Molecular Mimicry

• 

  Subject Areas on Research

  • A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics. 
  • A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity. 
  • A synthetic mimic of the secretory granule for drug delivery. 
  • AIDS/HIV. Host controls of HIV neutralizing antibodies. 
  • APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response. 
  • Amphipathic small molecules mimic the binding mode and function of endogenous transcription factors. 
  • Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds. 
  • Antibody-selected mimics of hepatitis C virus hypervariable region 1 activate both primary and memory Th lymphocytes. 
  • ApoB. 
  • Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A. 
  • Autoantibodies to the alpha/beta T-cell receptors in human immunodeficiency virus infection: dysregulation and mimicry. 
  • Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site. 
  • Biomimetic materials: marine inspiration. 
  • Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer. 
  • Boranophosphates support the RNase H cleavage of polyribonucleotides. 
  • Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. 
  • Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumors. 
  • Complex chemistry and biology of redox-active compounds, commonly known as SOD mimics, affect their therapeutic effects. 
  • Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold. 
  • Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine. 
  • Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae. 
  • Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry. 
  • Extreme electronic modulation of the cofacial porphyrin structural motif. 
  • Fe3O4 magnetic nanoparticles as peroxidase mimetics and their applications in H2O2 and glucose detection. 
  • GB virus type C envelope protein E2 elicits antibodies that react with a cellular antigen on HIV-1 particles and neutralize diverse HIV-1 isolates. 
  • HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism. 
  • Heparin mimicking polymer promotes myogenic differentiation of muscle progenitor cells. 
  • Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. 
  • Isomeric N-alkylpyridylporphyrins and their Zn(II) complexes: inactive as SOD mimics but powerful photosensitizers. 
  • Manganese porphyrins and related compounds as mimics of superoxide dismutase. 
  • Manganese superoxide dismutase, MnSOD and its mimics. 
  • Manganese superoxide dismutase-mediated inside-out signaling in HaCaT human keratinocytes and SKH-1 mouse skin. 
  • Manganese-based superoxide dismutase mimics modify both acute and long-term outcome severity in a Drosophila melanogaster model of classic galactosemia. 
  • Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide. 
  • Molecular mechanical properties of short-sequence peptide enzyme mimics. 
  • New approach to the activation of anti-cancer pro-drugs by metalloporphyrin-based cytochrome P450 mimics in all-aqueous biologically relevant system. 
  • New class of potent catalysts of O2.-dismutation. Mn(III) ortho-methoxyethylpyridyl- and di-ortho-methoxyethylimidazolylporphyrins. 
  • Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1. 
  • Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures. 
  • RNA surfaces as functional mimetics of proteins. 
  • Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth. 
  • Retinoid regulation of the zebrafish cyp26a1 promoter. 
  • SOD enzymes and their mimics in cancer: pro vs anti-oxidative mode of action. Part I. 
  • SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways. 
  • SOD-like activity of Mn(II) beta-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itself. 
  • Structural basis for highly effective HIV-1 neutralization by CD4-mimetic miniproteins revealed by 1.5 Å cocrystal structure of gp120 and M48U1. 
  • Structural mechanism of trimeric HIV-1 envelope glycoprotein activation. 
  • Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4. 
  • Synthesis and biological activity of a novel methylamine-bridged enkephalin analogue (MABE): a new route to cyclic peptides and peptidomimetics. 
  • Synthesis of a novel nucleic acid mimic: P-boranomethylphosphonate. 
  • Synthesis, siderophore activity and iron(III) chelation chemistry of a novel mono-hydroxamate, bis-catecholate siderophore mimic: N(alpha),-N(epsilon)-Bis[2,3-dihydroxybenzoyl]-l-lysyl-(gamma-N-methyl-N-hydroxyamido)-L-glutamic acid. 
  • The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3. 
  • The antigenic properties of bacterial DNA in normal and aberrant immunity. 
  • The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures. 
  • The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. 
  • The promotion of microvasculature formation in poly(ethylene glycol) diacrylate hydrogels by an immobilized VEGF-mimetic peptide. 
  • Use of SDS micelles to stabilize a ternary intermediate in the reaction of ferrioxamine B and 1,10-phenanthroline. 
  • Viral receptor-binding site antibodies with diverse germline origins. 
• 

  Keywords of People

  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology