus-mediated local B7/IL12 immunotherapy and radiotherapy.
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Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV(89.6P) challenge in rhesus macaques.
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Comparison of ophthalmic sponges for measurements of immune markers from cervical secretions.
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Costimulator dependence of lymphokine secretion by naive and activated CD4+ T lymphocytes from TCR transgenic mice.
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Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling.
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Cytokine therapy of cutaneous T-cell lymphoma: interferons, interleukin-12, and interleukin-2.
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Cytokine transcriptional events during helper T cell subset differentiation.
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Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunization.
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Cytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis.
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DNA Priming Increases Frequency of T-Cell Responses to a Vesicular Stomatitis Virus HIV Vaccine with Specific Enhancement of CD8+ T-Cell Responses by Interleukin-12 Plasmid DNA.
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DNA vaccine molecular adjuvants SP-D-BAFF and SP-D-APRIL enhance anti-gp120 immune response and increase HIV-1 neutralizing antibody titers.
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DNA-MVA vaccine protection after X4 SHIV challenge in macaques correlates with day-of-challenge antiviral CD4+ cell-mediated immunity levels and postchallenge preservation of CD4+ T cell memory.
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Deficiency of activation-induced cytidine deaminase in a murine model of ulcerative colitis.
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Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription.
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Dendritic cells stimulated with Actinobacillus actinomycetemcomitans elicit rapid gamma interferon responses by natural killer cells.
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Dendritic-NK cell interactions in P. gingivalis-specific responses.
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Depressed interleukin-12-producing activity by monocytes correlates with adverse clinical course and a shift toward Th2-type lymphocyte pattern in severely injured male trauma patients.
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Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii.
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Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease.
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Down-regulation of IL-2 receptor alpha (CD25) characterizes human gammadelta-T cells rendered resistant to apoptosis after CD2 engagement in the presence of IL-12.
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Effective tumor therapy with plasmid-encoded cytokines combined with in vivo electroporation.
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Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis.
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Enhanced activation of human dendritic cells by inducible CD40 and Toll-like receptor-4 ligation.
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Enhancement of radiotherapy by hyperthermia-regulated gene therapy.
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Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand.
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Ex vivo expansion, maturation, and activation of umbilical cord blood-derived T lymphocytes with IL-2, IL-12, anti-CD3, and IL-7. Potential for adoptive cellular immunotherapy post-umbilical cord blood transplantation.
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Expression of cytokine mRNA in murine splenic dendritic cells and better induction of T cell-derived cytokines by dendritic cells than by macrophages during in vitro costimulation assay using specific antigens.
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GPI-defective monocytes from paroxysmal nocturnal hemoglobinuria patients show impaired in vitro dendritic cell differentiation.
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Gastroesophageal reflux-associated aspiration alters the immune response in asthma.
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Heat-induced gene expression as a novel targeted cancer gene therapy strategy.
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Hepatic enrichment and activation of myeloid dendritic cells during chronic hepatitis C virus infection.
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Host response to infection: the role of CpG DNA in induction of cyclooxygenase 2 and nitric oxide synthase 2 in murine macrophages.
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Human gammadelta-T cells in adoptive immunotherapy of malignant and infectious diseases.
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IL-10 levels in Dengue patients: some findings from the exceptional epidemiological conditions in Cuba.
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IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques.
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IL-12-Dependent Cytomegalovirus-Specific CD4+ T Cell Proliferation, T-bet Induction, and Effector Multifunction during Primary Infection Are Key Determinants for Early Immune Control.
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IL-12/GM-CSF coadministration in an SIV DNA prime/protein boost protocol enhances Gag-specific T cells but not virus-specific neutralizing antibodies in rhesus macaques.
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IL-2-dependent adaptive control of NK cell homeostasis.
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Immune response profiling in patients with traumatic injuries associated with alcohol ingestion.
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Immune responses to DNA in normal and aberrant immunity.
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Immunostimulatory properties of genomic DNA from different bacterial species.
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Immunotherapy with vaccines combining MHC class II/CD80+ tumor cells with interleukin-12 reduces established metastatic disease and stimulates immune effectors and monokine induced by interferon gamma.
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Impact of anti-CD25 monoclonal antibody on dendritic cell-tumor fusion vaccine efficacy in a murine melanoma model.
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In-vivo impaired T helper 1 cell development in submandibular lymph nodes due to IL-12 deficiency following antigen injection into the anterior chamber of the eye.
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Induction of human dendritic cell maturation using transfection with RNA encoding a dominant positive toll-like receptor 4.
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Induction of immune activation by a novel immunomodulatory oligonucleotide without thymocyte apoptosis.
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Induction of the human heat shock promoter HSP70B by nutritional stress: implications for cancer gene therapy.
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Influence of backbone chemistry on immune activation by synthetic oligonucleotides.
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Influence of proinflammatory cytokines on Actinobacillus actinomycetemcomitans specific IgG responses.
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Inhibition of murine dendritic cell activation by synthetic phosphorothioate oligodeoxynucleotides.
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Inhibition of murine macrophage IL-12 production by natural and synthetic DNA.
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Interleukin 12 at the site of disease in tuberculosis.
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Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis.
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Interleukin-15 augments superoxide production and microbicidal activity of human monocytes against Candida albicans.
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Intraperitoneal fluid neopterin, nitrate, and tryptophan after regional administration of interleukin-12.
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Intratumoral Plasmid IL12 Expands CD8+ T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti-PD-1 Therapy.
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LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells.
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Local secretion of IL-12 augments the therapeutic impact of dendritic cell-tumor cell fusion vaccination.
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Long-term control of simian immunodeficiency virus mac251 viremia to undetectable levels in half of infected female rhesus macaques nasally vaccinated with simian immunodeficiency virus DNA/recombinant modified vaccinia virus Ankara.
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Low interleukin-12 activity in severe Plasmodium falciparum malaria.
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Macrophage colony-stimulating factor can modulate immune responses and attract dendritic cells in vivo.
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Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli.
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Modulation of interleukin-12 mRNA expression in leukocytes of cancer patients treated with CM101.
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Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model.
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Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand.
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Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system.
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Non-erythroid effects of erythropoietin.
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Paired Toll-like receptor agonists enhance vaccine therapy through induction of interleukin-12.
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Peripheral blood cytokine and chemokine profiles in juvenile localized scleroderma: T-helper cell-associated cytokine profiles.
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Peripheral blood dendritic cells, but not monocyte-derived dendritic cells, can augment human NK cell function.
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Pharmacokinetics of combined gene therapy expressing constitutive human GM-CSF and hyperthermia-regulated human IL-12.
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Phase I study of intraperitoneal recombinant human interleukin 12 in patients with Müllerian carcinoma, gastrointestinal primary malignancies, and mesothelioma.
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Plasma interleukin-12 in malaria-tolerant papua new guineans: inverse correlation with Plasmodium falciparum parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity.
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Platelets deliver costimulatory signals to antigen-presenting cells: a potential bridge between injury and immune activation.
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Plexin-B2 and Plexin-D1 in dendritic cells: expression and IL-12/IL-23p40 production.
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Priming with plasmid DNAs expressing interleukin-12 and simian immunodeficiency virus gag enhances the immunogenicity and efficacy of an experimental AIDS vaccine based on recombinant vesicular stomatitis virus.
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Prostaglandin E2-mediated regulation of immunoglobulin G2 via interferon gamma.
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Protection by SIV VLP DNA prime/protein boost following mucosal SIV challenge is markedly enhanced by IL-12/GM-CSF co-administration.
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Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse.
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Reduced interleukin-12 and transforming growth factor-beta1 in severe childhood malaria: relationship of cytokine balance with disease severity.
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Release of endogenous danger signals from HIFU-treated tumor cells and their stimulatory effects on APCs.
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Resistance of CD7-deficient mice to lipopolysaccharide-induced shock syndromes.
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Retrovirus-elicited interleukin-12 and tumour necrosis factor-alpha as inducers of interferon-gamma-mediated pathology in mouse AIDS.
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Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy.
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Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.
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Role of interleukin 12 and costimulators in T cell anergy in vivo.
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Safety and immunogenicity of a polyvalent peptide C4-V3 HIV vaccine in conjunction with IL-12.
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Sequential delivery of maturation stimuli increases human dendritic cell IL-12 production and enhances tumor antigen-specific immunogenicity.
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Stability of Th1 and Th2 populations.
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Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes.
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Systemic cytokine immunotherapy for experimental cytomegalovirus retinitis in mice with retrovirus-induced immunodeficiency.
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Systemic dissemination of viral vectors during intratumoral injection.
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Systemic vector leakage and transgene expression by intratumorally injected recombinant adenovirus vectors.
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The influence of DNA sequence on the immunostimulatory properties of plasmid DNA vectors.
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The influence of lipofectin on the in vitro stimulation of murine spleen cells by bacterial DNA and plasmid DNA vectors.
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The role for interleukin-12 therapy of cutaneous T cell lymphoma.
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The role of IL12 in helper T-cell differentiation.
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The role of the macrophage scavenger receptor in immune stimulation by bacterial DNA and synthetic oligonucleotides.
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Toll-like receptor agonists as third signals for dendritic cell-tumor fusion vaccines.
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Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning.
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Type B CpG oligodeoxynucleotides induce Th1 responses to peanut antigens: modulation of sensitization and utility in a truncated immunotherapy regimen in mice.
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Vasculitis as a Major Morbidity Factor in Patients With Partial RAG Deficiency.
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[Antitumoral action of interferons and interleukins in combination with radiotherapy. Part I: immunologic basis].
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[Study of immunoregulation of dendritic cells in allergic rhinitis].
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Keywords of People