-
Subject Areas on Research
-
A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics.
-
A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity.
-
A synthetic mimic of the secretory granule for drug delivery.
-
AIDS/HIV. Host controls of HIV neutralizing antibodies.
-
APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response.
-
Amphipathic small molecules mimic the binding mode and function of endogenous transcription factors.
-
Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds.
-
Antibody-selected mimics of hepatitis C virus hypervariable region 1 activate both primary and memory Th lymphocytes.
-
ApoB.
-
Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A.
-
Autoantibodies to the alpha/beta T-cell receptors in human immunodeficiency virus infection: dysregulation and mimicry.
-
Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site.
-
Biomimetic materials: marine inspiration.
-
Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer.
-
Boranophosphates support the RNase H cleavage of polyribonucleotides.
-
Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.
-
Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumors.
-
Complex chemistry and biology of redox-active compounds, commonly known as SOD mimics, affect their therapeutic effects.
-
Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold.
-
Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine.
-
Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae.
-
Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry.
-
Extreme electronic modulation of the cofacial porphyrin structural motif.
-
Fe3O4 magnetic nanoparticles as peroxidase mimetics and their applications in H2O2 and glucose detection.
-
GB virus type C envelope protein E2 elicits antibodies that react with a cellular antigen on HIV-1 particles and neutralize diverse HIV-1 isolates.
-
HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism.
-
Heparin mimicking polymer promotes myogenic differentiation of muscle progenitor cells.
-
Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma.
-
Isomeric N-alkylpyridylporphyrins and their Zn(II) complexes: inactive as SOD mimics but powerful photosensitizers.
-
Manganese porphyrins and related compounds as mimics of superoxide dismutase.
-
Manganese superoxide dismutase, MnSOD and its mimics.
-
Manganese superoxide dismutase-mediated inside-out signaling in HaCaT human keratinocytes and SKH-1 mouse skin.
-
Manganese-based superoxide dismutase mimics modify both acute and long-term outcome severity in a Drosophila melanogaster model of classic galactosemia.
-
Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.
-
Molecular mechanical properties of short-sequence peptide enzyme mimics.
-
New approach to the activation of anti-cancer pro-drugs by metalloporphyrin-based cytochrome P450 mimics in all-aqueous biologically relevant system.
-
New class of potent catalysts of O2.-dismutation. Mn(III) ortho-methoxyethylpyridyl- and di-ortho-methoxyethylimidazolylporphyrins.
-
Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1.
-
Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures.
-
RNA surfaces as functional mimetics of proteins.
-
Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.
-
Retinoid regulation of the zebrafish cyp26a1 promoter.
-
SOD enzymes and their mimics in cancer: pro vs anti-oxidative mode of action. Part I.
-
SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways.
-
SOD-like activity of Mn(II) beta-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itself.
-
Structural basis for highly effective HIV-1 neutralization by CD4-mimetic miniproteins revealed by 1.5 Å cocrystal structure of gp120 and M48U1.
-
Structural mechanism of trimeric HIV-1 envelope glycoprotein activation.
-
Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4.
-
Synthesis and biological activity of a novel methylamine-bridged enkephalin analogue (MABE): a new route to cyclic peptides and peptidomimetics.
-
Synthesis of a novel nucleic acid mimic: P-boranomethylphosphonate.
-
Synthesis, siderophore activity and iron(III) chelation chemistry of a novel mono-hydroxamate, bis-catecholate siderophore mimic: N(alpha),-N(epsilon)-Bis[2,3-dihydroxybenzoyl]-l-lysyl-(gamma-N-methyl-N-hydroxyamido)-L-glutamic acid.
-
The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3.
-
The antigenic properties of bacterial DNA in normal and aberrant immunity.
-
The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.
-
The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.
-
The promotion of microvasculature formation in poly(ethylene glycol) diacrylate hydrogels by an immobilized VEGF-mimetic peptide.
-
Use of SDS micelles to stabilize a ternary intermediate in the reaction of ferrioxamine B and 1,10-phenanthroline.
-
Viral receptor-binding site antibodies with diverse germline origins.
-
Keywords of People