Muscarinic Agonists

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  Subject Areas on Research

  • Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty. 
  • Chronic high-fat diet decreased detrusor mitochondrial respiration and increased nerve-mediated contractions. 
  • Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia. 
  • Elimination of GRK2 from cholinergic neurons reduces behavioral sensitivity to muscarinic receptor activation. 
  • Glutamate receptor involvement in dentate granule cell epileptiform activity evoked by mossy fiber stimulation. 
  • Modest increase in extracellular potassium unmasks effect of recurrent mossy fiber growth. 
  • Morphologic integration of hilar ectopic granule cells into dentate gyrus circuitry in the pilocarpine model of temporal lobe epilepsy. 
  • Muscarinic inhibition of substance P induced ion secretion in piglet jejunum. 
  • Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice. 
  • Nicotine therapy in adulthood reverses the synaptic and behavioral deficits elicited by prenatal exposure to phenobarbital. 
  • Nicotinic, muscarinic and dopaminergic actions in the ventral hippocampus and the nucleus accumbens: effects on spatial working memory in rats. 
  • Ontogeny of regulatory mechanisms for beta-adrenoceptor control of rat cardiac adenylyl cyclase: targeting of G-proteins and the cyclase catalytic subunit. 
  • Pilocarpine seizures cause age-dependent impairment in auditory location discrimination. 
  • Pilocarpine-induced dilation of Schlemm's canal and prevention of lumen collapse at elevated intraocular pressures in living mice visualized by OCT. 
  • Prenatal choline exposure alters hippocampal responsiveness to cholinergic stimulation in adulthood. 
  • Receptor crosstalk: effects of prolonged carbachol exposure on beta 1-adrenoceptors and adenylyl cyclase activity in neonatal rat ventricular myocytes. 
  • Status epilepticus-induced hilar basal dendrites on rodent granule cells contribute to recurrent excitatory circuitry. 
  • Stereological analysis of GluR2-immunoreactive hilar neurons in the pilocarpine model of temporal lobe epilepsy: correlation of cell loss with mossy fiber sprouting. 
  • Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses. 
  • The cellular and synaptic location of activated TrkB in mouse hippocampus during limbic epileptogenesis. 
  • The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival. 
  • The structure of the trabecular meshwork, its connections to the ciliary muscle, and the effect of pilocarpine on outflow facility in mice. 
  • Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits.