Toxicity Tests

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  Subject Areas on Research

  • 28-day toxicology test: indenopyridine RTI 4587-056 in male Sprague-Dawley rats. 
  • A call for fuller reporting of toxicity test data 
  • A mechanism-based complementary screening approach for the amelioration and reversal of neurobehavioral teratogenicity. 
  • A tiered approach to systemic toxicity testing for agricultural chemical safety assessment. 
  • Acute neuroactive drug exposures alter locomotor activity in larval zebrafish. 
  • Adapting the medaka embryo assay to a high-throughput approach for developmental toxicity testing. 
  • Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation. 
  • Advancing toxicology research using in vivo high throughput toxicology with small fish models. 
  • An adaptable mesocosm platform for performing integrated assessments of nanomaterial risk in complex environmental systems. 
  • An avian model for the reversal of neurobehavioral teratogenicity with neural stem cells. 
  • An expert-driven literature review of "negative" chemicals for developmental neurotoxicity (DNT) in vitro assay evaluation. 
  • Are quantum dots toxic? Exploring the discrepancy between cell culture and animal studies. 
  • Assessing the risks of manufactured nanomaterials. 
  • Atypical tubule hyperplasia and renal tubule tumors in conventional rats on 90-day toxicity studies. 
  • BDE 49 and developmental toxicity in zebrafish. 
  • Bacterial Growth Inhibition Screen (BGIS) identifies a loss-of-function mutant of the DEK oncogene, indicating DNA modulating activities of DEK in chromatin. 
  • Bacterial Growth Inhibition Screen (BGIS): harnessing recombinant protein toxicity for rapid and unbiased interrogation of protein function. 
  • Battery of neurobehavioral tests recommended to ATSDR: solvent-induced deficits in microelectronic workers. 
  • Biochemical approaches to studying neurotoxicity. 
  • Biotic and abiotic interactions in aquatic microcosms determine fate and toxicity of Ag nanoparticles: part 2-toxicity and Ag speciation. 
  • Brief embryonic strychnine exposure in zebrafish causes long-term adult behavioral impairment with indications of embryonic synaptic changes. 
  • Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors: implications for bronchiolitis obliterans in humans. 
  • Caenorhabditis elegans as a Model for Toxic Effects of Nanoparticles: Lethality, Growth, and Reproduction. 
  • Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology. 
  • Characterizing sources of variability in zebrafish embryo screening protocols. 
  • Choice of vehicle affects pyraclostrobin toxicity in mice. 
  • Clinical Trial in a Dish: Personalized Stem Cell-Derived Cardiomyocyte Assay Compared With Clinical Trial Results for Two QT-Prolonging Drugs. 
  • Comparative toxicities of selected compounds to nauplii of Balanus amphitrite amphitrite Darwin and Artemia sp. 
  • Comparative toxicity of C60 aggregates toward mammalian cells: role of tetrahydrofuran (THF) decomposition. 
  • Continuing education course #3: current practices and future trends in neuropathology assessment for developmental neurotoxicity testing. 
  • Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing. 
  • Determining the ecological impacts of organic contaminants in biosolids using a high-throughput colorimetric denitrification assay: a case study with antimicrobial agents. 
  • Development of a quantitative morphological assessment of toxicant-treated zebrafish larvae using brightfield imaging and high-content analysis. 
  • Developmental exposure to valproate and ethanol alters locomotor activity and retino-tectal projection area in zebrafish embryos. 
  • Developmental neurotoxic effects of chlorpyrifos on acetylcholine and serotonin pathways in an avian model. 
  • Discovery and ramifications of incidental Magnéli phase generation and release from industrial coal-burning. 
  • Does shaking alter the time of hatching in incubated medaka (Oryzias latipes) embryos? 
  • Effects of Toxic Leachate from Commercial Plastics on Larval Survival and Settlement of the Barnacle Amphibalanus amphitrite. 
  • Effects of immobilization restraint on Syrian golden hamsters. 
  • Effects of subchronic exposure to a complex mixture of persistent contaminants in male rats: systemic, immune, and reproductive effects. 
  • Evaluation of Maternal, Embryo, and Placental Effects in CD-1 Mice following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX). 
  • Expanding the test set: Chemicals with potential to disrupt mammalian brain development. 
  • Flow Cytometry for the Immunotoxicologist. 
  • Further assessment of an in vitro screen that may help identify organophosphorus pesticides that are more acutely toxic to the young. 
  • Generation and characterization of neurogenin1-GFP transgenic medaka with potential for rapid developmental neurotoxicity screening. 
  • High-throughput cardiac safety evaluation and multi-parameter arrhythmia profiling of cardiomyocytes using microelectrode arrays. 
  • Impact of strain type on detection of toxigenic Clostridium difficile: comparison of molecular diagnostic and enzyme immunoassay approaches. 
  • In vitro exposure systems and dosimetry assessment tools for inhaled tobacco products: Workshop proceedings, conclusions and paths forward for in vitro model use. 
  • Introduction to the special issue on emerging high throughput and complementary model screens for neurotoxicology. 
  • Is There a Space-Based Technology Solution to Problems with Preclinical Drug Toxicity Testing? 
  • Laboratory animal science issues in the design and conduct of studies with endocrine-active compounds. 
  • Larval biology of the crab Rhithropanopeus harrisii (Gould): a synthesis. 
  • Learning about cognition risk with the radial-arm maze in the developmental neurotoxicology battery. 
  • Life-cycle effects of single-walled carbon nanotubes (SWNTs) on an estuarine meiobenthic copepod. 
  • Methods to identify and characterize developmental neurotoxicity for human health risk assessment. III: pharmacokinetic and pharmacodynamic considerations. 
  • Nanomaterial categorization for assessing risk potential to facilitate regulatory decision-making. 
  • New Cembranolide Analogues from the Formosan Soft Coral Sinularia flexibilis and Their Cytotoxicity 
  • Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use. 
  • Repetitive Ozone Exposures and Evaluation of Pulmonary Inflammation and Remodeling in Diabetic Mouse Strains. 
  • Response to comment on "Determining the ecological impacts of organic contaminants in biosolids using a high-throughput colorimetric denitrification assay: a case study with antimicrobial agents". 
  • Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel. 
  • Sea urchin embryos and larvae as biosensors for neurotoxicants. 
  • Selected Resources for Pathology Evaluation of Nonhuman Primates in Nonclinical Safety Assessment. 
  • Selected contribution: a three-dimensional model for assessment of in vitro toxicity in balaena mysticetus renal tissue. 
  • Silver nanocolloids disrupt medaka embryogenesis through vital gene expressions. 
  • Silver nanoparticle toxicity to Atlantic killifish (Fundulus heteroclitus) and Caenorhabditis elegans: a comparison of mesocosm, microcosm, and conventional laboratory studies. 
  • Silver toxicity across salinity gradients: the role of dissolved silver chloride species (AgCl x ) in Atlantic killifish (Fundulus heteroclitus) and medaka (Oryzias latipes) early life-stage toxicity. 
  • Sublethal effects of pentachlorophenol in abalone (Haliotis rufescens) veliger larvae as measured by (31)P-NMR. 
  • Synergistic embryotoxicity of polycyclic aromatic hydrocarbon aryl hydrocarbon receptor agonists with cytochrome P4501A inhibitors in Fundulus heteroclitus. 
  • Taxonomic applicability of inflammatory cytokines in adverse outcome pathway (AOP) development. 
  • The fish embryo toxicity test as an animal alternative method in hazard and risk assessment and scientific research. 
  • The future of preclinical animal models in pharmaceutical discovery and development: a need to bring in cerebro to the in vivo discussions. 
  • The zebrafish embryo model in toxicology and teratology, September 2–3, 2010, Karlsruhe, Germany. 
  • Three-dimensional (3D) brain microphysiological system for organophosphates and neurochemical agent toxicity screening. 
  • Thyroid toxicity due to subchronic exposure to a complex mixture of 16 organochlorines, lead, and cadmium. 
  • Tissue-engineered blood vessels as promising tools for testing drug toxicity. 
  • Toxic actions of dinoseb in medaka (Oryzias latipes) embryos as determined by in vivo 31P NMR, HPLC-UV and 1H NMR metabolomics. 
  • Ultrasonic dispersion of nanoparticles for environmental, health and safety assessment--issues and recommendations. 
  • Ultraviolet photolysis of chlorpyrifos: developmental neurotoxicity modeled in PC12 cells. 
  • Unconventional oil and gas chemicals and wastewater-impacted water samples promote adipogenesis via PPARγ-dependent and independent mechanisms in 3T3-L1 cells. 
  • Use of medaka in toxicity testing. 
  • Use of short-term assays to evaluate the potential toxicity of two new biosoluble glasswool fibers. 
  • Zebrafish developmental screening of the ToxCast™ Phase I chemical library. 
  • Zebrafish model systems for developmental neurobehavioral toxicology. 
  • Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits. 
  • Zebrafish: as an integrative model for twenty-first century toxicity testing. 
  • t⁴ workshop report. Nanotoxicology: "the end of the beginning" - signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials. 
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  Keywords of People

  • Meyer, Joel, Associate Professor of Environmental Genomics in the Division of Environmental Sciences and Policy, Nicholas Institute-Energy Initiative