Anesthetics, Inhalation

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  Subject Areas on Research

  • A comparison of mivacurium dosage requirements during isoflurane and desflurane anesthesia. 
  • A comparison of the efficacy, safety, and patient satisfaction of ondansetron versus droperidol as antiemetics for elective outpatient surgical procedures. S3A-409 and S3A-410 Study Groups. 
  • A study of anesthetic drug utilization in different age groups. 
  • A survey of inhalational anaesthetic abuse in anaesthesia training programmes. 
  • Absence of biochemical evidence for renal and hepatic dysfunction after 8 hours of 1.25 minimum alveolar concentration sevoflurane anesthesia in volunteers. 
  • Absence of direct antioxidant effects from volatile anesthetics in primary mixed neuronal-glial cultures. 
  • Acute and Long-Term Effects of Brief Sevoflurane Anesthesia During the Early Postnatal Period in Rats. 
  • Adenosine-induced flow arrest to facilitate intracranial aneurysm clip ligation: dose-response data and safety profile. 
  • Adjunct Therapies for Refractory Status Asthmaticus in Children. 
  • Adverse drug reactions with halogenated anesthetics. 
  • Age-dependent decrease in minimum alveolar concentration of inhaled anaesthetics: a systematic search of published studies and meta-regression analysis. 
  • An evaluation of remifentanil-sevoflurane response surface models in patients emerging from anesthesia: model improvement using effect-site sevoflurane concentrations. 
  • Anesthetic effects on cerebral metabolic rate predict histologic outcome from near-complete forebrain ischemia in the rat. 
  • Anesthetic effects on the glycerol model of rhabdomyolysis-induced acute renal failure in rats. 
  • Apoptosis is not enhanced in primary mixed neuronal/glial cultures protected by isoflurane against N-methyl-D-aspartate excitotoxicity. 
  • Assessment of low-flow sevoflurane and isoflurane effects on renal function using sensitive markers of tubular toxicity. 
  • Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro: interindividual variability in N-acetylation, N-deacetylation, and beta-lyase-catalyzed metabolism. 
  • Biotransformation of sevoflurane. 
  • Bispectral analysis during cardiopulmonary bypass: the effect of hypothermia on the hypnotic state. 
  • Cardiopulmonary bypass reduces the minimum alveolar concentration for isoflurane. 
  • Cause of CO poisoning, relation to halogenated agents still not clear. 
  • Clinical isoflurane metabolism by cytochrome P450 2E1. 
  • Combined general-epidural anesthesia decreases the desflurane requirement for equivalent A-line ARX index in colorectal surgery. 
  • Comparing the effects of minimal low-flow desflurane with that of semi-close high flow desflurane on perioperative cytokine response in patients undergoing gastrectomy. 
  • Comparison of Amsorb, sodalime, and Baralyme degradation of volatile anesthetics and formation of carbon monoxide and compound a in swine in vivo. 
  • Comparison of electrophysiologic effects of propofol and isoflurane-based anesthetics in children undergoing radiofrequency catheter ablation for supraventricular tachycardia. 
  • Compound A uptake and metabolism to mercapturic acids and 3,3,3-trifluoro-2-fluoromethoxypropanoic acid during low-flow sevoflurane anesthesia: biomarkers for exposure, risk assessment, and interspecies comparison. 
  • Concordance between trifluoroacetic acid and hepatic protein trifluoroacetylation after disulfiram inhibition of halothane metabolism in rats. 
  • Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro. 
  • Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line. 
  • Differential effects of anesthetic agents on outcome from near-complete but not incomplete global ischemia in the rat. 
  • Dose-dependent metabolism of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), an anesthetic degradation product, to mercapturic acids and 3,3,3-trifluoro-2-(fluoromethoxy)propanoic acid in rats. 
  • Drug interactions: volatile anesthetics and opioids. 
  • Effect of nitrous oxide on cerebral blood velocity while reclining and standing. 
  • Effects of desflurane on jugular bulb gases and pressure in neurosurgical patients. 
  • Effects of isoflurane, ketamine, and fentanyl/N2O on concentrations of brain and plasma catecholamines during near-complete cerebral ischemia in the rat. 
  • Effects of postischemic halothane administration on outcome from transient focal cerebral ischemia in the rat. 
  • Effects of volatile anesthetics on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cultures. 
  • Evidence for metabolism of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product, by cysteine conjugate beta-lyase. 
  • Filling in the blanks. 
  • Gene expression profiling of nephrotoxicity from the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ("compound A") in rats. 
  • Glutathione S-conjugation of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human liver, kidney, and blood in vitro. 
  • Human halothane metabolism, lipid peroxidation, and cytochromes P(450)2A6 and P(450)3A4. 
  • Human halothane reduction in vitro by cytochrome P450 2A6 and 3A4: identification of low and high KM isoforms. 
  • Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4. 
  • Hyperbaric oxygen therapy and neurological disease. 
  • Impact of anesthesia on transcranial electric motor evoked potential monitoring during spine surgery: a review of the literature. 
  • Influence of nociception and stress-induced antinociception on genetic variation in isoflurane anesthetic potency among mouse strains. 
  • Intact cerebral blood flow reactivity during remifentanil/nitrous oxide anesthesia. 
  • Isoflurane for life-threatening bronchospasm: a 15-year single-center experience. 
  • Isoflurane neuroprotection: a passing fantasy, again? 
  • Isoflurane provides long-term protection against focal cerebral ischemia in the rat. 
  • Isoflurane, but not halothane, induces protection of human myocardium via adenosine A1 receptors and adenosine triphosphate-sensitive potassium channels. 
  • Isoflurane-induced neuronal degeneration: an evaluation in organotypic hippocampal slice cultures. 
  • Keep it flowing: a simulation involving defective anesthetic gas delivery equipment. 
  • Keep the blood red...the right way. 
  • Long-duration low-flow sevoflurane and isoflurane effects on postoperative renal and hepatic function. 
  • Low-flow sevoflurane compared with low-flow isoflurane anesthesia in patients with stable renal insufficiency. 
  • Mechanistic aspects of carbon monoxide formation from volatile anesthetics. 
  • Metabolism and toxicity of the new anesthetic agents. 
  • Myocardial ischemia and adverse cardiac outcomes in cardiac patients undergoing noncardiac surgery with sevoflurane and isoflurane. Sevoflurane Ischemia Study Group. 
  • NMDA-induced apoptosis in mixed neuronal/glial cortical cell cultures: the effects of isoflurane and dizocilpine. 
  • Neuroprotection by nitrous oxide and xenon and its relation to minimum alveolar concentration. 
  • New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 1): Identification of the nephrotoxic metabolic pathway. 
  • New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites. 
  • Nitrous oxide anesthesia and plasma homocysteine in adolescents. 
  • Onset and recovery of neuromuscular blockade after two doses of rocuronium in children. 
  • Opioid-volatile anesthetic synergy: a response surface model with remifentanil and sevoflurane as prototypes. 
  • P450-dependent and nonenzymatic human liver microsomal defluorination of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product. 
  • Paradox of age: older patients receive higher age-adjusted minimum alveolar concentration fractions of volatile anaesthetics yet display higher bispectral index values. 
  • Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats. 
  • Pharmacodynamic interactions between cisatracurium and rocuronium. 
  • Pharmacologically defined components of the normal porcine multifocal ERG. 
  • Pharmacovigilance and safety aspects of sevoflurane. 
  • Postischemic nitrous oxide alone versus intraischemic nitrous oxide in the presence of isoflurane: what it may change for neuroprotection against cerebral stroke in the rat. 
  • Prevention of intraoperative awareness. 
  • Putting the brakes on anesthetic breakdown. 
  • Renal cysteine conjugate beta-lyase and compound A nephrotoxicity: minimal evidence for an association. 
  • Response to 'Correlation between bispectral index and age-adjusted minimal alveolar concentration' (Br J Anaesth 2020; 124:e8). 
  • Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats. 
  • Role of renal cysteine conjugate beta-lyase in the mechanism of compound A nephrotoxicity in rats. 
  • Role of the renal cysteine conjugate beta-lyase pathway in inhaled compound A nephrotoxicity in rats. 
  • Safety of low-flow sevoflurane anesthesia in patients with chronically impaired renal function is not proven. 
  • Severe hypotension is not essential for isoflurane neuroprotection against forebrain ischemia in mice. 
  • Sevoflurane Induces Coherent Slow-Delta Oscillations in Rats. 
  • Sevoflurane formulation water content influences degradation by Lewis acids in vaporizers. 
  • Sleeping to survive?: The impact of volatile anesthetics on mortality in sepsis. 
  • Spectrum and subcellular determinants of fluorinated anesthetic-mediated proximal tubular injury. 
  • Speed of recovery and side-effect profile of sevoflurane sedation compared with midazolam. 
  • Stereoselective metabolism of enflurane by human liver cytochrome P450 2E1. 
  • Substantial postoperative pain is common among children undergoing laparoscopic appendectomy. 
  • Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A). 
  • Sympathetic ganglionic blockade masks beneficial effect of isoflurane on histologic outcome from near-complete forebrain ischemia in the rat. 
  • Technical communication: inhaled anesthetic agent-vaporizer mismatch: management in settings with limited resources: don't try this at home. 
  • The hematological effects of nitrous oxide anesthesia in pediatric patients. 
  • The hemodynamic and renal effects of sevoflurane and isoflurane in patients with coronary artery disease and chronic hypertension. Sevoflurane Ischemia Study Group. 
  • The influence of xenon, nitrous oxide and nitrogen on gas bubble expansion during cardiopulmonary bypass. 
  • Time-varying spectral analysis revealing differential effects of sevoflurane anaesthesia: non-rhythmic-to-rhythmic ratio. 
  • When is a bispectral index of 60 too low?: Rational processed electroencephalographic targets are dependent on the sedative-opioid ratio. 
  • Xenon and the inflammatory response to cardiopulmonary bypass in the rat. 
  • [Compound A: toxicology and clinical relevance]. 
  • gamma-Aminobutyric acid-A receptors contribute to isoflurane neuroprotection in organotypic hippocampal cultures. 
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  Keywords of People

  • Swaminathan, Madhav, Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology