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Subject Areas on Research
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A study of anesthetic drug utilization in different age groups.
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A survey of inhalational anaesthetic abuse in anaesthesia training programmes.
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Absence of biochemical evidence for renal and hepatic dysfunction after 8 hours of 1.25 minimum alveolar concentration sevoflurane anesthesia in volunteers.
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Absence of direct antioxidant effects from volatile anesthetics in primary mixed neuronal-glial cultures.
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Acute and Long-Term Effects of Brief Sevoflurane Anesthesia During the Early Postnatal Period in Rats.
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Adenosine-induced flow arrest to facilitate intracranial aneurysm clip ligation: dose-response data and safety profile.
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Adjunct Therapies for Refractory Status Asthmaticus in Children.
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Adverse drug reactions with halogenated anesthetics.
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Age-dependent decrease in minimum alveolar concentration of inhaled anaesthetics: a systematic search of published studies and meta-regression analysis.
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An evaluation of remifentanil-sevoflurane response surface models in patients emerging from anesthesia: model improvement using effect-site sevoflurane concentrations.
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Anesthetic MAC: Origin, Utility, and Nomenclature Revisited.
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Anesthetic effects on cerebral metabolic rate predict histologic outcome from near-complete forebrain ischemia in the rat.
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Anesthetic effects on the glycerol model of rhabdomyolysis-induced acute renal failure in rats.
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Apoptosis is not enhanced in primary mixed neuronal/glial cultures protected by isoflurane against N-methyl-D-aspartate excitotoxicity.
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Assessment of low-flow sevoflurane and isoflurane effects on renal function using sensitive markers of tubular toxicity.
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Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro: interindividual variability in N-acetylation, N-deacetylation, and beta-lyase-catalyzed metabolism.
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Biotransformation of sevoflurane.
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Bispectral analysis during cardiopulmonary bypass: the effect of hypothermia on the hypnotic state.
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Cardioprotective Effect of Anesthetics: Translating Science to Practice.
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Cardiopulmonary bypass reduces the minimum alveolar concentration for isoflurane.
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Cause of CO poisoning, relation to halogenated agents still not clear.
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Cerebral autoregulation and CO2 reactivity in anterior and posterior cerebral circulation during sevoflurane anesthesia.
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Clinical isoflurane metabolism by cytochrome P450 2E1.
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Combined general-epidural anesthesia decreases the desflurane requirement for equivalent A-line ARX index in colorectal surgery.
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Comparing the effects of minimal low-flow desflurane with that of semi-close high flow desflurane on perioperative cytokine response in patients undergoing gastrectomy.
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Comparison of Amsorb, sodalime, and Baralyme degradation of volatile anesthetics and formation of carbon monoxide and compound a in swine in vivo.
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Comparison of electrophysiologic effects of propofol and isoflurane-based anesthetics in children undergoing radiofrequency catheter ablation for supraventricular tachycardia.
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Compound A uptake and metabolism to mercapturic acids and 3,3,3-trifluoro-2-fluoromethoxypropanoic acid during low-flow sevoflurane anesthesia: biomarkers for exposure, risk assessment, and interspecies comparison.
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Concordance between trifluoroacetic acid and hepatic protein trifluoroacetylation after disulfiram inhibition of halothane metabolism in rats.
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Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro.
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Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line.
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Differential effects of anesthetic agents on outcome from near-complete but not incomplete global ischemia in the rat.
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Dose-dependent metabolism of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), an anesthetic degradation product, to mercapturic acids and 3,3,3-trifluoro-2-(fluoromethoxy)propanoic acid in rats.
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Drug interactions: volatile anesthetics and opioids.
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Dynamic Monitoring of Systemic Biomarkers with Gastric Sensors.
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Effect of nitrous oxide on cerebral blood velocity while reclining and standing.
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Effects of alfaxalone, propofol and isoflurane on cerebral blood flow and cerebrovascular reactivity to carbon dioxide in dogs: A pilot study.
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Effects of desflurane on jugular bulb gases and pressure in neurosurgical patients.
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Effects of isoflurane, ketamine, and fentanyl/N2O on concentrations of brain and plasma catecholamines during near-complete cerebral ischemia in the rat.
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Effects of postischemic halothane administration on outcome from transient focal cerebral ischemia in the rat.
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Effects of volatile anesthetics on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cultures.
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Evidence for metabolism of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product, by cysteine conjugate beta-lyase.
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Extending the use of inhaled anesthetics beyond the operating room: a giant snake creeping into the intensive care unit.
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Gene expression profiling of nephrotoxicity from the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ("compound A") in rats.
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General Anesthesia Alters the Diversity and Composition of the Intestinal Microbiota in Mice.
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Glutathione S-conjugation of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human liver, kidney, and blood in vitro.
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Human halothane metabolism, lipid peroxidation, and cytochromes P(450)2A6 and P(450)3A4.
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Human halothane reduction in vitro by cytochrome P450 2A6 and 3A4: identification of low and high KM isoforms.
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Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4.
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Hyperbaric oxygen therapy and neurological disease.
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Impact of anesthesia on transcranial electric motor evoked potential monitoring during spine surgery: a review of the literature.
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Influence of nociception and stress-induced antinociception on genetic variation in isoflurane anesthetic potency among mouse strains.
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Isoflurane for life-threatening bronchospasm: a 15-year single-center experience.
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Isoflurane prevents learning deficiencies caused by brief hypoxia and hypotension in adult Sprague Dawley rats.
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Isoflurane provides long-term protection against focal cerebral ischemia in the rat.
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Isoflurane, but not halothane, induces protection of human myocardium via adenosine A1 receptors and adenosine triphosphate-sensitive potassium channels.
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Isoflurane-induced neuronal degeneration: an evaluation in organotypic hippocampal slice cultures.
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Keep it flowing: a simulation involving defective anesthetic gas delivery equipment.
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Keep the blood red...the right way.
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Long-duration low-flow sevoflurane and isoflurane effects on postoperative renal and hepatic function.
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Low-flow sevoflurane compared with low-flow isoflurane anesthesia in patients with stable renal insufficiency.
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Mechanistic aspects of carbon monoxide formation from volatile anesthetics.
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Metabolism and toxicity of the new anesthetic agents.
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Myocardial ischemia and adverse cardiac outcomes in cardiac patients undergoing noncardiac surgery with sevoflurane and isoflurane. Sevoflurane Ischemia Study Group.
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NMDA-induced apoptosis in mixed neuronal/glial cortical cell cultures: the effects of isoflurane and dizocilpine.
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Neuroprotection by nitrous oxide and xenon and its relation to minimum alveolar concentration.
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New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 1): Identification of the nephrotoxic metabolic pathway.
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New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites.
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Nitrous oxide anesthesia and plasma homocysteine in adolescents.
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Onset and recovery of neuromuscular blockade after two doses of rocuronium in children.
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Opioid-volatile anesthetic synergy: a response surface model with remifentanil and sevoflurane as prototypes.
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P450-dependent and nonenzymatic human liver microsomal defluorination of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product.
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Paradox of age: older patients receive higher age-adjusted minimum alveolar concentration fractions of volatile anaesthetics yet display higher bispectral index values.
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Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats.
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Pharmacodynamic interactions between cisatracurium and rocuronium.
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Pharmacologically defined components of the normal porcine multifocal ERG.
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Pharmacovigilance and safety aspects of sevoflurane.
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Post-operative elimination of sevoflurane anesthetic and hexafluoroisopropanol metabolite in exhaled breath: pharmacokinetic models for assessing liver function.
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Prevention of intraoperative awareness.
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Prolonged propofol anesthesia is not associated with an increase in blood lactate.
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Propofol increased cerebral perfusion as compared with isoflurane during a cerebral angiography in a child with moyamoya disease.
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Putting the brakes on anesthetic breakdown.
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Randomized controlled trial of acupuncture to prevent emergence delirium in children undergoing myringotomy tube placement.
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Renal cysteine conjugate beta-lyase and compound A nephrotoxicity: minimal evidence for an association.
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Response to 'Correlation between bispectral index and age-adjusted minimal alveolar concentration' (Br J Anaesth 2020; 124:e8).
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Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats.
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Role of renal cysteine conjugate beta-lyase in the mechanism of compound A nephrotoxicity in rats.
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Role of the renal cysteine conjugate beta-lyase pathway in inhaled compound A nephrotoxicity in rats.
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Safety of low-flow sevoflurane anesthesia in patients with chronically impaired renal function is not proven.
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Severe hypotension is not essential for isoflurane neuroprotection against forebrain ischemia in mice.
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Sevoflurane formulation water content influences degradation by Lewis acids in vaporizers.
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Sleeping to survive?: The impact of volatile anesthetics on mortality in sepsis.
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Spectrum and subcellular determinants of fluorinated anesthetic-mediated proximal tubular injury.
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Speed of recovery and side-effect profile of sevoflurane sedation compared with midazolam.
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Stereoselective metabolism of enflurane by human liver cytochrome P450 2E1.
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Substantial postoperative pain is common among children undergoing laparoscopic appendectomy.
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Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A).
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Sympathetic ganglionic blockade masks beneficial effect of isoflurane on histologic outcome from near-complete forebrain ischemia in the rat.
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Technical communication: inhaled anesthetic agent-vaporizer mismatch: management in settings with limited resources: don't try this at home.
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The hematological effects of nitrous oxide anesthesia in pediatric patients.
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The hemodynamic and renal effects of sevoflurane and isoflurane in patients with coronary artery disease and chronic hypertension. Sevoflurane Ischemia Study Group.
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The influence of xenon, nitrous oxide and nitrogen on gas bubble expansion during cardiopulmonary bypass.
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Time-varying spectral analysis revealing differential effects of sevoflurane anaesthesia: non-rhythmic-to-rhythmic ratio.
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When is a bispectral index of 60 too low?: Rational processed electroencephalographic targets are dependent on the sedative-opioid ratio.
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Xenon and the inflammatory response to cardiopulmonary bypass in the rat.
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[Compound A: toxicology and clinical relevance].