Glutamic Acid

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  Subject Areas on Research

  • "Silent" NMDA Synapses Enhance Motion Sensitivity in a Mature Retinal Circuit. 
  • A Monte Carlo model reveals independent signaling at central glutamatergic synapses. 
  • A Neural Circuit for Gut-Induced Reward. 
  • A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition. 
  • A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors. 
  • Abnormal cerebellar signaling induces dystonia in mice. 
  • Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract. 
  • Activation in the region of parabrachial nucleus elicits neurogenically mediated coronary vasoconstriction. 
  • Adenosine-induced modulation of excitatory amino acid transport across isolated brain arterioles. 
  • Adenylyl cyclase expression and modulation of cAMP in rat taste cells. 
  • Alpha-receptor mediated inhibition of A2 noradrenergic neurons. 
  • Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. 
  • An in vitro study of horizontal connections in the intermediate layer of the superior colliculus. 
  • Apolipoprotein E protects against oxidative stress in mixed neuronal-glial cell cultures by reducing glutamate toxicity. 
  • Apoptosis and delayed neuronal damage after carbon monoxide poisoning in the rat. 
  • Aspartate release from rat hippocampal synaptosomes. 
  • Autocrine BDNF-TrkB signalling within a single dendritic spine. 
  • Autoreceptor regulation of glutamate and aspartate release from slices of the hippocampal CA1 area. 
  • Blockade of NAALADase: a novel neuroprotective strategy based on limiting glutamate and elevating NAAG. 
  • Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission. 
  • Brush border enzyme-cleavable linkers: Evaluation for reducing renal uptake of radiolabeled prostate-specific membrane antigen inhibitors. 
  • Calmodulin supports both inactivation and facilitation of L-type calcium channels. 
  • Capillary electrophoresis with electrochemiluminescence detection for measurement of aspartate aminotransferase and alanine aminotransferase activities in biofluids. 
  • Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer. 
  • Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV. 
  • Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell. 
  • Colocalization of excitatory and inhibitory neurotransmitter markers in striatal projection neurons in the rat. 
  • Comparison of the potency of competitive NMDA antagonists against the neurotoxicity of glutamate and NMDA. 
  • Complex binding of L-[3H]glutamate to hippocampal synaptic membranes in the absence of sodium. 
  • Contributions of mossy fiber and CA1 pyramidal cell sprouting to dentate granule cell hyperexcitability in kainic acid-treated hippocampal slice cultures. 
  • Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. 
  • Cystine-glutamate transport interactions in rat renal cortical tubules, brushborder vesicles, and cultured renal tubule cells. 
  • DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses. 
  • Developmental sensitivity of hippocampal interneurons to ethanol: involvement of the hyperpolarization-activated current, Ih. 
  • Dopamine Neurons That Cotransmit Glutamate, From Synapses to Circuits to Behavior. 
  • Effect of glutamate analogues on brain tumor cell lines. 
  • Effects of glucose deficiency on glutamate/aspartate release and excitatory synaptic responses in the hippocampal CA1 area in vitro. 
  • Effects of glutamine, glucose, and oxygen concentration on the metabolism and proliferation of rabbit adipose-derived stem cells. 
  • Effects of quisqualic acid and glutamate on subsequent learning, emotionality, and seizure susceptibility in the immature and mature animal. 
  • Effects of temperature changes on cerebral biochemistry in spontaneous intracerebral hematoma. 
  • Effects of volatile anesthetics on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cultures. 
  • Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice. 
  • Elevated prefrontal cortex γ-aminobutyric acid and glutamate-glutamine levels in schizophrenia measured in vivo with proton magnetic resonance spectroscopy. 
  • Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner. 
  • Ethanol inhibits release of excitatory amino acids from slices of hippocampal area CA1. 
  • Evidence for differential localization of two binding sites for L-[3H]glutamate in rat fascia dentata. 
  • Evidence for increased glutamatergic cortical facilitation in children and adolescents with major depressive disorder. 
  • Evidence that a catalytic glutamate and an 'Arginine Toggle' act in concert to mediate ATP hydrolysis and mechanochemical coupling in a viral DNA packaging motor. 
  • Evidence that zinc inhibits N-methyl-D-aspartate receptor-gated ion channel activation by noncompetitive antagonism of glycine binding. 
  • Excitatory amino acid neurotoxins: selectivity, specificity, and mechanisms of action. Based on an NRP one-day conference held June 30, 1980. 
  • Exploiting metabolic differences in glioma therapy. 
  • Exploring steric constraints on protein mutations using MAGE/PROBE. 
  • Expression and site-directed mutagenesis of the phosphatidylcholine-preferring phospholipase C of Bacillus cereus: probing the role of the active site Glu146. 
  • Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attack. 
  • Functional reconstitution of purified metabotropic glutamate receptor expressed in the fly eye. 
  • Genetic dissection of the glutamatergic neuron system in cerebral cortex. 
  • Genetic studies of body mass index yield new insights for obesity biology. 
  • Germline HOXB13 G84E mutation carriers and risk to twenty common types of cancer: results from the UK Biobank. 
  • Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase. 
  • Glutamate acting at NMDA receptors stimulates embryonic cortical neuronal migration. 
  • Glutamate and dynorphin release from a subcellular fraction enriched in hippocampal mossy fiber synaptosomes. 
  • Glutamate decreases mitochondrial size and movement in primary forebrain neurons. 
  • Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy. 
  • Glutamate mobilizes [Zn2+] through Ca2+ -dependent reactive oxygen species accumulation. 
  • Glutamate-binding affinity of Drosophila metabotropic glutamate receptor is modulated by association with lipid rafts. 
  • Glutamatergic neuronal differentiation of mouse embryonic stem cells after transient expression of neurogenin 1 and treatment with BDNF and GDNF: in vitro and in vivo studies. 
  • Glutamine metabolism during aerial mycelium growth of Neurospora crassa. 
  • Glutamine requirement for aerial mycelium growth in Neurospora crassa. 
  • HIF1α and HIF2α exert distinct nutrient preferences in renal cells. 
  • Hb Catonsville (glutamic acid inserted between Pro-37(C2)alpha and Thr-38(C3)alpha). Nonallelic gene conversion in the globin system? 
  • Histologic grading correlates with inflammatory biomarkers in tibialis posterior tendon dysfunction. 
  • How can a single second sphere amino acid substitution cause reduction midpoint potential changes of hundreds of millivolts? 
  • Hypoxia modulates nitric oxide-induced regulation of NMDA receptor currents and neuronal cell death. 
  • Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate. 
  • Identification of the second chromophore of Escherichia coli and yeast DNA photolyases as 5,10-methenyltetrahydrofolate. 
  • Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death. 
  • Imaging of brain tumors after administration of L-(N-13)glutamate: concise communication. 
  • Imaging of primary Ewing sarcoma with 13N-L-glutamate. 
  • Impaired volume regulation is the mechanism of excitotoxic sensitization to complement. 
  • Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I-deficient mice. 
  • Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation. 
  • Independent sources of quantal variability at single glutamatergic synapses. 
  • Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia. 
  • Ischemic injury and extracellular amino acid accumulation in hippocampal area CA1 are not dependent upon an intact septo-hippocampal pathway. 
  • Ischemic stroke: "acidotoxicity" is a perpetrator. 
  • Kindling enhances sensitivity of CA3 hippocampal pyramidal cells to NMDA. 
  • Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway. 
  • L-[3H]Glutamate binding to hippocampal synaptic membranes: two binding sites discriminated by their differing affinities for quisqualate. 
  • LTD at mossy fiber synapses onto stratum lucidum interneurons requires TrkB and retrograde endocannabinoid signaling. 
  • LTP in the mouse nucleus accumbens is developmentally regulated. 
  • Late onset N-acetylglutamate synthase deficiency caused by hypomorphic alleles. 
  • Lysophosphatidic acid stimulates neurotransmitter-like conductance changes that precede GABA and L-glutamate in early, presumptive cortical neuroblasts. 
  • Magnesium-dependent inhibition of N-methyl-D-aspartate receptor-mediated synaptic transmission by ethanol. 
  • Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy. 
  • Mechanism of the Class I KDPG aldolase. 
  • Mechanisms and functional roles of glutamatergic synapse diversity in a cerebellar circuit. 
  • Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects. 
  • Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants. 
  • Missense mutation in a von Willebrand factor type A domain of the alpha 3(VI) collagen gene (COL6A3) in a family with Bethlem myopathy. 
  • Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study. 
  • Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II. 
  • Mossy fiber-granule cell synapses in the normal and epileptic rat dentate gyrus studied with minimal laser photostimulation. 
  • N-methyl-D-aspartate receptor autoradiography in rat brain after angular bundle kindling. 
  • NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons in vitro. 
  • NMDA-Receptor-dependent synaptic activation of voltage-dependent calcium channels in basolateral amygdala. 
  • Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes. 
  • Neocortical disynaptic inhibition requires somatodendritic integration in interneurons. 
  • Nepsilon-(3-[*I]Iodobenzoyl)-Lys5-Nalpha-maleimido-Gly1-GEEEK ([*I]IB-Mal-D-GEEEK): a radioiodinated prosthetic group containing negatively charged D-glutamates for labeling internalizing monoclonal antibodies. 
  • Neural correlates of single-vessel haemodynamic responses in vivo. 
  • Neuregulin-1 enhances depolarization-induced GABA release. 
  • Neuronal-astrocyte metabolic interactions: understanding the transition into abnormal astrocytoma metabolism. 
  • Neuropeptide Y regulates recurrent mossy fiber synaptic transmission less effectively in mice than in rats: Correlation with Y2 receptor plasticity. 
  • Neuroprotective effect of curcumin in an experimental rat model of subarachnoid hemorrhage. 
  • Neuroprotective effects of NMDA receptor glycine recognition site antagonism: dependence on glycine concentration. 
  • Nitric oxide amplifies the excitatory to inhibitory neurotransmitter imbalance accelerating oxygen seizures. 
  • Nitric oxide in glutamate-induced compound action potential threshold shifts. 
  • Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion. 
  • Nitroxyl anion regulation of the NMDA receptor. 
  • Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene. 
  • Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes. 
  • Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding. 
  • Observation of coupled 1H metabolite resonances at long TE. 
  • Optical imaging reveals elevated intracellular chloride in hippocampal pyramidal neurons after oxidative stress. 
  • Organization of the intermediate gray layer of the superior colliculus. I. Intrinsic vertical connections. 
  • Perforant path lesion depletes glutamate content of fascia dentata synaptosomes. 
  • Pharmacological characterization and immunoaffinity purification of metabotropic glutamate receptor from Drosophila overexpressed in Sf9 cells. 
  • Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation. 
  • Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrate. 
  • Proline-induced inhibition of glutamate release in hippocampal area CA1. 
  • Proline-induced potentiation of glutamate transmission. 
  • Prometheus revisited. 
  • Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair. 
  • Protonation state of Glu142 differs in the green- and blue-absorbing variants of proteorhodopsin. 
  • Quantifying global-brain metabolite level changes with whole-head proton MR spectroscopy at 3T. 
  • Quantitative scanning of soft-tissue sarcomas with nitrogen-13-labeled L-glutamate. 
  • Quotient imaging with N-13 L-glutamate in osteogenic sarcoma: correlation with tumor viability. 
  • Redox regulation of neuronal migration in a Down Syndrome model. 
  • Reduced aspartate release from rat hippocampal synaptosomes loaded with Clostridial toxin light chain by electroporation: evidence for an exocytotic mechanism. 
  • Reduction of voltage-dependent currents by ethanol contributes to inhibition of NMDA receptor-mediated excitatory synaptic transmission. 
  • Region-specific impairments in striatal synaptic transmission and impaired instrumental learning in a mouse model of Angelman syndrome. 
  • Regulation of glutamate and aspartate release from slices of the hippocampal CA1 area: effects of adenosine and baclofen. 
  • Regulation of glutamate and aspartate release from the Schaffer collaterals and other projections of CA3 hippocampal pyramidal cells. 
  • Release of glutamate and aspartate from CA1 synaptosomes: selective modulation of aspartate release by ionotropic glutamate receptor ligands. 
  • Respiratory and telencephalic modulation of vocal motor neurons in the zebra finch. 
  • Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors. 
  • Role of arginine 180 and glutamic acid 177 of ricin toxin A chain in enzymatic inactivation of ribosomes. 
  • Role of the GLT-1 subtype of glutamate transporter in glutamate homeostasis: the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus. 
  • Scanning with L-(13 N) glutamate: Assessment of the response to chemotherapy of a patient with embryonal rhabdomyosarcoma. 
  • Selective and reversible increase in the number of quisqualate-sensitive glutamate binding sites on hippocampal synaptic membranes after angular bundle kindling. 
  • Selective increase in L-[3H]glutamate binding to a quisqualate-sensitive site on hippocampal synaptic membranes after angular bundle kindling. 
  • Self-phase modulation signatures of neuronal activity 
  • Sensory neuron signaling to the brain: properties of transmitter release from olfactory nerve terminals. 
  • Seven novel mutations in the adenosine deaminase (ADA) gene in patients with severe and delayed onset combined immunodeficiency: G74C, V129M, G140E, R149W, Q199P, 462delG, and E337del. Mutations in brief no. 142. Online. 
  • Short TE in vivo (1)H MR spectroscopic imaging at 1.5 T: acquisition and automated spectral analysis. 
  • Shuttle mission effects on glutamate receptor expression in the developing rodent spinal cord. 
  • Smoothened is a therapeutic target for reducing glutamate toxicity in ischemic stroke. 
  • Sodium-dependent proline and glutamate uptake by hippocampal synaptosomes during postnatal development. 
  • Sodium-dependent proline uptake in the rat hippocampal formation: association with ipsilateral-commissural projections of CA3 pyramidal cells. 
  • Specific chromosomal abnormalities characterize four established cell lines derived from malignant human gliomas. 
  • Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. 
  • Structural and functional analysis of the spontaneous re-formation of the thiol ester bond in human alpha 2-macroglobulin, rat alpha 1-inhibitor-3 and chemically modified derivatives. 
  • Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex. 
  • Structural basis of diverse membrane target recognitions by ankyrins. 
  • Structural conservation of ion conduction pathways in K channels and glutamate receptors. 
  • Structural mechanism of glutamate receptor activation and desensitization. 
  • Synaptic Organization of Anterior Olfactory Nucleus Inputs to Piriform Cortex. 
  • Synaptic activation of presynaptic glutamate transporter currents in nerve terminals. 
  • Synaptic connections from multiple subfields contribute to granule cell hyperexcitability in hippocampal slice cultures. 
  • Temporal changes in glutamate, glutamate transporters, basilar arteries wall thickness, and neuronal variability in an experimental rat model of subarachnoid hemorrhage. 
  • The Mechanism of HdeA Unfolding and Chaperone Activation. 
  • The NMDA receptor M3 segment is a conserved transduction element coupling ligand binding to channel opening. 
  • The role of protein synthesis in striatal long-term depression. 
  • The role of skeletal muscle in liver glutathione metabolism during acetaminophen overdose. 
  • The role of the N-methyl-D-aspartate receptor in Alzheimer's disease: therapeutic potential. 
  • The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding. 
  • Thermodynamics of metal ion binding. 2. Metal ion binding by carbonic anhydrase variants. 
  • Thrombomodulin increases the rate of thrombin inhibition by BPTI. 
  • Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants. 
  • Uncompetitive antagonist binding: a biochemical index of activation of the NMDA receptor-coupled ion channel. 
  • Use of non-mammalian alternative models for neurotoxicological study. 
  • VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. 
  • Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades. 
  • Ventral cochlear nucleus responses to contralateral sound are mediated by commissural and olivocochlear pathways. 
  • Viral packaging ATPases utilize a glutamate switch to couple ATPase activity and DNA translocation. 
  • d-Amino Acid Peptide Residualizing Agents for Protein Radioiodination: Effect of Aspartate for Glutamate Substitution. 
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  Keywords of People

  • Guan, Ziqiang, Research Professor in Biochemistry, Biochemistry
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Rada Rincon, Pedro Vicente, Senior Lecturer in Neuroscience at Duke Kunshan University, DKU Faculty
  • Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering
  • Velkey, John Matthew, Assistant Professor of the Practice of Medical Education in the Department of Cell Biology, Cell Biology